Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.187 0.283 -9999.0 0.0 -0.549 43.0 43.0 IHH -0.023 0.086 -9999.0 0.0 -0.163 4.0 4.0 SHH Np/Cholesterol/GAS1 0.017 0.042 -9999.0 0.0 -0.286 2.0 2.0 LRPAP1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.017 0.042 0.284 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.082 0.174 -9999.0 0.0 -0.299 42.0 42.0 SMO -0.094 0.174 -9999.0 0.0 -0.311 43.0 43.0 AKT1 -0.022 0.105 -9999.0 0.0 -0.489 2.0 2.0 ARRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.096 -9999.0 0.0 -0.5 4.0 4.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.172 -9999.0 0.0 -0.307 43.0 43.0 STIL -0.067 0.146 0.304 1.0 -0.244 42.0 43.0 DHH N/PTCH2 0.02 0.097 -9999.0 0.0 -0.363 7.0 7.0 DHH N/PTCH1 -0.089 0.186 -9999.0 0.0 -0.305 47.0 47.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 DHH 0.013 0.096 -9999.0 0.0 -0.5 4.0 4.0 PTHLH -0.344 0.473 -9999.0 0.0 -0.919 47.0 47.0 determination of left/right symmetry -0.093 0.172 -9999.0 0.0 -0.307 43.0 43.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 skeletal system development -0.34 0.467 -9999.0 0.0 -0.906 47.0 47.0 IHH N/Hhip -0.071 0.165 -9999.0 0.0 -0.408 21.0 21.0 DHH N/Hhip -0.04 0.171 -9999.0 0.0 -0.375 24.0 24.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.172 -9999.0 0.0 -0.307 43.0 43.0 pancreas development -0.062 0.203 -9999.0 0.0 -0.499 21.0 21.0 HHAT 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.075 -9999.0 0.0 -0.509 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.084 -9999.0 0.0 -0.5 3.0 3.0 somite specification -0.093 0.172 -9999.0 0.0 -0.307 43.0 43.0 SHH Np/Cholesterol/PTCH1 -0.077 0.139 -9999.0 0.0 -0.251 45.0 45.0 SHH Np/Cholesterol/PTCH2 0.015 0.05 -9999.0 0.0 -0.286 3.0 3.0 SHH Np/Cholesterol/Megalin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.012 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.1 0.184 -9999.0 0.0 -0.322 47.0 47.0 SMO/Vitamin D3 -0.079 0.163 -9999.0 0.0 -0.278 45.0 45.0 SHH Np/Cholesterol/Hhip -0.017 0.1 -9999.0 0.0 -0.284 14.0 14.0 LRP2 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.081 0.157 -9999.0 0.0 -0.275 43.0 43.0 SHH Np/Cholesterol/BOC 0.012 0.057 -9999.0 0.0 -0.286 4.0 4.0 SHH Np/Cholesterol/CDO 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.017 0.1 0.282 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.057 0.169 0.377 4.0 -0.252 45.0 49.0 IHH N/PTCH2 -0.006 0.086 -9999.0 0.0 -0.4 3.0 3.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.096 0.188 -9999.0 0.0 -0.324 47.0 47.0 Megalin/LRPAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.018 0.084 -9999.0 0.0 -0.5 3.0 3.0 SHH Np/Cholesterol 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.1 0.185 -9999.0 0.0 -0.323 47.0 47.0 HHIP -0.062 0.203 -9999.0 0.0 -0.5 21.0 21.0