Signaling events regulated by Ret tyrosine kinase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 -0.031 0.084 -9999.0 0.0 -0.425 3.0 3.0 Crk/p130 Cas/Paxillin -0.119 0.12 -9999.0 0.0 -0.33 8.0 8.0 JUN -0.164 0.191 -9999.0 0.0 -0.371 41.0 41.0 HRAS 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/GRB10 -0.126 0.179 -9999.0 0.0 -0.29 61.0 61.0 RAP1A 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 FRS2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GDP 0.02 0.035 -9999.0 0.0 -0.36 1.0 1.0 RET51/GFRalpha1/GDNF/DOK1 -0.124 0.181 -9999.0 0.0 -0.281 65.0 65.0 EntrezGene:5979 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Enigma 0.032 0.063 -9999.0 0.0 -0.269 4.0 4.0 RHOA 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP -0.116 0.162 -9999.0 0.0 -0.26 63.0 63.0 GRB7 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF -0.126 0.181 -9999.0 0.0 -0.29 62.0 62.0 MAPKKK cascade -0.127 0.153 -9999.0 0.0 -0.271 57.0 57.0 BCAR1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/IRS1 0.02 0.093 -9999.0 0.0 -0.296 8.0 8.0 lamellipodium assembly -0.089 0.117 -9999.0 0.0 -0.301 9.0 9.0 RET51/GFRalpha1/GDNF/SHC -0.122 0.168 -9999.0 0.0 -0.282 59.0 59.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 RET9/GFRalpha1/GDNF/SHC 0.033 0.045 -9999.0 0.0 -0.282 1.0 1.0 RET9/GFRalpha1/GDNF/Shank3 0.032 0.063 -9999.0 0.0 -0.269 4.0 4.0 MAPK3 -0.125 0.15 0.307 3.0 -0.261 54.0 57.0 DOK1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DOK6 -0.01 0.141 -9999.0 0.0 -0.5 9.0 9.0 PXN 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 neurite development -0.124 0.137 0.334 1.0 -0.364 8.0 9.0 DOK5 0.019 0.069 -9999.0 0.0 -0.5 2.0 2.0 GFRA1 0.008 0.107 -9999.0 0.0 -0.5 5.0 5.0 MAPK8 -0.135 0.159 -9999.0 0.0 -0.275 55.0 55.0 HRAS/GTP -0.134 0.177 -9999.0 0.0 -0.292 61.0 61.0 tube development 0.035 0.061 0.217 3.0 -0.267 3.0 6.0 MAPK1 -0.129 0.143 0.354 2.0 -0.261 54.0 56.0 RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.021 0.044 -9999.0 0.0 -0.232 3.0 3.0 Rac1/GDP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PDLIM7 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok6 -0.135 0.182 -9999.0 0.0 -0.286 65.0 65.0 SHC1 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok4 -0.128 0.178 -9999.0 0.0 -0.288 62.0 62.0 RET51/GFRalpha1/GDNF/Dok5 -0.126 0.178 -9999.0 0.0 -0.284 63.0 63.0 PRKCA 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CREB1 -0.042 0.083 -9999.0 0.0 -0.407 3.0 3.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.024 0.029 -9999.0 0.0 -0.232 1.0 1.0 RET51/GFRalpha1/GDNF/Grb7 -0.124 0.175 -9999.0 0.0 -0.286 61.0 61.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET -0.259 0.265 -9999.0 0.0 -0.5 65.0 65.0 DOK4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade -0.16 0.187 -9999.0 0.0 -0.451 26.0 26.0 RET9/GFRalpha1/GDNF/FRS2 0.032 0.059 -9999.0 0.0 -0.282 3.0 3.0 SHANK3 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.018 0.084 -9999.0 0.0 -0.5 3.0 3.0 NCK1 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.024 0.029 -9999.0 0.0 -0.234 1.0 1.0 RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.112 0.14 -9999.0 0.0 -0.241 60.0 60.0 RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.122 0.147 -9999.0 0.0 -0.248 64.0 64.0 RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.114 0.141 -9999.0 0.0 -0.243 57.0 57.0 PI3K -0.126 0.168 -9999.0 0.0 -0.452 9.0 9.0 SOS1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Shank3/Grb2 0.051 0.059 -9999.0 0.0 -0.267 3.0 3.0 GRB10 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 activation of MAPKK activity -0.065 0.107 -9999.0 0.0 -0.385 4.0 4.0 RET51/GFRalpha1/GDNF/FRS2 -0.124 0.179 -9999.0 0.0 -0.284 63.0 63.0 GAB1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.01 0.107 -9999.0 0.0 -0.5 5.0 5.0 IRS2 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.117 0.143 -9999.0 0.0 -0.245 59.0 59.0 RET51/GFRalpha1/GDNF/PKC alpha -0.125 0.178 -9999.0 0.0 -0.288 61.0 61.0 GRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GDNF 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/IRS1 -0.138 0.19 -9999.0 0.0 -0.299 64.0 64.0 Rac1/GTP -0.103 0.138 -9999.0 0.0 -0.36 9.0 9.0 RET9/GFRalpha1/GDNF 0.016 0.063 -9999.0 0.0 -0.301 4.0 4.0 GFRalpha1/GDNF 0.017 0.074 -9999.0 0.0 -0.356 4.0 4.0