Signaling events mediated by PTP1B Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB -0.04 0.181 -9999.0 0.0 -0.5 16.0 16.0 Jak2/Leptin Receptor -0.109 0.17 -9999.0 0.0 -0.383 22.0 22.0 PTP1B/AKT1 0.004 0.124 0.305 6.0 -0.271 8.0 14.0 FYN 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p210 bcr-abl/PTP1B -0.005 0.139 0.31 8.0 -0.3 9.0 17.0 EGFR 0.027 0.051 -9999.0 0.0 -0.507 1.0 1.0 EGF/EGFR 0.003 0.113 0.269 5.0 -0.313 5.0 10.0 CSF1 0.009 0.107 -9999.0 0.0 -0.5 5.0 5.0 AKT1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 INSR 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/N-cadherin -0.004 0.114 0.335 4.0 -0.281 7.0 11.0 Insulin Receptor/Insulin 0.019 0.118 0.299 6.0 -0.284 3.0 9.0 HCK 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 -0.004 0.137 0.311 9.0 -0.297 8.0 17.0 EGF 0.023 0.019 -9999.0 0.0 -9999.0 0.0 0.0 YES1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CAV1 0.008 0.138 0.312 11.0 -0.307 5.0 16.0 TXN 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTP1B/IRS1/GRB2 0.0 0.131 0.258 5.0 -0.289 10.0 15.0 cell migration 0.005 0.139 0.3 9.0 -0.31 8.0 17.0 STAT3 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRLR -0.108 0.227 -9999.0 0.0 -0.48 31.0 31.0 ITGA2B 0.019 0.068 -9999.0 0.0 -0.495 2.0 2.0 CSF1R 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Prolactin Receptor/Prolactin -0.121 0.218 -9999.0 0.0 -0.405 42.0 42.0 FGR 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 PTP1B/p130 Cas -0.004 0.12 0.244 6.0 -0.295 8.0 14.0 Crk/p130 Cas 0.005 0.121 0.252 6.0 -0.282 8.0 14.0 DOK1 -0.022 0.157 0.311 8.0 -0.324 14.0 22.0 JAK2 -0.089 0.168 0.324 1.0 -0.389 18.0 19.0 Jak2/Leptin Receptor/Leptin -0.131 0.147 -9999.0 0.0 -0.352 23.0 23.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 PTPN1 -0.006 0.139 0.311 8.0 -0.302 9.0 17.0 LYN 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH2 0.02 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.026 0.097 0.364 1.0 -0.54 2.0 3.0 ITGB3 -0.073 0.21 -9999.0 0.0 -0.502 23.0 23.0 CAT1/PTP1B -0.025 0.162 0.295 8.0 -0.363 11.0 19.0 CAPN1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CSK 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.019 0.122 0.258 1.0 -0.384 4.0 5.0 mol:H2O2 0.003 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.119 0.136 -9999.0 0.0 -0.33 22.0 22.0 negative regulation of transcription -0.088 0.166 0.323 1.0 -0.384 18.0 19.0 FCGR2A 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 FER 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 alphaIIb/beta3 Integrin -0.04 0.163 -9999.0 0.0 -0.359 24.0 24.0 BLK -0.04 0.181 -9999.0 0.0 -0.5 16.0 16.0 Insulin Receptor/Insulin/Shc 0.048 0.023 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 LEPR -0.033 0.169 -9999.0 0.0 -0.495 14.0 14.0 BCAR1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p210 bcr-abl/Grb2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:NADPH 0.002 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TRPV6 -0.044 0.188 -9999.0 0.0 -0.536 12.0 12.0 PRL -0.052 0.182 -9999.0 0.0 -0.466 18.0 18.0 SOCS3 -0.018 0.249 -9999.0 0.0 -1.201 5.0 5.0 SPRY2 0.016 0.098 -9999.0 0.0 -0.505 4.0 4.0 Insulin Receptor/Insulin/IRS1 0.038 0.075 -9999.0 0.0 -0.309 5.0 5.0 CSF1/CSF1R 0.005 0.147 0.307 6.0 -0.319 11.0 17.0 Ras protein signal transduction 0.021 0.132 0.553 6.0 -9999.0 0.0 6.0 IRS1 0.01 0.107 -9999.0 0.0 -0.5 5.0 5.0 INS 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0 LEP -0.202 0.25 -9999.0 0.0 -0.5 49.0 49.0 STAT5B -0.032 0.135 0.294 5.0 -0.299 13.0 18.0 STAT5A -0.032 0.135 0.294 5.0 -0.299 13.0 18.0 GRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB -0.03 0.167 0.304 6.0 -0.343 17.0 23.0 CSN2 -0.135 0.354 -9999.0 0.0 -1.418 8.0 8.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 LAT -0.013 0.138 -9999.0 0.0 -0.427 10.0 10.0 YBX1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.004 0.133 -9999.0 0.0 -0.5 8.0 8.0 SHC1 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NOX4 -0.024 0.168 -9999.0 0.0 -0.503 13.0 13.0