IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CD4-positive alpha-beta T cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.061 0.13 0.474 1.0 -9999.0 0.0 1.0 IL27/IL27R/JAK1 -0.052 0.178 -9999.0 0.0 -0.366 1.0 1.0 TBX21 -0.064 0.165 0.586 2.0 -0.417 3.0 5.0 IL12B 0.015 0.096 -9999.0 0.0 -0.5 4.0 4.0 IL12A 0.004 0.034 -9999.0 0.0 -0.361 1.0 1.0 IL6ST -0.188 0.266 -9999.0 0.0 -0.506 49.0 49.0 IL27RA/JAK1 0.016 0.05 -9999.0 0.0 -9999.0 0.0 0.0 IL27 0.022 0.02 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.1 0.153 -9999.0 0.0 -0.524 3.0 3.0 T-helper 2 cell differentiation 0.061 0.13 0.474 1.0 -9999.0 0.0 1.0 T cell proliferation during immune response 0.061 0.13 0.474 1.0 -9999.0 0.0 1.0 MAPKKK cascade -0.061 0.13 -9999.0 0.0 -0.474 1.0 1.0 STAT3 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of tyrosine phosphorylation of STAT protein 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.067 0.182 0.511 3.0 -0.56 4.0 7.0 IL27/IL27R/JAK2/TYK2 -0.061 0.131 -9999.0 0.0 -0.48 1.0 1.0 positive regulation of T cell mediated cytotoxicity -0.061 0.13 -9999.0 0.0 -0.474 1.0 1.0 STAT1 (dimer) -0.058 0.209 0.543 3.0 -0.541 3.0 6.0 JAK2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JAK1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 (dimer) -0.048 0.135 -9999.0 0.0 -0.459 1.0 1.0 T cell proliferation -0.151 0.187 -9999.0 0.0 -0.456 23.0 23.0 IL12/IL12R/TYK2/JAK2 0.005 0.196 -9999.0 0.0 -0.741 7.0 7.0 IL17A -0.101 0.153 -9999.0 0.0 -0.525 3.0 3.0 mast cell activation 0.061 0.13 0.474 1.0 -9999.0 0.0 1.0 IFNG -0.001 0.035 0.126 3.0 -0.083 3.0 6.0 T cell differentiation -0.004 0.006 -9999.0 0.0 -0.016 3.0 3.0 STAT3 (dimer) -0.049 0.129 -9999.0 0.0 -9999.0 0.0 0.0 STAT5A (dimer) -0.05 0.133 -9999.0 0.0 -0.459 1.0 1.0 STAT4 (dimer) -0.049 0.137 -9999.0 0.0 -0.437 1.0 1.0 STAT4 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 T cell activation -0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IL27R/JAK2/TYK2 -0.072 0.163 -9999.0 0.0 -9999.0 0.0 0.0 GATA3 -0.033 0.267 0.574 1.0 -1.276 5.0 6.0 IL18 0.009 0.002 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of mast cell cytokine production -0.048 0.128 -9999.0 0.0 -9999.0 0.0 0.0 IL27/EBI3 0.039 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IL27RA -0.002 0.025 -9999.0 0.0 -9999.0 0.0 0.0 IL6 -0.167 0.255 -9999.0 0.0 -0.5 44.0 44.0 STAT5A 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 monocyte differentiation 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL2 -0.006 0.031 -9999.0 0.0 -9999.0 0.0 0.0 IL1B 0.006 0.034 -9999.0 0.0 -0.361 1.0 1.0 EBI3 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.023 0.102 -9999.0 0.0 -0.361 10.0 10.0