ErbB2/ErbB3 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations USP8 -0.005 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.026 0.127 -9999.0 0.0 -0.293 15.0 15.0 NFATC4 -0.029 0.113 0.369 3.0 -0.237 15.0 18.0 ERBB2IP 0.023 0.068 -9999.0 0.0 -0.496 2.0 2.0 HSP90 (dimer) 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mammary gland morphogenesis -0.044 0.108 -9999.0 0.0 -0.29 17.0 17.0 JUN -0.017 0.1 0.261 4.0 -9999.0 0.0 4.0 HRAS 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DOCK7 -0.048 0.107 -9999.0 0.0 -0.282 17.0 17.0 ErbB2/ErbB3/neuregulin 1 beta/SHC -0.006 0.128 0.245 1.0 -0.305 17.0 18.0 AKT1 0.006 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BAD -0.004 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.025 0.086 0.226 4.0 -0.256 3.0 7.0 mol:GTP -0.002 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ErbB2/ErbB3/neuregulin 1 beta -0.047 0.117 -9999.0 0.0 -0.311 17.0 17.0 RAF1 -0.032 0.157 0.327 7.0 -0.313 15.0 22.0 ErbB2/ErbB3/neuregulin 2 -0.023 0.127 -9999.0 0.0 -0.313 18.0 18.0 STAT3 0.032 0.074 -9999.0 0.0 -0.759 1.0 1.0 cell migration -0.01 0.112 0.317 7.0 -0.222 4.0 11.0 mol:PI-3-4-5-P3 -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.216 0.328 0.512 2.0 -0.611 37.0 39.0 FOS -0.23 0.303 0.443 4.0 -0.476 69.0 73.0 NRAS 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.044 0.108 -9999.0 0.0 -0.29 17.0 17.0 MAPK3 -0.138 0.26 0.488 2.0 -0.519 24.0 26.0 MAPK1 -0.156 0.281 0.478 2.0 -0.544 28.0 30.0 JAK2 -0.05 0.105 -9999.0 0.0 -0.282 17.0 17.0 NF2 0.009 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.021 0.118 0.209 2.0 -0.286 17.0 19.0 NRG1 0.021 0.051 -9999.0 0.0 -0.507 1.0 1.0 GRB2/SOS1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.052 0.127 -9999.0 0.0 -0.302 22.0 22.0 MAPK9 -0.023 0.076 0.217 3.0 -0.232 1.0 4.0 ERBB2 -0.02 0.036 0.352 1.0 -9999.0 0.0 1.0 ERBB3 -0.05 0.186 -9999.0 0.0 -0.504 17.0 17.0 SHC1 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.005 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) 0.032 0.073 -9999.0 0.0 -0.744 1.0 1.0 RNF41 -0.009 0.01 -9999.0 0.0 -9999.0 0.0 0.0 FRAP1 -0.002 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAC1-CDC42/GTP -0.041 0.078 -9999.0 0.0 -0.217 17.0 17.0 ErbB2/ErbB2/HSP90 (dimer) -0.002 0.034 0.257 1.0 -9999.0 0.0 1.0 CHRNA1 -0.127 0.256 0.472 2.0 -0.502 26.0 28.0 myelination -0.008 0.147 0.4 8.0 -0.353 1.0 9.0 PPP3CB -0.046 0.1 -9999.0 0.0 -0.265 17.0 17.0 KRAS 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAC1-CDC42/GDP 0.013 0.119 -9999.0 0.0 -0.26 15.0 15.0 NRG2 0.017 0.084 -9999.0 0.0 -0.5 3.0 3.0 mol:GDP -0.021 0.118 0.208 2.0 -0.284 17.0 19.0 SOS1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 -0.056 0.163 0.32 6.0 -0.341 14.0 20.0 SRC 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:cAMP -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 -0.043 0.109 -9999.0 0.0 -0.28 17.0 17.0 MAP2K1 -0.14 0.244 0.428 2.0 -0.468 27.0 29.0 heart morphogenesis -0.044 0.108 -9999.0 0.0 -0.29 17.0 17.0 RAS family/GDP 0.004 0.13 0.28 1.0 -0.278 15.0 16.0 GRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CHRNE 0.001 0.024 0.133 1.0 -9999.0 0.0 1.0 HSP90AA1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 activation of caspase activity -0.006 0.009 -9999.0 0.0 -9999.0 0.0 0.0 nervous system development -0.044 0.108 -9999.0 0.0 -0.29 17.0 17.0 CDC42 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0