IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.097 0.264 0.637 1.0 -0.683 5.0 6.0 CRP -0.08 0.288 0.582 4.0 -0.687 5.0 9.0 cell cycle arrest -0.121 0.286 -9999.0 0.0 -0.637 13.0 13.0 TIMP1 -0.092 0.243 -9999.0 0.0 -0.588 6.0 6.0 IL6ST -0.186 0.261 -9999.0 0.0 -0.497 49.0 49.0 Rac1/GDP -0.174 0.258 -9999.0 0.0 -0.502 37.0 37.0 AP1 -0.127 0.216 -9999.0 0.0 -0.467 19.0 19.0 GAB2 0.024 0.068 -9999.0 0.0 -0.499 2.0 2.0 TNFSF11 -0.153 0.363 -9999.0 0.0 -1.031 12.0 12.0 HSP90B1 0.016 0.095 -9999.0 0.0 -0.642 1.0 1.0 GAB1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAPK14 -0.199 0.262 -9999.0 0.0 -0.578 32.0 32.0 AKT1 0.028 0.067 -9999.0 0.0 -0.403 2.0 2.0 FOXO1 0.03 0.071 0.329 1.0 -0.375 2.0 3.0 MAP2K6 -0.205 0.261 -9999.0 0.0 -0.54 37.0 37.0 mol:GTP 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.156 0.247 -9999.0 0.0 -0.476 36.0 36.0 MITF -0.195 0.262 -9999.0 0.0 -0.53 37.0 37.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 A2M 0.004 0.17 -9999.0 0.0 -1.05 3.0 3.0 CEBPB 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1/GAB family/SHP2 -0.033 0.089 -9999.0 0.0 -0.304 1.0 1.0 STAT3 -0.142 0.293 -9999.0 0.0 -0.681 13.0 13.0 STAT1 0.003 0.089 -9999.0 0.0 -0.924 1.0 1.0 CEBPD -0.096 0.271 0.583 2.0 -0.683 5.0 7.0 PIK3CA 0.028 0.049 -9999.0 0.0 -0.5 1.0 1.0 PI3K 0.038 0.075 -9999.0 0.0 -0.507 2.0 2.0 JUN -0.04 0.182 -9999.0 0.0 -0.5 16.0 16.0 PIAS3/MITF -0.178 0.254 -9999.0 0.0 -0.498 37.0 37.0 MAPK11 -0.199 0.264 -9999.0 0.0 -0.58 32.0 32.0 STAT3 (dimer)/FOXO1 -0.097 0.226 0.443 1.0 -0.525 9.0 10.0 GRB2/SOS1/GAB family -0.156 0.257 -9999.0 0.0 -0.528 30.0 30.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.203 0.264 -9999.0 0.0 -0.416 58.0 58.0 GRB2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LBP -0.119 0.297 0.584 1.0 -0.767 10.0 11.0 PIK3R1 0.024 0.069 -9999.0 0.0 -0.499 2.0 2.0 JAK1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.101 0.283 0.583 2.0 -0.733 6.0 8.0 FGG -0.106 0.26 -9999.0 0.0 -0.687 5.0 5.0 macrophage differentiation -0.121 0.286 -9999.0 0.0 -0.637 13.0 13.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.187 0.257 -9999.0 0.0 -0.386 66.0 66.0 JUNB -0.097 0.255 0.612 1.0 -0.659 5.0 6.0 FOS -0.237 0.265 -9999.0 0.0 -0.5 60.0 60.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.207 0.273 -9999.0 0.0 -0.548 38.0 38.0 STAT1/PIAS1 -0.16 0.253 -9999.0 0.0 -0.483 36.0 36.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.026 0.083 -9999.0 0.0 -0.509 2.0 2.0 STAT3 (dimer) -0.131 0.291 -9999.0 0.0 -0.663 13.0 13.0 PRKCD -0.127 0.262 0.55 3.0 -0.487 28.0 31.0 IL6R -0.03 0.165 -9999.0 0.0 -0.499 13.0 13.0 SOCS3 -0.198 0.304 0.439 1.0 -0.608 32.0 33.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.085 0.183 -9999.0 0.0 -0.3 49.0 49.0 Rac1/GTP -0.169 0.259 -9999.0 0.0 -0.505 36.0 36.0 HCK 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade 0.0 0.106 -9999.0 0.0 -0.505 2.0 2.0 bone resorption -0.141 0.339 -9999.0 0.0 -0.942 12.0 12.0 IRF1 -0.099 0.267 0.599 2.0 -0.683 5.0 7.0 mol:GDP -0.186 0.261 -9999.0 0.0 -0.511 38.0 38.0 SOS1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.192 0.263 -9999.0 0.0 -0.52 38.0 38.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.217 0.301 -9999.0 0.0 -0.66 32.0 32.0 PTPN11 0.006 0.06 -9999.0 0.0 -0.58 1.0 1.0 IL6/IL6RA -0.139 0.222 -9999.0 0.0 -0.383 50.0 50.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.087 0.182 -9999.0 0.0 -0.303 49.0 49.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.089 0.181 -9999.0 0.0 -0.303 49.0 49.0 IL6 -0.164 0.258 -9999.0 0.0 -0.501 44.0 44.0 PIAS3 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTPRE 0.019 0.052 -9999.0 0.0 -0.51 1.0 1.0 PIAS1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.212 0.267 -9999.0 0.0 -0.404 66.0 66.0 LMO4 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer)/PIAS3 -0.152 0.273 -9999.0 0.0 -0.586 25.0 25.0 MCL1 0.054 0.089 0.511 1.0 -9999.0 0.0 1.0