Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.053 0.173 -9999.0 0.0 -0.593 36.0 36.0 IHH -0.128 0.2 -9999.0 0.0 -0.393 189.0 189.0 SHH Np/Cholesterol/GAS1 -0.146 0.13 -9999.0 0.0 -0.234 348.0 348.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.145 0.129 0.233 348.0 -9999.0 0.0 348.0 SMO/beta Arrestin2 -0.051 0.154 -9999.0 0.0 -0.296 136.0 136.0 SMO -0.059 0.161 -9999.0 0.0 -0.316 137.0 137.0 AKT1 -0.017 0.095 -9999.0 0.0 -0.473 6.0 6.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.075 -9999.0 0.0 -0.41 18.0 18.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 STIL -0.048 0.115 -9999.0 0.0 -0.339 33.0 33.0 DHH N/PTCH2 -0.024 0.106 -9999.0 0.0 -0.295 70.0 70.0 DHH N/PTCH1 -0.059 0.137 -9999.0 0.0 -0.351 51.0 51.0 PIK3CA 0.01 0.018 -9999.0 0.0 -0.41 1.0 1.0 DHH -0.024 0.115 -9999.0 0.0 -0.41 44.0 44.0 PTHLH -0.068 0.21 -9999.0 0.0 -0.648 36.0 36.0 determination of left/right symmetry -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 PIK3R1 0.007 0.04 -9999.0 0.0 -0.41 5.0 5.0 skeletal system development -0.067 0.208 -9999.0 0.0 -0.641 36.0 36.0 IHH N/Hhip -0.079 0.132 -9999.0 0.0 -0.264 157.0 157.0 DHH N/Hhip -0.024 0.099 -9999.0 0.0 -0.264 77.0 77.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 pancreas development -0.012 0.087 -9999.0 0.0 -0.342 35.0 35.0 HHAT 0.008 0.036 -9999.0 0.0 -0.41 4.0 4.0 PI3K 0.013 0.031 -9999.0 0.0 -0.28 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.257 0.203 -9999.0 0.0 -0.41 346.0 346.0 somite specification -0.059 0.159 -9999.0 0.0 -0.312 137.0 137.0 SHH Np/Cholesterol/PTCH1 -0.051 0.115 -9999.0 0.0 -0.357 26.0 26.0 SHH Np/Cholesterol/PTCH2 -0.017 0.079 -9999.0 0.0 -0.179 99.0 99.0 SHH Np/Cholesterol/Megalin -0.067 0.103 -9999.0 0.0 -0.176 238.0 238.0 SHH -0.015 0.082 -9999.0 0.0 -0.223 73.0 73.0 catabolic process -0.053 0.136 -9999.0 0.0 -0.258 152.0 152.0 SMO/Vitamin D3 -0.048 0.139 -9999.0 0.0 -0.401 26.0 26.0 SHH Np/Cholesterol/Hhip -0.017 0.075 -9999.0 0.0 -0.223 19.0 19.0 LRP2 -0.11 0.162 -9999.0 0.0 -0.329 193.0 193.0 receptor-mediated endocytosis -0.074 0.136 -9999.0 0.0 -0.321 79.0 79.0 SHH Np/Cholesterol/BOC -0.012 0.073 -9999.0 0.0 -0.228 23.0 23.0 SHH Np/Cholesterol/CDO -0.029 0.096 -9999.0 0.0 -0.202 118.0 118.0 mesenchymal cell differentiation 0.017 0.074 0.222 19.0 -9999.0 0.0 19.0 mol:Vitamin D3 -0.04 0.122 -9999.0 0.0 -0.353 27.0 27.0 IHH N/PTCH2 -0.079 0.138 -9999.0 0.0 -0.277 148.0 148.0 CDON -0.035 0.131 -9999.0 0.0 -0.41 59.0 59.0 IHH N/PTCH1 -0.034 0.148 -9999.0 0.0 -0.26 152.0 152.0 Megalin/LRPAP1 -0.067 0.111 -9999.0 0.0 -0.217 193.0 193.0 PTCH2 -0.012 0.096 -9999.0 0.0 -0.41 30.0 30.0 SHH Np/Cholesterol -0.012 0.06 -9999.0 0.0 -0.165 73.0 73.0 PTCH1 -0.053 0.136 -9999.0 0.0 -0.258 152.0 152.0 HHIP -0.012 0.087 -9999.0 0.0 -0.343 35.0 35.0