Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Aurora B signaling	177.0	11901.0	67.0	-0.519	0.011	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	167.0	8546.0	51.0	-0.966	0.011	1000.0	-1000.0	-0.146	-1000.0
HIF-1-alpha transcription factor network	149.0	11356.0	76.0	-0.487	0.017	1000.0	-1000.0	-0.056	-1000.0
Aurora C signaling	137.0	961.0	7.0	-0.288	0.009	1000.0	-1000.0	-0.017	-1000.0
Signaling events regulated by Ret tyrosine kinase	118.0	9690.0	82.0	-0.188	0.011	1000.0	-1000.0	-0.049	-1000.0
Endothelins	108.0	10392.0	96.0	-0.337	0.011	1000.0	-1000.0	-0.046	-1000.0
Angiopoietin receptor Tie2-mediated signaling	107.0	9473.0	88.0	-0.317	0.043	1000.0	-1000.0	-0.073	-1000.0
PDGFR-alpha signaling pathway	99.0	4373.0	44.0	-0.294	0.025	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	98.0	12336.0	125.0	-0.2	0.03	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by the Hedgehog family	88.0	4601.0	52.0	-0.257	0.145	1000.0	-1000.0	-0.017	-1000.0
Integrins in angiogenesis	78.0	6619.0	84.0	-0.29	0.024	1000.0	-1000.0	-0.048	-1000.0
Cellular roles of Anthrax toxin	70.0	2760.0	39.0	-0.127	0.019	1000.0	-1000.0	-0.018	-1000.0
Nongenotropic Androgen signaling	67.0	3487.0	52.0	-0.216	0.107	1000.0	-1000.0	-0.035	-1000.0
Wnt signaling	61.0	430.0	7.0	-0.088	-0.003	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-alpha and p38-beta	60.0	2670.0	44.0	-0.084	0.011	1000.0	-1000.0	-0.029	-1000.0
Fc-epsilon receptor I signaling in mast cells	59.0	5786.0	97.0	-0.126	0.028	1000.0	-1000.0	-0.045	-1000.0
S1P3 pathway	59.0	2518.0	42.0	-0.411	0.016	1000.0	-1000.0	-0.023	-1000.0
Effects of Botulinum toxin	56.0	1473.0	26.0	-0.112	0.018	1000.0	-1000.0	-0.035	-1000.0
Glypican 1 network	55.0	2653.0	48.0	-0.217	0.022	1000.0	-1000.0	-0.015	-1000.0
LPA4-mediated signaling events	54.0	648.0	12.0	-0.124	0.015	1000.0	-1000.0	-0.008	-1000.0
PLK1 signaling events	53.0	4552.0	85.0	-0.295	0.044	1000.0	-1000.0	-0.024	-1000.0
Reelin signaling pathway	51.0	2882.0	56.0	-0.154	0.03	1000.0	-1000.0	-0.049	-1000.0
IGF1 pathway	50.0	2899.0	57.0	-0.075	0.022	1000.0	-1000.0	-0.049	-1000.0
Aurora A signaling	49.0	2998.0	60.0	-0.253	0.022	1000.0	-1000.0	-0.018	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	48.0	5840.0	120.0	-0.188	0.138	1000.0	-1000.0	-0.048	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	47.0	3237.0	68.0	-0.203	0.079	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	47.0	3672.0	78.0	-0.1	0.043	1000.0	-1000.0	-0.041	-1000.0
Noncanonical Wnt signaling pathway	46.0	1206.0	26.0	-0.136	0.011	1000.0	-1000.0	-0.022	-1000.0
TCGA08_retinoblastoma	46.0	368.0	8.0	-0.134	0.024	1000.0	-1000.0	-0.008	-1000.0
Thromboxane A2 receptor signaling	44.0	4680.0	105.0	-0.176	0.031	1000.0	-1000.0	-0.04	-1000.0
Plasma membrane estrogen receptor signaling	43.0	3725.0	86.0	-0.152	0.066	1000.0	-1000.0	-0.046	-1000.0
amb2 Integrin signaling	42.0	3456.0	82.0	-0.149	0.022	1000.0	-1000.0	-0.042	-1000.0
Syndecan-1-mediated signaling events	41.0	1412.0	34.0	-0.171	0.011	1000.0	-1000.0	-0.022	-1000.0
BMP receptor signaling	41.0	3379.0	81.0	-0.277	0.038	1000.0	-1000.0	-0.049	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	39.0	1358.0	34.0	-0.039	0.011	1000.0	-1000.0	-0.019	-1000.0
Ephrin A  reverse signaling	38.0	271.0	7.0	-0.023	-0.0	1000.0	-1000.0	-0.013	-1000.0
IL4-mediated signaling events	38.0	3463.0	91.0	-0.521	0.265	1000.0	-1000.0	-0.124	-1000.0
FOXA2 and FOXA3 transcription factor networks	38.0	1777.0	46.0	-0.225	0.016	1000.0	-1000.0	-0.065	-1000.0
Ras signaling in the CD4+ TCR pathway	37.0	643.0	17.0	-0.077	0.015	1000.0	-1000.0	-0.019	-1000.0
Ephrin B reverse signaling	35.0	1682.0	48.0	-0.098	0.016	1000.0	-1000.0	-0.037	-1000.0
Osteopontin-mediated events	34.0	1307.0	38.0	-0.118	0.014	1000.0	-1000.0	-0.056	-1000.0
TCGA08_p53	33.0	231.0	7.0	-0.089	0.047	1000.0	-1000.0	-0.008	-1000.0
LPA receptor mediated events	32.0	3337.0	102.0	-0.143	0.029	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	31.0	1129.0	36.0	-0.128	0.011	1000.0	-1000.0	-0.032	-1000.0
FAS signaling pathway (CD95)	31.0	1479.0	47.0	-0.076	0.038	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	30.0	526.0	17.0	-0.1	0.033	1000.0	-1000.0	-0.017	-1000.0
Glypican 2 network	30.0	123.0	4.0	-0.014	-0.001	1000.0	-1000.0	-0.009	-1000.0
EGFR-dependent Endothelin signaling events	30.0	642.0	21.0	-0.115	0.019	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	29.0	1837.0	62.0	-0.086	0.027	1000.0	-1000.0	-0.037	-1000.0
Visual signal transduction: Rods	29.0	1529.0	52.0	-0.11	0.011	1000.0	-1000.0	-0.045	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	28.0	2451.0	85.0	-0.21	0.012	1000.0	-1000.0	-0.041	-1000.0
Calcium signaling in the CD4+ TCR pathway	28.0	895.0	31.0	-0.118	0.015	1000.0	-1000.0	-0.035	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	27.0	1419.0	52.0	-0.078	0.022	1000.0	-1000.0	-0.034	-1000.0
Syndecan-4-mediated signaling events	27.0	1858.0	67.0	-0.256	0.016	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	26.0	2002.0	76.0	-0.132	0.022	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	26.0	997.0	38.0	-0.08	0.011	1000.0	-1000.0	-0.032	-1000.0
TCGA08_rtk_signaling	26.0	692.0	26.0	-0.147	0.023	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-gamma and p38-delta	25.0	376.0	15.0	-0.017	0.021	1000.0	-1000.0	-0.01	-1000.0
BCR signaling pathway	25.0	2567.0	99.0	-0.059	0.047	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3099.0	125.0	-0.068	0.029	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by STAT5	23.0	518.0	22.0	-0.103	0.056	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	22.0	1579.0	69.0	-0.104	0.028	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	22.0	1454.0	65.0	-0.1	0.039	1000.0	-1000.0	-0.046	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1384.0	61.0	-0.118	0.031	1000.0	-1000.0	-0.04	-1000.0
Glucocorticoid receptor regulatory network	22.0	2557.0	114.0	-0.239	0.046	1000.0	-1000.0	-0.051	-1000.0
IL6-mediated signaling events	22.0	1674.0	75.0	-0.118	0.061	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	22.0	571.0	25.0	-0.1	0.024	1000.0	-1000.0	-0.016	-1000.0
Regulation of Androgen receptor activity	22.0	1558.0	70.0	-0.216	0.023	1000.0	-1000.0	-0.046	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	21.0	1180.0	54.0	-0.144	0.022	1000.0	-1000.0	-0.053	-1000.0
Insulin Pathway	20.0	1524.0	74.0	-0.134	0.03	1000.0	-1000.0	-0.047	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	672.0	33.0	-0.156	0.034	1000.0	-1000.0	-0.019	-1000.0
Regulation of nuclear SMAD2/3 signaling	18.0	2483.0	136.0	-0.155	0.054	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PTP1B	18.0	1435.0	76.0	-0.113	0.023	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	18.0	1169.0	63.0	-0.068	0.021	1000.0	-1000.0	-0.047	-1000.0
Canonical Wnt signaling pathway	18.0	947.0	51.0	-0.097	0.05	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	18.0	378.0	20.0	-0.051	0.011	1000.0	-1000.0	-0.012	-1000.0
BARD1 signaling events	17.0	982.0	57.0	-0.126	0.028	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events mediated by Akt	17.0	1157.0	68.0	-0.239	0.04	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	17.0	1040.0	58.0	-0.053	0.022	1000.0	-1000.0	-0.042	-1000.0
Regulation of p38-alpha and p38-beta	17.0	954.0	54.0	-0.176	0.043	1000.0	-1000.0	-0.036	-1000.0
IL12-mediated signaling events	16.0	1400.0	87.0	-0.301	0.044	1000.0	-1000.0	-0.081	-1000.0
Regulation of Telomerase	16.0	1658.0	102.0	-0.301	0.038	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1354.0	93.0	-0.045	0.041	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PRL	14.0	482.0	34.0	-0.126	0.018	1000.0	-1000.0	-0.019	-1000.0
ErbB4 signaling events	13.0	905.0	69.0	-0.075	0.03	1000.0	-1000.0	-0.049	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	365.0	28.0	-0.1	0.032	1000.0	-1000.0	-0.019	-1000.0
IFN-gamma pathway	13.0	911.0	68.0	-0.225	0.048	1000.0	-1000.0	-0.056	-1000.0
IL1-mediated signaling events	13.0	852.0	62.0	-0.038	0.04	1000.0	-1000.0	-0.056	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1103.0	83.0	-0.239	0.044	1000.0	-1000.0	-0.045	-1000.0
FoxO family signaling	13.0	854.0	64.0	-0.239	0.042	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	13.0	1116.0	85.0	-0.034	0.029	1000.0	-1000.0	-0.053	-1000.0
PDGFR-beta signaling pathway	13.0	1332.0	97.0	-0.02	0.039	1000.0	-1000.0	-0.042	-1000.0
Insulin-mediated glucose transport	12.0	413.0	32.0	-0.239	0.025	1000.0	-1000.0	-0.033	-1000.0
mTOR signaling pathway	12.0	638.0	53.0	-0.026	0.018	1000.0	-1000.0	-0.034	-1000.0
HIF-2-alpha transcription factor network	12.0	530.0	43.0	-0.143	0.022	1000.0	-1000.0	-0.038	-1000.0
Syndecan-3-mediated signaling events	12.0	436.0	35.0	-0.09	0.03	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	11.0	729.0	65.0	-0.12	0.022	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by PI3K	11.0	694.0	58.0	-0.113	0.043	1000.0	-1000.0	-0.051	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.009	-1000.0
EPO signaling pathway	10.0	563.0	55.0	-0.024	0.035	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by HDAC Class III	10.0	408.0	40.0	-0.079	0.016	1000.0	-1000.0	-0.023	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	166.0	17.0	-0.014	0.034	1000.0	-1000.0	-0.022	-1000.0
Caspase cascade in apoptosis	8.0	616.0	74.0	-0.032	0.035	1000.0	-1000.0	-0.02	-1000.0
IL27-mediated signaling events	8.0	433.0	51.0	-0.056	0.014	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class II	7.0	588.0	75.0	-0.05	0.029	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	273.0	37.0	-0.02	0.027	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	6.0	477.0	76.0	-0.067	0.037	1000.0	-1000.0	-0.02	-1000.0
IL23-mediated signaling events	6.0	396.0	60.0	-0.046	0.043	1000.0	-1000.0	-0.132	-1000.0
ceramide signaling pathway	5.0	273.0	49.0	-0.031	0.038	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	379.0	74.0	-0.076	0.062	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	5.0	362.0	71.0	-0.195	0.035	1000.0	-1000.0	-0.041	-1000.0
p38 MAPK signaling pathway	5.0	236.0	44.0	-0.045	0.028	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	4.0	178.0	39.0	-0.032	0.058	1000.0	-1000.0	-0.048	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	0.007	0.015	1000.0	-1000.0	-0.008	-1000.0
TRAIL signaling pathway	4.0	203.0	48.0	-0.001	0.037	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	200.0	45.0	-0.032	0.057	1000.0	-1000.0	-0.049	-1000.0
Class I PI3K signaling events	4.0	317.0	73.0	-0.015	0.053	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class I	3.0	382.0	104.0	-0.032	0.044	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	138.0	36.0	-0.031	0.032	1000.0	-1000.0	-0.043	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	47.0	23.0	-0.005	0.036	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	11.0	5.0	0.009	0.015	1000.0	-1000.0	-0.012	-1000.0
VEGFR1 specific signals	2.0	142.0	56.0	-0.062	0.052	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	1.0	50.0	43.0	-0.023	0.023	1000.0	-1000.0	-0.019	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	94.0	76.0	-0.003	0.048	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling in keratinocytes	1.0	74.0	43.0	-0.034	0.037	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.009	0.021	1000.0	-1000.0	-0.014	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.011	0.04	1000.0	-1000.0	-0.027	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.028	1000.0	-1000.0	-0.029	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.0	0.028	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	0.0	0.033	1000.0	-1000.0	-0.015	-1000.0
Total	4080	242779	7203	-17.3108996258	4.34472425069	131000	-131000	-4.79861578475	-131000