E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.015 0.091 -9999.0 0.0 -0.272 57.0 57.0 KLHL20 -0.004 0.062 0.2 2.0 -0.201 29.0 31.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.35 3.0 3.0 Rac1/GDP 0.002 0.068 0.247 3.0 -0.266 7.0 10.0 ENAH -0.018 0.092 -9999.0 0.0 -0.276 58.0 58.0 AP1M1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.028 -9999.0 0.0 -0.216 1.0 1.0 ABI1/Sra1/Nap1 -0.013 0.037 -9999.0 0.0 -0.137 32.0 32.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.028 -9999.0 0.0 -0.191 2.0 2.0 RAPGEF1 -0.011 0.079 0.224 2.0 -0.314 9.0 11.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.099 -9999.0 0.0 -0.281 63.0 63.0 CRK -0.008 0.081 -9999.0 0.0 -0.269 40.0 40.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.027 -9999.0 0.0 -0.287 2.0 2.0 alphaE/beta7 Integrin 0.032 0.013 0.209 1.0 -9999.0 0.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.012 0.085 -9999.0 0.0 -0.276 49.0 49.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.016 -9999.0 0.0 -0.164 1.0 1.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.036 -9999.0 0.0 -0.185 12.0 12.0 PI3K -0.019 0.02 -9999.0 0.0 -0.209 1.0 1.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.027 -9999.0 0.0 -0.345 2.0 2.0 TIAM1 0.014 0.057 -9999.0 0.0 -0.35 13.0 13.0 E-cadherin(dimer)/Ca2+ 0.046 0.024 -9999.0 0.0 -0.17 2.0 2.0 AKT1 -0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.018 0.036 -9999.0 0.0 -0.35 5.0 5.0 CDH1 0.019 0.024 -9999.0 0.0 -0.35 2.0 2.0 RhoA/GDP 0.001 0.067 0.231 1.0 -0.272 5.0 6.0 actin cytoskeleton organization -0.002 0.047 0.16 4.0 -0.148 29.0 33.0 CDC42/GDP 0.003 0.068 0.247 3.0 -0.266 7.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.022 -9999.0 0.0 -0.325 2.0 2.0 ITGB7 0.023 0.011 0.279 1.0 -9999.0 0.0 1.0 RAC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.026 -9999.0 0.0 -0.182 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.019 -9999.0 0.0 -0.166 2.0 2.0 mol:GDP -0.01 0.073 0.254 3.0 -0.293 9.0 12.0 CDC42/GTP/IQGAP1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.017 -9999.0 0.0 -0.35 1.0 1.0 p120 catenin/RhoA/GDP 0.009 0.069 0.235 1.0 -0.28 4.0 5.0 RAC1/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.037 0.147 7.0 -0.101 13.0 20.0 NME1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.083 -9999.0 0.0 -0.272 47.0 47.0 regulation of cell-cell adhesion 0.008 0.023 -9999.0 0.0 -0.191 1.0 1.0 WASF2 -0.001 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.018 0.038 -9999.0 0.0 -0.237 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.034 -9999.0 0.0 -0.252 2.0 2.0 CCND1 0.004 0.043 0.168 7.0 -0.121 16.0 23.0 VAV2 -0.028 0.164 -9999.0 0.0 -0.57 34.0 34.0 RAP1/GDP 0.018 0.06 0.251 4.0 -0.256 4.0 8.0 adherens junction assembly -0.01 0.083 -9999.0 0.0 -0.266 49.0 49.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.029 -9999.0 0.0 -0.245 2.0 2.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.29 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.015 0.091 -9999.0 0.0 -0.276 56.0 56.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.35 1.0 1.0 Rac1/GTP -0.017 0.086 0.182 1.0 -0.31 31.0 32.0 E-cadherin/beta catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.198 2.0 2.0 ITGAE 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.101 -9999.0 0.0 -0.286 63.0 63.0