Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.003 0.09 0.255 52.0 -0.214 12.0 64.0 KIRREL -0.017 0.114 -9999.0 0.0 -0.356 54.0 54.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.003 0.091 0.215 12.0 -0.256 52.0 64.0 PLCG1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.023 0.079 0.311 2.0 -0.191 50.0 52.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.006 0.07 0.196 3.0 -0.206 50.0 53.0 FYN 0.017 0.116 0.227 101.0 -0.184 51.0 152.0 mol:Ca2+ 0.019 0.075 0.338 1.0 -0.188 51.0 52.0 mol:DAG 0.02 0.076 0.343 1.0 -0.189 51.0 52.0 NPHS2 -0.008 0.033 0.298 3.0 -9999.0 0.0 3.0 mol:IP3 0.02 0.076 0.343 1.0 -0.189 51.0 52.0 regulation of endocytosis 0.015 0.068 0.193 7.0 -0.174 51.0 58.0 Nephrin/NEPH1/podocin/Cholesterol 0.013 0.073 0.203 13.0 -0.186 52.0 65.0 establishment of cell polarity 0.003 0.09 0.214 12.0 -0.255 52.0 64.0 Nephrin/NEPH1/podocin/NCK1-2 0.029 0.08 0.309 2.0 -0.183 51.0 53.0 Nephrin/NEPH1/beta Arrestin2 0.016 0.069 0.2 7.0 -0.175 51.0 58.0 NPHS1 0.02 0.054 0.289 14.0 -9999.0 0.0 14.0 Nephrin/NEPH1/podocin 0.014 0.072 0.2 12.0 -0.184 51.0 63.0 TJP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.023 -9999.0 0.0 -0.35 2.0 2.0 NCK2 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.021 0.077 0.349 1.0 -0.19 51.0 52.0 CD2AP 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.02 0.077 0.349 1.0 -0.189 51.0 52.0 GRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.127 0.234 94.0 -0.204 67.0 161.0 cytoskeleton organization -0.017 0.079 0.215 19.0 -0.218 49.0 68.0 Nephrin/NEPH1 0.007 0.064 0.176 12.0 -0.171 52.0 64.0 Nephrin/NEPH1/ZO-1 0.014 0.078 0.203 12.0 -0.202 52.0 64.0