Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0 epithelial cell differentiation 0.042 0.022 -9999.0 0.0 -0.168 2.0 2.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.35 3.0 3.0 ENAH -0.006 0.056 0.267 12.0 -9999.0 0.0 12.0 EGFR 0.014 0.059 0.327 1.0 -0.35 13.0 14.0 EPHA2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.012 0.025 0.173 7.0 -9999.0 0.0 7.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.017 -9999.0 0.0 -0.208 1.0 1.0 AQP5 0.077 0.088 0.284 2.0 -0.41 5.0 7.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.018 0.169 3.0 -9999.0 0.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.037 0.17 7.0 -0.304 1.0 8.0 EGF 0.031 0.055 0.279 21.0 -0.35 2.0 23.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.001 0.057 -9999.0 0.0 -0.344 8.0 8.0 cortical microtubule organization 0.042 0.022 -9999.0 0.0 -0.168 2.0 2.0 GO:0000145 -0.013 0.017 0.158 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.024 -9999.0 0.0 -0.17 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.018 -9999.0 0.0 -0.166 3.0 3.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.031 0.208 1.0 -0.191 2.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.016 0.164 3.0 -9999.0 0.0 3.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.024 0.171 6.0 -9999.0 0.0 6.0 ARF6/GTP 0.047 0.033 -9999.0 0.0 -0.18 2.0 2.0 CDH1 0.019 0.024 -9999.0 0.0 -0.35 2.0 2.0 EGFR/EGFR/EGF/EGF 0.033 0.044 -9999.0 0.0 -0.179 14.0 14.0 RhoA/GDP 0.042 0.023 -9999.0 0.0 -0.163 2.0 2.0 actin cytoskeleton organization -0.014 0.022 0.159 6.0 -9999.0 0.0 6.0 IGF-1R heterotetramer 0.009 0.069 -9999.0 0.0 -0.349 19.0 19.0 GIT1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.069 -9999.0 0.0 -0.35 19.0 19.0 IGF1 -0.046 0.145 -9999.0 0.0 -0.35 100.0 100.0 DIAPH1 0.018 0.096 -9999.0 0.0 -0.502 11.0 11.0 Wnt receptor signaling pathway -0.042 0.022 0.168 2.0 -9999.0 0.0 2.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.018 -9999.0 0.0 -0.166 3.0 3.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.022 0.16 6.0 -9999.0 0.0 6.0 EFNA1 0.02 0.02 0.303 2.0 -9999.0 0.0 2.0 LPP -0.014 0.023 0.166 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.03 0.025 -9999.0 0.0 -0.162 2.0 2.0 SEC6/SEC8 -0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.016 0.037 0.172 7.0 -0.309 1.0 8.0 HGF/MET -0.003 0.088 -9999.0 0.0 -0.176 96.0 96.0 HGF -0.05 0.147 -9999.0 0.0 -0.35 104.0 104.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.025 -9999.0 0.0 -0.182 8.0 8.0 actin cable formation 0.046 0.105 0.231 95.0 -0.244 2.0 97.0 KIAA1543 -0.013 0.023 0.161 6.0 -0.166 2.0 8.0 KIFC3 -0.013 0.023 0.171 6.0 -9999.0 0.0 6.0 NCK1 0.021 0.023 -9999.0 0.0 -0.35 2.0 2.0 EXOC3 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.025 0.173 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.03 0.019 -9999.0 0.0 -0.246 2.0 2.0 mol:GDP 0.042 0.022 -9999.0 0.0 -0.168 2.0 2.0 EXOC4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.025 0.172 7.0 -9999.0 0.0 7.0 PIP5K1C -0.013 0.019 0.171 3.0 -9999.0 0.0 3.0 LIMA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.086 0.317 16.0 -9999.0 0.0 16.0 adherens junction assembly -0.044 0.14 0.205 1.0 -0.554 31.0 32.0 IGF-1R heterotetramer/IGF1 -0.007 0.092 -9999.0 0.0 -0.184 107.0 107.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.042 0.279 4.0 -0.35 5.0 9.0 PLEKHA7 -0.013 0.025 0.172 6.0 -0.174 1.0 7.0 mol:GTP 0.042 0.03 0.202 1.0 -0.19 2.0 3.0 establishment of epithelial cell apical/basal polarity 0.001 0.077 0.351 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0 regulation of cell-cell adhesion -0.014 0.022 0.159 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.025 -9999.0 0.0 -0.182 8.0 8.0