Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.093 0.168 -9999.0 0.0 -0.526 5.0 5.0 IHH -0.144 0.187 -9999.0 0.0 -0.364 21.0 21.0 SHH Np/Cholesterol/GAS1 -0.04 0.086 -9999.0 0.0 -0.18 14.0 14.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.086 0.179 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.106 0.182 -9999.0 0.0 -0.347 13.0 13.0 SMO -0.115 0.179 -9999.0 0.0 -0.357 14.0 14.0 AKT1 -0.069 0.164 -9999.0 0.0 -0.504 5.0 5.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 STIL -0.069 0.142 0.191 2.0 -0.303 9.0 11.0 DHH N/PTCH2 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.069 0.132 -9999.0 0.0 -0.263 9.0 9.0 PIK3CA 0.019 0.051 -9999.0 0.0 -0.346 1.0 1.0 DHH 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.129 0.209 -9999.0 0.0 -0.593 5.0 5.0 determination of left/right symmetry -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 PIK3R1 -0.007 0.099 -9999.0 0.0 -0.346 4.0 4.0 skeletal system development -0.128 0.207 -9999.0 0.0 -0.588 5.0 5.0 IHH N/Hhip -0.107 0.14 -9999.0 0.0 -0.258 22.0 22.0 DHH N/Hhip -0.0 0.089 -9999.0 0.0 -0.241 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 pancreas development -0.024 0.117 -9999.0 0.0 -0.345 6.0 6.0 HHAT -0.026 0.125 -9999.0 0.0 -0.346 7.0 7.0 PI3K 0.013 0.084 -9999.0 0.0 -0.307 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.048 0.137 -9999.0 0.0 -0.346 9.0 9.0 somite specification -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.081 0.135 -9999.0 0.0 -0.284 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.005 0.069 -9999.0 0.0 -0.179 7.0 7.0 SHH Np/Cholesterol/Megalin -0.009 0.069 -9999.0 0.0 -0.181 7.0 7.0 SHH -0.018 0.08 -9999.0 0.0 -0.241 6.0 6.0 catabolic process -0.082 0.137 -9999.0 0.0 -0.295 9.0 9.0 SMO/Vitamin D3 -0.076 0.173 -9999.0 0.0 -0.351 10.0 10.0 SHH Np/Cholesterol/Hhip -0.029 0.089 -9999.0 0.0 -0.193 11.0 11.0 LRP2 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.081 0.169 -9999.0 0.0 -0.406 7.0 7.0 SHH Np/Cholesterol/BOC -0.005 0.065 -9999.0 0.0 -0.181 6.0 6.0 SHH Np/Cholesterol/CDO -0.008 0.069 -9999.0 0.0 -0.181 7.0 7.0 mesenchymal cell differentiation 0.029 0.088 0.192 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.066 0.154 0.211 2.0 -0.316 9.0 11.0 IHH N/PTCH2 -0.068 0.114 -9999.0 0.0 -0.22 18.0 18.0 CDON 0.023 0.019 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.09 0.141 -9999.0 0.0 -0.251 21.0 21.0 Megalin/LRPAP1 0.033 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.065 -9999.0 0.0 -0.177 7.0 7.0 PTCH1 -0.083 0.138 -9999.0 0.0 -0.296 9.0 9.0 HHIP -0.024 0.118 -9999.0 0.0 -0.346 6.0 6.0