Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	8.0	640.0	76.0	-0.203	0.031	1000.0	-1000.0	-0.007	-1000.0
Ephrin B reverse signaling	8.0	407.0	48.0	-0.222	0.028	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by the Hedgehog family	7.0	395.0	52.0	-0.144	0.04	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	577.0	78.0	-0.233	0.089	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.048	0.02	1000.0	-1000.0	0.0	-1000.0
IGF1 pathway	6.0	363.0	57.0	-0.064	0.046	1000.0	-1000.0	-0.022	-1000.0
Plasma membrane estrogen receptor signaling	6.0	519.0	86.0	-0.165	0.155	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	6.0	356.0	51.0	-0.442	0.027	1000.0	-1000.0	-0.075	-1000.0
Noncanonical Wnt signaling pathway	5.0	152.0	26.0	-0.078	0.027	1000.0	-1000.0	-0.022	-1000.0
Glypican 1 network	5.0	279.0	48.0	-0.057	0.03	1000.0	-1000.0	-0.017	-1000.0
Nectin adhesion pathway	5.0	340.0	63.0	-0.084	0.055	1000.0	-1000.0	-0.032	-1000.0
Endothelins	5.0	517.0	96.0	-0.155	0.032	1000.0	-1000.0	-0.027	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	367.0	68.0	-0.211	0.118	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	5.0	46.0	8.0	-0.037	0.024	1000.0	-1000.0	-0.004	-1000.0
IL12-mediated signaling events	4.0	425.0	87.0	-0.263	0.051	1000.0	-1000.0	-0.03	-1000.0
Osteopontin-mediated events	4.0	189.0	38.0	-0.096	0.028	1000.0	-1000.0	-0.011	-1000.0
IL4-mediated signaling events	4.0	390.0	91.0	-0.557	0.359	1000.0	-1000.0	-0.095	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	184.0	44.0	-0.068	0.028	1000.0	-1000.0	-0.016	-1000.0
EPHB forward signaling	4.0	369.0	85.0	-0.057	0.046	1000.0	-1000.0	-0.039	-1000.0
Wnt signaling	4.0	33.0	7.0	-0.073	0.024	1000.0	-1000.0	-0.005	-1000.0
IL23-mediated signaling events	4.0	297.0	60.0	-0.312	0.028	1000.0	-1000.0	-0.05	-1000.0
Caspase cascade in apoptosis	3.0	230.0	74.0	-0.039	0.035	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	491.0	136.0	-0.414	0.084	1000.0	-1000.0	-0.026	-1000.0
Syndecan-1-mediated signaling events	3.0	132.0	34.0	-0.08	0.038	1000.0	-1000.0	-0.012	-1000.0
Thromboxane A2 receptor signaling	3.0	345.0	105.0	-0.078	0.051	1000.0	-1000.0	-0.026	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	145.0	46.0	-0.17	0.033	1000.0	-1000.0	-0.059	-1000.0
BMP receptor signaling	3.0	256.0	81.0	-0.102	0.047	1000.0	-1000.0	-0.02	-1000.0
Reelin signaling pathway	3.0	179.0	56.0	-0.045	0.05	1000.0	-1000.0	-0.019	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.036	0.023	1000.0	-1000.0	-0.004	-1000.0
FAS signaling pathway (CD95)	3.0	182.0	47.0	-0.084	0.034	1000.0	-1000.0	-0.03	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	279.0	93.0	-0.047	0.037	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	137.0	45.0	-0.034	0.049	1000.0	-1000.0	-0.031	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.011	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	3.0	186.0	52.0	-0.1	0.049	1000.0	-1000.0	-0.016	-1000.0
LPA receptor mediated events	3.0	323.0	102.0	-0.105	0.028	1000.0	-1000.0	-0.055	-1000.0
Syndecan-4-mediated signaling events	3.0	209.0	67.0	-0.062	0.039	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	3.0	178.0	56.0	-0.047	0.028	1000.0	-1000.0	-0.03	-1000.0
Regulation of Androgen receptor activity	3.0	216.0	70.0	-0.144	0.034	1000.0	-1000.0	-0.036	-1000.0
Coregulation of Androgen receptor activity	2.0	221.0	76.0	-0.135	0.046	1000.0	-1000.0	-0.008	-1000.0
Visual signal transduction: Cones	2.0	81.0	38.0	-0.014	0.043	1000.0	-1000.0	-0.0	-1000.0
Syndecan-2-mediated signaling events	2.0	147.0	69.0	-0.036	0.041	1000.0	-1000.0	-0.032	-1000.0
Cellular roles of Anthrax toxin	2.0	113.0	39.0	-0.057	0.027	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by PTP1B	2.0	167.0	76.0	-0.071	0.047	1000.0	-1000.0	-0.024	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	173.0	65.0	-0.318	0.066	1000.0	-1000.0	-0.034	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	150.0	61.0	-0.085	0.051	1000.0	-1000.0	-0.031	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	289.0	97.0	-0.062	0.046	1000.0	-1000.0	-0.036	-1000.0
PLK1 signaling events	2.0	223.0	85.0	-0.044	0.029	1000.0	-1000.0	-0.017	-1000.0
PDGFR-alpha signaling pathway	2.0	114.0	44.0	-0.132	0.038	1000.0	-1000.0	-0.033	-1000.0
mTOR signaling pathway	2.0	111.0	53.0	-0.019	0.034	1000.0	-1000.0	-0.037	-1000.0
IFN-gamma pathway	2.0	200.0	68.0	-0.05	0.038	1000.0	-1000.0	-0.031	-1000.0
Glucocorticoid receptor regulatory network	2.0	244.0	114.0	-0.134	0.071	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	2.0	112.0	48.0	-0.014	0.037	1000.0	-1000.0	-0.018	-1000.0
IL1-mediated signaling events	2.0	177.0	62.0	-0.042	0.044	1000.0	-1000.0	-0.017	-1000.0
S1P5 pathway	2.0	40.0	17.0	-0.025	0.027	1000.0	-1000.0	-0.009	-1000.0
ceramide signaling pathway	2.0	126.0	49.0	-0.026	0.04	1000.0	-1000.0	-0.021	-1000.0
HIF-2-alpha transcription factor network	2.0	122.0	43.0	-0.05	0.049	1000.0	-1000.0	-0.038	-1000.0
S1P1 pathway	2.0	92.0	36.0	-0.101	0.026	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	36.0	15.0	-0.026	0.026	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	2.0	173.0	58.0	-0.106	0.055	1000.0	-1000.0	-0.015	-1000.0
Syndecan-3-mediated signaling events	2.0	71.0	35.0	-0.057	0.051	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by PI3K	2.0	130.0	58.0	-0.101	0.028	1000.0	-1000.0	-0.019	-1000.0
Integrins in angiogenesis	2.0	223.0	84.0	-0.075	0.056	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	2.0	145.0	51.0	-0.085	0.068	1000.0	-1000.0	-0.032	-1000.0
IL27-mediated signaling events	2.0	151.0	51.0	-0.098	0.05	1000.0	-1000.0	-0.031	-1000.0
IL6-mediated signaling events	2.0	203.0	75.0	-0.079	0.074	1000.0	-1000.0	-0.031	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	215.0	74.0	-0.057	0.05	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	157.0	76.0	-0.028	0.054	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by STAT5	2.0	45.0	22.0	-0.071	0.032	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	2.0	166.0	73.0	-0.03	0.045	1000.0	-1000.0	-0.016	-1000.0
BCR signaling pathway	2.0	245.0	99.0	-0.049	0.055	1000.0	-1000.0	-0.031	-1000.0
Visual signal transduction: Rods	2.0	110.0	52.0	-0.077	0.061	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling in keratinocytes	2.0	113.0	43.0	-0.031	0.042	1000.0	-1000.0	-0.014	-1000.0
S1P4 pathway	2.0	62.0	25.0	-0.025	0.038	1000.0	-1000.0	-0.012	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	37.0	17.0	-0.015	0.043	1000.0	-1000.0	-0.014	-1000.0
Aurora B signaling	2.0	166.0	67.0	-0.085	0.043	1000.0	-1000.0	-0.021	-1000.0
LPA4-mediated signaling events	1.0	20.0	12.0	-0.023	0.002	1000.0	-1000.0	-0.017	-1000.0
ErbB2/ErbB3 signaling events	1.0	75.0	65.0	-0.039	0.067	1000.0	-1000.0	-0.036	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	23.0	23.0	0.002	0.039	1000.0	-1000.0	-0.01	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	59.0	34.0	-0.023	0.057	1000.0	-1000.0	-0.018	-1000.0
Canonical NF-kappaB pathway	1.0	41.0	39.0	-0.018	0.062	1000.0	-1000.0	-0.018	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	35.0	28.0	-0.025	0.038	1000.0	-1000.0	-0.012	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	83.0	54.0	-0.035	0.039	1000.0	-1000.0	-0.019	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	32.0	17.0	-0.03	0.048	1000.0	-1000.0	-0.014	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.011	0.026	1000.0	-1000.0	0.015	-1000.0
Arf6 signaling events	1.0	107.0	62.0	-0.01	0.043	1000.0	-1000.0	-0.006	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	123.0	85.0	-0.131	0.052	1000.0	-1000.0	-0.034	-1000.0
Aurora A signaling	1.0	96.0	60.0	-0.022	0.047	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	1.0	241.0	125.0	-0.087	0.061	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	1.0	96.0	55.0	-0.075	0.049	1000.0	-1000.0	-0.015	-1000.0
amb2 Integrin signaling	1.0	155.0	82.0	-0.026	0.063	1000.0	-1000.0	-0.015	-1000.0
Ceramide signaling pathway	1.0	146.0	76.0	-0.046	0.064	1000.0	-1000.0	-0.018	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	62.0	37.0	-0.026	0.048	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	1.0	76.0	40.0	-0.053	0.053	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	100.0	52.0	-0.054	0.064	1000.0	-1000.0	-0.016	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	116.0	83.0	-0.031	0.058	1000.0	-1000.0	-0.015	-1000.0
FoxO family signaling	1.0	65.0	64.0	-0.038	0.041	1000.0	-1000.0	-0.047	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	58.0	36.0	-0.036	0.043	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	-0.007	0.028	1000.0	-1000.0	-0.006	-1000.0
Regulation of p38-alpha and p38-beta	1.0	57.0	54.0	-0.043	0.059	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	46.0	31.0	-0.032	0.034	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	238.0	125.0	-0.03	0.045	1000.0	-1000.0	-0.025	-1000.0
TCGA08_rtk_signaling	1.0	34.0	26.0	-0.056	0.062	1000.0	-1000.0	-0.011	-1000.0
Regulation of Telomerase	1.0	124.0	102.0	-0.066	0.058	1000.0	-1000.0	-0.035	-1000.0
EGFR-dependent Endothelin signaling events	1.0	30.0	21.0	-0.015	0.041	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	1.0	127.0	74.0	-0.043	0.059	1000.0	-1000.0	-0.021	-1000.0
S1P3 pathway	1.0	65.0	42.0	-0.03	0.038	1000.0	-1000.0	-0.027	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	166.0	120.0	-0.046	0.075	1000.0	-1000.0	-0.028	-1000.0
PDGFR-beta signaling pathway	1.0	151.0	97.0	-0.028	0.063	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.014	0.042	1000.0	-1000.0	0.014	-1000.0
p38 MAPK signaling pathway	1.0	51.0	44.0	-0.034	0.049	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	0.0	66.0	75.0	-0.066	0.069	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	0.0	32.0	69.0	-0.032	0.058	1000.0	-1000.0	-0.033	-1000.0
BARD1 signaling events	0.0	56.0	57.0	-0.049	0.062	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.01	0.059	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	0.0	33.0	43.0	-0.041	0.047	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.011	-1000.0
Insulin-mediated glucose transport	0.0	26.0	32.0	-0.003	0.05	1000.0	-1000.0	-0.011	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	65.0	68.0	-0.041	0.047	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	80.0	82.0	-0.018	0.05	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class I	0.0	80.0	104.0	-0.04	0.065	1000.0	-1000.0	-0.028	-1000.0
Effects of Botulinum toxin	0.0	8.0	26.0	-0.0	0.046	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	18.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.017	-1000.0
Arf6 trafficking events	0.0	22.0	71.0	-0.039	0.049	1000.0	-1000.0	-0.019	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	87.0	88.0	-0.043	0.047	1000.0	-1000.0	-0.051	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	24.0	33.0	-0.043	0.068	1000.0	-1000.0	-0.031	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.034	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by PRL	0.0	25.0	34.0	-0.031	0.041	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.017	-1000.0
Arf1 pathway	0.0	21.0	54.0	-0.001	0.05	1000.0	-1000.0	-0.006	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.067	1000.0	-1000.0	0.0	-1000.0
Total	273	19359	7203	-9.39072072502	6.40404370774	131000	-131000	-3.00141238474	-131000