feature type start end label R G B shape direction protein Name=TP53; Synonyms=P53; 1 393 Name=TP53; Synonyms=P53; 0.7 0.9 0.9 - - domain DNA-binding (experimentally determined) 102 292 DNA-binding (experimentally determined) 0.69 0.69 0.27 - - domain Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 1 320 Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 0.76 0.38 0.62 - - domain Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 1 83 Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 0.43 0.67 0.46 - - domain Transcription activation (acidic). 1 44 Transcription activation (acidic). 0.46 0.33 0.58 - - domain Interaction with WWOX. 66 110 Interaction with WWOX. 0.62 0.37 0.23 - - domain Interaction with HIPK1. {ECO:0000250}. 100 370 Interaction with HIPK1. {ECO:0000250}. 0.39 0.76 0.75 - - domain Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 100 300 Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 0.27 0.43 0.31 - - domain Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 113 236 Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 0.75 0.7 0.59 - - domain Interaction with AXIN1. {ECO:0000250}. 116 292 Interaction with AXIN1. {ECO:0000250}. 0.56 0.49 0.8 - - domain Interaction with the 53BP2 SH3 domain. 241 248 Interaction with the 53BP2 SH3 domain. 0.21 0.3 0.73 - - domain Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 256 294 Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 0.27 0.79 0.23 - - domain Interaction with DNA. 273 280 Interaction with DNA. 0 0.73 0.87 - - domain Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 300 393 Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 0.7 0 0.65 - - domain Interaction with HIPK2. 319 360 Interaction with HIPK2. 0.2 0.54 0.58 - - domain Oligomerization. 325 356 Oligomerization. 0.98 0.99 0 - - domain Interaction with USP7. 359 363 Interaction with USP7. 0.69 0.87 0 - - domain Basic (repression of DNA-binding). 368 387 Basic (repression of DNA-binding). 0.98 0 0.77 - - domain TADI. 17 25 TADI. 0.96 0.64 0 - - domain TADII. 48 56 TADII. 0.67 0 0.95 - - domain Bipartite nuclear localization signal. 305 321 Bipartite nuclear localization signal. 0 0.99 0.66 - - domain Nuclear export signal. 339 350 Nuclear export signal. 0.0 1.0 0.0 - - domain [KR]-[STA]-K motif. 370 372 [KR]-[STA]-K motif. 0 1.0 0.99 - - mutation Missense_Mutation 110 110 p.R110P 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273C 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 112 112 p.GFLHSG112fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 124 124 p.C124* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 218 218 p.V218fs 1.0 0.0 0.0 square up mutation Missense_Mutation 273 273 p.R273L 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 327 327 p.Y327* 1.0 0.0 0.0 triangle up mutation In_Frame_Del 177 177 p.PHH177del 0.0 0.0 1.0 square up mutation Missense_Mutation 194 194 p.L194R 1.0 1.0 0.0 circle up mutation Missense_Mutation 193 193 p.H193R 1.0 1.0 0.0 circle up mutation Missense_Mutation 236 236 p.Y236C 1.0 1.0 0.0 circle up mutation Splice_Site 125 125 p.T125T 0.6 0.0 0.6 inv_triangle up mutation Nonsense_Mutation 196 196 p.R196* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 196 196 p.R196* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 205 205 p.Y205C 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 212 212 p.F212fs 1.0 0.0 0.0 square up mutation Missense_Mutation 217 217 p.V217G 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 213 213 p.R213* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 258 258 p.E258* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 127 127 p.S127Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 127 127 p.S127F 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 306 306 p.R306* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 280 280 p.R280fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 241 241 p.S241fs 1.0 0.0 0.0 square up mutation Missense_Mutation 249 249 p.R249S 1.0 1.0 0.0 circle up mutation Missense_Mutation 249 249 p.R249K 1.0 1.0 0.0 circle up mutation In_Frame_Del 218 218 p.V218del 0.0 0.0 1.0 square up mutation Nonsense_Mutation 91 91 p.W91* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 278 278 p.P278T 1.0 1.0 0.0 circle up mutation Missense_Mutation 132 132 p.K132N 1.0 1.0 0.0 circle up mutation Missense_Mutation 193 193 p.H193R 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 192 192 p.Q192* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 175 175 p.R175H 1.0 1.0 0.0 circle up mutation Missense_Mutation 234 234 p.Y234N 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248Q 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 289 289 p.L289fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 306 306 p.R306* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 286 286 p.E286K 1.0 1.0 0.0 circle up mutation Missense_Mutation 258 258 p.E258G 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273H 1.0 1.0 0.0 circle up mutation Missense_Mutation 337 337 p.R337C 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 213 213 p.R213* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 204 204 p.E204fs 1.0 0.0 0.0 square up mutation Missense_Mutation 176 176 p.C176Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 193 193 p.H193R 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248W 1.0 1.0 0.0 circle up mutation Missense_Mutation 220 220 p.Y220C 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 213 213 p.R213* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 171 171 p.E171* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 333 333 p.R333fs 1.0 0.0 0.0 square up mutation Missense_Mutation 273 273 p.R273C 1.0 1.0 0.0 circle up mutation Silent 272 272 p.V272V 0.8 0.8 0.8 circle up mutation Missense_Mutation 238 238 p.C238Y 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 196 196 p.R196* 1.0 0.0 0.0 triangle up