q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

This figure depicts the distribution of mutations and mutation types across the PIK3CA significant gene.

This figure depicts the distribution of mutations and mutation types across the TP53 significant gene.

This figure depicts the distribution of mutations and mutation types across the PTEN significant gene.

This figure depicts the distribution of mutations and mutation types across the CDH1 significant gene.

This figure depicts the distribution of mutations and mutation types across the MAP3K1 significant gene.

This figure depicts the distribution of mutations and mutation types across the AKT1 significant gene.

This figure depicts the distribution of mutations and mutation types across the GATA3 significant gene.

This figure depicts the distribution of mutations and mutation types across the CBFB significant gene.

This figure depicts the distribution of mutations and mutation types across the KMT2C significant gene.

This figure depicts the distribution of mutations and mutation types across the SF3B1 significant gene.

This figure depicts the distribution of mutations and mutation types across the ARID1A significant gene.

This figure depicts the distribution of mutations and mutation types across the MLLT4 significant gene.

A kinase (PRKA) anchor protein (yotiao) 9
acyl-CoA synthetase long-chain family member 3
acyl-CoA synthetase long-chain family member 6
additional sex combs like 1 (Drosophila)
ADP-ribosylation factor related protein 1
aldehyde dehydrogenase 2 family (mitochondrial)
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
alveolar soft part sarcoma chromosome region, candidate 1
anaplastic lymphoma receptor tyrosine kinase
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
aryl hydrocarbon receptor nuclear translocator
AT rich interactive domain 1A (SWI-like)
AT rich interactive domain 1B (SWI1-like)
AT rich interactive domain 2 (ARID, RFX-like)
AT rich interactive domain 5B (MRF1-like)
ATPase, Ca++ transporting, plasma membrane 3
ATPase, Na+/K+ transporting, alpha 1 polypeptide
B-cell CLL/lymphoma 11A (zinc finger protein)
B-cell CLL/lymphoma 11B (zinc finger protein)
B-cell CLL/lymphoma 6 (zinc finger protein 51)
B-cell translocation gene 1, anti-proliferative
baculoviral IAP repeat-containing 7 (livin)
bone morphogenetic protein receptor, type IA
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRCA1 interacting protein C-terminal helicase 1
bromodomain PHD finger transcription factor
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)
c-abl oncogene 1, receptor tyrosine kinase
c-ros oncogene 1 , receptor tyrosine kinase
cadherin 1, type 1, E-cadherin (epithelial)
cadherin 11, type 2, OB-cadherin (osteoblast)
calcium channel, voltage-dependent, L type, alpha 1D subunit
calmodulin binding transcription activator 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 3-like 1
cAMP responsive element binding protein 3-like 2
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
caspase 8, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 11
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), delta 1
CCAAT/enhancer binding protein (C/EBP), alpha
CCCTC-binding factor (zinc finger protein)
CCHC-type zinc finger, nucleic acid binding protein
CCR4-NOT transcription complex, subunit 3
CD74 molecule, major histocompatibility complex, class II invariant chain
CDC28 protein kinase regulatory subunit 1B
cell division cycle 6 homolog (S. cerevisiae)
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chromodomain helicase DNA binding protein 1
chromodomain helicase DNA binding protein 1-like
chromodomain helicase DNA binding protein 2
chromodomain helicase DNA binding protein 8
class II, major histocompatibility complex, transactivator
CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
colony stimulating factor 3 receptor (granulocyte)
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CREB binding protein (Rubinstein-Taybi syndrome)
CREB regulated transcription coactivator 1
CREB regulated transcription coactivator 3
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
damage-specific DNA binding protein 2, 48kDa
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
discoidin domain receptor tyrosine kinase 2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E74-like factor 4 (ets domain transcription factor)
echinoderm microtubule associated protein like 4
elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
ELK3, ETS-domain protein (SRF accessory protein 2)
ELK4, ETS-domain protein (SRF accessory protein 1)
enhancer of zeste homolog 2 (Drosophila)
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
epidermal growth factor receptor pathway substrate 15
epithelial cell transforming sequence 2 oncogene-like
ets variant gene 4 (E1A enhancer binding protein, E1AF)
ets variant gene 5 (ets-related molecule)
eukaryotic translation elongation factor 1 alpha 2
eukaryotic translation initiation factor 1A, X-linked
eukaryotic translation initiation factor 4A, isoform 2
eukaryotic translation initiation factor 5A2
excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
excision repair cross-complementing rodent repair deficiency, complementation group 4
excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
family with sequence similarity 46, member C
Fanconi anemia, complementation group D2
far upstream element (FUSE) binding protein 1
Fas (TNF receptor superfamily, member 6)
Fas (TNFRSF6)-associated via death domain
Fc fragment of IgG, low affinity IIb, receptor (CD32)
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fusion (involved in t(12;16) in malignant liposarcoma)
GATA binding protein 1 (globin transcription factor 1)
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
golgi associated PDZ and coiled-coil motif containing
golgi autoantigen, golgin subfamily a, 5
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
guanine nucleotide binding protein (G protein), q polypeptide
hairy/enhancer-of-split related with YRPW motif 1
heat shock protein 90kDa alpha (cytosolic), class A member 1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
interleukin 6 signal transducer (gp130, oncostatin M receptor)
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 2 (NADP+), mitochondrial
Janus kinase 1 (a protein tyrosine kinase)
Janus kinase 2 (a protein tyrosine kinase)
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
kinase insert domain receptor (a type III receptor tyrosine kinase)
leucine-rich repeats and immunoglobulin-like domains 3
leukemia inhibitory factor receptor alpha
LIM domain containing preferred translocation partner in lipoma
low density lipoprotein-related protein 1B (deleted in tumors)
lymphoblastic leukemia derived sequence 1
lymphocyte cytosolic protein 1 (L-plastin)
Mdm2 p53 binding protein homolog (mouse)
Mdm4 p53 binding protein homolog (mouse)
mechanistic target of rapamycin (serine/threonine kinase)
meningioma (disrupted in balanced translocation) 1
met proto-oncogene (hepatocyte growth factor receptor)
mitogen-activated protein kinase kinase 1
mitogen-activated protein kinase kinase 2
mitogen-activated protein kinase kinase 4
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 6
mitogen-activated protein kinase kinase 7
mitogen-activated protein kinase kinase kinase 1
mitogen-activated protein kinase kinase kinase 11
mitogen-activated protein kinase kinase kinase 12
mitogen-activated protein kinase kinase kinase 13
mitogen-activated protein kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase 3
mitogen-activated protein kinase kinase kinase 4
mitogen-activated protein kinase kinase kinase 5
mitogen-activated protein kinase kinase kinase 6
mitogen-activated protein kinase kinase kinase 7
mitogen-activated protein kinase kinase kinase 8
mitogen-activated protein kinase kinase kinase 9
mitogen-activated protein kinase kinase kinase kinase 3
mitogen-activated protein kinase kinase kinase kinase 4
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
mucosa associated lymphoid tissue lymphoma translocation gene 1
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
myelodysplastic syndrome 2 translocation associated
myeloid cell leukemia sequence 1 (BCL2-related)
myeloid differentiation primary response gene (88)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
myeloid/lymphoid or mixed-lineage leukemia 2
myeloid/lymphoid or mixed-lineage leukemia 3
myocilin, trabecular meshwork inducible glucocorticoid response
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
nascent polypeptide-associated complex alpha subunit
nerve growth factor receptor (TNFR superfamily, member 16)
neuroblastoma breakpoint family, member 10
neuroblastoma RAS viral (v-ras) oncogene homolog
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
neurotrophic tyrosine kinase, receptor, type 1
neurotrophic tyrosine kinase, receptor, type 2
neurotrophic tyrosine kinase, receptor, type 3
Notch homolog 1, translocation-associated (Drosophila)
nuclear factor (erythroid-derived 2)-like 2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
nuclear receptor binding SET domain protein 1
nuclear receptor subfamily 4, group A, member 3
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
oligodendrocyte lineage transcription factor 2
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
papillary renal cell carcinoma (translocation-associated)
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
phosphatidylinositol binding clathrin assembly protein
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
phosphodiesterase 4D interacting protein (myomegalin)
phosphoinositide-3-kinase, class 2, alpha polypeptide
phosphoinositide-3-kinase, class 2, beta polypeptide
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, beta polypeptide
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POT1 protection of telomeres 1 homolog (S. pombe)
potassium inwardly-rectifying channel, subfamily J, member 5
POZ (BTB) and AT hook containing zinc finger 1
proprotein convertase subtilisin/kexin type 7
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
protein phosphatase 1D magnesium-dependent, delta isoform
protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform
protein phosphatase 6, catalytic subunit
protein tyrosine phosphatase type IVA, member 1
protein tyrosine phosphatase type IVA, member 3
protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
protein tyrosine phosphatase, receptor type, B
protein tyrosine phosphatase, receptor type, C
protein tyrosine phosphatase, receptor type, D
protein tyrosine phosphatase, receptor type, J
protein tyrosine phosphatase, receptor type, K
protein tyrosine phosphatase, receptor type, M
protein tyrosine phosphatase, receptor type, S
protein tyrosine phosphatase, receptor type, T
purinergic receptor P2Y, G-protein coupled, 8
rabaptin, RAB GTPase binding effector protein 1
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
ral guanine nucleotide dissociation stimulator
RAS protein activator like 1 (GAP1 like)
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
regenerating islet-derived family, member 4
regulatory associated protein of MTOR, complex 1
Rho guanine nucleotide exchange factor (GEF) 12
ribonucleotide reductase M2 B (TP53 inducible)
ribosomal protein S6 kinase, 70kDa, polypeptide 1
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPTOR independent companion of MTOR, complex 2
runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S-phase kinase-associated protein 2 (p45)
SHC (Src homology 2 domain containing) transforming protein 1
signal transducer and activator of transcription 3 (acute-phase response factor)
signal transducer and activator of transcription 4
signal transducer and activator of transcription 5B
SLIT-ROBO Rho GTPase activating protein 3
SMAD specific E3 ubiquitin protein ligase 1
solute carrier family 34 (sodium phosphate), member 2
spen homolog, transcriptional regulator (Drosophila)
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
sprouty-related, EVH1 domain containing 1
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
structural maintenance of chromosomes 1A
succinate dehydrogenase complex assembly factor 2
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
succinate dehydrogenase complex, subunit D, integral membrane protein
suppressor of fused homolog (Drosophila)
suppressor of zeste 12 homolog (Drosophila)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
synovial sarcoma translocation gene on chromosome 18-like 1
synovial sarcoma translocation, chromosome 18
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCF3 (E2A) fusion partner (in childhood Leukemia)
thyroid hormone receptor associated protein 3
transcription elongation factor A (SII), 1
transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
transcription factor 7-like 2 (T-cell specific, HMG-box)
transcription factor binding to IGHM enhancer 3
transducin (beta)-like 1 X-linked receptor 1
transforming growth factor, beta receptor II (70/80kDa)
transient receptor potential cation channel, subfamily M, member 3
translocated promoter region (to activated MET oncogene)
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
tumor necrosis factor receptor superfamily, member 17
tumor necrosis factor, alpha-induced protein 3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
ubiquitin protein ligase E3 component n-recognin 5
ubiquitin specific peptidase 6 (Tre-2 oncogene)
ubiquitin specific peptidase 9, X-linked
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
v-ets erythroblastosis virus E26 oncogene homolog (avian)
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
v-myb myeloblastosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
v-raf murine sarcoma 3611 viral oncogene homolog
v-raf murine sarcoma viral oncogene homolog B1
v-raf-1 murine leukemia viral oncogene homolog 1
v-rel reticuloendotheliosis viral oncogene homolog (avian)
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
vesicle transport through interaction with t-SNAREs homolog 1A (yeast)
Wolf-Hirschhorn syndrome candidate 1-like 1
WW domain containing transcription regulator 1
xeroderma pigmentosum, complementation group A
xeroderma pigmentosum, complementation group C
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
zinc finger and BTB domain containing 10
zinc finger and BTB domain containing 16