feature type start end label R G B shape direction protein Name=TP53; Synonyms=P53; 1 393 Name=TP53; Synonyms=P53; 0.7 0.9 0.9 - - domain DNA-binding (experimentally determined) 102 292 DNA-binding (experimentally determined) 0.78 0.78 0.26 - - domain Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 1 320 Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 0.63 0.39 0.35 - - domain Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 1 83 Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 0.37 0.31 0.76 - - domain Transcription activation (acidic). 1 44 Transcription activation (acidic). 0.45 0.76 0.5 - - domain Interaction with WWOX. 66 110 Interaction with WWOX. 0.67 0.36 0.76 - - domain Interaction with HIPK1. {ECO:0000250}. 100 370 Interaction with HIPK1. {ECO:0000250}. 0.33 0.21 0.45 - - domain Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 100 300 Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 0.24 0.59 0.24 - - domain Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 113 236 Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 0.25 0.68 0.73 - - domain Interaction with AXIN1. {ECO:0000250}. 116 292 Interaction with AXIN1. {ECO:0000250}. 0.74 0.79 0.63 - - domain Interaction with the 53BP2 SH3 domain. 241 248 Interaction with the 53BP2 SH3 domain. 0.24 0.47 0.54 - - domain Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 256 294 Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 0.48 0.74 0.21 - - domain Interaction with DNA. 273 280 Interaction with DNA. 0.8 0.21 0.54 - - domain Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 300 393 Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 0.77 0 0.9 - - domain Interaction with HIPK2. 319 360 Interaction with HIPK2. 0.97 0.86 0 - - domain Oligomerization. 325 356 Oligomerization. 0.53 0.61 0.75 - - domain Interaction with USP7. 359 363 Interaction with USP7. 0 0.95 0.89 - - domain Basic (repression of DNA-binding). 368 387 Basic (repression of DNA-binding). 0.8 0.21 0.21 - - domain TADI. 17 25 TADI. 0.98 0 0.7 - - domain TADII. 48 56 TADII. 0.21 0.28 0.2 - - domain Bipartite nuclear localization signal. 305 321 Bipartite nuclear localization signal. 0.68 0.69 0 - - domain Nuclear export signal. 339 350 Nuclear export signal. 0 0.64 0.99 - - domain [KR]-[STA]-K motif. 370 372 [KR]-[STA]-K motif. 0 0.61 0.61 - - mutation Missense_Mutation 341 341 p.F341Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 337 337 p.R337L 1.0 1.0 0.0 circle up mutation Missense_Mutation 334 334 p.G334W 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 331 331 p.Q331* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 331 331 p.Q331* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 317 317 p.Q317* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 298 298 p.E298* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 283 283 p.R283P 1.0 1.0 0.0 circle up mutation Missense_Mutation 280 280 p.R280K 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 280 280 p.R280Efs*65 1.0 0.0 0.0 square up mutation Missense_Mutation 277 277 p.C277F 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273H 1.0 1.0 0.0 circle up mutation Missense_Mutation 272 272 p.V272L 1.0 1.0 0.0 circle up mutation Missense_Mutation 259 259 p.D259V 1.0 1.0 0.0 circle up mutation Missense_Mutation 254 254 p.I254T 1.0 1.0 0.0 circle up mutation Missense_Mutation 249 249 p.R249M 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248L 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248W 1.0 1.0 0.0 circle up mutation Missense_Mutation 246 246 p.M246V 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245V 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245V 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245S 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245S 1.0 1.0 0.0 circle up mutation Missense_Mutation 244 244 p.G244S 1.0 1.0 0.0 circle up mutation Missense_Mutation 242 242 p.C242F 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 234 234 p.Y234Lfs*22 1.0 0.0 0.0 square up mutation Missense_Mutation 241 241 p.S241F 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 237 237 p.M237* 1.0 0.0 0.0 square up mutation Missense_Mutation 237 237 p.M237I 1.0 1.0 0.0 circle up mutation Missense_Mutation 236 236 p.Y236C 1.0 1.0 0.0 circle up mutation Missense_Mutation 234 234 p.Y234H 1.0 1.0 0.0 circle up mutation Splice_Site 225 225 p.X225_splice 0.6 0.0 0.6 inv_triangle up mutation Missense_Mutation 220 220 p.Y220C 1.0 1.0 0.0 circle up mutation Missense_Mutation 218 218 p.V218G 1.0 1.0 0.0 circle up mutation Missense_Mutation 215 215 p.S215I 1.0 1.0 0.0 circle up mutation Missense_Mutation 213 213 p.R213P 1.0 1.0 0.0 circle up mutation Missense_Mutation 213 213 p.R213L 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 213 213 p.R213* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 211 211 p.T211Ffs*4 1.0 0.0 0.0 square up mutation Missense_Mutation 199 199 p.G199V 1.0 1.0 0.0 circle up mutation Missense_Mutation 195 195 p.I195T 1.0 1.0 0.0 circle up mutation Frame_Shift_Ins 191 191 p.P191Sfs*18 1.0 0.0 0.0 square up mutation Missense_Mutation 190 190 p.P190T 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179Q 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 178 178 p.H178Tfs*69 1.0 0.0 0.0 square up mutation Missense_Mutation 176 176 p.C176Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 173 173 p.V173L 1.0 1.0 0.0 circle up mutation Missense_Mutation 156 156 p.R156P 1.0 1.0 0.0 circle up mutation Missense_Mutation 156 156 p.R156P 1.0 1.0 0.0 circle up mutation Missense_Mutation 154 154 p.G154V 1.0 1.0 0.0 circle up mutation Missense_Mutation 131 131 p.N131I 1.0 1.0 0.0 circle up mutation Missense_Mutation 127 127 p.S127F 1.0 1.0 0.0 circle up mutation Splice_Site 126 126 p.X126_splice 0.6 0.0 0.6 inv_triangle up mutation Splice_Site 126 126 p.X126_splice 0.6 0.0 0.6 inv_triangle up mutation Missense_Mutation 105 105 p.G105C 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 91 91 p.W91* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 62 62 p.E62* 1.0 0.0 0.0 triangle up