be found at different copy numbers in the germ line of two different

individuals. Such germ line variations can confound a GISTIC

analysis, which finds significant  somatic copy number variations in

cancer. A more in depth discussion is provided in

. GISTIC currently uses two CNV exclusion lists. One is based on the

literature describing copy number variation, and a second one comes

from an analysis of significant variations among the blood normals in

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

The landscape of somatic copy-number alteration across human cancers

Integrated detection and population-genetic analysis of SNPs and copy number variation

The Sanger Institute: Cancer Gene Census