E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.017 0.074 -9999.0 0.0 -0.345 16.0 16.0 KLHL20 0.011 0.065 -9999.0 0.0 -0.189 33.0 33.0 CYFIP2 -0.02 0.099 -9999.0 0.0 -0.254 75.0 75.0 Rac1/GDP 0.028 0.072 -9999.0 0.0 -0.275 23.0 23.0 ENAH 0.012 0.087 -9999.0 0.0 -0.376 20.0 20.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 22.0 22.0 RAP1A 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 CTNNB1 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 CDC42/GTP -0.012 0.052 -9999.0 0.0 -0.236 22.0 22.0 ABI1/Sra1/Nap1 -0.019 0.043 -9999.0 0.0 -0.138 49.0 49.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.04 0.033 -9999.0 0.0 -0.136 11.0 11.0 RAPGEF1 0.02 0.074 -9999.0 0.0 -0.307 21.0 21.0 CTNND1 0.001 0.073 -9999.0 0.0 -0.292 31.0 31.0 regulation of calcium-dependent cell-cell adhesion 0.015 0.076 -9999.0 0.0 -0.356 16.0 16.0 CRK 0.017 0.08 -9999.0 0.0 -0.335 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.046 -9999.0 0.0 -0.129 36.0 36.0 alphaE/beta7 Integrin 0.024 0.027 -9999.0 0.0 -0.191 7.0 7.0 IQGAP1 -0.009 0.087 -9999.0 0.0 -0.274 50.0 50.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.01 -9999.0 0.0 -0.141 2.0 2.0 DLG1 0.015 0.078 -9999.0 0.0 -0.351 17.0 17.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.02 0.054 -9999.0 0.0 -0.198 36.0 36.0 MLLT4 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.015 0.036 -9999.0 0.0 -0.143 24.0 24.0 PI3K -0.026 0.071 -9999.0 0.0 -0.258 36.0 36.0 ARF6 0.018 0.015 -9999.0 0.0 -0.202 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.0 36.0 36.0 E-cadherin/gamma catenin 0.016 0.039 -9999.0 0.0 -0.135 25.0 25.0 TIAM1 0.003 0.066 -9999.0 0.0 -0.23 35.0 35.0 E-cadherin(dimer)/Ca2+ 0.027 0.06 -9999.0 0.0 -0.182 34.0 34.0 AKT1 0.006 0.061 -9999.0 0.0 -0.186 38.0 38.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.292 54.0 54.0 CDH1 0.012 0.03 -9999.0 0.0 -0.111 29.0 29.0 RhoA/GDP 0.029 0.069 -9999.0 0.0 -0.261 23.0 23.0 actin cytoskeleton organization 0.01 0.049 -9999.0 0.0 -0.139 33.0 33.0 CDC42/GDP 0.029 0.068 -9999.0 0.0 -0.258 22.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.068 -9999.0 0.0 -0.236 33.0 33.0 ITGB7 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.03 0.065 -9999.0 0.0 -0.194 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.025 0.033 -9999.0 0.0 -0.145 15.0 15.0 mol:GDP 0.021 0.075 -9999.0 0.0 -0.307 21.0 21.0 CDC42/GTP/IQGAP1 0.009 0.053 -9999.0 0.0 -0.161 45.0 45.0 JUP 0.008 0.037 -9999.0 0.0 -0.111 47.0 47.0 p120 catenin/RhoA/GDP 0.029 0.077 -9999.0 0.0 -0.246 33.0 33.0 RAC1/GTP/IQGAP1 0.007 0.056 -9999.0 0.0 -0.16 51.0 51.0 PIP5K1C/AP1M1 0.005 0.041 -9999.0 0.0 -0.164 27.0 27.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 CDC42 0.017 0.016 -9999.0 0.0 -0.111 8.0 8.0 CTNNA1 0.011 0.048 -9999.0 0.0 -0.292 13.0 13.0 positive regulation of S phase of mitotic cell cycle 0.0 0.054 -9999.0 0.0 -0.145 50.0 50.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 105.0 105.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.014 0.081 -9999.0 0.0 -0.373 17.0 17.0 regulation of cell-cell adhesion -0.011 0.045 -9999.0 0.0 -0.209 22.0 22.0 WASF2 -0.011 0.023 -9999.0 0.0 -0.075 49.0 49.0 Rap1/GTP 0.019 0.067 -9999.0 0.0 -0.266 22.0 22.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.049 -9999.0 0.0 -0.144 20.0 20.0 CCND1 -0.001 0.066 -9999.0 0.0 -0.177 50.0 50.0 VAV2 0.024 0.079 -9999.0 0.0 -0.401 13.0 13.0 RAP1/GDP 0.022 0.068 -9999.0 0.0 -0.274 21.0 21.0 adherens junction assembly 0.015 0.078 -9999.0 0.0 -0.361 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.008 0.055 -9999.0 0.0 -0.243 22.0 22.0 PIP5K1C 0.006 0.061 -9999.0 0.0 -0.245 27.0 27.0 regulation of heterotypic cell-cell adhesion 0.037 0.048 -9999.0 0.0 -0.143 18.0 18.0 E-cadherin/beta catenin 0.008 0.034 -9999.0 0.0 -0.148 16.0 16.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 105.0 105.0 SRC 0.017 0.074 -9999.0 0.0 -0.343 16.0 16.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.224 66.0 66.0 Rac1/GTP -0.031 0.082 -9999.0 0.0 -0.304 33.0 33.0 E-cadherin/beta catenin/alpha catenin 0.029 0.04 -9999.0 0.0 -0.173 15.0 15.0 ITGAE 0.014 0.037 -9999.0 0.0 -0.238 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.015 0.078 -9999.0 0.0 -0.364 16.0 16.0