E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.005 0.076 -9999.0 0.0 -0.291 26.0 26.0 KLHL20 0.045 0.097 0.215 66.0 -0.191 23.0 89.0 CYFIP2 0.032 0.013 -9999.0 0.0 0.0 76.0 76.0 Rac1/GDP 0.007 0.065 0.218 4.0 -0.276 11.0 15.0 ENAH 0.005 0.078 -9999.0 0.0 -0.312 23.0 23.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 56.0 -0.0 5.0 61.0 RAP1A 0.037 0.005 -9999.0 0.0 0.0 10.0 10.0 CTNNB1 0.037 0.007 -9999.0 0.0 0.0 17.0 17.0 CDC42/GTP -0.026 0.056 0.124 22.0 -0.221 16.0 38.0 ABI1/Sra1/Nap1 -0.017 0.036 -9999.0 0.0 -0.137 32.0 32.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.084 0.04 -9999.0 0.0 -0.127 8.0 8.0 RAPGEF1 -0.004 0.08 0.227 2.0 -0.278 22.0 24.0 CTNND1 0.035 0.01 -9999.0 0.0 0.0 36.0 36.0 regulation of calcium-dependent cell-cell adhesion 0.018 0.08 -9999.0 0.0 -0.293 26.0 26.0 CRK 0.003 0.082 0.182 22.0 -0.291 23.0 45.0 E-cadherin/gamma catenin/alpha catenin 0.063 0.036 -9999.0 0.0 -0.122 9.0 9.0 alphaE/beta7 Integrin 0.051 0.024 -9999.0 0.0 -0.14 6.0 6.0 IQGAP1 0.034 0.011 -9999.0 0.0 0.0 47.0 47.0 NCKAP1 0.038 0.003 -9999.0 0.0 0.0 3.0 3.0 Rap1/GTP/I-afadin 0.044 0.015 -9999.0 0.0 -0.099 1.0 1.0 DLG1 0.004 0.079 -9999.0 0.0 -0.297 26.0 26.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.044 -9999.0 0.0 -0.176 31.0 31.0 MLLT4 0.035 0.01 -9999.0 0.0 0.0 36.0 36.0 ARF6/GTP/NME1/Tiam1 0.038 0.032 -9999.0 0.0 -0.1 22.0 22.0 PI3K -0.044 0.058 0.063 2.0 -0.227 31.0 33.0 ARF6 0.035 0.009 -9999.0 0.0 0.0 31.0 31.0 mol:Ca2+ 0.0 0.0 0.001 67.0 -0.0 29.0 96.0 E-cadherin/gamma catenin 0.049 0.019 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.035 0.011 -9999.0 0.0 0.0 44.0 44.0 E-cadherin(dimer)/Ca2+ 0.071 0.055 -9999.0 0.0 -0.134 26.0 26.0 AKT1 -0.022 0.058 0.148 16.0 -0.191 21.0 37.0 PIK3R1 0.033 0.013 -9999.0 0.0 0.0 67.0 67.0 CDH1 0.035 0.01 -9999.0 0.0 0.0 39.0 39.0 RhoA/GDP 0.013 0.079 0.236 9.0 -0.264 12.0 21.0 actin cytoskeleton organization 0.038 0.079 0.18 66.0 -0.14 23.0 89.0 CDC42/GDP 0.011 0.075 0.221 9.0 -0.255 12.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.052 -9999.0 0.0 -0.192 25.0 25.0 ITGB7 0.037 0.006 -9999.0 0.0 0.0 14.0 14.0 RAC1 0.026 0.017 -9999.0 0.0 0.0 156.0 156.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.06 -9999.0 0.0 -0.144 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.033 -9999.0 0.0 -0.108 11.0 11.0 mol:GDP -0.004 0.082 0.24 10.0 -0.287 13.0 23.0 CDC42/GTP/IQGAP1 0.037 0.042 -9999.0 0.0 -0.113 34.0 34.0 JUP 0.034 0.011 -9999.0 0.0 0.0 52.0 52.0 p120 catenin/RhoA/GDP 0.027 0.085 0.245 9.0 -0.247 17.0 26.0 RAC1/GTP/IQGAP1 0.025 0.043 -9999.0 0.0 -0.115 32.0 32.0 PIP5K1C/AP1M1 0.021 0.03 -9999.0 0.0 -0.129 19.0 19.0 RHOA 0.036 0.007 -9999.0 0.0 0.0 20.0 20.0 CDC42 0.036 0.008 -9999.0 0.0 0.0 26.0 26.0 CTNNA1 0.036 0.007 -9999.0 0.0 0.0 19.0 19.0 positive regulation of S phase of mitotic cell cycle 0.013 0.048 0.126 16.0 -0.12 32.0 48.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 31.0 31.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.007 0.076 -9999.0 0.0 -0.301 23.0 23.0 regulation of cell-cell adhesion -0.029 0.04 -9999.0 0.0 -0.17 25.0 25.0 WASF2 -0.009 0.019 -9999.0 0.0 -0.074 33.0 33.0 Rap1/GTP -0.022 0.066 0.155 29.0 -0.252 15.0 44.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.091 0.053 -9999.0 0.0 -0.128 13.0 13.0 CCND1 0.015 0.057 0.144 16.0 -0.146 32.0 48.0 VAV2 0.016 0.126 -9999.0 0.0 -0.561 14.0 14.0 RAP1/GDP -0.01 0.071 0.171 28.0 -0.25 15.0 43.0 adherens junction assembly 0.007 0.074 -9999.0 0.0 -0.293 23.0 23.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.017 -9999.0 0.0 0.0 136.0 136.0 PIP5K1C 0.035 0.01 -9999.0 0.0 0.0 42.0 42.0 regulation of heterotypic cell-cell adhesion 0.063 0.049 0.204 2.0 -0.132 15.0 17.0 E-cadherin/beta catenin 0.008 0.02 -9999.0 0.0 -0.097 5.0 5.0 mol:GTP 0.0 0.0 0.001 63.0 -0.0 31.0 94.0 SRC 0.004 0.073 -9999.0 0.0 -0.29 24.0 24.0 PIK3CA 0.032 0.013 -9999.0 0.0 0.0 74.0 74.0 Rac1/GTP -0.008 0.077 0.179 2.0 -0.291 24.0 26.0 E-cadherin/beta catenin/alpha catenin 0.064 0.038 -9999.0 0.0 -0.131 11.0 11.0 ITGAE 0.036 0.007 -9999.0 0.0 0.0 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.082 -9999.0 0.0 -0.299 26.0 26.0