Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.028 0.206 -9999.0 0.0 -0.653 11.0 11.0 IHH -0.013 0.096 -9999.0 0.0 -0.455 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.097 0.168 -9999.0 0.0 -0.369 27.0 27.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.097 0.167 0.367 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.019 0.144 -9999.0 0.0 -0.616 4.0 4.0 SMO -0.027 0.152 -9999.0 0.0 -0.566 6.0 6.0 AKT1 0.002 0.097 -9999.0 0.0 -0.593 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.073 -9999.0 0.0 -0.516 3.0 3.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.026 0.149 -9999.0 0.0 -0.556 6.0 6.0 STIL -0.074 0.173 -9999.0 0.0 -0.593 6.0 6.0 DHH N/PTCH2 -0.029 0.135 -9999.0 0.0 -0.393 18.0 18.0 DHH N/PTCH1 -0.04 0.171 -9999.0 0.0 -0.468 14.0 14.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.036 0.153 -9999.0 0.0 -0.518 14.0 14.0 PTHLH -0.028 0.22 -9999.0 0.0 -0.704 11.0 11.0 determination of left/right symmetry -0.026 0.149 -9999.0 0.0 -0.556 6.0 6.0 PIK3R1 0.002 0.077 -9999.0 0.0 -0.545 3.0 3.0 skeletal system development -0.027 0.218 -9999.0 0.0 -0.696 11.0 11.0 IHH N/Hhip -0.098 0.201 -9999.0 0.0 -0.429 40.0 40.0 DHH N/Hhip -0.11 0.205 -9999.0 0.0 -0.412 46.0 46.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.026 0.149 -9999.0 0.0 -0.556 6.0 6.0 pancreas development -0.118 0.234 -9999.0 0.0 -0.533 37.0 37.0 HHAT -0.005 0.101 -9999.0 0.0 -0.556 5.0 5.0 PI3K 0.011 0.057 -9999.0 0.0 -0.389 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.044 0.164 -9999.0 0.0 -0.508 17.0 17.0 somite specification -0.026 0.149 -9999.0 0.0 -0.556 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.085 0.182 -9999.0 0.0 -0.561 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.076 0.154 -9999.0 0.0 -0.298 47.0 47.0 SHH Np/Cholesterol/Megalin -0.173 0.211 -9999.0 0.0 -0.357 79.0 79.0 SHH -0.095 0.182 -9999.0 0.0 -0.378 44.0 44.0 catabolic process -0.021 0.163 -9999.0 0.0 -0.5 11.0 11.0 SMO/Vitamin D3 -0.074 0.182 -9999.0 0.0 -0.613 7.0 7.0 SHH Np/Cholesterol/Hhip -0.139 0.193 -9999.0 0.0 -0.33 70.0 70.0 LRP2 -0.181 0.265 -9999.0 0.0 -0.54 54.0 54.0 receptor-mediated endocytosis -0.139 0.212 -9999.0 0.0 -0.508 26.0 26.0 SHH Np/Cholesterol/BOC -0.072 0.143 -9999.0 0.0 -0.321 21.0 21.0 SHH Np/Cholesterol/CDO -0.08 0.149 -9999.0 0.0 -0.289 50.0 50.0 mesenchymal cell differentiation 0.138 0.191 0.328 70.0 -9999.0 0.0 70.0 mol:Vitamin D3 -0.083 0.183 -9999.0 0.0 -0.561 8.0 8.0 IHH N/PTCH2 -0.009 0.098 -9999.0 0.0 -0.354 10.0 10.0 CDON -0.011 0.112 -9999.0 0.0 -0.524 7.0 7.0 IHH N/PTCH1 -0.02 0.164 -9999.0 0.0 -0.503 11.0 11.0 Megalin/LRPAP1 -0.122 0.194 -9999.0 0.0 -0.385 54.0 54.0 PTCH2 -0.005 0.101 -9999.0 0.0 -0.556 5.0 5.0 SHH Np/Cholesterol -0.081 0.136 -9999.0 0.0 -0.291 44.0 44.0 PTCH1 -0.021 0.164 -9999.0 0.0 -0.502 11.0 11.0 HHIP -0.118 0.235 -9999.0 0.0 -0.534 37.0 37.0