Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.107 -9999.0 0.0 -0.248 26.0 26.0 epithelial cell differentiation -0.058 0.112 -9999.0 0.0 -0.286 24.0 24.0 CYFIP2 0.009 0.047 -9999.0 0.0 -0.573 1.0 1.0 ENAH 0.01 0.09 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.22 0.27 -9999.0 0.0 -0.53 66.0 66.0 EPHA2 -0.001 0.083 -9999.0 0.0 -0.509 4.0 4.0 MYO6 -0.026 0.119 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.03 -9999.0 0.0 -0.345 1.0 1.0 AQP5 -0.147 0.225 -9999.0 0.0 -0.536 34.0 34.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.119 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.134 -9999.0 0.0 -0.548 2.0 2.0 EGF -0.046 0.173 -9999.0 0.0 -0.552 16.0 16.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.067 0.123 -9999.0 0.0 -0.431 9.0 9.0 cortical microtubule organization -0.058 0.112 -9999.0 0.0 -0.286 24.0 24.0 GO:0000145 -0.027 0.113 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.034 0.125 -9999.0 0.0 -0.289 24.0 24.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.049 0.086 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.054 -9999.0 0.0 -0.307 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.113 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.026 0.119 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.028 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.108 0.232 -9999.0 0.0 -0.55 33.0 33.0 EGFR/EGFR/EGF/EGF -0.178 0.174 -9999.0 0.0 -0.523 20.0 20.0 RhoA/GDP -0.054 0.103 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.019 0.115 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.007 0.057 -9999.0 0.0 -0.487 2.0 2.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.057 -9999.0 0.0 -0.487 2.0 2.0 IGF1 -0.029 0.146 -9999.0 0.0 -0.53 12.0 12.0 DIAPH1 -0.001 0.056 -9999.0 0.0 -0.692 1.0 1.0 Wnt receptor signaling pathway 0.058 0.112 0.286 24.0 -9999.0 0.0 24.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.087 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.117 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.009 0.047 -9999.0 0.0 -0.573 1.0 1.0 LPP -0.021 0.116 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.058 0.103 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.046 0.088 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.038 0.136 -9999.0 0.0 -0.56 2.0 2.0 HGF/MET -0.163 0.193 -9999.0 0.0 -0.545 22.0 22.0 HGF -0.092 0.218 -9999.0 0.0 -0.544 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.108 -9999.0 0.0 -0.25 26.0 26.0 actin cable formation 0.026 0.089 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.118 0.18 -9999.0 0.0 -0.535 12.0 12.0 KIFC3 -0.028 0.12 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.028 0.12 -9999.0 0.0 -0.271 1.0 1.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.058 0.112 -9999.0 0.0 -0.286 24.0 24.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.119 -9999.0 0.0 -0.268 24.0 24.0 PIP5K1C -0.028 0.12 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.005 0.066 -9999.0 0.0 -0.573 2.0 2.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.001 0.101 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.098 0.18 -9999.0 0.0 -0.526 12.0 12.0 IGF-1R heterotetramer/IGF1 -0.072 0.127 -9999.0 0.0 -0.495 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.135 0.242 -9999.0 0.0 -0.528 42.0 42.0 PLEKHA7 -0.037 0.135 -9999.0 0.0 -0.466 3.0 3.0 mol:GTP 0.023 0.054 -9999.0 0.0 -0.305 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.002 0.107 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.027 0.107 -9999.0 0.0 -0.248 26.0 26.0 regulation of cell-cell adhesion -0.019 0.115 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.108 -9999.0 0.0 -0.25 26.0 26.0