Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	53.0	430.0	8.0	-0.18	0.113	1000.0	-1000.0	-0.012	-1000.0
Syndecan-1-mediated signaling events	29.0	1016.0	34.0	-0.306	0.013	1000.0	-1000.0	-0.048	-1000.0
IL23-mediated signaling events	28.0	1730.0	60.0	-0.535	0.013	1000.0	-1000.0	-0.147	-1000.0
Ephrin A  reverse signaling	25.0	175.0	7.0	-0.066	-0.0	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	24.0	2003.0	82.0	-0.233	0.013	1000.0	-1000.0	-0.077	-1000.0
EGFR-dependent Endothelin signaling events	21.0	455.0	21.0	-0.22	0.019	1000.0	-1000.0	-0.057	-1000.0
E-cadherin signaling events	20.0	101.0	5.0	-0.108	0.013	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by the Hedgehog family	19.0	1008.0	52.0	-0.181	0.138	1000.0	-1000.0	-0.051	-1000.0
Glypican 2 network	19.0	78.0	4.0	-0.063	-0.047	1000.0	-1000.0	-0.017	-1000.0
IL12-mediated signaling events	18.0	1611.0	87.0	-0.412	0.066	1000.0	-1000.0	-0.129	-1000.0
PDGFR-alpha signaling pathway	18.0	817.0	44.0	-0.1	0.023	1000.0	-1000.0	-0.049	-1000.0
Glypican 1 network	17.0	840.0	48.0	-0.252	0.027	1000.0	-1000.0	-0.032	-1000.0
Reelin signaling pathway	17.0	968.0	56.0	-0.247	0.029	1000.0	-1000.0	-0.077	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1626.0	93.0	-0.187	0.038	1000.0	-1000.0	-0.08	-1000.0
IL4-mediated signaling events	16.0	1533.0	91.0	-0.548	0.414	1000.0	-1000.0	-0.154	-1000.0
Effects of Botulinum toxin	16.0	439.0	26.0	-0.169	0.013	1000.0	-1000.0	-0.053	-1000.0
Syndecan-4-mediated signaling events	16.0	1072.0	67.0	-0.188	0.023	1000.0	-1000.0	-0.083	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1436.0	88.0	-0.192	0.03	1000.0	-1000.0	-0.109	-1000.0
Visual signal transduction: Cones	15.0	579.0	38.0	-0.133	0.013	1000.0	-1000.0	-0.049	-1000.0
Arf6 signaling events	15.0	977.0	62.0	-0.22	0.024	1000.0	-1000.0	-0.045	-1000.0
TCGA08_p53	15.0	110.0	7.0	-0.129	0.043	1000.0	-1000.0	-0.011	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1225.0	85.0	-0.157	0.013	1000.0	-1000.0	-0.064	-1000.0
Endothelins	14.0	1361.0	96.0	-0.226	0.036	1000.0	-1000.0	-0.074	-1000.0
HIF-1-alpha transcription factor network	13.0	994.0	76.0	-0.255	0.044	1000.0	-1000.0	-0.143	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	637.0	46.0	-0.42	0.016	1000.0	-1000.0	-0.095	-1000.0
Signaling mediated by p38-alpha and p38-beta	13.0	598.0	44.0	-0.173	0.013	1000.0	-1000.0	-0.049	-1000.0
Caspase cascade in apoptosis	12.0	930.0	74.0	-0.177	0.051	1000.0	-1000.0	-0.039	-1000.0
p75(NTR)-mediated signaling	12.0	1580.0	125.0	-0.206	0.039	1000.0	-1000.0	-0.09	-1000.0
amb2 Integrin signaling	12.0	1043.0	82.0	-0.212	0.014	1000.0	-1000.0	-0.071	-1000.0
Glucocorticoid receptor regulatory network	12.0	1474.0	114.0	-0.447	0.278	1000.0	-1000.0	-0.062	-1000.0
ErbB2/ErbB3 signaling events	11.0	715.0	65.0	-0.175	0.019	1000.0	-1000.0	-0.06	-1000.0
Thromboxane A2 receptor signaling	11.0	1183.0	105.0	-0.22	0.024	1000.0	-1000.0	-0.064	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	11.0	791.0	68.0	-0.365	0.031	1000.0	-1000.0	-0.124	-1000.0
Visual signal transduction: Rods	11.0	598.0	52.0	-0.143	0.013	1000.0	-1000.0	-0.076	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	327.0	31.0	-0.231	0.013	1000.0	-1000.0	-0.08	-1000.0
Syndecan-2-mediated signaling events	9.0	651.0	69.0	-0.171	0.026	1000.0	-1000.0	-0.027	-1000.0
BMP receptor signaling	9.0	771.0	81.0	-0.175	0.029	1000.0	-1000.0	-0.088	-1000.0
IL1-mediated signaling events	9.0	596.0	62.0	-0.149	0.041	1000.0	-1000.0	-0.083	-1000.0
Syndecan-3-mediated signaling events	9.0	345.0	35.0	-0.22	0.039	1000.0	-1000.0	-0.045	-1000.0
Wnt signaling	9.0	67.0	7.0	-0.067	0.002	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	9.0	242.0	26.0	-0.22	0.016	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by STAT5	9.0	203.0	22.0	-0.191	0.014	1000.0	-1000.0	-0.046	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1123.0	120.0	-0.193	0.072	1000.0	-1000.0	-0.066	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	471.0	54.0	-0.178	0.026	1000.0	-1000.0	-0.092	-1000.0
Noncanonical Wnt signaling pathway	8.0	228.0	26.0	-0.085	0.013	1000.0	-1000.0	-0.042	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	40.0	5.0	-0.026	-0.002	1000.0	-1000.0	-0.019	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	813.0	97.0	-0.178	0.038	1000.0	-1000.0	-0.075	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	454.0	52.0	-0.143	0.029	1000.0	-1000.0	-0.042	-1000.0
Retinoic acid receptors-mediated signaling	8.0	501.0	58.0	-0.149	0.024	1000.0	-1000.0	-0.064	-1000.0
Integrins in angiogenesis	8.0	713.0	84.0	-0.16	0.029	1000.0	-1000.0	-0.071	-1000.0
LPA receptor mediated events	8.0	821.0	102.0	-0.22	0.025	1000.0	-1000.0	-0.077	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	655.0	76.0	-0.108	0.024	1000.0	-1000.0	-0.079	-1000.0
LPA4-mediated signaling events	7.0	89.0	12.0	-0.037	0.016	1000.0	-1000.0	-0.02	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	7.0	269.0	34.0	-0.043	0.013	1000.0	-1000.0	-0.048	-1000.0
S1P1 pathway	7.0	256.0	36.0	-0.091	0.013	1000.0	-1000.0	-0.049	-1000.0
Nongenotropic Androgen signaling	7.0	398.0	52.0	-0.055	0.013	1000.0	-1000.0	-0.05	-1000.0
IL6-mediated signaling events	7.0	574.0	75.0	-0.162	0.045	1000.0	-1000.0	-0.077	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	586.0	74.0	-0.22	0.058	1000.0	-1000.0	-0.078	-1000.0
BCR signaling pathway	7.0	701.0	99.0	-0.136	0.033	1000.0	-1000.0	-0.083	-1000.0
Rapid glucocorticoid signaling	7.0	154.0	20.0	-0.081	0.014	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in keratinocytes	7.0	328.0	43.0	-0.22	0.015	1000.0	-1000.0	-0.054	-1000.0
FOXM1 transcription factor network	7.0	375.0	51.0	-0.186	0.108	1000.0	-1000.0	-0.156	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	598.0	78.0	-0.059	0.035	1000.0	-1000.0	-0.079	-1000.0
Coregulation of Androgen receptor activity	6.0	496.0	76.0	-0.18	0.026	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	6.0	476.0	69.0	-0.22	0.074	1000.0	-1000.0	-0.078	-1000.0
Osteopontin-mediated events	6.0	261.0	38.0	-0.062	0.016	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by PTP1B	6.0	504.0	76.0	-0.221	0.02	1000.0	-1000.0	-0.072	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	424.0	61.0	-0.218	0.04	1000.0	-1000.0	-0.067	-1000.0
Nectin adhesion pathway	6.0	429.0	63.0	-0.108	0.022	1000.0	-1000.0	-0.074	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	223.0	37.0	-0.062	0.019	1000.0	-1000.0	-0.045	-1000.0
Ephrin B reverse signaling	6.0	316.0	48.0	-0.127	0.063	1000.0	-1000.0	-0.057	-1000.0
FAS signaling pathway (CD95)	6.0	326.0	47.0	-0.198	0.015	1000.0	-1000.0	-0.042	-1000.0
IL2 signaling events mediated by PI3K	6.0	379.0	58.0	-0.182	0.024	1000.0	-1000.0	-0.075	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	277.0	45.0	-0.083	0.022	1000.0	-1000.0	-0.079	-1000.0
Canonical Wnt signaling pathway	6.0	345.0	51.0	-0.218	0.083	1000.0	-1000.0	-0.046	-1000.0
EPHB forward signaling	6.0	585.0	85.0	-0.126	0.071	1000.0	-1000.0	-0.081	-1000.0
Plasma membrane estrogen receptor signaling	6.0	570.0	86.0	-0.09	0.035	1000.0	-1000.0	-0.078	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	715.0	136.0	-0.157	0.155	1000.0	-1000.0	-0.061	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.05	0.013	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	5.0	35.0	7.0	-0.017	0.0	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	5.0	443.0	76.0	-0.107	0.022	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	5.0	250.0	48.0	-0.04	0.026	1000.0	-1000.0	-0.062	-1000.0
IL27-mediated signaling events	5.0	265.0	51.0	-0.147	0.014	1000.0	-1000.0	-0.081	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	176.0	33.0	-0.18	0.036	1000.0	-1000.0	-0.035	-1000.0
Regulation of Androgen receptor activity	5.0	377.0	70.0	-0.266	0.037	1000.0	-1000.0	-0.075	-1000.0
Aurora B signaling	5.0	376.0	67.0	-0.147	0.013	1000.0	-1000.0	-0.066	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.001	0.006	1000.0	-1000.0	-0.02	-1000.0
S1P5 pathway	4.0	84.0	17.0	-0.056	0.013	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	4.0	225.0	49.0	-0.107	0.017	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	4.0	201.0	43.0	-0.065	0.028	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	501.0	125.0	-0.064	0.023	1000.0	-1000.0	-0.081	-1000.0
Regulation of Telomerase	4.0	470.0	102.0	-0.221	0.044	1000.0	-1000.0	-0.101	-1000.0
S1P4 pathway	4.0	110.0	25.0	-0.056	0.021	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	77.0	17.0	-0.032	0.025	1000.0	-1000.0	-0.033	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	105.0	28.0	-0.056	0.026	1000.0	-1000.0	-0.03	-1000.0
Cellular roles of Anthrax toxin	3.0	135.0	39.0	-0.08	0.017	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	237.0	65.0	-0.07	0.053	1000.0	-1000.0	-0.053	-1000.0
EPO signaling pathway	3.0	196.0	55.0	-0.07	0.044	1000.0	-1000.0	-0.081	-1000.0
PLK1 signaling events	3.0	257.0	85.0	-0.041	0.028	1000.0	-1000.0	-0.039	-1000.0
Insulin-mediated glucose transport	3.0	114.0	32.0	-0.077	0.029	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class III	3.0	154.0	40.0	-0.07	0.024	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	266.0	83.0	-0.146	0.031	1000.0	-1000.0	-0.07	-1000.0
Regulation of p38-alpha and p38-beta	3.0	212.0	54.0	-0.152	0.034	1000.0	-1000.0	-0.054	-1000.0
IGF1 pathway	3.0	210.0	57.0	-0.032	0.026	1000.0	-1000.0	-0.085	-1000.0
VEGFR1 specific signals	3.0	207.0	56.0	-0.064	0.034	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	3.0	160.0	42.0	-0.062	0.022	1000.0	-1000.0	-0.036	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.008	-1000.0
Canonical NF-kappaB pathway	2.0	81.0	39.0	-0.08	0.071	1000.0	-1000.0	-0.079	-1000.0
Circadian rhythm pathway	2.0	48.0	22.0	-0.011	0.039	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	36.0	15.0	-0.001	0.028	1000.0	-1000.0	-0.021	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	80.0	36.0	-0.032	0.027	1000.0	-1000.0	-0.065	-1000.0
Atypical NF-kappaB pathway	2.0	77.0	31.0	-0.067	0.026	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events	2.0	175.0	73.0	-0.067	0.037	1000.0	-1000.0	-0.06	-1000.0
Insulin Pathway	2.0	214.0	74.0	-0.08	0.033	1000.0	-1000.0	-0.078	-1000.0
PDGFR-beta signaling pathway	2.0	198.0	97.0	-0.059	0.051	1000.0	-1000.0	-0.075	-1000.0
p38 MAPK signaling pathway	2.0	127.0	44.0	-0.058	0.025	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class II	1.0	92.0	75.0	-0.037	0.037	1000.0	-1000.0	-0.041	-1000.0
BARD1 signaling events	1.0	61.0	57.0	-0.024	0.054	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	1.0	82.0	60.0	-0.023	0.035	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	1.0	54.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.039	-1000.0
mTOR signaling pathway	1.0	88.0	53.0	-0.015	0.026	1000.0	-1000.0	-0.054	-1000.0
IFN-gamma pathway	1.0	135.0	68.0	-0.137	0.069	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class I	1.0	139.0	104.0	-0.08	0.049	1000.0	-1000.0	-0.054	-1000.0
FoxO family signaling	1.0	81.0	64.0	-0.077	0.094	1000.0	-1000.0	-0.08	-1000.0
Arf6 trafficking events	1.0	91.0	71.0	-0.098	0.039	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by PRL	1.0	46.0	34.0	-0.014	0.025	1000.0	-1000.0	-0.036	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	-0.026	0.04	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	45.0	68.0	-0.077	0.046	1000.0	-1000.0	-0.05	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	13.0	27.0	-0.023	0.031	1000.0	-1000.0	-0.048	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.003	0.03	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.039	1000.0	-1000.0	-0.031	-1000.0
Total	1052	59760	7203	-17.8394972037	4.79852239039	131000	-131000	-7.77911234054	-131000