Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.001 0.121 -9999.0 0.0 -0.493 8.0 8.0 IHH 0.023 0.051 -9999.0 0.0 -0.163 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.01 0.071 -9999.0 0.0 -0.223 13.0 13.0 LRPAP1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.071 0.221 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.046 0.114 -9999.0 0.0 -0.506 3.0 3.0 SMO -0.004 0.09 -9999.0 0.0 -0.468 4.0 4.0 AKT1 -0.003 0.102 -9999.0 0.0 -0.374 8.0 8.0 ARRB2 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.036 -9999.0 0.0 -0.38 1.0 1.0 ADRBK1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.003 0.088 -9999.0 0.0 -0.461 4.0 4.0 STIL 0.021 0.121 0.182 30.0 -0.32 6.0 36.0 DHH N/PTCH2 0.024 0.075 -9999.0 0.0 -0.273 8.0 8.0 DHH N/PTCH1 0.009 0.103 -9999.0 0.0 -0.344 9.0 9.0 PIK3CA 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.015 0.07 -9999.0 0.0 -0.38 4.0 4.0 PTHLH -0.011 0.149 -9999.0 0.0 -0.595 8.0 8.0 determination of left/right symmetry -0.003 0.088 -9999.0 0.0 -0.461 4.0 4.0 PIK3R1 0.029 0.035 -9999.0 0.0 -0.38 1.0 1.0 skeletal system development -0.011 0.147 -9999.0 0.0 -0.59 8.0 8.0 IHH N/Hhip -0.01 0.119 -9999.0 0.0 -0.309 18.0 18.0 DHH N/Hhip -0.011 0.114 -9999.0 0.0 -0.282 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.003 0.088 -9999.0 0.0 -0.461 4.0 4.0 pancreas development -0.028 0.134 -9999.0 0.0 -0.379 18.0 18.0 HHAT 0.027 0.048 -9999.0 0.0 -0.38 2.0 2.0 PI3K 0.044 0.03 -9999.0 0.0 -0.27 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.071 -9999.0 0.0 -0.38 4.0 4.0 somite specification -0.003 0.088 -9999.0 0.0 -0.461 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.016 0.087 -9999.0 0.0 -0.314 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.006 0.067 -9999.0 0.0 -0.224 11.0 11.0 SHH Np/Cholesterol/Megalin -0.033 0.096 -9999.0 0.0 -0.233 25.0 25.0 SHH -0.031 0.066 -9999.0 0.0 -0.27 10.0 10.0 catabolic process 0.002 0.097 -9999.0 0.0 -0.356 9.0 9.0 SMO/Vitamin D3 -0.013 0.101 -9999.0 0.0 -0.456 4.0 4.0 SHH Np/Cholesterol/Hhip -0.022 0.078 -9999.0 0.0 -0.212 20.0 20.0 LRP2 -0.065 0.165 -9999.0 0.0 -0.38 31.0 31.0 receptor-mediated endocytosis -0.038 0.123 -9999.0 0.0 -0.439 8.0 8.0 SHH Np/Cholesterol/BOC -0.003 0.059 -9999.0 0.0 -0.207 10.0 10.0 SHH Np/Cholesterol/CDO -0.004 0.061 -9999.0 0.0 -0.207 11.0 11.0 mesenchymal cell differentiation 0.022 0.078 0.21 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.03 0.127 0.196 31.0 -0.315 7.0 38.0 IHH N/PTCH2 0.031 0.067 -9999.0 0.0 -0.313 4.0 4.0 CDON 0.023 0.059 -9999.0 0.0 -0.38 3.0 3.0 IHH N/PTCH1 0.012 0.1 -9999.0 0.0 -0.358 9.0 9.0 Megalin/LRPAP1 -0.029 0.128 -9999.0 0.0 -0.27 31.0 31.0 PTCH2 0.021 0.067 -9999.0 0.0 -0.38 4.0 4.0 SHH Np/Cholesterol -0.008 0.054 -9999.0 0.0 -0.202 10.0 10.0 PTCH1 0.002 0.097 -9999.0 0.0 -0.358 9.0 9.0 HHIP -0.028 0.134 -9999.0 0.0 -0.38 18.0 18.0