Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.085 -9999.0 0.0 -0.199 24.0 24.0 epithelial cell differentiation 0.026 0.097 -9999.0 0.0 -0.196 23.0 23.0 CYFIP2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.041 0.066 0.418 1.0 -9999.0 0.0 1.0 EGFR -0.065 0.152 -9999.0 0.0 -0.38 28.0 28.0 EPHA2 0.028 0.037 -9999.0 0.0 -0.38 1.0 1.0 MYO6 -0.044 0.067 0.175 2.0 -0.193 22.0 24.0 CTNNB1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.032 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.095 0.191 -9999.0 0.0 -0.441 31.0 31.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.065 0.174 2.0 -0.19 20.0 22.0 regulation of calcium-dependent cell-cell adhesion -0.049 0.077 0.174 2.0 -0.203 26.0 28.0 EGF 0.003 0.104 -9999.0 0.0 -0.38 10.0 10.0 NCKAP1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.025 0.096 -9999.0 0.0 -0.349 6.0 6.0 cortical microtubule organization 0.026 0.097 -9999.0 0.0 -0.196 23.0 23.0 GO:0000145 -0.042 0.062 0.158 2.0 -0.182 20.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.1 -9999.0 0.0 -0.198 23.0 23.0 MLLT4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.055 0.054 -9999.0 0.0 -0.186 21.0 21.0 ARF6 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.074 0.043 -9999.0 0.0 -0.212 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.028 0.06 0.167 1.0 -9999.0 0.0 1.0 PVRL2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.035 0.065 0.175 2.0 -0.192 19.0 21.0 ARF6/GTP 0.076 0.048 -9999.0 0.0 -0.193 2.0 2.0 CDH1 -0.036 0.149 -9999.0 0.0 -0.38 23.0 23.0 EGFR/EGFR/EGF/EGF -0.05 0.11 -9999.0 0.0 -0.227 37.0 37.0 RhoA/GDP 0.028 0.096 -9999.0 0.0 -0.191 23.0 23.0 actin cytoskeleton organization -0.04 0.067 0.158 1.0 -0.194 22.0 23.0 IGF-1R heterotetramer 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.013 0.083 -9999.0 0.0 -0.38 6.0 6.0 DIAPH1 -0.098 0.246 -9999.0 0.0 -0.553 3.0 3.0 Wnt receptor signaling pathway -0.026 0.097 0.196 23.0 -9999.0 0.0 23.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.054 -9999.0 0.0 -0.187 21.0 21.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.068 0.16 1.0 -0.198 22.0 23.0 EFNA1 0.03 0.034 -9999.0 0.0 -0.38 1.0 1.0 LPP -0.047 0.063 0.163 1.0 -0.189 22.0 23.0 Ephrin A1/EPHA2 0.021 0.09 -9999.0 0.0 -0.191 21.0 21.0 SEC6/SEC8 -0.041 0.057 -9999.0 0.0 -0.188 18.0 18.0 MGAT3 -0.05 0.078 0.175 2.0 -0.205 26.0 28.0 HGF/MET -0.029 0.117 -9999.0 0.0 -0.226 34.0 34.0 HGF -0.006 0.098 -9999.0 0.0 -0.38 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.014 0.085 -9999.0 0.0 -0.2 24.0 24.0 actin cable formation -0.026 0.074 0.327 2.0 -0.368 1.0 3.0 KIAA1543 -0.049 0.067 0.159 1.0 -0.191 25.0 26.0 KIFC3 -0.048 0.062 -9999.0 0.0 -0.193 22.0 22.0 NCK1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.046 0.065 0.175 1.0 -0.193 22.0 23.0 NCK1/GIT1 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.026 0.097 -9999.0 0.0 -0.196 23.0 23.0 EXOC4 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.047 0.065 0.175 1.0 -0.192 23.0 24.0 PIP5K1C -0.044 0.066 0.175 2.0 -0.193 20.0 22.0 LIMA1 0.03 0.034 -9999.0 0.0 -0.38 1.0 1.0 ABI1 0.023 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.044 0.073 0.446 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.04 0.08 0.245 1.0 -0.301 5.0 6.0 IGF-1R heterotetramer/IGF1 0.013 0.103 -9999.0 0.0 -0.199 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.025 0.118 -9999.0 0.0 -0.38 14.0 14.0 PLEKHA7 -0.051 0.071 0.175 1.0 -0.2 25.0 26.0 mol:GTP 0.071 0.042 -9999.0 0.0 -0.211 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.01 0.12 0.317 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.014 0.085 -9999.0 0.0 -0.199 24.0 24.0 regulation of cell-cell adhesion -0.04 0.067 0.158 1.0 -0.194 22.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.014 0.085 -9999.0 0.0 -0.2 24.0 24.0