rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MAX(1), SP3(1), TP53(65), WT1(7)	1367658	75	60	65	8	5	18	17	10	25	0	0.00478	<1.00e-15	<4.10e-13
2	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), MAP3K14(1), NFKB1(2), TP53(65)	1900041	71	59	61	7	5	13	19	10	24	0	0.00431	1.33e-15	4.10e-13
3	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(14), ATR(9), CHEK1(6), CHEK2(2), TP53(65)	3108126	96	68	85	7	5	21	24	15	31	0	0.00113	2.55e-15	5.24e-13
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF3(1), CCND1(2), CDK2(4), CDK4(2), CDKN1B(2), CDKN2A(7), MDM2(1), PRB1(3), TP53(65)	1666809	87	62	77	7	11	17	18	13	28	0	0.000113	4.22e-15	6.50e-13
5	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(3), IFNGR1(3), IFNGR2(2), IKBKB(2), JAK2(2), LIN7A(1), NFKB1(2), RB1(5), TNFRSF1B(1), TP53(65), USH1C(3), WT1(7)	3567108	96	68	86	9	9	22	23	12	30	0	0.000225	8.88e-15	1.09e-12
6	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(2), DAXX(2), HRAS(1), PAX3(3), PML(4), RARA(2), RB1(5), SIRT1(1), SP100(4), TNFRSF1B(1), TP53(65)	3730422	90	64	80	7	7	17	23	14	29	0	9.09e-05	4.23e-14	4.34e-12
7	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(4), ATM(14), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), GADD45A(1), MDM2(1), RB1(5), TP53(65)	3530085	103	73	92	12	11	22	22	16	32	0	0.00320	1.11e-12	9.79e-11
8	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(14), CDC25A(2), CDC25B(1), CDK2(4), CDK4(2), CHEK1(6), MYT1(5), RB1(5), TP53(65), WEE1(1)	3419532	105	72	94	12	9	24	22	16	34	0	0.00416	1.73e-11	1.33e-09
9	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(1), CDKN2A(7), MDM2(1), PIK3CA(5), PIK3R1(1), POLR1A(5), POLR1B(8), POLR1D(1), RB1(5), TP53(65), TWIST1(1)	3965073	100	66	88	11	11	18	24	16	31	0	0.000784	2.33e-08	1.60e-06
10	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(10), ATM(14), BAX(1), CSNK1A1(1), CSNK1D(1), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(1), NQO1(3), TP53(65)	4040280	103	69	92	13	11	24	22	13	33	0	0.00721	1.62e-06	0.000100
11	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(1), ATM(14), BRCA1(6), CHEK1(6), CHEK2(2), GADD45A(1), MAPK8(3), MDM2(1), NFKB1(2), RAD50(1), RBBP8(2), TP53(65), TP73(3)	5789907	107	71	96	13	10	25	27	15	30	0	0.00581	4.26e-05	0.00239
12	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(1), ATM(14), ATR(9), CCNA1(2), CCND1(2), CCNE1(3), CDC25A(2), CDK2(4), CDK4(2), CDKN1B(2), CDKN2A(7), GSK3B(1), HDAC1(1), RB1(5), SKP2(3), TFDP1(2), TGFB1(2), TGFB2(5), TGFB3(1), TP53(65)	5897493	133	76	122	21	12	30	29	22	40	0	0.0186	0.00238	0.122
13	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(4), CDKN1B(2), CUL1(3), NEDD8(2), RB1(5), SKP2(3), TFDP1(2), UBE2M(1)	1678032	25	19	25	3	5	4	8	4	4	0	0.0845	0.0175	0.827
14	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FXYD2(1), KEAP1(24), MAPK14(1), MAPK8(3), NFE2L2(1), PRKCA(7)	1736727	37	32	36	7	7	6	13	6	5	0	0.134	0.0214	0.942
15	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(3), CDC34(1), CDK2(4), CUL1(3), RB1(5), SKP2(3), TFDP1(2)	1675581	23	18	23	2	6	5	6	3	3	0	0.0565	0.0482	1.000
16	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(3), IFNGR1(3), JAK1(5), JAK2(2), PLA2G2A(3), PTPRU(6), REG1A(5), STAT1(2)	2243697	29	22	29	3	5	6	6	5	7	0	0.0428	0.105	1.000
17	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(3), IL12A(2), IL2(3)	581919	10	8	10	1	2	5	2	0	1	0	0.265	0.136	1.000
18	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(3), IFNGR2(2), JAK1(5), JAK2(2), STAT1(2)	1595988	17	14	17	2	3	1	6	3	4	0	0.122	0.166	1.000
19	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(4), CUL1(3), FBXW7(2), RB1(5), TFDP1(2)	1630818	20	15	20	2	5	4	5	3	3	0	0.108	0.171	1.000
20	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(2), MMP2(6), MMP9(8), RECK(5), TIMP4(1)	1454862	23	16	23	4	3	4	7	4	5	0	0.239	0.213	1.000
21	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(3), UXS1(4)	755037	10	9	10	2	1	2	4	0	3	0	0.556	0.224	1.000
22	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(4), DCN(1), FMOD(2), KERA(3), LUM(3)	700083	13	11	13	3	2	4	3	3	1	0	0.462	0.227	1.000
23	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(4), ATM(14), BAX(1), BCL2(1), BID(1), CASP3(4), CASP9(2), PRKCA(7), PTK2(7), STAT1(2), TLN1(9), TP53(65)	5324991	117	78	106	22	12	28	25	17	35	0	0.0648	0.237	1.000
24	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5), CYP2C9(2)	389193	7	6	7	2	2	2	0	1	2	0	0.685	0.238	1.000
25	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(1), MTMR6(3), NFS1(3), TPK1(4)	1249623	13	11	13	2	0	5	3	3	1	1	0.410	0.292	1.000
26	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), IFNG(3), IL2(3), IL2RA(3), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2), TGFBR3(11), TOB1(1), TOB2(1)	2055099	34	23	33	7	4	14	5	4	7	0	0.326	0.301	1.000
27	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(3), JAK1(5), PTPRU(6), REG1A(5), STAT1(2), STAT2(2), TYK2(2)	2432811	25	20	25	2	4	7	4	5	5	0	0.0408	0.324	1.000
28	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(3), COQ5(3), COQ6(2), NDUFA12(2), NDUFA13(2), NDUFB11(1)	777612	13	7	13	1	5	4	3	0	1	0	0.103	0.328	1.000
29	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BRAF(13), CREB5(4), RAF1(2), SNX13(3), SRC(2)	2218929	26	19	22	4	7	7	3	6	3	0	0.127	0.335	1.000
30	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(7), EGFR(24), RAB5A(1), TF(2), TFRC(5)	2487636	41	25	31	8	4	10	9	10	8	0	0.336	0.343	1.000
31	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(4), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP3(4), CASP8(3), CASP9(2), FAS(2), FASLG(2), GZMB(3), MAP2K4(2), MAP3K1(3), MAP3K14(1), MAPK10(1), MCL1(1), MDM2(1), NFKB1(2), PARP1(2), PRF1(4), RIPK1(3), TNFRSF1B(1), TNFSF10(1), TP53(65)	7267344	116	73	106	20	10	30	27	19	30	0	0.0250	0.345	1.000
32	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), CSF1(1), HLA-DRA(2), IFNB1(3), IFNG(3), IL12A(2), IL15(1), IL1A(2), IL2(3), IL3(1), PDGFA(6), TGFB1(2), TGFB2(5), TGFB3(1)	2560521	33	23	33	5	3	9	8	8	5	0	0.100	0.353	1.000
33	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(14), ATR(9), BRCA1(6), BRCA2(9), CHEK1(6), CHEK2(2), FANCA(4), FANCD2(8), FANCE(2), FANCF(1), FANCG(1), RAD1(3), RAD17(2), RAD50(1), RAD9A(1), TP53(65), TREX1(1)	8555667	135	75	120	21	9	35	32	17	42	0	0.0738	0.360	1.000
34	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(14), ATR(9), BRCA1(6), CCNB1(1), CDC25A(2), CDC25B(1), CDC34(1), CDKN2D(1), CHEK1(6), CHEK2(2), EP300(1), GADD45A(1), MDM2(1), MYT1(5), PRKDC(14), TP53(65), WEE1(1)	8239875	131	77	120	20	10	32	34	18	37	0	0.0298	0.365	1.000
35	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(3), UGP2(1), UXS1(4)	957180	11	9	11	2	2	2	4	0	3	0	0.477	0.404	1.000
36	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(4), SNAP25(3)	630165	8	7	8	2	3	1	2	1	1	0	0.473	0.411	1.000
37	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(4), CASP8(3), CFLAR(1), PDE6D(1)	741621	10	6	10	2	4	0	3	1	2	0	0.367	0.429	1.000
38	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNA2(2), CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(2), CDKN2A(7), PRB1(3)	1772202	27	18	27	5	6	6	5	4	6	0	0.202	0.444	1.000
39	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11B2(6), CYP17A1(2), HSD11B1(2), HSD11B2(1), HSD3B1(7), HSD3B2(12)	1348437	31	19	31	8	5	13	5	6	2	0	0.371	0.479	1.000
40	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	BCL2(1), EGFR(24), IGF1R(6), POLR2A(6), PRKCA(7), RB1(5), TEP1(16), TERT(2), TNKS(2), TP53(65), XRCC5(5)	5454378	139	78	119	27	17	31	30	24	37	0	0.0352	0.508	1.000
41	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), OXCT1(4)	653643	5	4	5	1	1	1	0	1	1	1	0.653	0.521	1.000
42	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(4), HDC(6), TH(1), TPH1(10)	1180995	21	11	21	4	6	5	5	4	1	0	0.238	0.528	1.000
43	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	97782	1	1	1	3	0	0	0	0	1	0	0.995	0.536	1.000
44	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CSAD(1), GAD1(4), GAD2(5), GGT1(1)	1093404	14	11	14	3	4	2	4	2	2	0	0.287	0.565	1.000
45	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(4), PRKCA(7), PTK2B(6)	1295934	17	13	17	4	7	4	5	1	0	0	0.340	0.580	1.000
46	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(9), HSD17B2(1), HSD3B1(7), HSD3B2(12)	1578573	31	18	31	7	6	9	7	5	3	1	0.323	0.621	1.000
47	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(12), NRG2(2), NRG3(10), PRKCA(7), PSEN1(1)	1734276	37	23	37	8	5	18	8	3	3	0	0.306	0.626	1.000
48	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(3), JAK1(5), STAT1(2), STAT2(2), TYK2(2)	2102829	15	14	15	1	1	3	3	5	3	0	0.126	0.627	1.000
49	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), SPCS3(1)	599076	5	5	5	1	0	1	1	2	1	0	0.589	0.639	1.000
50	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(2), IL3(1)	583209	4	4	4	1	0	1	1	2	0	0	0.717	0.663	1.000
51	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), DFFA(3), GZMB(3), HMGB2(4), TOP2A(3), TOP2B(4)	1862115	21	12	21	3	7	4	3	3	4	0	0.229	0.665	1.000
52	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(3), GBA3(7), GGT1(1), SHMT1(2), SHMT2(1)	1083987	14	12	14	4	3	4	4	1	2	0	0.570	0.674	1.000
53	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(2), IL2(3)	765744	7	7	7	2	0	4	2	1	0	0	0.686	0.700	1.000
54	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(2), DFFA(3), GZMA(1), GZMB(3), HMGB2(4), PRF1(4)	2057034	19	12	19	1	5	5	4	2	3	0	0.0436	0.728	1.000
55	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), HADH(2), HADHA(2), HADHB(2), PPT1(2), PPT2(5)	1647330	16	10	15	3	4	1	6	0	4	1	0.0843	0.748	1.000
56	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), HRAS(1), KLK2(2), MAP2K1(4), MAPK3(1), NGFR(2), RAF1(2)	1609791	13	10	13	1	3	5	0	3	2	0	0.0969	0.751	1.000
57	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(5), DLL1(2), FURIN(5), NOTCH1(5), PSEN1(1)	1824834	18	13	18	4	4	4	4	3	3	0	0.214	0.754	1.000
58	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(2), ALDOC(1), TPI1(3)	755037	7	5	7	0	0	3	2	1	1	0	0.159	0.767	1.000
59	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(3), HRAS(1), PTK2B(6), SHC1(2), SOS1(9), SRC(2)	1707573	23	13	23	5	6	7	3	6	1	0	0.298	0.768	1.000
60	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(3)	318888	3	2	3	0	0	2	1	0	0	0	0.501	0.800	1.000
61	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	220074	1	1	1	0	0	0	1	0	0	0	0.752	0.808	1.000
62	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(3)	434988	4	3	4	1	1	2	0	0	1	0	0.615	0.815	1.000
63	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), ALDOC(1), GOT1(2), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME2(6), ME3(2), PGK1(4), PKLR(4), PKM2(2), RPE(1), RPIA(2), TPI1(3)	3473583	37	21	36	6	8	10	10	5	4	0	0.0534	0.835	1.000
64	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(3), FYN(2), MAPK14(1), THBS1(4)	1424547	14	8	14	4	5	3	0	3	3	0	0.565	0.837	1.000
65	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(7), GGT1(1), SHMT1(2), SHMT2(1)	806637	11	10	11	4	3	2	3	1	2	0	0.713	0.855	1.000
66	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(3), TAT(2)	508518	7	6	7	3	3	2	2	0	0	0	0.711	0.856	1.000
67	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(7), EGFR(24), MAP2K1(4), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(2), THRA(1), THRB(4)	3336198	52	33	42	11	6	10	11	13	12	0	0.227	0.864	1.000
68	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH2(1), HMGCS1(2), HMGCS2(5), OXCT1(4)	1396683	13	7	13	3	1	6	1	2	2	1	0.598	0.868	1.000
69	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(2)	456144	4	4	4	2	0	2	1	1	0	0	0.871	0.873	1.000
70	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACAT1(1), HADHA(2)	1040385	6	6	6	4	0	0	0	2	3	1	0.947	0.873	1.000
71	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(6), GOT1(2), GOT2(3), TAT(2), TYR(6)	909063	19	16	19	6	6	3	4	4	2	0	0.532	0.876	1.000
72	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3D(1), CD4(1), CD58(1), CD8A(1), IL3(1)	1202538	9	7	9	1	3	2	3	0	1	0	0.163	0.884	1.000
73	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), HSD3B7(2)	944409	5	5	5	1	0	4	1	0	0	0	0.613	0.894	1.000
74	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(1), BMPR1B(3), BMPR2(2)	1218663	10	7	10	2	3	2	2	2	1	0	0.457	0.899	1.000
75	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), GZMB(3), HLA-A(1), ITGAL(17), ITGB2(2), PRF1(4)	1692222	28	19	28	8	5	6	8	4	5	0	0.407	0.902	1.000
76	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2)	295281	2	1	2	0	1	1	0	0	0	0	0.608	0.903	1.000
77	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), FOSB(2), GRIA2(7), PPP1R1B(1)	746781	11	11	11	5	1	3	3	1	3	0	0.770	0.905	1.000
78	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(6), BCMO1(2)	751812	9	7	9	3	1	4	2	1	1	0	0.638	0.910	1.000
79	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2)	1087857	26	14	26	8	2	20	1	1	2	0	0.696	0.916	1.000
80	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), ARHGAP5(4), CASP1(2), CASP10(3), CASP3(4), CASP8(3), CASP9(2), GZMB(3), PRF1(4)	2491377	29	18	29	5	5	9	6	7	2	0	0.202	0.921	1.000
81	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(3), IFNG(3), IL12A(2), IL15(1), IL16(4), IL1A(2), IL2(3), IL3(1)	1921455	19	14	19	4	1	8	6	3	1	0	0.337	0.926	1.000
82	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	HPRT1(1), IMPDH1(3), POLB(2), POLD1(1), POLG(8), PRPS2(1), RRM1(5)	2454354	21	13	21	2	10	2	5	4	0	0	0.0257	0.929	1.000
83	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(1), CCND1(2), CCND3(1), CCNE1(3), CDC25A(2), CDK2(4), CDK4(2), CDK7(2), CDKN1B(2), CDKN2A(7), CDKN2D(1), RB1(5), RBL1(4), TFDP1(2)	3159339	40	26	40	9	8	10	9	6	7	0	0.321	0.933	1.000
84	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1E(2), PER1(2)	1660617	13	8	13	3	6	3	2	0	2	0	0.417	0.937	1.000
85	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(3), DPYD(10), DPYS(6), ENPP1(3), ENPP3(5), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1)	2700873	37	25	37	8	4	12	13	3	4	1	0.233	0.960	1.000
86	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(1)	620232	3	3	3	2	0	0	2	0	1	0	0.859	0.962	1.000
87	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(5), PDE1B(6), PLCB1(9), PLCB2(4), TRH(1), VIP(1)	2155590	29	22	29	7	4	9	9	2	5	0	0.393	0.963	1.000
88	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), LARS(3), LARS2(1), PDHA1(1), PDHA2(8)	1939257	16	12	16	4	3	6	3	2	2	0	0.531	0.964	1.000
89	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(5), JAK1(5), JAK2(2), JAK3(3), PIAS3(4), PTPRU(6), REG1A(5), SRC(2), STAT3(4)	2987124	36	24	36	8	7	9	8	7	5	0	0.234	0.967	1.000
90	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), LDLR(1), LPL(2)	1032516	5	5	5	2	0	1	2	1	1	0	0.781	0.969	1.000
91	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(5), JAK2(2), JAK3(3), MAPK3(1), STAT3(4), TYK2(2)	2290782	17	15	17	4	2	3	5	5	2	0	0.400	0.970	1.000
92	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(4), BAX(1), BCL2(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(3), CASP2(2), CASP3(4), CASP4(1), CASP8(3), CASP9(2), CHUK(1), DFFA(3), FAS(2), FASLG(2), GZMB(3), HELLS(1), IKBKB(2), IRF1(1), IRF2(1), IRF3(1), IRF4(1), IRF6(3), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKB1(2), NFKBIE(1), PLEKHG5(3), PRF1(4), RIPK1(3), TNFRSF10B(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFSF10(1), TP53(65), TP73(3), TRAF3(1)	11214357	147	76	137	27	16	38	36	22	35	0	0.0169	0.971	1.000
93	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(1), RB1(5), SP3(1)	1295934	8	7	8	3	1	1	1	1	4	0	0.832	0.972	1.000
94	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(2), DHRS3(1), HSD3B7(2), PON1(1), PON3(5)	1755948	14	13	14	4	1	7	5	1	0	0	0.510	0.977	1.000
95	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(2), NR3C1(1), PPARG(2)	1124493	7	7	7	3	0	3	2	1	1	0	0.846	0.978	1.000
96	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(3), HADHA(2)	929574	5	3	5	4	0	2	1	0	1	1	0.974	0.979	1.000
97	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(2), FPGS(1), GCH1(3), GGH(1)	1289226	14	12	14	5	2	1	4	3	4	0	0.655	0.980	1.000
98	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(7), GNA12(1), PRKACB(2), PRKACG(1)	1963122	11	8	11	1	2	5	2	2	0	0	0.226	0.982	1.000
99	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(4)	1193766	11	8	11	4	1	4	3	2	1	0	0.701	0.982	1.000
100	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(4), BCKDK(2), CBS(1), MUT(4)	949440	11	9	11	4	2	3	2	1	3	0	0.706	0.983	1.000
101	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(2), FUT3(1), ST3GAL3(1)	988527	5	5	5	2	3	0	1	1	0	0	0.708	0.983	1.000
102	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(5), SNCA(2), SNCAIP(2), UBE2L6(1)	1238013	12	10	12	4	1	5	3	2	1	0	0.696	0.984	1.000
103	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(3), CPOX(3), HMBS(2), PPOX(2)	1480146	12	7	12	4	4	2	2	2	2	0	0.641	0.984	1.000
104	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), HMOX1(3), IL10RA(3), IL10RB(2), IL1A(2), JAK1(5), STAT1(2), STAT3(4), STAT5A(2)	2365602	24	18	24	5	1	4	8	7	4	0	0.279	0.986	1.000
105	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(2), GNB1(1), GNGT1(1), HTR2C(5), PLCB1(9), TUB(3)	1384428	22	18	22	6	4	11	6	0	1	0	0.536	0.986	1.000
106	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25A(2), CDC25B(1), CDK7(2), MNAT1(2), SHH(3), XPO1(3)	1709637	14	10	14	4	1	6	3	2	2	0	0.663	0.986	1.000
107	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), CD8A(1), CSF1(1), EPO(1), IL2(3), IL3(1)	1162548	8	7	8	3	0	5	3	0	0	0	0.708	0.987	1.000
108	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3D(1), CD4(1)	620748	4	4	4	4	0	2	1	0	1	0	0.971	0.987	1.000
109	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2)	1555095	20	14	20	6	4	9	5	2	0	0	0.467	0.988	1.000
110	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2)	1555095	20	14	20	6	4	9	5	2	0	0	0.467	0.988	1.000
111	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(14), CDC25A(2), CDC25B(1), CHEK1(6), MYT1(5), WEE1(1)	2666559	29	20	28	8	0	10	6	5	8	0	0.732	0.990	1.000
112	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), GGPS1(1), IDI1(1)	828567	4	4	4	3	0	1	2	0	1	0	0.914	0.990	1.000
113	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(2), CCNE1(3), CDK2(4), CDK4(2), CDKN1B(2), HRAS(1), MAPK3(1), NFKB1(2), PAK1(5), PIK3CA(5), PIK3R1(1), RAF1(2), RB1(5), TFDP1(2)	3916311	37	23	36	9	14	6	7	5	5	0	0.215	0.991	1.000
114	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACYP2(1), EHHADH(3), GCDH(1), HADHA(2)	1505172	8	6	8	3	0	2	3	0	2	1	0.798	0.994	1.000
115	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ACPP(6), ENPP1(3), ENPP3(5), FLAD1(1), TYR(6)	1881852	25	22	25	7	3	4	11	4	3	0	0.464	0.995	1.000
116	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), FDPS(1), HMGCR(3), IDI1(1), LSS(3), MVD(1), NQO1(3), NQO2(2), SC5DL(2), VKORC1(1)	2160879	19	15	19	5	3	5	6	3	2	0	0.448	0.995	1.000
117	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(10), ABCB11(5), ABCB4(10), ABCC1(3), ABCC3(3), GSTP1(2)	2777499	33	25	33	9	3	9	9	6	6	0	0.424	0.995	1.000
118	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(2), ALDOC(1), GOT1(2), GOT2(3), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(4), PGK2(11), PKLR(4), PKM2(2), RPE(1), RPIA(2), TKTL1(6), TKTL2(6), TPI1(3)	3882642	54	35	53	11	10	15	14	8	7	0	0.0877	0.995	1.000
119	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(5), APC(6), AXIN1(2), BTRC(5), CTNNB1(9), DLL1(2), FZD1(2), GSK3B(1), NOTCH1(5), PSEN1(1), WNT1(3)	4184631	41	26	39	8	8	9	12	7	5	0	0.0844	0.995	1.000
120	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(6), PNPO(1), PSAT1(1)	940668	8	6	8	5	2	4	0	0	2	0	0.950	0.996	1.000
121	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CCL3(1), EPO(1), FLT3(7), IGF1(3), IL1A(2), IL3(1), TGFB1(2), TGFB2(5), TGFB3(1)	1582959	23	15	23	9	3	6	3	7	4	0	0.809	0.996	1.000
122	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(7), CSF1R(3), EGF(7), EGFR(24), GRB2(3), MET(10), PDGFRA(7), PRKCA(7), SH3GLB1(1), SH3KBP1(2), SRC(2)	3753513	73	45	63	19	11	17	12	17	16	0	0.460	0.996	1.000
123	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(3), ACAT1(1), EHHADH(3), HADHA(2), HADHB(2)	1606566	11	8	11	4	0	2	5	0	3	1	0.740	0.996	1.000
124	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(1), FH(1), IDH1(2), IDH2(2), MDH1(1)	1717764	9	8	9	3	1	2	2	2	2	0	0.736	0.997	1.000
125	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(3), IARS2(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(8), VARS(5), VARS2(6)	3578073	31	21	31	7	7	10	7	2	5	0	0.269	0.997	1.000
126	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(12), PGM1(2), PYGM(3), TPI1(3), TREH(1)	2598576	25	14	25	5	4	9	8	1	3	0	0.222	0.997	1.000
127	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(5), MST1R(2)	1278648	8	8	6	7	1	1	4	0	2	0	0.992	0.997	1.000
128	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	GRB2(3), HRAS(1), KLK2(2), MAP2K1(4), MAPK3(1), MAPK8(3), NGFR(2), PIK3CA(5), PIK3R1(1), PLCG1(4), RAF1(2), SHC1(2), SOS1(9)	3692625	39	25	38	9	7	12	9	8	3	0	0.254	0.997	1.000
129	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(2), CASP8(3), RIPK1(3), TNFRSF1B(1)	1642944	9	6	9	2	0	2	3	1	3	0	0.584	0.997	1.000
130	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), BIRC2(2), BIRC3(2), CASP10(3), CASP3(4), CASP8(3), CASP9(2), DFFA(3), GZMB(3), PRF1(4), SCAP(4), SREBF1(1)	3552015	35	22	35	8	6	8	7	7	7	0	0.286	0.998	1.000
131	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), LCMT1(1), LCMT2(4), METTL2B(3), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), WBSCR22(1)	2744862	29	19	28	7	7	4	13	3	2	0	0.268	0.998	1.000
132	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(3), GLUD2(3)	876297	9	8	9	4	1	3	4	1	0	0	0.823	0.998	1.000
133	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(3), G6PD(2), GCLC(6), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(3), GSS(2), GSTA1(1), GSTA2(2), GSTA3(2), GSTM2(1), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), IDH1(2), IDH2(2), MGST1(1), MGST3(2), PGD(1)	3467649	41	22	41	9	6	14	14	2	4	1	0.171	0.998	1.000
134	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(2), NAT1(1), NAT2(1), XDH(8)	1542195	18	16	18	9	1	5	6	1	5	0	0.811	0.998	1.000
135	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(1), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(1)	2325096	12	8	12	3	2	3	3	2	2	0	0.445	0.998	1.000
136	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(3), NR1I3(1), PTGS1(3), PTGS2(4)	1026969	12	9	12	7	2	3	4	1	2	0	0.902	0.999	1.000
137	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(2), HLA-DRA(2), LCK(5), PTPRC(10), ZAP70(2)	1761108	23	16	23	7	3	8	6	2	4	0	0.692	0.999	1.000
138	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), NFKB1(2), PLCB1(9), PRKCA(7)	1589538	20	18	20	6	5	7	7	0	1	0	0.584	0.999	1.000
139	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	GRB2(3), HRAS(1), IL6R(5), JAK1(5), JAK2(2), JAK3(3), MAP2K1(4), MAPK3(1), PTPN11(1), RAF1(2), SHC1(2), SOS1(9), STAT3(4)	4642452	42	28	42	9	6	9	9	14	4	0	0.196	0.999	1.000
140	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(2), GRB2(3), HRAS(1), MAP2K1(4), NGFR(2), NTRK1(6), PIK3CA(5), SHC1(2), SOS1(9)	3167466	35	25	34	9	2	12	8	9	4	0	0.424	0.999	1.000
141	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(5), F12(1), F13B(9), F2(5), F5(17), F7(2), F8(14), F9(8), FGA(2), FGB(10), FGG(2), LPA(16), PLAT(4), PLG(8), SERPINB2(3), SERPINE1(3), VWF(7)	6813006	117	58	117	25	12	37	28	23	16	1	0.169	0.999	1.000
142	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(2), ASAH1(2), GAL3ST1(3), GALC(3), GBA(3), GLA(2), LCT(12), NEU3(1), NEU4(5), PPAP2B(1), SMPD1(1), SMPD2(1), SPTLC1(1), SPTLC2(1)	4733010	40	32	39	8	6	15	12	3	4	0	0.128	0.999	1.000
143	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), HRAS(1), MAP2K1(4), MAPK3(1), NFKB1(2), PLCB1(9), PRKCA(7), RAF1(2)	2984673	27	22	27	7	8	7	7	3	2	0	0.324	0.999	1.000
144	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(4), KARS(3)	915642	8	4	8	5	2	3	2	0	1	0	0.965	0.999	1.000
145	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(1), POLE(12), POLG(8), POLQ(10)	3233643	33	19	33	8	13	2	12	3	3	0	0.213	0.999	1.000
146	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), CS(1), MDH1(1), ME1(1), PC(1), PDHA1(1), SLC25A11(2)	1784586	8	7	8	3	2	1	1	3	1	0	0.699	0.999	1.000
147	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(13), CPEB1(2), EGFR(24), ERBB2(5), ERBB4(12), ETS1(1), ETS2(1), ETV6(3), FMN2(13), GRB2(3), KRAS(35), MAP2K1(4), MAPK3(1), NOTCH1(5), NOTCH2(20), NOTCH3(4), NOTCH4(15), PIWIL1(4), PIWIL2(6), PIWIL3(5), PIWIL4(3), RAF1(2), SOS1(9), SOS2(5), SPIRE1(4), SPIRE2(1)	10160556	200	95	153	35	26	83	36	33	22	0	0.00402	0.999	1.000
148	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), EIF4E(2), LDHA(3), LDHC(4), MAPK14(1), NCL(4)	1712991	18	13	18	9	4	4	5	2	3	0	0.924	0.999	1.000
149	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(3), AASDHPPT(1), AASS(4), KARS(3)	1348179	11	6	11	6	3	3	2	1	2	0	0.954	0.999	1.000
150	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(7), EGF(7), EGFR(24), GRB2(3), HRAS(1), MAP2K1(4), MAPK3(1), PTPRB(9), RAF1(2), RASA1(1), SHC1(2), SOS1(9), SPRY1(1), SPRY2(2), SPRY3(4), SPRY4(2), SRC(2)	4849110	81	45	71	19	13	20	13	21	14	0	0.253	0.999	1.000
151	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(1), GLUD1(3), OAT(1)	1081278	7	6	7	4	2	0	3	1	1	0	0.866	1.000	1.000
152	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(3), HK1(3), PFKL(1), PGK1(4), PKLR(4), TPI1(3)	1805871	21	15	20	9	5	8	3	2	3	0	0.802	1.000	1.000
153	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT1(2), GOT2(3), LDHA(3), LDHC(4)	1325088	13	10	13	8	5	2	5	0	1	0	0.942	1.000	1.000
154	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22(2), IL22RA2(1), JAK1(5), JAK2(2), JAK3(3), STAT1(2), STAT3(4), STAT5A(2), STAT5B(3), TYK2(2)	3596133	29	26	29	7	2	6	6	9	6	0	0.395	1.000	1.000
155	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(16), RANGAP1(2)	1629399	18	12	18	7	5	7	3	1	1	1	0.861	1.000	1.000
156	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(2), IL4R(5), JAK1(5), JAK2(2), TYK2(2)	2032266	16	15	16	5	1	3	4	5	3	0	0.655	1.000	1.000
157	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(2), IL4R(5), JAK1(5), JAK2(2), TYK2(2)	2032266	16	15	16	5	1	3	4	5	3	0	0.655	1.000	1.000
158	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), HDAC9(6), MEF2C(1), MEF2D(1), MYOD1(2)	1567608	12	11	12	7	2	5	2	0	3	0	0.962	1.000	1.000
159	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(3), G6PD(2), GCLC(6), GCLM(1), GGT1(1), GPX1(1), GPX3(1), GPX5(3), GPX6(1), GPX7(2), GSR(1), GSS(2), GSTA1(1), GSTA2(2), GSTA3(2), GSTA5(3), GSTK1(4), GSTM2(1), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), IDH1(2), IDH2(2), MGST1(1), MGST3(2), OPLAH(3), TXNDC12(1)	4186179	55	31	55	11	8	16	22	3	5	1	0.0564	1.000	1.000
160	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACPP(6), ENPP1(3), ENPP3(5), FLAD1(1), MTMR1(2), MTMR2(1), MTMR6(3), TYR(6)	2925462	31	27	31	9	3	6	12	6	4	0	0.516	1.000	1.000
161	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(5), LEP(2), LEPR(8), PRKAA1(1), PRKAB1(3), PRKAG2(4)	2801235	31	21	31	9	4	16	2	4	5	0	0.768	1.000	1.000
162	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), ARPC3(1), CDC42(2), WASF1(4), WASL(4)	1571091	15	12	15	7	1	5	6	1	2	0	0.952	1.000	1.000
163	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(8), SLC18A3(5)	1355790	18	16	18	8	7	2	5	2	2	0	0.730	1.000	1.000
164	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), PRKCA(7), TGM2(3)	965823	11	9	11	5	3	3	3	1	1	0	0.810	1.000	1.000
165	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), DPAGT1(1), FUT8(4), MGAT1(1), MGAT3(3), MGAT4A(2), MGAT4B(1), MGAT5(2), RPN2(4)	3866259	28	18	28	6	8	6	7	3	4	0	0.184	1.000	1.000
166	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(2), FOSL2(1), IFNAR2(1), IFNB1(3), MAPK8(3), NFKB1(2), TNFRSF11A(4), TNFSF11(1), TRAF6(3)	2152107	20	16	19	7	6	4	4	3	3	0	0.683	1.000	1.000
167	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(3), SRP19(1), SRP68(2), SRP72(1), SRPR(4)	1448154	11	6	11	7	3	3	4	0	1	0	0.964	1.000	1.000
168	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREBBP(2), EP300(1), NCOA3(6), PRKACB(2), PRKACG(1), PRKAR1B(4), RARA(2)	4017189	21	16	20	4	2	8	7	2	2	0	0.331	1.000	1.000
169	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC3B(1), APOBEC3G(2), APOBEC4(1)	1421838	9	9	9	5	2	3	2	0	2	0	0.917	1.000	1.000
170	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(1), LTB4R(2), P2RY1(5), P2RY6(1)	1143972	10	9	10	9	2	1	5	1	1	0	0.962	1.000	1.000
171	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CD44(1), CSF1(1), FCGR3A(5), IL6R(5), SELL(1), SPN(2), TGFB1(2), TGFB2(5), TNFRSF1B(1), TNFRSF8(1)	2590707	31	21	31	9	4	3	10	8	6	0	0.507	1.000	1.000
172	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(5), PIK3R1(1), PLCB1(9), PLCG1(4), PRKCA(7), VAV1(1)	2458224	27	24	26	8	5	7	12	1	2	0	0.558	1.000	1.000
173	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(3), FUT1(2), FUT9(1), GCNT2(1)	1188993	8	8	7	5	3	1	2	1	1	0	0.884	1.000	1.000
174	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(3), AOC3(2), CES1(1)	1174674	10	9	10	5	2	2	4	1	1	0	0.814	1.000	1.000
175	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), UGDH(3)	1659714	17	13	17	6	3	5	6	2	1	0	0.588	1.000	1.000
176	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(3), HADH(2), HADHA(2), SIRT1(1), SIRT2(1), SIRT7(2), VNN2(2)	2296974	13	7	13	6	0	7	2	0	3	1	0.867	1.000	1.000
177	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(4), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP3(4), CASP8(3), CASP9(2), DFFA(3)	2644500	23	16	23	7	4	6	5	3	5	0	0.681	1.000	1.000
178	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(3), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), NFKB1(2), NSMAF(2), RAF1(2), RIPK1(3), SMPD1(1)	3979779	28	20	28	7	6	5	11	2	4	0	0.289	1.000	1.000
179	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(3), HRAS(1), KLK2(2), NTRK1(6), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), SHC1(2), SOS1(9)	3005700	40	29	39	10	6	14	10	7	3	0	0.402	1.000	1.000
180	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1)	1263813	13	11	13	7	2	5	4	1	1	0	0.928	1.000	1.000
181	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(1), GNA12(1), GNA13(1), GNAQ(2), GNB1(1), GNGT1(1), MYL2(2), MYLK(10), PLCB1(9), PPP1R12B(4), PRKCA(7), ROCK1(7)	4016286	50	33	49	11	9	19	13	3	6	0	0.287	1.000	1.000
182	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(6), GABRA2(9), GABRA3(6), GABRA4(7), GABRA5(8), GABRA6(6), GPX1(1), PRKCE(1)	1538325	44	31	43	13	6	17	7	9	5	0	0.699	1.000	1.000
183	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), BIRC2(2), BIRC3(2), CASP1(2), CASP10(3), CASP2(2), CASP3(4), CASP4(1), CASP8(3), CASP9(2), DFFA(3), GZMB(3), LMNB1(1), LMNB2(1), PRF1(4)	3763962	37	21	37	9	6	12	8	6	5	0	0.453	1.000	1.000
184	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(5), JAK2(2), JAK3(3), PIAS3(4), PTPRU(6), REG1A(5), SOAT1(3)	2708871	28	18	28	9	4	9	6	4	4	1	0.667	1.000	1.000
185	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(12), MAN2C1(3), MANBA(4), NEU3(1), NEU4(5)	3233256	29	25	29	8	4	10	10	2	3	0	0.504	1.000	1.000
186	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(1), B3GNT5(1), FUT1(2), FUT3(1), ST3GAL3(1), ST3GAL4(1)	1392684	9	7	9	4	4	2	2	1	0	0	0.737	1.000	1.000
187	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(3), CPO(1), HBB(2), HMBS(2)	1533939	10	6	10	5	3	5	0	1	1	0	0.866	1.000	1.000
188	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(4), MAP2K3(3), MAP3K1(3), MAPK14(1), MAPK3(1), NFKB1(2), PIK3CA(5), PIK3R1(1), RB1(5)	3757512	25	22	24	6	2	6	5	4	8	0	0.516	1.000	1.000
189	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT5(3), FUT8(4), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1)	1529037	20	14	19	7	7	1	8	2	2	0	0.491	1.000	1.000
190	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(3), HADHA(2)	2354379	25	16	25	9	4	11	6	2	1	1	0.650	1.000	1.000
191	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(2), NFKB1(2), NOX1(1), XDH(8)	1929969	15	11	15	5	2	6	5	1	1	0	0.601	1.000	1.000
192	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(1), GFPT1(3), GNPDA1(1), GNPDA2(1), HEXA(1), HK1(3), HK2(5), HK3(5), PGM3(2), RENBP(3), UAP1(5)	3272472	32	16	32	9	11	8	5	4	4	0	0.454	1.000	1.000
193	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(6), AXIN1(2), BTRC(5), CCND1(2), CREBBP(2), CSNK1A1(1), CSNK1D(1), CTNNB1(9), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(3), PPARD(1), TLE1(3), WNT1(3)	5738565	42	26	40	8	11	9	10	6	6	0	0.100	1.000	1.000
194	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(1), MAPK3(1), PELP1(2), SRC(2)	2849223	8	6	8	1	3	1	3	0	1	0	0.257	1.000	1.000
195	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(1), CS(1), GRHPR(1), HAO1(2), HAO2(5), MDH1(1), MTHFD1(1), MTHFD1L(4)	2472285	18	12	18	7	5	5	3	2	3	0	0.763	1.000	1.000
196	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), GREB1(9), HSPB2(1), MTA3(2), PDZK1(1)	2131467	15	10	15	5	5	4	4	2	0	0	0.548	1.000	1.000
197	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(1), HEXA(1), LCT(12), MAN2B1(1), MAN2B2(3), MAN2C1(3), MANBA(4), NEU3(1), NEU4(5)	3983004	33	28	33	9	5	12	10	3	3	0	0.445	1.000	1.000
198	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GUSB(2), HEXA(1), IDS(2), IDUA(1), LCT(12), NAGLU(1)	2774274	20	17	20	6	3	6	4	3	4	0	0.548	1.000	1.000
199	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(1), FH(1), IDH2(2), MDH1(1), SDHA(5)	1811934	11	7	11	9	4	2	3	1	1	0	0.964	1.000	1.000
200	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(5), ANKRD1(3), EIF4E(2), IFNG(3), IL1A(2), NR4A3(1)	2124114	16	9	16	5	4	6	3	1	2	0	0.605	1.000	1.000
201	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(1), AFMID(1), CS(1), GRHPR(1), HAO1(2), HAO2(5), MDH1(1), MTHFD1(1), MTHFD1L(4)	2590707	19	12	19	9	5	6	3	2	3	0	0.891	1.000	1.000
202	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(6), GABRA2(9), GABRA3(6), GABRA4(7), GABRA5(8), GABRA6(6), GPHN(2), NSF(1), SRC(2), UBQLN1(3)	2315034	51	31	50	15	10	16	9	9	7	0	0.655	1.000	1.000
203	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(6), AR(2), ASAH1(2), BRAF(13), CCL15(3), DAG1(2), EGFR(24), GNAI1(1), GNAQ(2), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), KCNJ3(10), MAPK10(1), MAPK14(1), PHKA2(6), PIK3CA(5), PIK3R1(1), PITX2(3), PTX3(2), RAF1(2), SRC(2)	10418943	119	64	103	27	20	31	29	19	20	0	0.130	1.000	1.000
204	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), DHRS2(2), DHRS3(1), LCMT1(1), LCMT2(4), METTL2B(3), METTL6(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), WBSCR22(1)	2917980	29	20	28	9	7	5	13	2	2	0	0.452	1.000	1.000
205	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(4), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1)	1974861	24	14	24	9	8	5	5	4	2	0	0.763	1.000	1.000
206	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), CLTB(1), COPA(4), GBF1(7), GPLD1(1), KDELR1(1), KDELR2(1), KDELR3(2)	3115092	24	13	24	7	3	12	3	3	3	0	0.634	1.000	1.000
207	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(4), AOC2(3), AOC3(2), CES1(1), CES7(3), DDHD1(3), ESCO1(5), ESCO2(2), LIPA(1), MYST3(7), MYST4(6), PLA1A(4), PNPLA3(1), PPME1(2), PRDX6(1), SH3GLB1(1)	4906257	46	28	46	11	9	15	8	8	6	0	0.302	1.000	1.000
208	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ACAT1(1), ACYP2(1), ADH5(3), AKR1B1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), DLAT(3), DLD(3), GLO1(1), GRHPR(1), HAGHL(1), LDHA(3), LDHC(4), MDH1(1), ME1(1), ME2(6), ME3(2), PC(1), PCK1(8), PDHA1(1), PDHA2(8), PKLR(4), PKM2(2)	7180914	84	43	83	19	20	26	21	8	9	0	0.102	1.000	1.000
209	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(4), CAMKK1(2), CAMKK2(1), SYT1(3)	2252856	17	14	17	6	2	9	1	3	2	0	0.744	1.000	1.000
210	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CDK5(1), CSNK1A1(1), CSNK1D(1), GSK3B(1), MAPT(2)	1846248	9	7	9	9	1	4	1	2	1	0	0.996	1.000	1.000
211	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(8), ARHGEF1(1), F2(5), F2R(2), F2RL3(2), GNA12(1), GNA13(1), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), MAP3K7(3), PIK3CA(5), PIK3R1(1), PLCB1(9), PPP1R12B(4), PRKCA(7), PTK2B(6), ROCK1(7)	5043255	67	41	66	15	13	22	19	5	8	0	0.179	1.000	1.000
212	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(2), CD33(4), CD5(4), IFNB1(3), IFNG(3), IL12A(2), IL3(1), ITGAX(11), TLR4(23), TLR7(6), TLR9(5)	3598584	67	40	67	18	6	23	16	11	11	0	0.349	1.000	1.000
213	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(6), CDH1(4), CREBBP(2), EP300(1), MAP2K1(4), MAP3K7(3), MAPK3(1), SKIL(4), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2)	4951536	35	24	35	8	2	9	6	9	9	0	0.442	1.000	1.000
214	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA6(1), PSMB4(3), PSMB9(1)	1690287	6	3	6	6	2	1	1	1	1	0	0.969	1.000	1.000
215	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO1(2), ACO2(1), ACSS1(1), ACSS2(3), FH(1), IDH1(2), IDH2(2), MDH1(1)	2566455	14	10	14	6	4	3	3	2	2	0	0.765	1.000	1.000
216	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(5), EIF2AK4(4), EIF2B5(3), EIF2S3(1), GSK3B(1), PPP1CA(1)	2251566	15	8	15	5	4	7	2	1	1	0	0.757	1.000	1.000
217	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA6(1), PSMB4(3), PSMD14(1), RPN2(4), UBE2A(2), UBE3A(2)	2507631	14	9	14	5	3	2	3	3	3	0	0.645	1.000	1.000
218	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(3), DPYD(10), DPYS(6), ENPP1(3), ENPP3(5), PANK1(2), PANK2(4), PANK3(2), PANK4(1), PPCS(1), VNN1(1)	3346518	38	26	38	10	4	13	13	3	4	1	0.391	1.000	1.000
219	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), ESCO1(5), ESCO2(2), MYST3(7), MYST4(6), PNPLA3(1), SH3GLB1(1)	3209907	25	15	25	9	5	10	2	4	4	0	0.769	1.000	1.000
220	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(1), FDFT1(1), FDPS(1), HMGCR(3), HMGCS1(2), IDI1(1), LSS(3), MVD(1), NSDHL(1), SC4MOL(1), SC5DL(2)	2572002	20	16	20	7	2	7	7	3	1	0	0.743	1.000	1.000
221	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(16), MAP2(12), PPP1CA(1), PRKACB(2), PRKACG(1), PRKCE(1)	3525828	33	24	33	10	2	18	7	3	3	0	0.837	1.000	1.000
222	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), CBS(1), GGT1(1), MARS(1), MARS2(4), MAT1A(2), MAT2B(3), PAPSS1(2), PAPSS2(1), SCLY(2), SEPHS1(3)	2393079	22	12	22	8	9	6	5	0	2	0	0.555	1.000	1.000
223	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(6), AXIN1(2), CCND1(2), CD14(1), CTNNB1(9), FZD1(2), GJA1(2), GNAI1(1), GSK3B(1), IRAK1(2), LBP(2), LEF1(6), LY96(1), MYD88(2), NFKB1(2), PIK3CA(5), PIK3R1(1), TLR4(23), WNT1(3)	5959800	73	43	71	16	12	18	24	11	8	0	0.146	1.000	1.000
224	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), PGM1(2), PGM3(2), TGDS(2)	1990986	21	10	21	9	8	6	5	1	1	0	0.768	1.000	1.000
225	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(2), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL23A(2), RPL29(1), RPL30(2), RPL35(1), RPL36A(1), RPL37(1), RPL3L(1), RPL6(1), RPL8(1), RPS10(1), RPS12(1), RPS13(2), RPS26(1), RPS29(1), RPS4Y1(1)	4487523	28	17	28	7	9	7	5	3	4	0	0.383	1.000	1.000
226	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAQ(2), GNAS(3), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(4), MAPK3(1), MYL2(2), NOX1(1), PIK3C2G(3), PLCB1(9), PPP1R12B(4), PRKCA(7), PTK2(7), RAF1(2), ROCK2(3)	4938894	52	33	52	11	10	18	12	6	6	0	0.287	1.000	1.000
227	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(6), ASAH1(2), CASP3(4), CERK(3), CREB5(4), DAG1(2), EPHB2(4), GNAQ(2), ITPKA(1), ITPKB(4), MAP2K4(2), MAP2K7(1), MAPK10(1), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5)	5553837	48	30	48	11	12	11	12	6	7	0	0.186	1.000	1.000
228	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(3), HRAS(1), IGF1R(6), IRS1(12), MAP2K1(4), MAPK3(1), PIK3CA(5), PIK3R1(1), RAF1(2), SHC1(2), SOS1(9)	3643734	46	25	45	12	11	14	8	10	3	0	0.319	1.000	1.000
229	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(2), CASP1(2), CASP3(4), CASP8(3), GAPDH(2), INSR(1), ITCH(3), MAGI1(10), MAGI2(9), RERE(7), WWP1(2), WWP2(2)	4665672	49	25	49	12	15	14	9	5	6	0	0.224	1.000	1.000
230	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(2), PRKACG(1), PRKAR1B(4)	2483121	17	14	17	6	3	6	6	1	1	0	0.634	1.000	1.000
231	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(7), EGFR(24), GRB2(3), HRAS(1), JAK1(5), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), RAF1(2), RASA1(1), SHC1(2), SOS1(9), STAT1(2), STAT3(4), STAT5A(2)	7241286	92	56	81	22	14	18	22	23	15	0	0.239	1.000	1.000
232	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	ATF2(2), CDC42(2), DLD(3), DUSP10(6), GAB1(2), GADD45A(1), GCK(1), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K10(1), MAP3K11(6), MAP3K12(4), MAP3K13(6), MAP3K2(4), MAP3K3(2), MAP3K4(8), MAP3K5(8), MAP3K7(3), MAP3K9(5), MAPK10(1), MAPK7(4), MAPK8(3), MAPK9(5), MYEF2(3), NFATC3(7), NR2C2(1), PAPPA(6), SHC1(2), TP53(65), TRAF6(3), ZAK(1)	9737565	171	83	160	31	36	35	46	23	31	0	0.00450	1.000	1.000
233	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2)	2582451	43	22	43	14	5	27	5	3	3	0	0.661	1.000	1.000
234	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(5), HK3(5), IMPA1(1), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(2), TGDS(2)	2269239	24	12	24	9	10	6	5	2	1	0	0.611	1.000	1.000
235	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(5), F2R(2), F2RL3(2), GNAI1(1), GNB1(1), GNGT1(1), HRAS(1), ITGA1(5), ITGB1(2), MAP2K1(4), MAPK3(1), PLA2G4A(5), PLCB1(9), PRKCA(7), PTGS1(3), PTK2(7), RAF1(2), SRC(2), SYK(1), TBXAS1(4)	4719336	65	37	65	17	12	19	13	11	10	0	0.473	1.000	1.000
236	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(6), AXIN1(2), CREBBP(2), CTNNB1(9), EP300(1), FZD1(2), GSK3B(1), HDAC1(1), LDB1(1), LEF1(6), PITX2(3), TRRAP(14), WNT1(3)	6438003	51	27	50	10	13	11	14	7	6	0	0.0796	1.000	1.000
237	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGTR1(1), ATF2(2), CALM1(1), EGFR(24), GNAQ(2), GRB2(3), HRAS(1), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), MEF2C(1), MEF2D(1), PAK1(5), PRKCA(7), PTK2(7), PTK2B(6), RAF1(2), SHC1(2), SOS1(9), SRC(2), SYT1(3)	6517209	92	49	82	25	20	27	13	18	14	0	0.398	1.000	1.000
238	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(6), CD38(1), ENPP1(3), ENPP3(5), NMNAT1(1), NNMT(3), NNT(4), NT5E(1), NT5M(1)	2822520	25	16	25	9	4	11	7	1	2	0	0.721	1.000	1.000
239	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CSNK1D(1), DRD1(2), DRD2(7), GRM1(14), PLCB1(9), PPP1CA(1), PPP1R1B(1), PPP3CA(2), PRKACB(2), PRKACG(1), PRKAR1B(4)	3125928	45	34	45	13	7	17	16	2	3	0	0.418	1.000	1.000
240	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	GRB2(3), HRAS(1), IL2(3), IL2RA(3), IL2RB(4), JAK1(5), JAK3(3), LCK(5), MAP2K1(4), MAPK3(1), MAPK8(3), RAF1(2), SHC1(2), SOS1(9), STAT5A(2), STAT5B(3), SYK(1)	4554603	54	28	53	14	11	13	10	14	6	0	0.281	1.000	1.000
241	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(2), EP300(1), FYN(2), IL7R(6), JAK1(5), JAK3(3), LCK(5), NMI(1), PIK3CA(5), PIK3R1(1), PTK2B(6), STAT5A(2), STAT5B(3)	5444703	43	31	42	10	6	9	10	12	6	0	0.306	1.000	1.000
242	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(4), BAX(1), BTK(7), CAD(9), CASP10(3), CASP3(4), CASP8(3), CASP8AP2(7), CDK2AP1(1), CSNK1A1(1), DAXX(2), DEDD(1), DFFA(3), EGFR(24), EPHB2(4), FAF1(2), FAIM2(1), IL1A(2), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K5(8), MAPK10(1), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5), MET(10), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIE(1), PFN2(3), PTPN13(7), RALBP1(1), RIPK1(3), ROCK1(7), SMPD1(1), TP53(65), TPX2(1), TUFM(1)	14276301	215	93	195	40	30	53	52	32	48	0	0.00607	1.000	1.000
243	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(1), LPL(2), NCOA1(4), NCOA2(4), PPARG(2)	3584394	15	12	15	5	2	6	4	2	1	0	0.713	1.000	1.000
244	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(4), ACADM(3), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), AOC2(3), AOC3(2), CNDP1(4), DPYD(10), DPYS(6), EHHADH(3), GAD1(4), GAD2(5), HADHA(2), HIBCH(3), MLYCD(4), SMS(1)	5237529	69	32	69	18	12	23	17	9	6	2	0.227	1.000	1.000
245	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	GRB2(3), HRAS(1), JAK2(2), MAP2K1(4), MAPK3(1), MPL(1), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), RAF1(2), RASA1(1), SHC1(2), SOS1(9), STAT1(2), STAT3(4), STAT5A(2), STAT5B(3)	5794164	54	37	53	13	9	13	13	11	8	0	0.284	1.000	1.000
246	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(3), CHIT1(3), CMAS(2), GFPT1(3), GFPT2(1), GNPDA1(1), GNPDA2(1), HEXA(1), HK1(3), HK2(5), HK3(5), MTMR1(2), MTMR2(1), MTMR6(3), NAGK(1), NANS(2), NPL(1), PGM3(2), RENBP(3), UAP1(5)	5558481	48	27	48	13	14	12	8	8	6	0	0.385	1.000	1.000
247	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), CALM1(1), CRKL(2), GNAQ(2), GRB2(3), HRAS(1), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(5), PLCG1(4), PRKCA(7), PTK2B(6), RAF1(2), SHC1(2), SOS1(9), SRC(2), SYT1(3)	5510364	67	37	67	18	19	20	12	8	8	0	0.263	1.000	1.000
248	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(2), AOC2(3), AOC3(2), ASPA(1), CNDP1(4), DDC(6), HAL(1), HARS(2), HDC(6), HNMT(1), PRPS1(3), PRPS2(1)	4754940	57	31	57	16	12	19	14	9	3	0	0.285	1.000	1.000
249	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(5), AP2A1(1), AP2M1(3), BIN1(1), CALM1(1), DNM1(1), EPN1(2), EPS15(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYNJ1(3), SYNJ2(1), SYT1(3)	4196757	27	20	27	9	3	14	6	2	2	0	0.789	1.000	1.000
250	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(7), CALM1(1), FCER1A(5), FCER1G(1), GRB2(3), HRAS(1), LYN(3), MAP2K1(4), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAPK3(1), MAPK8(3), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), PAK2(3), PIK3CA(5), PIK3R1(1), PLA2G4A(5), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SHC1(2), SOS1(9), SYK(1), SYT1(3), VAV1(1)	8322306	90	49	89	22	16	21	26	14	13	0	0.155	1.000	1.000
251	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA6(1), PSMB4(3), PSMC2(2), PSMD1(2), PSMD11(3), PSMD12(3), PSMD13(2), PSMD2(2), PSMD6(1)	3087486	20	12	20	7	6	5	4	4	1	0	0.584	1.000	1.000
252	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1(2), FPR1(1), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(4), MAP2K3(3), MAP3K1(3), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NFKB1(2), PAK1(5), PIK3C2G(3), PLCB1(9), PPP3CA(2), PPP3CB(1), PPP3CC(1), RAF1(2), SYT1(3)	7463424	65	40	65	16	16	21	16	4	8	0	0.166	1.000	1.000
253	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(1), EPHB2(4), F2(5), F2RL1(1), F2RL2(2), F2RL3(2), MAPK7(4), MAPK8(3), MYEF2(3), PLD1(7), PLD2(3), PTK2(7), RAF1(2), RASAL1(6), SRC(2), TEC(4), VAV1(1)	5335569	64	34	64	16	11	16	19	10	8	0	0.240	1.000	1.000
254	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(4), HDAC5(2), MEF2C(1), MEF2D(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYT1(3)	3963783	22	17	22	9	2	10	5	3	2	0	0.813	1.000	1.000
255	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(2), AMDHD1(3), AOC2(3), AOC3(2), ASPA(1), CARM1(3), CNDP1(4), DDC(6), FTCD(2), HAL(1), HARS(2), HARS2(1), HDC(6), HNMT(1), LCMT1(1), LCMT2(4), METTL2B(3), METTL6(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), PRPS1(3), PRPS2(1), UROC1(6), WBSCR22(1)	7711749	90	48	89	22	18	25	29	11	7	0	0.0812	1.000	1.000
256	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(2), ASAH1(2), B4GALT6(3), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(3), GBA(3), GLA(2), LCT(12), NEU3(1), NEU4(5), PPAP2B(1), SGMS1(1), SGMS2(2), SGPP1(1), SMPD1(1), SMPD2(1), SMPD3(1), SPHK2(1), SPTLC1(1), SPTLC2(1), UGT8(1)	6989607	58	39	57	14	10	20	16	7	5	0	0.176	1.000	1.000
257	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCR4(3), GNAI1(1), GNAQ(2), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(4), MAPK3(1), NFKB1(2), PIK3C2G(3), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), PTK2(7), PTK2B(6), RAF1(2)	5390910	52	32	51	14	12	16	13	6	5	0	0.357	1.000	1.000
258	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(3), CRKL(2), GRB2(3), HRAS(1), JAK2(2), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), PIK3CA(5), PIK3R1(1), RAF1(2), SOS1(9), STAT1(2), STAT5A(2), STAT5B(3)	5414259	49	34	48	13	7	9	13	10	10	0	0.316	1.000	1.000
259	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(2), BTRC(5), CDC16(1), CDC20(2), CDC23(1), CDC27(2), CUL1(3), CUL2(4), CUL3(3), FBXW7(2), FZR1(2), ITCH(3), SKP1(1), SKP2(3), SMURF1(2), SMURF2(2), TCEB1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), VHL(1), WWP1(2), WWP2(2)	7840491	57	35	56	14	17	8	13	11	8	0	0.232	1.000	1.000
260	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(3), CBS(1), GGT1(1), LCMT1(1), LCMT2(4), MARS(1), MARS2(4), MAT1A(2), MAT2B(3), METTL2B(3), METTL6(1), PAPSS1(2), PAPSS2(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), SCLY(2), SEPHS1(3), WBSCR22(1)	4830663	48	28	47	14	15	10	18	1	4	0	0.280	1.000	1.000
261	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(2), DAXX(2), DDIT3(4), GRB2(3), HRAS(1), HSPB2(1), MAP2K4(2), MAP3K1(3), MAP3K5(8), MAP3K7(3), MAP3K9(5), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MAX(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(3), RPS6KA5(2), SHC1(2), STAT1(2), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2)	7139763	70	39	70	18	11	14	18	14	13	0	0.344	1.000	1.000
262	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(4), ACADM(3), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(3), AOC3(2), CNDP1(4), DPYD(10), DPYS(6), EHHADH(3), GAD1(4), GAD2(5), HADHA(2), MLYCD(4), SMS(1)	5625948	72	32	72	21	13	27	17	8	5	2	0.370	1.000	1.000
263	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), NFAT5(4), PDE6A(6), PDE6B(3), PDE6C(2), PDE6D(1), SLC6A13(3), TF(2)	7005087	58	29	57	15	15	20	12	4	7	0	0.260	1.000	1.000
264	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	GRB2(3), HRAS(1), IGF1(3), IGF1R(6), IRS1(12), MAP2K1(4), MAPK3(1), MAPK8(3), PIK3CA(5), PIK3R1(1), PTPN11(1), RAF1(2), RASA1(1), SHC1(2), SOS1(9)	4777644	54	29	53	16	14	15	11	10	4	0	0.440	1.000	1.000
265	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRKL(2), DOCK1(4), GAB1(2), GRB2(3), HGF(18), HRAS(1), ITGA1(5), ITGB1(2), MAP2K1(4), MAP4K1(2), MAPK3(1), MAPK8(3), MET(10), PAK1(5), PIK3CA(5), PIK3R1(1), PTEN(3), PTK2(7), PTK2B(6), PTPN11(1), RAF1(2), RAP1A(1), RAP1B(1), RASA1(1), SOS1(9), SRC(2), STAT3(4)	8543283	105	53	103	29	19	28	18	25	15	0	0.440	1.000	1.000
266	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), ALDH5A1(2), CAD(9), CPS1(23), EPRS(9), GAD1(4), GAD2(5), GCLC(6), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(3), GMPS(5), GOT1(2), GOT2(3), GPT2(2), GSS(2), PPAT(3), QARS(2)	6443937	89	38	89	24	17	29	22	11	9	1	0.397	1.000	1.000
267	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(3), CARS(1), CARS2(1), DARS2(2), EARS2(1), EPRS(9), FARS2(1), FARSA(1), FARSB(1), GARS(3), HARS(2), HARS2(1), IARS(3), IARS2(4), KARS(3), LARS(3), LARS2(1), MARS(1), MARS2(4), MTFMT(1), NARS(2), NARS2(2), QARS(2), RARS(4), RARS2(1), TARS(3), TARS2(5), VARS(5), VARS2(6), WARS(2), WARS2(8), YARS(1), YARS2(2)	10533753	90	38	90	22	20	35	17	10	8	0	0.196	1.000	1.000
268	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(5), ABAT(1), ACAT1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), ALDH9A1(2), EHHADH(3), GAD1(4), GAD2(5), HADHA(2), OXCT1(4), PDHA1(1), PDHA2(8)	4979529	56	33	56	17	11	20	13	5	5	2	0.458	1.000	1.000
269	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	GRB2(3), HRAS(1), INSR(1), IRS1(12), MAP2K1(4), MAPK3(1), MAPK8(3), PIK3CA(5), PIK3R1(1), PTPN11(1), RAF1(2), RASA1(1), SHC1(2), SOS1(9)	4923285	46	26	45	14	12	9	10	11	4	0	0.448	1.000	1.000
270	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(2), ACTN2(14), ACTN3(2), ACTN4(1), AKT2(1), AKT3(2), ARHGAP5(4), BCAR1(1), BCL2(1), BIRC2(2), BIRC3(2), BRAF(13), CCND1(2), CCND3(1), CDC42(2), CHAD(1), COL11A1(35), COL11A2(1), COL1A1(2), COL1A2(8), COL2A1(2), COL3A1(24), COL4A1(7), COL4A2(9), COL4A4(8), COL4A6(9), COL5A1(14), COL5A2(17), COL5A3(4), COL6A1(2), COL6A2(3), COL6A3(21), COL6A6(11), COMP(1), CRKL(2), CTNNB1(9), DIAPH1(3), DOCK1(4), EGF(7), EGFR(24), ERBB2(5), FARP2(2), FIGF(1), FLNA(7), FLNB(9), FLNC(9), FLT1(12), FN1(4), FYN(2), GRB2(3), GRLF1(6), GSK3B(1), HGF(18), HRAS(1), IBSP(1), IGF1(3), IGF1R(6), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGA7(2), ITGA8(15), ITGA9(1), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(3), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(1), KDR(16), LAMA1(14), LAMA2(16), LAMA3(22), LAMA4(7), LAMA5(7), LAMB1(12), LAMB2(8), LAMB3(4), LAMB4(14), LAMC1(8), LAMC2(8), LAMC3(9), MAP2K1(4), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(5), MET(10), MYL2(2), MYL5(1), MYL7(1), MYLK(10), MYLK2(2), MYLPF(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PARVA(2), PARVG(2), PDGFA(6), PDGFD(3), PDGFRA(7), PDGFRB(6), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(7), PRKCG(5), PTEN(3), PTK2(7), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF1(1), RELN(28), RHOA(1), ROCK1(7), ROCK2(3), SHC1(2), SHC2(1), SHC3(2), SHC4(4), SOS1(9), SOS2(5), SRC(2), THBS1(4), THBS2(12), THBS3(1), THBS4(4), TLN1(9), TLN2(4), TNC(9), TNN(18), TNR(19), TNXB(6), VAV1(1), VAV2(2), VAV3(9), VCL(2), VEGFA(1), VEGFC(6), VTN(2), VWF(7), ZYX(2)	72282183	918	121	895	315	154	303	197	131	130	3	0.986	1.000	1.000
271	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN2(14), ACTN3(2), ACTN4(1), APC(6), APC2(1), ARAF(3), ARHGEF1(1), ARHGEF12(5), ARHGEF6(4), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC3(1), ARPC5(1), BAIAP2(2), BCAR1(1), BRAF(13), CD14(1), CDC42(2), CFL2(1), CHRM1(1), CHRM2(4), CHRM3(4), CHRM4(2), CRKL(2), CYFIP1(4), CYFIP2(7), DIAPH1(3), DIAPH2(3), DIAPH3(4), DOCK1(4), EGF(7), EGFR(24), F2(5), F2R(2), FGD1(1), FGD3(2), FGF10(2), FGF12(2), FGF13(4), FGF14(5), FGF19(1), FGF20(1), FGF21(1), FGF23(3), FGF3(1), FGF4(2), FGF5(1), FGF9(1), FGFR1(5), FGFR2(5), FGFR3(2), FGFR4(1), FN1(4), GNA12(1), GNA13(1), GNG12(2), GRLF1(6), GSN(2), HRAS(1), IQGAP1(5), IQGAP2(7), IQGAP3(3), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGA7(2), ITGA8(15), ITGA9(1), ITGAD(12), ITGAE(6), ITGAL(17), ITGAM(9), ITGAV(5), ITGAX(11), ITGB1(2), ITGB2(2), ITGB3(2), ITGB4(3), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(35), LIMK2(1), MAP2K1(4), MAPK3(1), MRAS(1), MYH10(4), MYH14(2), MYH9(4), MYL2(2), MYL5(1), MYL7(1), MYLK(10), MYLK2(2), MYLPF(1), NCKAP1(2), NCKAP1L(7), NRAS(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PDGFA(6), PDGFRA(7), PDGFRB(6), PFN2(3), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(5), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), PTK2(7), RAF1(2), RDX(1), RHOA(1), ROCK1(7), ROCK2(3), RRAS2(1), SCIN(3), SLC9A1(1), SOS1(9), SOS2(5), SSH1(2), SSH2(2), SSH3(1), TIAM1(10), TIAM2(6), TMSL3(1), VAV1(1), VAV2(2), VAV3(9), VCL(2), WAS(2), WASF1(4), WASL(4)	53950638	606	120	558	190	110	184	137	96	79	0	0.659	1.000	1.000
272	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(4), ACVR1C(2), AKT2(1), AKT3(2), ARRB1(1), ARRB2(1), ATF2(2), BDNF(1), BRAF(13), CACNA1A(6), CACNA1B(9), CACNA1C(8), CACNA1D(7), CACNA1E(26), CACNA1F(5), CACNA1G(3), CACNA1H(5), CACNA1I(5), CACNA1S(5), CACNA2D1(10), CACNA2D2(1), CACNA2D3(6), CACNA2D4(3), CACNB1(1), CACNB2(5), CACNB4(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(4), CACNG6(1), CACNG8(1), CASP3(4), CD14(1), CDC25B(1), CDC42(2), CHUK(1), CRKL(2), DAXX(2), DDIT3(4), DUSP10(6), DUSP16(2), DUSP2(1), DUSP6(1), DUSP7(2), EGF(7), EGFR(24), ELK4(4), FAS(2), FASLG(2), FGF10(2), FGF12(2), FGF13(4), FGF14(5), FGF19(1), FGF20(1), FGF21(1), FGF23(3), FGF3(1), FGF4(2), FGF5(1), FGF9(1), FGFR1(5), FGFR2(5), FGFR3(2), FGFR4(1), FLNA(7), FLNB(9), FLNC(9), GADD45A(1), GNA12(1), GNG12(2), GRB2(3), HRAS(1), IKBKB(2), IL1A(2), IL1R2(4), KRAS(35), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K10(1), MAP3K12(4), MAP3K13(6), MAP3K14(1), MAP3K2(4), MAP3K3(2), MAP3K4(8), MAP3K5(8), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP4K1(2), MAP4K3(2), MAPK10(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MAPT(2), MAX(1), MEF2C(1), MKNK1(1), MRAS(1), NF1(16), NFATC2(5), NFATC4(2), NFKB1(2), NFKB2(3), NR4A1(1), NRAS(1), NTF3(2), NTRK1(6), NTRK2(5), PAK1(5), PAK2(3), PDGFA(6), PDGFRA(7), PDGFRB(6), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PPM1B(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PPP5C(1), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKX(3), PTPN5(2), PTPRR(7), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(1), RASA2(2), RASGRF1(1), RASGRF2(9), RASGRP2(1), RASGRP3(5), RASGRP4(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(1), RPS6KA5(2), RPS6KA6(3), RRAS2(1), SOS1(9), SOS2(5), STK4(3), TAOK2(5), TAOK3(3), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2), TP53(65), TRAF6(3), ZAK(1)	55867707	687	119	629	194	127	181	159	110	107	3	0.104	1.000	1.000
273	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY7(3), ADCY8(13), ADCY9(1), ADRA1A(2), ADRA1D(2), ADRB3(1), AGTR1(1), ATP2A1(2), ATP2A2(5), ATP2A3(1), ATP2B1(5), ATP2B2(8), ATP2B3(6), ATP2B4(6), AVPR1A(4), AVPR1B(1), CACNA1A(6), CACNA1B(9), CACNA1C(8), CACNA1D(7), CACNA1E(26), CACNA1F(5), CACNA1G(3), CACNA1H(5), CACNA1I(5), CACNA1S(5), CALM1(1), CALML3(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(4), CCKAR(4), CCKBR(8), CD38(1), CHRM1(1), CHRM2(4), CHRM3(4), CHRNA7(2), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(24), ERBB2(5), ERBB3(1), ERBB4(12), F2R(2), GNAQ(2), GNAS(3), GRIN1(1), GRIN2A(19), GRIN2C(3), GRIN2D(5), GRM1(14), GRM5(9), GRPR(5), HRH1(4), HRH2(2), HTR2A(2), HTR2C(5), HTR5A(6), HTR6(3), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), LHCGR(3), MYLK(10), MYLK2(2), NOS1(5), NOS3(1), NTSR1(2), OXTR(1), P2RX2(3), P2RX4(1), P2RX5(2), P2RX7(2), PDE1A(5), PDE1B(6), PDE1C(11), PDGFRA(7), PDGFRB(6), PHKA1(3), PHKA2(6), PHKB(4), PHKG1(1), PHKG2(2), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(8), PLCG1(4), PLCG2(4), PLCZ1(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKX(3), PTAFR(2), PTGER3(1), PTGFR(5), PTK2B(6), RYR1(26), RYR2(89), RYR3(27), SLC25A5(1), SLC25A6(4), SLC8A1(17), SLC8A2(1), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TNNC2(2), TRPC1(7)	52607748	710	118	693	273	112	237	190	103	66	2	0.990	1.000	1.000
274	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA1(1), ADORA3(1), ADRA1A(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB3(1), AGTR1(1), AGTR2(2), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(6), C3AR1(2), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(4), CCKBR(8), CGA(1), CHRM1(1), CHRM2(4), CHRM3(4), CHRM4(2), CNR1(3), CNR2(1), CRHR1(1), CRHR2(2), CTSG(1), CYSLTR2(1), DRD1(2), DRD2(7), DRD3(7), DRD5(3), EDNRB(2), F2(5), F2R(2), F2RL1(1), F2RL2(2), F2RL3(2), FPR1(1), FSHB(1), FSHR(11), GABBR1(3), GABBR2(2), GABRA1(6), GABRA2(9), GABRA3(6), GABRA4(7), GABRA5(8), GABRA6(6), GABRB1(7), GABRB2(1), GABRB3(7), GABRE(3), GABRG1(6), GABRG2(9), GABRG3(6), GABRP(4), GABRQ(4), GABRR1(5), GABRR2(1), GALR1(2), GALR2(1), GH1(2), GH2(3), GHR(1), GHRHR(2), GHSR(2), GIPR(2), GLP2R(5), GLRA1(2), GLRA2(3), GLRA3(1), GLRB(2), GNRHR(2), GPR156(4), GPR50(5), GPR63(4), GPR83(3), GRIA1(8), GRIA2(7), GRIA3(5), GRIA4(3), GRID1(11), GRID2(7), GRIK1(5), GRIK2(9), GRIK3(7), GRIK4(7), GRIK5(2), GRIN1(1), GRIN2A(19), GRIN2B(13), GRIN2C(3), GRIN2D(5), GRIN3A(12), GRM1(14), GRM2(3), GRM3(4), GRM4(3), GRM5(9), GRM6(2), GRM7(8), GRM8(8), GRPR(5), GZMA(1), HCRTR2(7), HRH1(4), HRH2(2), HRH3(1), HRH4(3), HTR1A(8), HTR1B(2), HTR1E(4), HTR1F(3), HTR2A(2), HTR2C(5), HTR5A(6), HTR6(3), LEP(2), LEPR(8), LHB(1), LHCGR(3), LTB4R(2), MAS1(2), MC2R(1), MC3R(5), MC5R(5), MCHR2(4), MLNR(1), MTNR1A(3), MTNR1B(5), NMBR(3), NMUR1(3), NMUR2(6), NPBWR1(2), NPBWR2(2), NPFFR2(9), NPY1R(6), NPY2R(6), NPY5R(5), NR3C1(1), NTSR1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(1), P2RX2(3), P2RX4(1), P2RX5(2), P2RX7(2), P2RY1(5), P2RY10(5), P2RY14(1), P2RY4(1), P2RY6(1), P2RY8(1), PARD3(4), PPYR1(1), PRLHR(1), PRLR(7), PRSS1(10), PTAFR(2), PTGER2(1), PTGER3(1), PTGER4(4), PTGFR(5), PTGIR(1), PTH2R(7), RXFP1(5), RXFP2(4), SCTR(1), SSTR1(2), SSTR3(2), SSTR4(4), TAAR1(1), TAAR2(3), TAAR5(3), TAAR6(5), TAAR8(4), TAAR9(2), TACR1(1), TACR3(2), THRA(1), THRB(4), TRPV1(2), TSHR(2), UTS2R(1), VIPR2(2)	42936618	708	114	705	306	97	241	179	118	73	0	1.000	1.000	1.000
275	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), CHAD(1), COL11A1(35), COL11A2(1), COL17A1(5), COL1A1(2), COL1A2(8), COL2A1(2), COL3A1(24), COL4A1(7), COL4A2(9), COL4A4(8), COL4A6(9), COL5A1(14), COL5A2(17), COL5A3(4), COL6A1(2), COL6A2(3), COL6A3(21), COL6A6(11), COMP(1), DSC1(4), DSC2(3), DSC3(5), DSG1(5), DSG2(8), DSG3(9), DSG4(9), FN1(4), GJA1(2), GJA10(2), GJA5(1), GJA8(4), GJA9(1), GJB1(3), GJB3(1), GJB4(2), GJC1(2), GJD2(1), GJD4(1), IBSP(1), ITGA6(3), ITGB4(3), KRT1(1), KRT12(1), KRT13(4), KRT15(1), KRT16(2), KRT17(2), KRT18(1), KRT19(1), KRT2(6), KRT20(2), KRT23(1), KRT24(2), KRT25(2), KRT28(4), KRT3(2), KRT31(2), KRT33A(1), KRT33B(2), KRT34(2), KRT35(2), KRT36(2), KRT37(1), KRT38(5), KRT39(3), KRT4(1), KRT40(1), KRT5(3), KRT6A(4), KRT6B(8), KRT6C(1), KRT7(3), KRT71(3), KRT73(7), KRT74(4), KRT75(5), KRT76(2), KRT78(1), KRT79(3), KRT81(1), KRT82(5), KRT83(1), KRT84(3), KRT85(1), KRT86(3), LAMA1(14), LAMA2(16), LAMA3(22), LAMA4(7), LAMA5(7), LAMB1(12), LAMB2(8), LAMB3(4), LAMB4(14), LAMC1(8), LAMC2(8), LAMC3(9), LMNB1(1), LMNB2(1), NES(3), RELN(28), THBS1(4), THBS2(12), THBS3(1), THBS4(4), TNC(9), TNN(18), TNR(19), TNXB(6), VIM(2), VTN(2), VWF(7)	48347136	618	107	615	234	98	216	145	64	92	3	0.999	1.000	1.000
276	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), CSNK1D(1), DRD1(2), DRD2(7), EGF(7), EGFR(24), GJA1(2), GJD2(1), GNAI1(1), GNAI3(1), GNAQ(2), GNAS(3), GRB2(3), GRM1(14), GRM5(9), GUCY1A2(3), GUCY1A3(6), GUCY1B3(2), GUCY2C(4), GUCY2F(8), HRAS(1), HTR2A(2), HTR2C(5), ITPR1(7), ITPR2(15), ITPR3(4), KRAS(35), MAP2K1(4), MAP3K2(4), MAPK3(1), MAPK7(4), NPR1(3), NPR2(2), NRAS(1), PDGFA(6), PDGFD(3), PDGFRA(7), PDGFRB(6), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKG1(1), PRKG2(4), PRKX(3), RAF1(2), SOS1(9), SOS2(5), SRC(2), TJP1(4), TUBA1A(2), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(6), TUBA3E(1), TUBA4A(2), TUBB1(2), TUBB2B(1), TUBB2C(3), TUBB4(3), TUBB4Q(5), TUBB8(3)	25679514	366	107	323	128	58	138	88	52	30	0	0.894	1.000	1.000
277	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(6), APC2(1), AXIN1(2), AXIN2(2), BTRC(5), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(2), CCND3(1), CER1(1), CHD8(8), CREBBP(2), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CTNNB1(9), CUL1(3), CXXC4(2), DAAM1(2), DAAM2(3), DKK1(1), DKK2(3), DKK4(1), DVL2(1), DVL3(2), EP300(1), FOSL1(2), FZD1(2), FZD10(5), FZD2(1), FZD3(3), FZD4(3), FZD7(1), FZD9(1), GSK3B(1), LEF1(6), LRP5(3), LRP6(9), MAP3K7(3), MAPK10(1), MAPK8(3), MAPK9(5), MMP7(2), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NKD1(4), NKD2(2), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PORCN(2), PPARD(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRICKLE1(2), PRICKLE2(1), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKX(3), PSEN1(1), RHOA(1), ROCK1(7), ROCK2(3), RUVBL1(2), SENP2(3), SFRP4(1), SKP1(1), SMAD2(2), SMAD3(3), SMAD4(6), SOX17(1), TBL1XR1(2), TCF7(1), TCF7L1(1), TCF7L2(2), TP53(65), VANGL1(3), VANGL2(2), WNT1(3), WNT10A(2), WNT10B(2), WNT11(1), WNT16(2), WNT2(2), WNT3A(2), WNT4(1), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(4), WNT7B(2), WNT8A(1), WNT8B(1), WNT9A(2), WNT9B(2)	31468518	355	106	343	99	71	74	100	48	62	0	0.122	1.000	1.000
278	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(1), ABL2(5), AKT2(1), AKT3(2), ARAF(3), BRAF(13), BTC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBL(7), CBLB(2), CDKN1B(2), CRKL(2), EGF(7), EGFR(24), ERBB2(5), ERBB3(1), ERBB4(12), EREG(3), GAB1(2), GRB2(3), GSK3B(1), HRAS(1), KRAS(35), MAP2K1(4), MAP2K4(2), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(5), NCK1(1), NCK2(3), NRAS(1), NRG1(6), NRG2(2), NRG3(10), NRG4(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLCG1(4), PLCG2(4), PRKCA(7), PRKCG(5), PTK2(7), RAF1(2), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(2), SHC4(4), SOS1(9), SOS2(5), SRC(2), STAT5A(2), STAT5B(3), TGFA(1)	19963008	285	105	237	71	47	98	56	43	41	0	0.0944	1.000	1.000
279	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(1), ABLIM1(4), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(2), CDK5(1), CFL2(1), CXCR4(3), DCC(10), DPYSL2(1), DPYSL5(2), EFNB2(1), EPHA1(8), EPHA2(1), EPHA3(15), EPHA4(4), EPHA5(13), EPHA6(18), EPHA7(12), EPHA8(4), EPHB1(17), EPHB2(4), EPHB3(2), EPHB4(6), EPHB6(16), FES(1), FYN(2), GNAI1(1), GNAI3(1), GSK3B(1), HRAS(1), ITGB1(2), KRAS(35), L1CAM(7), LIMK2(1), LRRC4C(6), MAPK3(1), MET(10), NCK1(1), NCK2(3), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NGEF(2), NRAS(1), NRP1(2), NTN4(4), NTNG1(4), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PLXNA1(3), PLXNA2(10), PLXNA3(5), PLXNB1(3), PLXNB2(5), PLXNB3(2), PLXNC1(9), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PTK2(7), RASA1(1), RGS3(4), RHOA(1), RHOD(1), ROBO1(9), ROBO2(12), ROBO3(6), ROCK1(7), ROCK2(3), SEMA3A(11), SEMA3B(2), SEMA3C(4), SEMA3D(14), SEMA3E(3), SEMA3F(3), SEMA3G(2), SEMA4A(2), SEMA4C(1), SEMA4D(3), SEMA4F(3), SEMA4G(2), SEMA5A(7), SEMA5B(4), SEMA6A(5), SEMA6B(3), SEMA6C(5), SEMA6D(15), SEMA7A(5), SLIT1(11), SLIT2(13), SLIT3(8), SRGAP1(5), SRGAP2(3), SRGAP3(4), UNC5A(3), UNC5B(7), UNC5C(8), UNC5D(8)	38425488	547	105	515	169	90	193	127	67	70	0	0.500	1.000	1.000
280	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD36(3), CD44(1), CD47(1), CHAD(1), COL11A1(35), COL11A2(1), COL1A1(2), COL1A2(8), COL2A1(2), COL3A1(24), COL4A1(7), COL4A2(9), COL4A4(8), COL4A6(9), COL5A1(14), COL5A2(17), COL5A3(4), COL6A1(2), COL6A2(3), COL6A3(21), COL6A6(11), DAG1(2), FN1(4), FNDC1(7), FNDC3A(6), GP5(2), GP6(1), HMMR(2), HSPG2(11), IBSP(1), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGA7(2), ITGA8(15), ITGA9(1), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(3), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(14), LAMA2(16), LAMA3(22), LAMA4(7), LAMA5(7), LAMB1(12), LAMB2(8), LAMB3(4), LAMB4(14), LAMC1(8), LAMC2(8), LAMC3(9), RELN(28), SDC1(2), SDC3(1), SV2A(3), SV2B(4), SV2C(7), THBS1(4), THBS2(12), THBS3(1), THBS4(4), TNC(9), TNN(18), TNR(19), TNXB(6), VTN(2), VWF(7)	43848906	554	105	551	207	86	196	121	66	82	3	0.998	1.000	1.000
281	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(2), ACTN2(14), ACTN3(2), ACTN4(1), AKT2(1), AKT3(2), AMOTL1(5), ASH1L(15), CASK(1), CDC42(2), CDK4(2), CGN(4), CLDN1(3), CLDN10(1), CLDN11(2), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(1), CLDN8(3), CSDA(2), CTNNA1(2), CTNNA2(15), CTNNA3(11), CTNNB1(9), CTTN(2), EPB41(1), EPB41L1(3), EPB41L2(7), EPB41L3(12), EXOC3(2), EXOC4(3), F11R(1), GNAI1(1), GNAI3(1), HCLS1(5), HRAS(1), IGSF5(2), INADL(20), JAM2(5), KRAS(35), LLGL1(1), LLGL2(2), MAGI1(10), MAGI2(9), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(1), MRAS(1), MYH1(17), MYH10(4), MYH11(10), MYH13(10), MYH14(2), MYH15(10), MYH2(20), MYH3(6), MYH4(11), MYH6(12), MYH7(14), MYH7B(4), MYH8(15), MYH9(4), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), NRAS(1), PARD3(4), PARD6B(1), PPM1J(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(3), PPP2R3A(1), PPP2R3B(4), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCI(5), PRKCQ(3), PTEN(3), RAB13(1), RAB3B(1), RHOA(1), RRAS2(1), SPTAN1(7), SRC(2), SYMPK(5), TJAP1(1), TJP1(4), TJP2(4), TJP3(2), YES1(2), ZAK(1)	37696380	475	105	441	162	93	160	114	62	45	1	0.849	1.000	1.000
282	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), CACNA1C(8), CACNA1D(7), CACNA1F(5), CACNA1S(5), CALM1(1), CALML3(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CDC42(2), CGA(1), EGFR(24), FSHB(1), GNAQ(2), GNAS(3), GNRHR(2), GRB2(3), HRAS(1), ITPR1(7), ITPR2(15), ITPR3(4), KRAS(35), LHB(1), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K2(4), MAP3K3(2), MAP3K4(8), MAPK10(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(3), MAPK9(5), MMP14(2), MMP2(6), NRAS(1), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLD1(7), PLD2(3), PRKACB(2), PRKACG(1), PRKCA(7), PRKCD(1), PRKX(3), PTK2B(6), RAF1(2), SOS1(9), SOS2(5), SRC(2)	24821793	324	105	281	95	63	104	79	47	31	0	0.335	1.000	1.000
283	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(4), ACVR2A(1), ACVR2B(3), AMH(1), BMP2(1), BMP7(3), BMPR1A(1), BMPR1B(3), BMPR2(2), CCL15(3), CCL28(1), CCL3(1), CCL4(1), CCL7(1), CCR1(1), CCR2(5), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(5), CD40LG(4), CNTFR(1), CSF1(1), CSF1R(3), CSF2RA(5), CSF2RB(3), CSF3R(3), CX3CL1(1), CX3CR1(5), CXCL1(2), CXCL16(1), CXCL5(1), CXCL6(3), CXCL9(2), CXCR3(1), CXCR4(3), CXCR6(1), EDA(2), EDA2R(1), EDAR(1), EGF(7), EGFR(24), EPO(1), FAS(2), FASLG(2), FLT1(12), FLT3(7), FLT3LG(1), FLT4(8), GDF5(3), GH1(2), GH2(3), GHR(1), HGF(18), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), IFNAR2(1), IFNB1(3), IFNG(3), IFNGR1(3), IFNGR2(2), IFNW1(1), IL10RA(3), IL10RB(2), IL12A(2), IL12RB1(2), IL12RB2(6), IL15(1), IL15RA(1), IL17A(2), IL17B(2), IL17RA(2), IL18RAP(3), IL1A(2), IL1R2(4), IL1RAP(2), IL2(3), IL20RA(1), IL21R(7), IL22(2), IL22RA2(1), IL23R(1), IL24(3), IL25(1), IL28B(2), IL28RA(2), IL2RA(3), IL2RB(4), IL3(1), IL3RA(4), IL4R(5), IL5RA(1), IL6R(5), IL7R(6), IL9R(2), INHBA(7), INHBB(1), INHBC(1), INHBE(2), KDR(16), KIT(3), LEP(2), LEPR(8), LIF(2), LIFR(5), MET(10), MPL(1), NGFR(2), OSM(2), OSMR(4), PDGFRA(7), PDGFRB(6), PLEKHO2(2), PRLR(7), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2), TNFRSF10B(1), TNFRSF10C(1), TNFRSF11A(4), TNFRSF11B(1), TNFRSF13B(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1B(1), TNFRSF21(2), TNFRSF25(1), TNFRSF4(1), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TPO(9), TSLP(3), VEGFA(1), VEGFC(6), XCL1(3), XCL2(4), XCR1(1)	34459383	444	104	432	140	50	145	101	88	60	0	0.747	1.000	1.000
284	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), ADRA1A(2), ADRA1D(2), ADRB3(1), ARRB1(1), ARRB2(1), ATP1A4(9), ATP1B3(1), ATP2A2(5), ATP2A3(1), ATP2B1(5), ATP2B2(8), ATP2B3(6), CACNA1A(6), CACNA1B(9), CACNA1C(8), CACNA1D(7), CACNA1E(26), CACNA1S(5), CACNB1(1), CALM1(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(4), CASQ1(2), CASQ2(2), CHRM1(1), CHRM2(4), CHRM3(4), CHRM4(2), FXYD2(1), GJA1(2), GJA5(1), GJB1(3), GJB3(1), GJB4(2), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(1), GNB1(1), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(3), GNG3(2), GNGT1(1), GRK4(1), GRK5(6), GRK6(1), ITPR1(7), ITPR2(15), ITPR3(4), KCNB1(8), KCNJ3(10), MIB1(5), NME7(3), PEA15(2), PLCB3(3), PRKACB(2), PRKAR1B(4), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCQ(3), PRKD1(8), RGS1(4), RGS11(1), RGS16(1), RGS18(2), RGS2(1), RGS20(2), RGS3(4), RGS4(3), RGS5(4), RGS6(1), RGS7(7), RGS9(3), RYR1(26), RYR2(89), RYR3(27), SLC8A1(17), SLC8A3(3), USP5(2)	36804603	503	103	499	186	82	181	136	58	44	2	0.928	1.000	1.000
285	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(8), ADCY8(13), ARAF(3), BRAF(13), CACNA1C(8), CALM1(1), CALML3(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(4), CREBBP(2), EP300(1), GNAQ(2), GRIA1(8), GRIA2(7), GRIN1(1), GRIN2A(19), GRIN2B(13), GRIN2C(3), GRIN2D(5), GRM1(14), GRM5(9), HRAS(1), ITPR1(7), ITPR2(15), ITPR3(4), KRAS(35), MAP2K1(4), MAPK3(1), NRAS(1), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R1A(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKX(3), RAF1(2), RAP1A(1), RAP1B(1), RAPGEF3(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3)	19544532	278	103	241	82	46	108	60	38	26	0	0.429	1.000	1.000
286	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(8), ACACB(7), AKT2(1), AKT3(2), ARAF(3), BRAF(13), CALM1(1), CALML3(2), CBL(7), CBLB(2), CRKL(2), EXOC7(1), FASN(1), FLOT1(2), G6PC(1), G6PC2(1), GCK(1), GRB2(3), GSK3B(1), GYS1(1), GYS2(1), HRAS(1), IKBKB(2), INPP5D(3), INSR(1), IRS1(12), IRS2(2), IRS4(7), KRAS(35), LIPE(1), MAP2K1(4), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(5), MKNK1(1), NRAS(1), PCK1(8), PCK2(1), PDE3A(5), PDE3B(3), PFKL(1), PFKM(2), PFKP(3), PHKA1(3), PHKA2(6), PHKB(4), PHKG1(1), PHKG2(2), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PKLR(4), PKM2(2), PPARGC1A(7), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3A(6), PPP1R3B(1), PPP1R3C(1), PPP1R3D(4), PRKAA1(1), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAG3(1), PRKAR1B(4), PRKCI(5), PRKX(3), PTPN1(1), PTPRF(3), PYGB(1), PYGM(3), RAF1(2), RAPGEF1(1), RHEB(3), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(2), SHC4(4), SOCS4(1), SORBS1(4), SOS1(9), SOS2(5), SREBF1(1), TSC1(7), TSC2(2)	31219935	305	102	267	116	59	98	71	43	34	0	0.932	1.000	1.000
287	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(3), BID(1), BRAF(13), CASP3(4), CD244(4), CD48(2), FAS(2), FASLG(2), FCER1G(1), FCGR3A(5), FCGR3B(5), FYN(2), GRB2(3), GZMB(3), HCST(2), HLA-A(1), HLA-B(1), HRAS(1), ICAM2(1), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), IFNAR2(1), IFNB1(3), IFNG(3), IFNGR1(3), IFNGR2(2), ITGAL(17), ITGB2(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR3DL1(5), KLRC1(1), KLRC2(2), KLRC3(3), KLRD1(1), KLRK1(2), KRAS(35), LAT(3), LCK(5), LCP2(3), MAP2K1(4), MAPK3(1), NCR1(1), NCR3(1), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NRAS(1), PAK1(5), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLCG1(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRF1(4), PRKCA(7), PRKCG(5), PTK2B(6), PTPN11(1), PTPN6(2), RAF1(2), SH2D1B(1), SH3BP2(2), SHC1(2), SHC2(1), SHC3(2), SHC4(4), SOS1(9), SOS2(5), SYK(1), TNFRSF10B(1), TNFRSF10C(1), TNFSF10(1), ULBP1(1), VAV1(1), VAV2(2), VAV3(9), ZAP70(2)	22166457	307	101	269	82	45	103	72	48	39	0	0.165	1.000	1.000
288	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(1), ANAPC1(2), ANAPC10(1), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(2), ATM(14), ATR(9), BUB1(4), BUB1B(5), BUB3(1), CCNA1(2), CCNA2(2), CCNB1(1), CCNB3(4), CCND1(2), CCND3(1), CCNE1(3), CDC14A(6), CDC14B(1), CDC16(1), CDC20(2), CDC23(1), CDC25A(2), CDC25B(1), CDC27(2), CDC6(1), CDC7(3), CDK2(4), CDK4(2), CDK7(2), CDKN1B(2), CDKN2A(7), CDKN2D(1), CHEK1(6), CHEK2(2), CREBBP(2), CUL1(3), DBF4(3), E2F3(1), EP300(1), ESPL1(4), FZR1(2), GADD45A(1), GSK3B(1), HDAC1(1), HDAC2(6), MAD1L1(5), MAD2L1(1), MCM2(4), MCM3(3), MCM4(5), MCM5(1), MCM6(5), MCM7(1), MDM2(1), ORC1L(2), ORC2L(1), ORC4L(1), ORC5L(3), PKMYT1(2), PLK1(1), PRKDC(14), PTTG2(2), RB1(5), RBL1(4), RBL2(1), SKP1(1), SKP2(3), SMAD2(2), SMAD3(3), SMAD4(6), SMC1A(3), SMC1B(3), TFDP1(2), TGFB1(2), TGFB2(5), TGFB3(1), TP53(65), WEE1(1), YWHAG(1)	26613990	290	100	279	63	48	66	83	37	56	0	0.0225	1.000	1.000
289	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(13), CACNA1A(6), CRHR1(1), GNA12(1), GNA13(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(3), GNAZ(1), GRIA1(8), GRIA2(7), GRIA3(5), GRID2(7), GRM1(14), GRM5(9), GUCY1A2(3), GUCY1A3(6), GUCY1B3(2), GUCY2C(4), GUCY2F(8), HRAS(1), IGF1(3), IGF1R(6), ITPR1(7), ITPR2(15), ITPR3(4), KRAS(35), LYN(3), MAP2K1(4), MAPK3(1), NOS1(5), NOS3(1), NPR1(3), NPR2(2), NRAS(1), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PPP2CB(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(3), PRKCA(7), PRKCG(5), PRKG1(1), PRKG2(4), RAF1(2), RYR1(26)	21486369	304	99	266	92	50	109	76	42	27	0	0.480	1.000	1.000
290	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(1), ATM(14), BUB1(4), BUB1B(5), BUB3(1), CCNA1(2), CCNA2(2), CCNB1(1), CCNB3(4), CCND3(1), CCNE1(3), CDAN1(1), CDC14A(6), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(1), CDC6(1), CDC7(3), CDH1(4), CDK2(4), CDK4(2), CDKN2A(7), CHEK1(6), CHEK2(2), DTX4(1), E2F3(1), E2F6(2), EP300(1), ESPL1(4), GADD45A(1), GSK3B(1), HDAC1(1), HDAC2(6), HDAC3(1), HDAC4(10), HDAC5(2), HDAC6(4), HDAC8(1), MAD1L1(5), MAD2L1(1), MCM2(4), MCM3(3), MCM4(5), MCM5(1), MCM6(5), MCM7(1), MDM2(1), MPEG1(3), MPL(1), ORC1L(2), ORC2L(1), ORC4L(1), ORC5L(3), PLK1(1), PRKDC(14), PTPRA(2), PTTG2(2), RB1(5), RBL1(4), SKP2(3), SMAD4(6), TBC1D8(1), TFDP1(2), TGFB1(2), TP53(65), WEE1(1)	21534873	261	96	250	56	44	70	67	31	49	0	0.0160	1.000	1.000
291	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), ARRB1(1), ARRB2(1), ATF2(2), ATP2A2(5), ATP2A3(1), CALM1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CORIN(8), CRHR1(1), DGKZ(3), ETS2(1), GABPA(1), GBA2(1), GJA1(2), GNAQ(2), GNB1(1), GNB3(2), GNB4(1), GNB5(1), GNG12(2), GNG2(3), GNG3(2), GNGT1(1), GRK4(1), GRK5(6), GRK6(1), GUCA2B(1), GUCY1A3(6), IGFBP1(2), IGFBP2(1), IGFBP3(2), ITPR1(7), ITPR2(15), ITPR3(4), MIB1(5), MYL2(2), MYL4(1), MYLK2(2), NFKB1(2), NOS1(5), NOS3(1), OXT(1), OXTR(1), PDE4B(4), PDE4D(4), PLCB3(3), PLCD1(1), PLCG1(4), PLCG2(4), PRKACB(2), PRKAR1B(4), PRKCA(7), PRKCD(1), PRKCE(1), PRKCH(2), PRKCQ(3), PRKD1(8), RAMP2(1), RAMP3(1), RGS1(4), RGS11(1), RGS16(1), RGS18(2), RGS2(1), RGS20(2), RGS3(4), RGS4(3), RGS5(4), RGS6(1), RGS7(7), RGS9(3), RYR1(26), RYR2(89), RYR3(27), SLC8A1(17), TNXB(6), USP5(2)	33915261	412	96	409	163	64	145	122	49	30	2	0.991	1.000	1.000
292	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN2(14), ACTN3(2), ACTN4(1), ARHGAP5(4), BCAR1(1), CD99(3), CDC42(2), CDH5(3), CLDN1(3), CLDN10(1), CLDN11(2), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(1), CLDN8(3), CTNNA1(2), CTNNA2(15), CTNNA3(11), CTNNB1(9), CTNND1(7), CXCR4(3), CYBB(7), F11R(1), GNAI1(1), GNAI3(1), GRLF1(6), ITGA4(11), ITGAL(17), ITGAM(9), ITGB1(2), ITGB2(2), ITK(4), JAM2(5), MAPK14(1), MLLT4(3), MMP2(6), MMP9(8), MYL2(2), MYL5(1), MYL7(1), MYLPF(1), NCF1(1), NCF2(2), NCF4(1), NOX1(1), NOX3(4), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLCG1(4), PLCG2(4), PRKCA(7), PRKCG(5), PTK2(7), PTK2B(6), PTPN11(1), RAP1A(1), RAP1B(1), RAPGEF3(2), RAPGEF4(2), RHOA(1), ROCK1(7), ROCK2(3), SIPA1(1), TXK(4), VAV1(1), VAV2(2), VAV3(9), VCAM1(8), VCL(2)	24141318	291	95	289	107	46	93	78	43	31	0	0.941	1.000	1.000
293	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(1), ADORA3(1), ADRA1A(2), ADRA1D(2), ADRA2A(1), ADRA2C(1), ADRB3(1), AGTR1(1), AGTR2(2), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(6), C3AR1(2), CCBP2(2), CCKAR(4), CCKBR(8), CCR1(1), CCR2(5), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(5), CCRL1(1), CCRL2(2), CHML(3), CHRM1(1), CHRM2(4), CHRM3(4), CHRM4(2), CMKLR1(7), CNR1(3), CNR2(1), CX3CR1(5), CXCR3(1), CXCR4(3), DRD1(2), DRD2(7), DRD3(7), DRD5(3), EDNRB(2), F2R(2), F2RL1(1), F2RL2(2), F2RL3(2), FPR1(1), FSHR(11), GALR1(2), GALR2(1), GALT(1), GHSR(2), GNB2L1(1), GPR17(1), GPR174(5), GPR27(1), GPR37(2), GPR37L1(2), GPR4(3), GPR50(5), GPR6(1), GPR63(4), GPR77(1), GPR83(3), GPR85(3), GPR87(1), GRPR(5), HCRTR2(7), HRH1(4), HRH2(2), HRH3(1), HTR1A(8), HTR1B(2), HTR1E(4), HTR1F(3), HTR2A(2), HTR2C(5), HTR5A(6), HTR6(3), LHCGR(3), LTB4R(2), MAS1(2), MC3R(5), MC5R(5), MLNR(1), MTNR1A(3), MTNR1B(5), NMBR(3), NMUR1(3), NMUR2(6), NPY1R(6), NPY2R(6), NPY5R(5), NTSR1(2), OPN1SW(1), OPRK1(2), OPRL1(3), OPRM1(1), OR10A5(3), OR11A1(2), OR1C1(4), OR1F1(1), OR1Q1(2), OR2H1(4), OR5V1(1), OR7A5(1), OR8B8(2), OXTR(1), P2RY1(5), P2RY10(5), P2RY12(2), P2RY14(1), P2RY6(1), PPYR1(1), PTAFR(2), PTGER2(1), PTGER4(4), PTGFR(5), PTGIR(1), RRH(1), SSTR1(2), SSTR3(2), SSTR4(4), SUCNR1(1)	23525730	348	94	347	149	38	130	98	53	29	0	0.969	1.000	1.000
294	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(3), CADM1(2), CADM3(3), CD2(2), CD22(3), CD226(3), CD274(2), CD276(1), CD28(1), CD34(2), CD4(1), CD40LG(4), CD58(1), CD6(3), CD86(2), CD8A(1), CD8B(1), CD99(3), CDH1(4), CDH15(3), CDH2(13), CDH3(2), CDH4(5), CDH5(3), CLDN1(3), CLDN10(1), CLDN11(2), CLDN14(1), CLDN15(1), CLDN17(1), CLDN18(3), CLDN2(1), CLDN20(1), CLDN4(1), CLDN8(3), CNTN1(11), CNTN2(7), CNTNAP1(4), CNTNAP2(26), CTLA4(1), F11R(1), GLG1(7), HLA-A(1), HLA-B(1), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(2), ICAM2(1), ITGA4(11), ITGA6(3), ITGA8(15), ITGA9(1), ITGAL(17), ITGAM(9), ITGAV(5), ITGB1(2), ITGB2(2), ITGB7(1), ITGB8(1), JAM2(5), L1CAM(7), MADCAM1(2), MAG(2), MPZL1(1), NCAM1(3), NCAM2(7), NEGR1(3), NEO1(10), NFASC(5), NLGN1(11), NLGN2(3), NLGN3(1), NRCAM(10), NRXN1(27), NRXN2(5), NRXN3(8), PDCD1LG2(1), PTPRC(10), PTPRF(3), PTPRM(3), PVRL1(3), SDC1(2), SDC3(1), SELE(2), SELL(1), SELP(11), SELPLG(3), SIGLEC1(3), SPN(2), VCAM1(8), VCAN(13)	28694631	398	94	398	142	68	135	101	52	41	1	0.921	1.000	1.000
295	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTG1(2), ACTN2(14), ACTN3(2), ACTN4(1), ACVR1B(4), ACVR1C(2), BAIAP2(2), CDC42(2), CDH1(4), CREBBP(2), CTNNA1(2), CTNNA2(15), CTNNA3(11), CTNNB1(9), CTNND1(7), EGFR(24), EP300(1), ERBB2(5), FARP2(2), FER(3), FGFR1(5), FYN(2), IGF1R(6), INSR(1), IQGAP1(5), LEF1(6), LMO7(7), MAP3K7(3), MAPK3(1), MET(10), MLLT4(3), PARD3(4), PTPN1(1), PTPN6(2), PTPRB(9), PTPRF(3), PTPRJ(4), PTPRM(3), PVRL1(3), PVRL4(1), RHOA(1), SMAD2(2), SMAD3(3), SMAD4(6), SNAI1(3), SNAI2(2), SORBS1(4), SRC(2), SSX2IP(2), TCF7(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(4), VCL(2), WAS(2), WASF1(4), WASF3(2), WASL(4), YES1(2)	23237931	245	94	232	83	44	62	57	43	39	0	0.817	1.000	1.000
296	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT2(1), AKT3(2), BCL10(1), CARD11(11), CBL(7), CBLB(2), CD28(1), CD3D(1), CD4(1), CD40LG(4), CD8A(1), CD8B(1), CDC42(2), CDK4(2), CHUK(1), CTLA4(1), FYN(2), GRAP2(3), GRB2(3), HRAS(1), IFNG(3), IKBKB(2), IL2(3), ITK(4), KRAS(35), LAT(3), LCK(5), LCP2(3), MALT1(2), MAP3K14(1), MAP3K8(1), NCK1(1), NCK2(3), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NFKB1(2), NFKB2(3), NFKBIE(1), NRAS(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PDK1(2), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRKCQ(3), PTPN6(2), PTPRC(10), RHOA(1), SOS1(9), SOS2(5), TEC(4), VAV1(1), VAV2(2), VAV3(9), ZAP70(2)	19720230	248	94	215	75	39	87	64	27	31	0	0.526	1.000	1.000
297	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(4), AKT2(1), AKT3(2), APAF1(4), ATM(14), BAX(1), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP10(3), CASP3(4), CASP8(3), CASP9(2), CFLAR(1), CHUK(1), CSF2RB(3), DFFA(3), FAS(2), FASLG(2), IKBKB(2), IL1A(2), IL1RAP(2), IL3(1), IL3RA(4), IRAK1(2), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(2), NFKB1(2), NFKB2(3), NTRK1(6), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRKACB(2), PRKACG(1), PRKAR1B(4), RIPK1(3), TNFRSF10B(1), TNFRSF10C(1), TNFSF10(1), TP53(65)	16312437	193	92	181	59	19	43	55	33	43	0	0.679	1.000	1.000
298	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), AKAP1(2), AKAP10(1), AKAP11(7), AKAP12(4), AKAP3(4), AKAP4(1), AKAP5(1), AKAP6(9), AKAP9(16), ARHGEF1(1), CALM1(1), GNA12(1), GNA13(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAZ(1), GNB1(1), GNB3(2), GNB5(1), GNG12(2), GNG3(2), GNGT1(1), GNGT2(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(10), KRAS(35), NRAS(1), PDE1A(5), PDE1B(6), PDE1C(11), PDE4B(4), PDE4C(1), PDE4D(4), PDE7A(1), PDE7B(1), PDE8A(1), PDE8B(4), PLCB3(3), PPP3CA(2), PPP3CC(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCI(5), PRKCQ(3), PRKD1(8), PRKD3(1), RHOA(1), SLC9A1(1), USP5(2)	22767081	256	90	224	89	31	112	64	21	28	0	0.930	1.000	1.000
299	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN2(14), ACTN3(2), ACTN4(1), DMD(21), FAM48A(2), MYBPC1(4), MYBPC2(2), MYBPC3(4), MYH3(6), MYH6(12), MYH7(14), MYH8(15), MYL1(2), MYL2(2), MYL4(1), MYOM1(2), NEB(21), TMOD1(1), TNNC2(2), TNNI1(2), TNNI2(3), TNNI3(1), TNNT2(2), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(220), VIM(2)	26804523	363	90	362	141	49	125	91	59	34	5	1.000	1.000	1.000
300	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(1), ACTR2(1), ACTR3(1), AKT2(1), AKT3(2), ANGPTL2(2), ARHGEF6(4), ARHGEF7(3), BCAR1(1), BRAF(13), CDC42(2), CDKN2A(7), CSE1L(3), DOCK1(4), EPHB2(4), FYN(2), GRB2(3), GRB7(2), GRLF1(6), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(4), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGA7(2), ITGA8(15), ITGA9(1), MAP2K4(2), MAP2K7(1), MAP3K11(6), MAPK10(1), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5), MRAS(1), MYLK(10), MYLK2(2), P4HB(2), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PIK3CA(5), PIK3CB(2), PKLR(4), PLCG1(4), PLCG2(4), PTEN(3), PTK2(7), RAF1(2), RALA(2), ROCK1(7), ROCK2(3), SHC1(2), SOS1(9), SOS2(5), SRC(2), TLN1(9), TLN2(4), WAS(2), ZYX(2)	23716650	256	89	248	77	57	65	56	43	35	0	0.445	1.000	1.000
301	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(14), CCNA1(2), CCNB1(1), CCND1(2), CCND3(1), CCNE1(3), CDC25A(2), CDK2(4), CDK4(2), CDK7(2), CDKN1B(2), CDKN2A(7), CDKN2D(1), CREB3L1(1), CREB3L3(1), E2F3(1), E2F6(2), GADD45A(1), GBA2(1), MCM2(4), MCM3(3), MCM4(5), MCM5(1), MCM6(5), MCM7(1), MDM2(1), MNAT1(2), MYT1(5), NACA(1), ORC1L(2), ORC2L(1), ORC4L(1), ORC5L(3), POLE(12), PRIM1(2), RB1(5), RBL1(4), RPA2(1), TFDP1(2), TFDP2(1), TNXB(6), TP53(65), WEE1(1)	15025662	184	87	173	40	33	37	46	25	43	0	0.0370	1.000	1.000
302	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), ADSSL1(1), AK2(3), AK5(7), AK7(2), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(2), ATIC(2), CANT1(1), DCK(1), DGUOK(2), ENPP1(3), ENPP3(5), ENTPD1(4), ENTPD2(2), ENTPD4(1), ENTPD6(1), FHIT(1), GART(1), GDA(5), GMPR(2), GMPS(5), GUCY1A2(3), GUCY1A3(6), GUCY1B3(2), GUCY2C(4), GUCY2F(8), GUK1(1), HPRT1(1), IMPDH1(3), NME7(3), NPR1(3), NPR2(2), NT5C1A(2), NT5C1B(1), NT5C3(1), NT5E(1), NT5M(1), NUDT2(2), NUDT5(1), NUDT9(1), PAPSS1(2), PAPSS2(1), PDE10A(9), PDE11A(7), PDE1A(5), PDE1C(11), PDE2A(5), PDE3B(3), PDE4B(4), PDE4C(1), PDE4D(4), PDE6D(1), PDE7A(1), PDE7B(1), PDE8A(1), PDE8B(4), PDE9A(2), PFAS(3), PKLR(4), PKM2(2), PNPT1(2), POLA1(1), POLD1(1), POLD3(2), POLE(12), POLR1A(5), POLR1B(8), POLR1D(1), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(7), POLR3B(10), POLR3H(1), PPAT(3), PRIM1(2), PRIM2(7), PRPS1(3), PRPS1L1(2), PRPS2(1), PRUNE(1), RRM1(5), RRM2(4), XDH(8)	31848939	329	87	327	123	62	96	86	43	42	0	0.952	1.000	1.000
303	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10(5), ALG10B(3), ALG12(2), ALG13(5), ALG14(1), ALG2(4), ALG3(3), ALG8(1), ALG9(2), B3GNT1(3), B3GNT2(1), B3GNT6(2), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(3), C1GALT1(2), C1GALT1C1(1), CHPF(1), CHST1(8), CHST12(3), CHST13(2), CHST2(4), CHST3(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(5), EXTL1(1), EXTL3(4), FUT11(2), FUT8(4), GALNT1(1), GALNT10(1), GALNT11(1), GALNT12(3), GALNT13(9), GALNT14(6), GALNT2(1), GALNT3(2), GALNT4(3), GALNT5(4), GALNT6(2), GALNT7(4), GALNT8(6), GALNT9(1), GALNTL1(2), GALNTL2(5), GALNTL4(2), GALNTL5(2), GANAB(3), GCNT1(2), GCNT3(2), HS3ST1(1), HS3ST3A1(1), HS3ST5(6), HS6ST1(1), HS6ST3(1), MAN1A2(8), MAN1C1(2), MAN2A1(7), MGAT1(1), MGAT3(3), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(1), NDST2(5), NDST3(6), NDST4(6), OGT(1), RPN2(4), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(1), STT3B(1), UST(1), WBSCR17(8), XYLT1(13)	21336471	234	87	232	106	48	71	64	29	22	0	0.999	1.000	1.000
304	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), ADCY9(1), CALM1(1), CALML3(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(3), CREB3L3(1), CREBBP(2), CTNNB1(9), DCT(4), DVL2(1), DVL3(2), EDNRB(2), EP300(1), FZD1(2), FZD10(5), FZD2(1), FZD3(3), FZD4(3), FZD7(1), FZD9(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAQ(2), GNAS(3), GSK3B(1), HRAS(1), KIT(3), KRAS(35), LEF1(6), MAP2K1(4), MAPK3(1), MITF(1), NRAS(1), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PRKACB(2), PRKACG(1), PRKCA(7), PRKCG(5), PRKX(3), RAF1(2), TCF7(1), TCF7L1(1), TCF7L2(2), TYR(6), TYRP1(2), WNT1(3), WNT10A(2), WNT10B(2), WNT11(1), WNT16(2), WNT2(2), WNT3A(2), WNT4(1), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(4), WNT7B(2), WNT8A(1), WNT8B(1), WNT9A(2), WNT9B(2)	21114333	247	87	214	96	43	89	67	28	20	0	0.936	1.000	1.000
305	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT2(1), AKT3(2), CBL(7), CBLB(2), CCND1(2), CCND3(1), CNTFR(1), CREBBP(2), CSF2RA(5), CSF2RB(3), CSF3R(3), EP300(1), EPO(1), GH1(2), GH2(3), GHR(1), GRB2(3), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), IFNAR2(1), IFNB1(3), IFNG(3), IFNGR1(3), IFNGR2(2), IFNW1(1), IL10RA(3), IL10RB(2), IL12A(2), IL12RB1(2), IL12RB2(6), IL13RA2(2), IL15(1), IL15RA(1), IL2(3), IL20RA(1), IL21R(7), IL22(2), IL22RA2(1), IL23R(1), IL24(3), IL28B(2), IL28RA(2), IL2RA(3), IL2RB(4), IL3(1), IL3RA(4), IL4R(5), IL5RA(1), IL6R(5), IL7R(6), IL9R(2), IRF9(1), JAK1(5), JAK2(2), JAK3(3), LEP(2), LEPR(8), LIF(2), LIFR(5), MPL(1), OSM(2), OSMR(4), PIAS2(4), PIAS3(4), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PRLR(7), PTPN11(1), PTPN6(2), SOCS4(1), SOCS5(1), SOS1(9), SOS2(5), SPRED1(1), SPRED2(2), SPRY1(1), SPRY2(2), SPRY3(4), SPRY4(2), STAM(3), STAM2(2), STAT1(2), STAT2(2), STAT3(4), STAT4(5), STAT5A(2), STAT5B(3), STAT6(1), TPO(9), TSLP(3), TYK2(2)	28162506	281	86	279	108	30	93	70	50	38	0	0.992	1.000	1.000
306	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(4), ACVRL1(3), BMPR1A(1), BMPR2(2), BUB1(4), CDIPT(1), CDKL2(1), CDS1(2), CDS2(2), CLK1(2), CLK2(5), CLK4(5), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKZ(3), IMPA1(1), INPP1(1), INPP4A(3), INPP4B(10), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), MAP3K10(1), NEK1(3), NEK3(2), OCRL(1), PAK4(1), PIK3C2A(6), PIK3C2B(5), PIK3C2G(3), PIK3CA(5), PIK3CB(2), PIK3CG(6), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLCD1(1), PLCG1(4), PLCG2(4), PLK3(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCQ(3), PRKD1(8), PRKG1(1), RAF1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(1), STK11(18), TGFBR1(2), VRK1(1)	22040940	215	85	212	76	38	55	57	29	36	0	0.896	1.000	1.000
307	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT2(1), AKT3(2), CASP9(2), CDC42(2), HRAS(1), KDR(16), KRAS(35), MAP2K1(4), MAPK14(1), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NOS3(1), NRAS(1), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLCG1(4), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PRKCA(7), PRKCG(5), PTGS2(4), PTK2(7), RAF1(2), SH2D2A(7), SHC2(1), SPHK2(1), SRC(2), VEGFA(1)	14018946	180	84	146	55	28	68	38	29	17	0	0.532	1.000	1.000
308	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(11), AMY2A(4), AMY2B(15), ASCC3(8), ATP13A2(4), DDX18(1), DDX19A(1), DDX23(5), DDX4(2), DDX41(1), DDX47(1), DDX50(4), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENPP1(3), ENPP3(5), ENTPD7(1), EP400(4), ERCC2(2), ERCC3(4), G6PC(1), G6PC2(1), GAA(1), GANC(1), GBA(3), GBA3(7), GBE1(1), GCK(1), GPI(3), GUSB(2), GYS1(1), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), MGAM(15), MOV10L1(5), NUDT5(1), NUDT8(1), PGM1(2), PGM3(2), PYGB(1), PYGM(3), RAD54B(6), RUVBL2(1), SETX(11), SI(31), SKIV2L2(9), SMARCA2(6), SMARCA5(1), TREH(1), UGDH(3), UGP2(1), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2A1(3), UGT2A3(4), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B28(6), UGT2B4(6), UGT2B7(5), UXS1(4)	24189564	292	83	290	97	51	108	73	28	31	1	0.865	1.000	1.000
309	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(4), ATM(14), ATR(9), BAI1(5), BAX(1), BID(1), CASP3(4), CASP8(3), CASP9(2), CCNB1(1), CCNB3(4), CCND1(2), CCND3(1), CCNE1(3), CD82(1), CDK2(4), CDK4(2), CDKN2A(7), CHEK1(6), CHEK2(2), EI24(1), FAS(2), GADD45A(1), GTSE1(1), IGF1(3), IGFBP3(2), LRDD(1), MDM2(1), PPM1D(2), PTEN(3), RRM2(4), SERPINB5(3), SERPINE1(3), SESN2(1), THBS1(4), TNFRSF10B(1), TP53(65), TP53I3(1), TP73(3), TSC2(2), ZMAT3(1)	12734493	181	82	169	42	26	42	42	32	39	0	0.111	1.000	1.000
310	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT2(1), AKT3(2), BCL10(1), BTK(7), CARD11(11), CD19(1), CD22(3), CD72(1), CD79B(1), CHUK(1), CR2(4), FCGR2B(2), GSK3B(1), HRAS(1), IKBKB(2), INPP5D(3), KRAS(35), LYN(3), MALT1(2), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NFKB1(2), NFKB2(3), NFKBIE(1), NRAS(1), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLCG2(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PPP3R1(2), PPP3R2(2), PTPN6(2), RASGRP3(5), SYK(1), VAV1(1), VAV2(2), VAV3(9)	14446968	160	82	127	55	18	63	43	18	18	0	0.829	1.000	1.000
311	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT3(2), BCAR1(1), CAPN10(3), CAPN11(4), CAPN3(4), CAPN5(7), CAPN6(7), CAPN7(2), CAPN9(4), CDC42(2), DOCK1(4), FYN(2), GIT2(1), GRB2(3), ITGA10(2), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGA7(2), ITGA8(15), ITGA9(1), ITGAD(12), ITGAE(6), ITGAL(17), ITGAM(9), ITGAV(5), ITGAX(11), ITGB1(2), ITGB2(2), ITGB3(2), ITGB4(3), ITGB5(6), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K1(4), MAP2K3(3), MAPK10(1), MAPK4(5), MAPK7(4), MYLK2(2), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PIK3R2(1), PTK2(7), RAP1B(1), RAPGEF1(1), ROCK1(7), ROCK2(3), SDCCAG8(6), SHC1(2), SHC3(2), SORBS1(4), SOS1(9), SRC(2), TLN1(9), TNS1(8), VAV2(2), VAV3(9), VCL(2), ZYX(2)	26089992	282	82	282	104	53	85	61	39	43	1	0.939	1.000	1.000
312	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(8), ABCA12(14), ABCA13(29), ABCA2(4), ABCA3(4), ABCA4(18), ABCA5(5), ABCA6(5), ABCA7(4), ABCA8(6), ABCA9(5), ABCB1(10), ABCB10(6), ABCB11(5), ABCB4(10), ABCB5(16), ABCB6(1), ABCB7(2), ABCB8(3), ABCB9(3), ABCC1(3), ABCC10(2), ABCC11(7), ABCC12(9), ABCC2(5), ABCC3(3), ABCC4(4), ABCC5(5), ABCC6(3), ABCC8(7), ABCC9(15), ABCD2(4), ABCD3(5), ABCG1(2), ABCG2(3), ABCG4(2), ABCG5(7), ABCG8(4), CFTR(5), TAP2(3)	23078100	263	81	263	87	46	83	63	39	32	0	0.597	1.000	1.000
313	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(4), ACVR1C(2), ACVR2A(1), ACVR2B(3), ACVRL1(3), AMH(1), BMP2(1), BMP4(2), BMP5(3), BMP6(2), BMP7(3), BMP8A(1), BMPR1A(1), BMPR1B(3), BMPR2(2), CHRD(8), COMP(1), CREBBP(2), CUL1(3), DCN(1), EP300(1), FST(2), GDF5(3), GDF6(3), IFNG(3), INHBA(7), INHBB(1), INHBC(1), INHBE(2), LEFTY1(2), LEFTY2(2), LTBP1(14), MAPK3(1), NODAL(1), PITX2(3), PPP2CB(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(3), PPP2R2B(4), PPP2R2C(3), RBL1(4), RBL2(1), RHOA(1), ROCK1(7), ROCK2(3), RPS6KB2(1), SKP1(1), SMAD1(1), SMAD2(2), SMAD3(3), SMAD4(6), SMAD5(1), SMAD9(1), SMURF1(2), SMURF2(2), TFDP1(2), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2), THBS1(4), THBS2(12), THBS3(1), THBS4(4), ZFYVE16(1), ZFYVE9(2)	19241511	183	81	183	63	32	45	49	30	27	0	0.772	1.000	1.000
314	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT2(1), AKT3(2), BTK(7), FCER1A(5), FCER1G(1), FYN(2), GAB2(1), GRB2(3), HRAS(1), IL3(1), INPP5D(3), KRAS(35), LAT(3), LCP2(3), LYN(3), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(5), MS4A2(2), NRAS(1), PDK1(2), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLCG1(4), PLCG2(4), PRKCA(7), PRKCD(1), PRKCE(1), RAF1(2), SOS1(9), SOS2(5), SYK(1), VAV1(1), VAV2(2), VAV3(9)	14046552	181	81	148	51	23	66	47	28	17	0	0.402	1.000	1.000
315	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(8), C1QB(2), C1QC(1), C1R(1), C1S(1), C2(1), C3(3), C3AR1(2), C4BPA(2), C5(1), C5AR1(2), C6(7), C7(14), C8A(2), C8B(7), C9(7), CD46(1), CD55(2), CFB(3), CFH(12), CFI(3), CR1(8), CR2(4), F10(1), F11(5), F12(1), F13A1(7), F13B(9), F2(5), F2R(2), F3(4), F5(17), F7(2), F8(14), F9(8), FGA(2), FGB(10), FGG(2), KLKB1(3), MASP1(2), MASP2(1), PLAT(4), PLG(8), PROC(2), PROS1(10), SERPINA1(1), SERPINA5(2), SERPINC1(5), SERPINE1(3), SERPING1(2), TFPI(1), VWF(7)	17627205	234	80	233	84	29	80	56	38	28	3	0.986	1.000	1.000
316	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(8), ADCY2(6), ADCY3(2), ADCY4(5), ADCY5(5), ADCY6(5), ADCY7(3), ADCY8(13), AK2(3), AK5(7), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(2), ATIC(2), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(1), ATP5G3(1), CANT1(1), DCK(1), DGUOK(2), ENPP1(3), ENPP3(5), ENTPD1(4), ENTPD2(2), FHIT(1), GART(1), GDA(5), GMPS(5), GUCY1A2(3), GUCY1A3(6), GUCY1B3(2), GUCY2C(4), GUCY2F(8), GUK1(1), HPRT1(1), IMPDH1(3), NPR1(3), NPR2(2), NT5E(1), NT5M(1), NUDT2(2), PAPSS1(2), PAPSS2(1), PDE1A(5), PDE4B(4), PDE4C(1), PDE4D(4), PDE6B(3), PDE6C(2), PDE7B(1), PDE8A(1), PDE9A(2), PFAS(3), PKLR(4), PKM2(2), POLB(2), POLD1(1), POLE(12), POLG(8), POLQ(10), POLR1B(8), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), PPAT(3), PRPS1(3), PRPS1L1(2), PRPS2(1), PRUNE(1), RRM1(5), RRM2(4)	24951438	258	80	256	97	52	65	75	35	31	0	0.927	1.000	1.000
317	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALML3(2), CDIPT(1), CDS1(2), CDS2(2), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKI(12), DGKZ(3), IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(10), INPP5A(3), INPP5B(1), INPP5D(3), INPPL1(3), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), OCRL(1), PI4KA(6), PI4KB(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(3), PIK3C3(4), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PIP4K2A(1), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(5), PIP5K1C(2), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(8), PLCG1(4), PLCG2(4), PLCZ1(2), PRKCA(7), PRKCG(5), PTEN(3), PTPMT1(1), SYNJ1(3), SYNJ2(1)	24418410	235	79	232	80	42	75	62	27	28	1	0.801	1.000	1.000
318	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(15), CARM1(3), CTCFL(13), DOT1L(6), EED(3), EHMT1(4), EHMT2(1), EZH1(1), EZH2(6), FBXO11(1), HCFC1(6), HSF4(1), JMJD4(1), KDM6A(1), MEN1(2), MLL(7), MLL2(17), MLL3(33), MLL4(1), MLL5(2), NSD1(7), OGT(1), PAXIP1(3), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(4), PRDM7(2), PRDM9(17), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), RBBP5(2), SATB1(2), SETD1A(5), SETD2(16), SETD8(2), SETDB1(3), SETDB2(2), SETMAR(1), SMYD3(3), STK38(2), SUV39H1(1), SUV39H2(2), SUV420H1(2), WHSC1(2), WHSC1L1(1)	23026242	218	78	217	65	40	58	66	20	31	3	0.429	1.000	1.000
319	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(7), ACSL1(4), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(6), ADIPOQ(2), ADIPOR1(3), ADIPOR2(1), AKT2(1), AKT3(2), CAMKK1(2), CAMKK2(1), CD36(3), CHUK(1), CPT1A(5), CPT1B(3), CPT1C(2), CPT2(2), G6PC(1), G6PC2(1), IKBKB(2), IRS1(12), IRS2(2), IRS4(7), JAK1(5), JAK2(2), JAK3(3), LEP(2), LEPR(8), MAPK10(1), MAPK8(3), MAPK9(5), NFKB1(2), NFKB2(3), NFKBIE(1), PCK1(8), PCK2(1), PPARGC1A(7), PRKAA1(1), PRKAB1(3), PRKAG2(4), PRKAG3(1), PRKCQ(3), PTPN11(1), RXRG(6), STAT3(4), STK11(18), TNFRSF1B(1), TYK2(2)	16100232	168	77	167	66	32	50	32	28	26	0	0.933	1.000	1.000
320	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(2), ASAH1(2), BRAF(13), DAG1(2), DRD2(7), EGFR(24), EPHB2(4), GRB2(3), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), KCNJ3(10), PI3(1), PIK3CB(2), PITX2(3), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), RAF1(2), RGS20(2), SHC1(2), SOS1(9), SOS2(5), SRC(2), STAT3(4)	11402826	157	77	142	35	24	46	40	27	20	0	0.0670	1.000	1.000
321	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(3), CD14(1), CD19(1), CD1A(3), CD1B(7), CD1C(6), CD1D(6), CD1E(10), CD2(2), CD22(3), CD33(4), CD34(2), CD36(3), CD38(1), CD3D(1), CD4(1), CD44(1), CD5(4), CD55(2), CD8A(1), CD8B(1), CR1(8), CR2(4), CSF1(1), CSF1R(3), CSF2RA(5), CSF3R(3), DNTT(2), EPO(1), FCER2(1), FCGR1A(1), FLT3(7), FLT3LG(1), GP5(2), HLA-DRA(2), IL1A(2), IL1R2(4), IL2RA(3), IL3(1), IL3RA(4), IL4R(5), IL5RA(1), IL6R(5), IL7R(6), IL9R(2), ITGA1(5), ITGA2(4), ITGA2B(3), ITGA3(1), ITGA4(11), ITGA5(4), ITGA6(3), ITGAM(9), ITGB3(2), KIT(3), MME(2), MS4A1(2), TFRC(5), TPO(9)	15836298	200	76	199	74	36	76	39	28	21	0	0.936	1.000	1.000
322	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), CCKBR(8), CCR2(5), CCR3(1), CCR5(1), CELSR1(5), CELSR2(5), CELSR3(13), CHRM2(4), CHRM3(4), CXCR3(1), EMR2(2), EMR3(4), F2R(2), FSHR(11), GHRHR(2), GNRHR(2), GPR116(5), GPR132(1), GPR133(4), GPR135(1), GPR143(1), GPR17(1), GPR18(1), GPR55(6), GPR56(2), GPR61(3), GPR77(1), GPR84(3), GRM1(14), GRPR(5), HRH4(3), LGR6(4), LPHN2(13), LPHN3(19), NTSR1(2), OR2M4(7), OR8G2(2), PTGFR(5), SMO(4), TAAR5(3), TSHR(2)	12968628	183	75	183	66	24	59	51	30	19	0	0.746	1.000	1.000
323	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(1), AKT3(2), CDC42(2), CDK2(4), CDKN1B(2), CDKN2A(7), CREB5(4), EBP(1), ERBB4(12), F2RL2(2), GAB1(2), GADD45A(1), GRB2(3), GSK3B(1), IGF1(3), IGFBP1(2), INPPL1(3), IRS1(12), IRS2(2), IRS4(7), MET(10), NOLC1(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PARD3(4), PDK1(2), PIK3CA(5), PPP1R13B(2), PREX1(12), PTEN(3), PTK2(7), PTPN1(1), RPS6KA2(2), RPS6KA3(1), SHC1(2), SOS1(9), SOS2(5), TSC1(7), TSC2(2), YWHAG(1)	15026307	175	75	173	58	41	47	33	28	26	0	0.626	1.000	1.000
324	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT2(1), AKT3(2), CASP8(3), CCL3(1), CCL4(1), CD14(1), CD86(2), CHUK(1), CXCL9(2), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), IFNAR2(1), IFNB1(3), IKBKB(2), IKBKE(2), IL12A(2), IRAK1(2), IRAK4(2), IRF3(1), IRF7(1), LBP(2), LY96(1), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(5), MYD88(2), NFKB1(2), NFKB2(3), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), RIPK1(3), STAT1(2), TBK1(1), TICAM1(1), TLR1(3), TLR4(23), TLR5(1), TLR6(2), TLR7(6), TLR8(6), TLR9(5), TRAF3(1), TRAF6(3)	17423643	159	73	156	63	22	42	47	26	22	0	0.967	1.000	1.000
325	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(4), CDC40(2), CLK2(5), CLK3(1), CLK4(5), COL2A1(2), CPSF1(5), CPSF2(3), CPSF4(2), CSTF2T(2), CSTF3(1), DDIT3(4), DDX1(2), DDX20(1), DHX15(2), DHX16(4), DHX38(5), DHX8(6), DHX9(2), DICER1(5), DNAJC8(1), FUS(1), GIPC1(1), LOC440563(6), METTL3(1), NCBP2(1), NONO(1), NXF1(5), PABPN1(1), PAPOLA(1), POLR2A(6), PPM1G(4), PRPF18(1), PRPF3(2), PRPF4(3), PRPF4B(3), PRPF8(4), PSKH1(1), PTBP1(2), PTBP2(6), RBM17(1), RBM5(2), RNGTT(2), RNMT(3), SF3A1(3), SF3A3(1), SF3B1(5), SF3B2(3), SF3B4(3), SF3B5(2), SF4(2), SFRS14(4), SFRS16(1), SFRS4(4), SFRS6(4), SFRS8(2), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNRPN(3), SNURF(1), SRPK1(2), SRRM1(1), SUPT5H(2), TXNL4A(3), U2AF1(4), U2AF2(5), XRN2(3)	20541444	184	72	178	50	55	36	46	24	23	0	0.230	1.000	1.000
326	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(1), CABIN1(2), CALM1(1), CAMK4(4), CD69(1), CNR1(3), CREBBP(2), CTLA4(1), EGR2(1), EP300(1), FCER1A(5), FCGR3A(5), FOSL1(2), GATA3(5), GATA4(2), GRLF1(6), GSK3B(1), HRAS(1), IFNB1(3), IFNG(3), IL2(3), IL2RA(3), IL3(1), ITK(4), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK8(3), MAPK9(5), MEF2D(1), MYF5(2), NCK2(3), NFAT5(4), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NFKB2(3), NFKBIE(1), NUP214(12), P2RX7(2), PAK1(5), PPP3CB(1), PPP3CC(1), PPP3R1(2), PTPRC(10), SLA(1), SP3(1), TGFB1(2), TRPV6(4), VAV1(1), VAV2(2), VAV3(9), XPO5(2)	17657133	156	71	154	58	27	54	36	18	21	0	0.822	1.000	1.000
327	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(1), INPP1(1), INPP4A(3), INPP4B(10), INPP5A(3), INPP5B(1), INPPL1(3), IPMK(4), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(4), OCRL(1), PI4KA(6), PI4KB(3), PIK3C3(4), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIP4K2A(1), PIP4K2B(2), PIP4K2C(3), PIP5K1A(5), PIP5K1B(5), PIP5K1C(2), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(8), PLCG1(4), PLCG2(4), PLCZ1(2), PTEN(3), PTPMT1(1), SYNJ1(3), SYNJ2(1)	14454321	137	67	135	51	21	42	38	18	18	0	0.892	1.000	1.000
328	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(5), ADAM17(5), ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1G1(1), ATP6V1H(2), CASP3(4), CDC42(2), CHUK(1), CXCL1(2), EGFR(24), F11R(1), IGSF5(2), IKBKB(2), JAM2(5), LYN(3), MAP2K4(2), MAP3K14(1), MAPK10(1), MAPK14(1), MAPK8(3), MAPK9(5), MET(10), NFKB1(2), NFKB2(3), NOD1(1), PAK1(5), PLCG1(4), PLCG2(4), PTPN11(1), PTPRZ1(22), SRC(2), TJP1(4)	13585119	153	67	143	50	32	36	38	24	23	0	0.700	1.000	1.000
329	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), AKT3(2), BRAF(13), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(1), IGF1(3), MAPK3(1), PIK3CA(5), PIK3CB(2), PIK3CG(6), PIK3R1(1), PIK3R2(1), PIK3R3(2), PIK3R5(3), PRKAA1(1), RHEB(3), RICTOR(15), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3), RPS6KB2(1), STK11(18), TSC1(7), TSC2(2), ULK1(3), ULK3(1), VEGFA(1), VEGFC(6)	10412751	110	66	104	35	11	30	27	21	21	0	0.680	1.000	1.000
330	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(7), COL4A2(9), COL4A3(3), COL4A4(8), COL4A5(13), COL4A6(9), F10(1), F11(5), F12(1), F2(5), F2R(2), F5(17), F8(14), F9(8), FGA(2), FGB(10), FGG(2), KLKB1(3), PROC(2), PROS1(10), SERPINC1(5), SERPING1(2)	8716530	138	66	138	48	12	49	31	24	22	0	0.942	1.000	1.000
331	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(2), BRAF(13), CHUK(1), DAXX(2), GRB2(3), HRAS(1), IKBKB(2), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K10(1), MAP3K11(6), MAP3K12(4), MAP3K13(6), MAP3K14(1), MAP3K2(4), MAP3K3(2), MAP3K4(8), MAP3K5(8), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP3K9(5), MAP4K1(2), MAP4K3(2), MAP4K5(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(5), MAPK7(4), MAPK8(3), MAPK9(5), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MAX(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(2), PAK1(5), PAK2(3), RAF1(2), RIPK1(3), RPS6KA2(2), RPS6KA3(1), RPS6KA4(1), RPS6KA5(2), RPS6KB2(1), SHC1(2), STAT1(2), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2)	18581031	158	64	154	51	40	32	39	24	23	0	0.503	1.000	1.000
332	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CALM1(1), CHRM1(1), CHRNA1(4), FLT1(12), FLT4(8), KDR(16), NOS3(1), PDE2A(5), PDE3A(5), PDE3B(3), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKG1(1), PRKG2(4), RYR2(89), SLC7A1(2), SYT1(3), TNNI1(2)	8006772	164	64	160	48	22	57	37	26	20	2	0.532	1.000	1.000
333	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(2), ATP8A1(2), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(6), C3AR1(2), CCKAR(4), CCKBR(8), CCR1(1), CCR2(5), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(5), CX3CR1(5), CXCR3(1), CXCR4(3), CXCR6(1), EDNRB(2), FPR1(1), FSHR(11), GALR1(2), GALR2(1), GALT(1), GHSR(2), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(5), LHCGR(3), MC2R(1), MC3R(5), MC5R(5), NMBR(3), NPY1R(6), NPY2R(6), NPY5R(5), NTSR1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(1), PPYR1(1), SSTR1(2), SSTR3(2), SSTR4(4), TACR1(1), TACR3(2), TSHR(2)	10110762	144	64	143	53	17	53	41	20	13	0	0.614	1.000	1.000
334	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	CALM1(1), CALR(1), CAMK1(2), CAMK4(4), CREBBP(2), CSNK1A1(1), ELSPBP1(2), F2(5), GATA4(2), GSK3B(1), HAND1(1), HAND2(2), HRAS(1), IGF1(3), LIF(2), MAP2K1(4), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(1), MYH2(20), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NKX2-5(2), NPPA(1), PIK3CA(5), PIK3R1(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(1), PRKAR1B(4), RAF1(2), SYT1(3)	9826704	100	63	99	35	18	36	27	8	11	0	0.706	1.000	1.000
335	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTG1(2), ARHGEF2(4), ARPC5(1), CD14(1), CDC42(2), CDH1(4), CLDN1(3), CTNNB1(9), CTTN(2), FYN(2), HCLS1(5), ITGB1(2), KRT18(1), LY96(1), NCK1(1), NCK2(3), NCL(4), PRKCA(7), RHOA(1), ROCK1(7), ROCK2(3), TLR4(23), TLR5(1), TUBA1A(2), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(6), TUBA3E(1), TUBA4A(2), TUBB1(2), TUBB2B(1), TUBB2C(3), TUBB4(3), TUBB4Q(5), TUBB8(3), WAS(2), WASL(4)	10159911	133	62	132	57	29	47	27	20	10	0	0.986	1.000	1.000
336	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTG1(2), ARHGEF2(4), ARPC5(1), CD14(1), CDC42(2), CDH1(4), CLDN1(3), CTNNB1(9), CTTN(2), FYN(2), HCLS1(5), ITGB1(2), KRT18(1), LY96(1), NCK1(1), NCK2(3), NCL(4), PRKCA(7), RHOA(1), ROCK1(7), ROCK2(3), TLR4(23), TLR5(1), TUBA1A(2), TUBA1B(1), TUBA1C(2), TUBA3C(6), TUBA3D(6), TUBA3E(1), TUBA4A(2), TUBB1(2), TUBB2B(1), TUBB2C(3), TUBB4(3), TUBB4Q(5), TUBB8(3), WAS(2), WASL(4)	10159911	133	62	132	57	29	47	27	20	10	0	0.986	1.000	1.000
337	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(1), AKT2(1), AKT3(2), ANGPTL2(2), ARHGAP1(1), ARHGAP4(2), ARHGEF11(6), BTK(7), CDC42(2), CFL2(1), GDI1(3), GDI2(1), INPPL1(3), ITPR1(7), ITPR2(15), ITPR3(4), MYLK(10), MYLK2(2), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PDK1(2), PIK3CA(5), PIK3CG(6), PIK3R1(1), PITX2(3), PPP1R13B(2), PTEN(3), RACGAP1(2), ROCK1(7), ROCK2(3), SAG(2), WASF1(4), WASL(4)	13670388	141	61	137	42	33	38	36	15	19	0	0.457	1.000	1.000
338	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(2), ARSD(2), CARM1(3), CYP11B1(3), CYP11B2(6), CYP19A1(2), HSD11B1(2), HSD11B2(1), HSD17B12(1), HSD17B2(1), HSD3B1(7), HSD3B2(12), LCMT1(1), LCMT2(4), METTL2B(3), METTL6(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), SRD5A1(3), STS(3), SULT2A1(1), SULT2B1(1), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2A1(3), UGT2A3(4), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B28(6), UGT2B4(6), UGT2B7(5), WBSCR22(1)	9808902	141	60	139	45	17	53	38	21	12	0	0.666	1.000	1.000
339	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B2(3), AOC2(3), AOC3(2), AOX1(6), CARM1(3), DCT(4), DDC(6), ESCO1(5), ESCO2(2), FAH(1), GOT1(2), GOT2(3), HGD(3), HPD(2), LCMT1(1), LCMT2(4), METTL2B(3), METTL6(1), MYST3(7), MYST4(6), PNPLA3(1), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), SH3GLB1(1), TAT(2), TH(1), TPO(9), TYR(6), TYRP1(2), WBSCR22(1)	11557110	138	60	137	49	24	53	31	11	19	0	0.799	1.000	1.000
340	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), AKR1C1(2), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH1A3(1), ALDH3A1(1), ALDH3B2(3), CYP1A1(3), CYP1A2(1), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(5), CYP2C8(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), DHDH(1), EPHX1(1), GSTA1(1), GSTA2(2), GSTA3(2), GSTA5(3), GSTK1(4), GSTM2(1), GSTM3(1), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), MGST1(1), MGST3(2), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2A1(3), UGT2A3(4), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B28(6), UGT2B4(6), UGT2B7(5)	11128185	165	60	164	64	21	68	39	19	18	0	0.958	1.000	1.000
341	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), AKT3(2), BCL2(1), BCR(3), BTK(7), CD19(1), CD22(3), CR2(4), DAG1(2), FLOT1(2), GRB2(3), GSK3B(1), INPP5D(3), ITPR1(7), ITPR2(15), ITPR3(4), LYN(3), MAP4K1(2), MAPK3(1), NFATC1(1), NFATC2(5), PDK1(2), PIK3CA(5), PIK3R1(1), PLCG2(4), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PPP3CC(1), PTPRC(10), RAF1(2), SHC1(2), SOS1(9), SOS2(5), SYK(1), VAV1(1)	14394594	119	60	117	41	20	34	33	14	18	0	0.679	1.000	1.000
342	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(3), ACYP2(1), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), DLAT(3), DLD(3), ENO1(1), ENO3(1), G6PC(1), G6PC2(1), GAPDH(2), GAPDHS(4), GCK(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHAL6A(3), LDHC(4), PDHA1(1), PDHA2(8), PFKL(1), PFKM(2), PFKP(3), PGAM2(1), PGAM4(1), PGK1(4), PGK2(11), PGM1(2), PGM3(2), PKLR(4), PKM2(2), TPI1(3)	11304915	143	59	142	53	31	60	26	15	11	0	0.845	1.000	1.000
343	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(9), CANT1(1), CTPS(4), CTPS2(1), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(6), DTYMK(2), ENTPD1(4), ENTPD4(1), ENTPD6(1), NME7(3), NT5C1A(2), NT5C1B(1), NT5C3(1), NT5E(1), NT5M(1), NUDT2(2), PNPT1(2), POLA1(1), POLD1(1), POLD3(2), POLE(12), POLR1A(5), POLR1B(8), POLR1D(1), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(7), POLR3B(10), POLR3H(1), PRIM1(2), PRIM2(7), RRM1(5), RRM2(4), TXNRD1(1), TXNRD2(1), UCK2(2), UMPS(2), UPP1(6), UPP2(4), UPRT(2)	15815916	156	59	155	50	38	49	35	15	18	1	0.546	1.000	1.000
344	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), AGK(1), AGPAT1(1), AGPAT2(3), AGPAT3(2), AGPAT4(1), AGPAT6(1), AKR1B1(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), CEL(3), DAK(1), DGAT1(1), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKI(12), DGKZ(3), GK(2), GK2(4), GLA(2), GPAM(1), LCT(12), LIPA(1), LIPC(5), LIPF(2), LIPG(2), LPL(2), MGLL(1), PNLIP(4), PNLIPRP1(5), PNLIPRP2(4), PNPLA3(1), PPAP2B(1)	11473776	141	59	141	39	18	56	31	16	19	1	0.365	1.000	1.000
345	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(3), ACOX1(2), ACOX2(2), ACOX3(4), ACSL1(4), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(6), ADIPOQ(2), APOA1(1), APOA5(2), APOC3(2), CD36(3), CPT1A(5), CPT1B(3), CPT1C(2), CPT2(2), CYP27A1(3), CYP4A11(3), CYP7A1(4), CYP8B1(2), EHHADH(3), FABP1(1), FABP2(1), FABP3(2), GK(2), GK2(4), HMGCS2(5), LPL(2), ME1(1), MMP1(3), NR1H3(2), OLR1(2), PCK1(8), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRG(6), SCP2(3), SLC27A1(1), SLC27A2(3), SLC27A4(1), SLC27A5(1), SLC27A6(4), SORBS1(4), UBC(7), UCP1(1)	12709983	131	59	131	39	30	47	27	14	13	0	0.370	1.000	1.000
346	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(3), ACTR2(1), ACTR3(1), ANGPTL2(2), CDC42(2), CFL2(1), FLNA(7), FLNC(9), FSCN1(1), FSCN3(4), GDI1(3), GDI2(1), MYH2(20), MYLK(10), MYLK2(2), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PFN2(3), ROCK1(7), ROCK2(3), WASF1(4), WASL(4)	9297933	116	58	115	38	22	38	26	12	18	0	0.707	1.000	1.000
347	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(2), BMP5(3), BMP6(2), BMP7(3), BMP8A(1), BTRC(5), CSNK1A1(1), CSNK1A1L(3), CSNK1D(1), CSNK1E(2), CSNK1G1(1), CSNK1G3(1), DHH(1), GLI1(6), GLI2(4), GLI3(6), GSK3B(1), IHH(1), LRP2(26), PRKACB(2), PRKACG(1), PRKX(3), PTCH1(8), PTCH2(1), SHH(3), SMO(4), STK36(5), WNT1(3), WNT10A(2), WNT10B(2), WNT11(1), WNT16(2), WNT2(2), WNT3A(2), WNT4(1), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(4), WNT7B(2), WNT8A(1), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(4)	11853552	132	56	130	43	32	37	34	18	10	1	0.602	1.000	1.000
348	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(1), DAXX(2), EGF(7), EGFR(24), ETS1(1), ETS2(1), HOXA7(2), HRAS(1), IKBKB(2), MAP2K1(4), MAP2K3(3), MAP2K4(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(8), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(2), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCQ(3), RAF1(2), RIPK1(3), TNFRSF1B(1)	9507945	96	56	86	36	18	22	22	18	16	0	0.880	1.000	1.000
349	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(7), CD28(1), CD3D(1), CTLA4(1), DAG1(2), DTYMK(2), EPHB2(4), FBXW7(2), GRAP2(3), GRB2(3), ITK(4), ITPKA(1), ITPKB(4), LAT(3), LCK(5), LCP2(3), NCK1(1), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIE(1), PAK1(5), PAK2(3), PAK3(2), PAK4(1), PAK7(15), PLCG1(4), PTPRC(10), RAF1(2), RASGRP2(1), RASGRP3(5), RASGRP4(2), SOS1(9), SOS2(5), VAV1(1), ZAP70(2)	10894566	124	56	124	31	25	40	29	11	19	0	0.169	1.000	1.000
350	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(11), AMY2A(4), AMY2B(15), ENPP1(3), ENPP3(5), G6PC(1), GAA(1), GANAB(3), GBA3(7), GBE1(1), GCK(1), GPI(3), GUSB(2), GYS1(1), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(15), PGM1(2), PGM3(2), PYGB(1), PYGM(3), SI(31), UGDH(3), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2B15(4), UGT2B4(6), UXS1(4)	11162241	162	56	160	58	31	63	39	13	16	0	0.918	1.000	1.000
351	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(4), ACAT1(1), ACMSD(2), AFMID(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), AOC2(3), AOC3(2), AOX1(6), ASMT(4), CARM1(3), CAT(3), CYP1A1(3), CYP1A2(1), CYP1B1(2), DDC(6), EHHADH(3), GCDH(1), HADH(2), HADHA(2), INMT(4), KMO(3), KYNU(2), LCMT1(1), LCMT2(4), LNX1(2), METTL2B(3), METTL6(1), NFX1(1), OGDHL(5), PRMT2(1), PRMT3(1), PRMT5(1), PRMT6(2), PRMT7(3), PRMT8(5), TDO2(2), TPH1(10), TPH2(4), WARS(2), WARS2(8), WBSCR22(1)	11759898	129	55	127	38	16	37	41	15	19	1	0.311	1.000	1.000
352	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(2), ASCC3(8), ATP13A2(4), DDX18(1), DDX19A(1), DDX23(5), DDX4(2), DDX41(1), DDX47(1), DDX50(4), DDX52(2), DDX54(1), DDX55(1), DDX56(1), ENTPD7(1), EP400(4), ERCC2(2), ERCC3(4), FPGS(1), GCH1(3), GGH(1), IFIH1(4), MOV10L1(5), NUDT5(1), NUDT8(1), QDPR(2), RAD54B(6), RUVBL2(1), SETX(11), SKIV2L2(9), SMARCA2(6), SMARCA5(1)	12239004	104	55	104	37	19	27	28	12	17	1	0.745	1.000	1.000
353	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(5), ADCY6(5), ADCY8(13), CACNA1A(6), CACNA1B(9), GNAS(3), GNB1(1), GNB3(2), GNG3(2), GRM4(3), ITPR3(4), KCNB1(8), PDE1A(5), PLCB2(4), PRKACB(2), PRKACG(1), PRKX(3), SCNN1B(1), SCNN1G(2), TAS1R1(2), TAS1R2(5), TAS1R3(2), TAS2R1(4), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(1), TAS2R3(2), TAS2R38(2), TAS2R39(3), TAS2R40(1), TAS2R41(1), TAS2R46(2), TAS2R5(1), TAS2R50(2), TAS2R60(6), TAS2R9(1), TRPM5(1)	11152953	121	55	120	42	18	49	28	13	13	0	0.662	1.000	1.000
354	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(4), ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOC2(3), AOC3(2), AOX1(6), ASMT(4), CAT(3), CYP19A1(2), CYP1A1(3), CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(2), CYP2B6(5), CYP2C18(2), CYP2C19(5), CYP2C8(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A7(3), CYP4B1(5), CYP4F8(3), CYP51A1(3), DDC(6), EHHADH(3), GCDH(1), HADHA(2), KMO(3), KYNU(2), TDO2(2), TPH1(10), WARS(2), WARS2(8)	10712805	141	54	141	45	22	47	34	16	20	2	0.470	1.000	1.000
355	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(4), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP3(4), CASP8(3), CASP9(2), CFLAR(1), CHUK(1), DAXX(2), DFFA(3), GSN(2), LMNB1(1), LMNB2(1), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(8), MAPK8(3), MDM2(1), NFKB1(2), NUMA1(4), PAK2(3), PRKCD(1), PRKDC(14), PSEN1(1), PSEN2(3), PTK2(7), RASA1(1), RB1(5), RIPK1(3), SPTAN1(7), TNFRSF1B(1)	13576347	103	53	103	37	23	28	24	10	18	0	0.899	1.000	1.000
356	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(5), CREBBP(2), DLL1(2), DLL3(3), DLL4(1), DTX1(2), DTX2(1), DTX3(3), DTX3L(1), DTX4(1), DVL2(1), DVL3(2), EP300(1), HDAC1(1), HDAC2(6), HES1(1), JAG1(1), JAG2(1), LFNG(1), MAML1(4), MAML2(2), MAML3(5), NCOR2(6), NCSTN(4), NOTCH1(5), NOTCH2(20), NOTCH3(4), NOTCH4(15), NUMB(2), NUMBL(1), PSEN1(1), PSEN2(3), PTCRA(1), RBPJ(2), RBPJL(1), SNW1(2)	13533777	114	53	114	47	22	35	30	11	16	0	0.906	1.000	1.000
357	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(1), INPP4A(3), INPP4B(10), INPP5A(3), INPPL1(3), ITPKA(1), ITPKB(4), OCRL(1), PIK3C2A(6), PIK3C2B(5), PIK3C2G(3), PIK3CA(5), PIK3CB(2), PIK3CG(6), PLCB1(9), PLCB2(4), PLCB3(3), PLCB4(10), PLCD1(1), PLCG1(4), PLCG2(4)	8740395	89	53	88	33	14	23	30	9	13	0	0.837	1.000	1.000
358	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(29), CDR1(1), DGKI(12), RPL11(1), RPL12(1), RPL14(1), RPL19(2), RPL21(1), RPL22(1), RPL29(1), RPL30(2), RPL35(1), RPL37(1), RPL3L(1), RPL4(4), RPL5(1), RPL6(1), RPL7A(1), RPL8(1), RPLP0(1), RPLP2(1), RPS10(1), RPS12(1), RPS13(2), RPS15(1), RPS26(1), RPS29(1), RPS4Y1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(3), RPS6KB2(1), SLC36A2(2), UBC(7)	10292523	89	53	89	26	19	34	18	9	8	1	0.537	1.000	1.000
359	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(6), AXIN1(2), CCND1(2), CCND3(1), CSNK1E(2), CTNNB1(9), DVL2(1), DVL3(2), FBXW2(1), FOSL1(2), FZD1(2), FZD10(5), FZD2(1), FZD3(3), FZD7(1), FZD9(1), GSK3B(1), LDLR(1), MAPK10(1), MAPK9(5), PPP2R5E(2), PRKCA(7), PRKCD(1), PRKCE(1), PRKCG(5), PRKCH(2), PRKCI(5), PRKCQ(3), PRKD1(8), RHOA(1), SFRP4(1), TCF7(1), WNT1(3), WNT10A(2), WNT10B(2), WNT11(1), WNT16(2), WNT2(2), WNT4(1), WNT5A(1), WNT5B(1), WNT6(1), WNT7A(4), WNT7B(2)	11624835	108	53	107	38	29	30	27	10	12	0	0.653	1.000	1.000
360	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), DLAT(3), DLD(3), ENO1(1), ENO3(1), G6PC(1), GAPDH(2), GCK(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(1), PDHA2(8), PFKM(2), PFKP(3), PGK1(4), PGM1(2), PGM3(2), PKLR(4), PKM2(2), TPI1(3)	9475308	120	52	119	42	27	52	22	10	9	0	0.708	1.000	1.000
361	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT2(3), AGPAT3(2), AGPAT4(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), CEL(3), DGAT1(1), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKZ(3), GK(2), GLA(2), LCT(12), LIPC(5), LIPF(2), LIPG(2), LPL(2), PNLIP(4), PNLIPRP1(5), PNLIPRP2(4), PPAP2B(1)	9440607	121	52	121	33	13	50	26	14	18	0	0.369	1.000	1.000
362	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(2), ALDOA(1), ALDOB(2), ALDOC(1), DLAT(3), DLD(3), ENO1(1), ENO3(1), G6PC(1), GAPDH(2), GCK(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), PDHA1(1), PDHA2(8), PFKM(2), PFKP(3), PGK1(4), PGM1(2), PGM3(2), PKLR(4), PKM2(2), TPI1(3)	9475308	120	52	119	42	27	52	22	10	9	0	0.708	1.000	1.000
363	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(9), CANT1(1), CTPS(4), CTPS2(1), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(6), DTYMK(2), ENTPD1(4), NT5E(1), NT5M(1), NUDT2(2), POLB(2), POLD1(1), POLE(12), POLG(8), POLQ(10), POLR1B(8), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1), RRM1(5), RRM2(4), TXNRD1(1), UCK2(2), UMPS(2), UNG(2), UPP1(6)	11156823	125	52	124	36	34	28	35	12	15	1	0.271	1.000	1.000
364	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(1), AKT3(2), BRD4(3), CBL(7), CDC42(2), CDKN2A(7), F2RL2(2), FLOT1(2), GRB2(3), GSK3B(1), IGFBP1(2), INPPL1(3), IRS1(12), IRS2(2), IRS4(7), LNPEP(1), MAPK3(1), PARD3(4), PDK1(2), PIK3CA(5), PIK3R1(1), PPYR1(1), PTEN(3), PTPN1(1), RAF1(2), RPS6KA2(2), RPS6KA3(1), SHC1(2), SORBS1(4), SOS1(9), SOS2(5), YWHAG(1)	11518281	101	52	99	46	28	16	28	17	12	0	0.951	1.000	1.000
365	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT2(3), AGPAT3(2), AGPAT4(1), AGPAT6(1), CDIPT(1), CDS1(2), CDS2(2), CHAT(2), CHKB(2), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKI(12), DGKZ(3), ESCO1(5), ESCO2(2), ETNK1(1), GNPAT(3), GPAM(1), GPD1(1), GPD1L(3), GPD2(2), LCAT(1), LYPLA2(1), MYST3(7), MYST4(6), PCYT1A(2), PCYT1B(1), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLD1(7), PLD2(3), PNPLA3(1), PPAP2B(1), PTDSS1(4), PTDSS2(1), SH3GLB1(1)	12806346	123	51	123	40	25	34	27	19	17	1	0.670	1.000	1.000
366	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(1), GRIN1(1), GRIN2A(19), GRIN2B(13), GRIN2C(3), GRIN2D(5), NOS1(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), SYT1(3)	4971273	69	51	69	36	10	23	18	10	8	0	0.995	1.000	1.000
367	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), AKT3(2), BCR(3), BTK(7), CD19(1), CDKN2A(7), DAPP1(1), FLOT1(2), GAB1(2), ITPR1(7), ITPR2(15), ITPR3(4), LYN(3), PDK1(2), PIK3CA(5), PITX2(3), PLCG2(4), PPP1R13B(2), PREX1(12), PTEN(3), PTPRC(10), RPS6KA2(2), RPS6KA3(1), SAG(2), SYK(1), TEC(4), VAV1(1)	10841031	107	51	104	33	19	32	29	13	14	0	0.561	1.000	1.000
368	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), AKT3(2), BCR(3), BTK(7), CD19(1), DAG1(2), EPHB2(4), GRB2(3), ITPKA(1), ITPKB(4), LYN(3), MAP2K1(4), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIE(1), PI3(1), PIK3CA(5), PIK3R1(1), PLCG2(4), PPP1R13B(2), RAF1(2), SERPINA4(7), SHC1(2), SOS1(9), SOS2(5), SYK(1), VAV1(1)	10191903	85	51	84	28	11	22	25	15	12	0	0.630	1.000	1.000
369	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CD3D(1), FYN(2), GRB2(3), HRAS(1), LAT(3), LCK(5), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), NFKB1(2), PIK3CA(5), PIK3R1(1), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(7), RAF1(2), RASA1(1), SHC1(2), SOS1(9), SYT1(3), VAV1(1), ZAP70(2)	9240915	87	51	86	27	18	22	26	10	11	0	0.476	1.000	1.000
370	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(24), GNAS(3), GNB1(1), GNGT1(1), GRB2(3), HRAS(1), IGF1R(6), ITGB1(2), KLK2(2), MAP2K1(4), MAPK3(1), MKNK1(1), NGFR(2), PDGFRA(7), PTPRR(7), RAF1(2), RPS6KA5(2), SHC1(2), SOS1(9), SRC(2), STAT3(4)	6408462	86	50	76	27	11	27	17	21	10	0	0.776	1.000	1.000
371	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(4), CALCRL(5), CD97(3), CRHR1(1), CRHR2(2), ELTD1(8), EMR1(4), EMR2(2), GHRHR(2), GIPR(2), GLP2R(5), GPR64(3), LPHN1(1), LPHN2(13), LPHN3(19), SCTR(1), VIPR2(2)	5222307	80	50	80	34	6	30	17	19	8	0	0.966	1.000	1.000
372	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B2(2), EIF2B3(3), EIF2B4(2), EIF2B5(3), EIF2S3(1), ELAVL1(2), FLT1(12), FLT4(8), HIF1A(1), HRAS(1), KDR(16), NOS3(1), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), PTK2(7), SHC1(2), VHL(1)	6616152	81	50	79	23	14	25	21	10	11	0	0.442	1.000	1.000
373	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CXCR3(1), EGF(7), EGFR(24), HRAS(1), ITGA1(5), ITGB1(2), MAPK3(1), MYL2(2), MYLK(10), PRKACB(2), PRKACG(1), PRKAR1B(4), PTK2(7), TLN1(9)	6358926	76	49	65	23	9	19	15	19	14	0	0.678	1.000	1.000
374	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(6), ASAH1(2), DAG1(2), DLG4(1), EPHB2(4), GNAI1(1), GNAQ(2), ITPR1(7), ITPR2(15), ITPR3(4), KCNJ3(10), PITX2(3), PTX3(2), RYR1(26)	8974401	85	49	84	22	14	26	29	7	9	0	0.189	1.000	1.000
375	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(2), ARHGEF11(6), BCL2(1), CDC42(2), DLG4(1), GNA13(1), LPA(16), MAP2K4(2), MAP3K1(3), MAP3K5(8), MAPK8(3), NFKB1(2), NFKB2(3), NFKBIE(1), PDK1(2), PHKA2(6), PI3(1), PIK3CB(2), PLD1(7), PLD2(3), PTK2(7), RDX(1), ROCK1(7), ROCK2(3), SERPINA4(7)	9502011	98	48	98	27	21	25	22	17	13	0	0.383	1.000	1.000
376	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(1), ALDH9A1(2), AMD1(1), AOC2(3), AOC3(2), ARG1(1), ASL(2), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(1), CPS1(23), DAO(1), GATM(3), GLUD1(3), GOT1(2), GOT2(3), NOS1(5), NOS3(1), OAT(1), OTC(2), P4HA1(2), P4HA3(1), P4HB(2), RARS(4), SMS(1)	8605977	92	47	92	37	17	28	28	10	9	0	0.885	1.000	1.000
377	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(2), CALM1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CDK5(1), F2(5), FYN(2), GNAI1(1), GNB1(1), GNGT1(1), GRB2(3), HRAS(1), JAK2(2), MAP2K1(4), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(2), MYLK(10), PLCG1(4), PRKCA(7), PTK2B(6), RAF1(2), SHC1(2), SOS1(9), STAT1(2), STAT3(4), STAT5A(2), SYT1(3)	8096685	86	47	85	30	19	24	17	14	12	0	0.726	1.000	1.000
378	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), ALDOC(1), DLAT(3), DLD(3), ENO1(1), ENO3(1), G6PC(1), GAPDH(2), GAPDHS(4), GCK(1), GOT1(2), GOT2(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(3), LDHC(4), MDH1(1), PC(1), PCK1(8), PDHA1(1), PDHA2(8), PDHX(1), PFKL(1), PFKM(2), PFKP(3), PGAM2(1), PGK1(4), PGK2(11), PKLR(4), PKM2(2), TPI1(3)	8238972	99	47	98	36	27	29	21	13	9	0	0.676	1.000	1.000
379	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(7), ACAT1(1), ACOT12(3), ACSS1(1), ACSS2(3), ACYP2(1), AKR1B1(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), DLAT(3), DLD(3), GLO1(1), GRHPR(1), HAGHL(1), LDHA(3), LDHAL6A(3), LDHC(4), MDH1(1), ME1(1), ME2(6), ME3(2), PC(1), PCK1(8), PCK2(1), PDHA1(1), PDHA2(8), PKLR(4), PKM2(2)	9068313	93	47	92	30	24	28	22	9	10	0	0.536	1.000	1.000
380	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(1), IKBKB(2), IRAK1(2), LY96(1), MAP2K3(3), MAP2K4(2), MAP3K1(3), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(3), MYD88(2), NFKB1(2), TLR10(4), TLR4(23), TLR6(2), TLR7(6), TLR9(5), TRAF6(3)	7059138	70	47	69	28	9	21	19	10	11	0	0.921	1.000	1.000
381	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	GRB2(3), HRAS(1), JAK1(5), MAP2K1(4), MAP2K4(2), MAP3K1(3), MAPK3(1), MAPK8(3), PDGFA(6), PDGFRA(7), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), RAF1(2), RASA1(1), SHC1(2), SOS1(9), STAT1(2), STAT3(4), STAT5A(2)	6742701	74	46	73	21	13	16	21	14	10	0	0.428	1.000	1.000
382	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA1(1), CD36(3), CITED2(1), CPT1B(3), CREBBP(2), EHHADH(3), EP300(1), FABP1(1), LPL(2), MAPK3(1), ME1(1), NCOA1(4), NCOR1(8), NCOR2(6), NR1H3(2), NRIP1(2), PDGFA(6), PIK3CA(5), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), PTGS2(4), RB1(5), STAT5A(2), STAT5B(3)	12247260	83	46	82	33	19	23	20	9	12	0	0.880	1.000	1.000
383	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(7), CALM1(1), CD79B(1), GRB2(3), HRAS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(7), RAF1(2), SHC1(2), SOS1(9), SYK(1), SYT1(3), VAV1(1)	7393635	76	45	76	23	16	20	21	10	9	0	0.392	1.000	1.000
384	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(3), CYP2B6(5), CYP2C18(2), CYP2C19(5), CYP2C8(2), CYP2C9(2), CYP2E1(3), CYP2J2(8), CYP2U1(1), CYP4A11(3), CYP4F2(3), CYP4F3(7), DHRS4(1), GGT1(1), GPX1(1), GPX3(1), GPX5(3), GPX6(1), GPX7(2), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PTGDS(2), PTGIS(1), PTGS1(3), PTGS2(4), TBXAS1(4)	7539276	90	45	90	33	16	24	28	12	9	1	0.609	1.000	1.000
385	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(3), BLVRB(1), COX15(2), CP(4), CPOX(3), EARS2(1), EPRS(9), FTMT(1), GUSB(2), HMBS(2), HMOX1(3), PPOX(2), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2A1(3), UGT2A3(4), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B28(6), UGT2B4(6), UGT2B7(5)	8246841	102	45	101	36	13	41	21	15	12	0	0.868	1.000	1.000
386	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(1), CANX(2), CD4(1), CD8A(1), CD8B(1), CIITA(1), CTSS(1), HLA-A(1), HLA-B(1), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(2), HSP90AA1(4), HSP90AB1(2), HSPA5(3), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(5), KLRC1(1), KLRC2(2), KLRC3(3), KLRD1(1), LGMN(3), NFYB(1), NFYC(1), PSME1(1), PSME2(1), RFX5(5), TAP2(3)	9100434	76	45	76	33	15	19	20	11	11	0	0.940	1.000	1.000
387	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CALM1(1), GNAI1(1), GNAQ(2), GNAS(3), GNB1(1), GNGT1(1), HRAS(1), MAP2K1(4), MAPK3(1), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), RAF1(2), RPS6KA3(1), SYT1(3)	6758052	66	44	66	19	15	20	18	6	7	0	0.380	1.000	1.000
388	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(2), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT11(1), GALNT12(3), GALNT13(9), GALNT14(6), GALNT2(1), GALNT3(2), GALNT4(3), GALNT5(4), GALNT6(2), GALNT7(4), GALNT8(6), GALNT9(1), GALNTL1(2), GALNTL2(5), GALNTL4(2), GALNTL5(2), GCNT1(2), GCNT3(2), OGT(1), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(1), WBSCR17(8)	6248502	81	44	81	37	21	20	18	15	7	0	0.981	1.000	1.000
389	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(2), BRAF(13), CREB5(4), CREBBP(2), CRKL(2), DAG1(2), EGR2(1), EGR4(1), FRS2(1), GNAQ(2), MAP1B(5), MAP2K4(2), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5), NTRK1(6), OPN1LW(1), PIK3C2G(3), PIK3CA(5), PIK3R1(1), PTPN11(1), RPS6KA3(1), SHC1(2), SRC(2), TH(1)	10057227	75	44	70	25	15	20	19	12	9	0	0.590	1.000	1.000
390	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(2), GRB2(3), IARS(3), IL4R(5), INPP5D(3), JAK1(5), JAK2(2), JAK3(3), PI3(1), PIK3CA(5), PPP1R13B(2), SERPINA4(7), SHC1(2), SOS1(9), SOS2(5), SRC(2), STAT6(1), TYK2(2)	7166079	63	44	62	20	6	17	17	14	9	0	0.637	1.000	1.000
391	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(4), ACAT1(1), AKR1B10(3), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(6), EHHADH(3), EHMT1(4), EHMT2(1), GCDH(1), HADH(2), HADHA(2), HSD3B7(2), NSD1(7), OGDHL(5), PLOD1(2), PLOD2(2), PLOD3(2), SETD1A(5), SETDB1(3), SHMT1(2), SHMT2(1), SPCS3(1), SUV39H1(1), SUV39H2(2), TMLHE(2)	11287242	82	43	82	27	16	22	22	11	9	2	0.495	1.000	1.000
392	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B2(3), AOC2(3), AOC3(2), AOX1(6), DCT(4), DDC(6), FAH(1), GOT1(2), GOT2(3), HGD(3), HPD(2), TAT(2), TH(1), TPO(9), TYR(6)	6165426	85	43	85	36	14	37	16	7	11	0	0.924	1.000	1.000
393	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(6), ATF2(2), AXIN1(2), BMP10(4), BMP2(1), BMP4(2), BMP5(3), BMP7(3), BMPR1A(1), BMPR2(2), CHRD(8), CTNNB1(9), FZD1(2), GATA4(2), GSK3B(1), MAP3K7(3), MEF2C(1), MYL2(2), NKX2-5(2), NPPA(1), RFC1(6), TGFB1(2), TGFB2(5), TGFB3(1), TGFBR1(2), TGFBR3(11), WNT1(3)	7077456	89	42	88	26	17	28	20	12	12	0	0.486	1.000	1.000
394	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT2(3), AGPAT3(2), AGPAT4(1), AGPS(2), CDIPT(1), CDS1(2), CDS2(2), CHAT(2), CHKB(2), CPT1B(3), DGKA(2), DGKB(8), DGKD(2), DGKE(3), DGKG(4), DGKZ(3), ETNK1(1), GNPAT(3), GPD1(1), GPD2(2), LCAT(1), LYPLA2(1), PAFAH2(1), PCYT1A(2), PCYT1B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1)	9782457	84	42	84	27	16	16	25	16	11	0	0.590	1.000	1.000
395	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(1), C6(7), C7(14), IL1A(2), ITGA4(11), ITGAL(17), ITGB1(2), ITGB2(2), SELP(11), SELPLG(3), VCAM1(8)	4829244	81	42	80	29	13	26	19	14	9	0	0.876	1.000	1.000
396	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(14), BMPR1B(3), CDK4(2), CDKN1B(2), DMC1(1), ESR2(2), FSHR(11), LHCGR(3), MLH1(3), MSH5(2), NCOR1(8), NRIP1(2), PGR(5), PRLR(7), PTGER2(1), SMPD1(1), ZP2(2)	6797913	69	42	68	22	9	20	17	8	15	0	0.692	1.000	1.000
397	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(4), ARHGAP6(5), ARHGEF1(1), ARHGEF11(6), ARHGEF5(4), ARPC1B(1), ARPC2(1), ARPC3(1), BAIAP2(2), DIAPH1(3), GSN(2), MYL2(2), MYLK(10), OPHN1(3), PIP5K1A(5), PIP5K1B(5), PPP1R12B(4), ROCK1(7), SRC(2), TLN1(9), VCL(2)	8861397	84	42	83	24	22	21	22	9	10	0	0.375	1.000	1.000
398	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT2(1), AKT3(2), BTK(7), CDKN2A(7), DAPP1(1), GRB2(3), GSK3B(1), IARS(3), IGFBP1(2), INPP5D(3), PDK1(2), PIK3CA(5), PPP1R13B(2), PTEN(3), RPS6KA2(2), RPS6KA3(1), SHC1(2), SOS1(9), SOS2(5), TEC(4), YWHAG(1)	7023276	67	42	65	26	6	14	22	14	11	0	0.931	1.000	1.000
399	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(2), AGXT2(6), ALAS1(3), AMT(2), AOC2(3), AOC3(2), BHMT(4), CBS(1), CHKB(2), CPT1B(3), DAO(1), DLD(3), DMGDH(2), GARS(3), GATM(3), GCAT(2), GLDC(3), PLCB2(4), PLCG1(4), PLCG2(4), PSPH(3), SARDH(2), SHMT1(2), SHMT2(1), TARS(3)	8219493	72	41	72	23	17	22	20	10	3	0	0.508	1.000	1.000
400	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(10), GABBR1(3), GPRC5A(1), GPRC5B(4), GRM1(14), GRM2(3), GRM3(4), GRM4(3), GRM5(9), GRM7(8), GRM8(8)	4043892	67	41	67	28	11	17	23	13	3	0	0.821	1.000	1.000
401	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(3), ACADM(3), ACAT1(1), ACOX1(2), ACOX3(4), ACSL1(4), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(6), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), CPT1A(5), CPT1B(3), CPT1C(2), CPT2(2), CYP4A11(3), DCI(2), EHHADH(3), GCDH(1), HADH(2), HADHA(2), HADHB(2)	9487305	96	41	96	33	15	41	17	11	11	1	0.666	1.000	1.000
402	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(1), ALDH5A1(2), CAD(9), CPS1(23), EARS2(1), EPRS(9), GAD1(4), GAD2(5), GCLC(6), GCLM(1), GFPT1(3), GFPT2(1), GLS(1), GLS2(2), GLUD1(3), GLUD2(3), GMPS(5), GOT1(2), GOT2(3), GPT2(2), GSR(1), GSS(2), NAGK(1), PPAT(3), QARS(2)	7674339	96	41	96	28	19	33	22	11	10	1	0.502	1.000	1.000
403	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ACPP(6), ALPI(2), ALPL(2), ALPP(3), ALPPL2(2), CYP19A1(2), CYP1A1(3), CYP1A2(1), CYP2A13(3), CYP2A6(2), CYP2A7(2), CYP2B6(5), CYP2C18(2), CYP2C19(5), CYP2C8(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(8), CYP3A4(1), CYP3A7(3), CYP4B1(5), CYP4F8(3), CYP51A1(3), PON1(1)	5697027	77	40	77	30	13	19	21	9	14	1	0.713	1.000	1.000
404	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(2), RPE(1), UGDH(3), UGP2(1), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2A1(3), UGT2A3(4), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B28(6), UGT2B4(6), UGT2B7(5), XYLB(3)	5334279	79	40	78	29	8	33	17	12	9	0	0.885	1.000	1.000
405	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(4), ATP4A(4), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(2), ATP5F1(1), ATP5G3(1), ATP5L(2), ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1G1(1), ATP6V1H(2), COX15(2), COX4I1(1), COX5B(1), COX6B1(1), COX6B2(1), COX8A(1), CYC1(1), NDUFA10(1), NDUFA11(1), NDUFA12(2), NDUFA13(2), NDUFA4(1), NDUFA8(2), NDUFA9(3), NDUFB11(1), NDUFB2(3), NDUFB4(1), NDUFB5(2), NDUFB9(1), NDUFC2(1), NDUFS1(4), NDUFS2(3), NDUFS3(1), NDUFS6(1), NDUFS8(1), NDUFV1(2), PPA1(1), SDHA(5), SDHD(1), UQCRB(2), UQCRC2(2), UQCRFS1(2), UQCRQ(1)	10811361	99	40	99	44	27	23	25	10	14	0	0.957	1.000	1.000
406	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(3), ACADM(3), ACAT1(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), AOX1(6), AUH(1), BCKDHB(4), DBT(8), DLD(3), EHHADH(3), HADH(2), HADHA(2), HADHB(2), HIBADH(1), HIBCH(3), HMGCS1(2), HMGCS2(5), MCCC1(2), MCCC2(2), MUT(4), OXCT1(4), PCCA(4), PCCB(1)	8341011	81	40	81	25	7	32	15	9	16	2	0.580	1.000	1.000
407	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(5), ALG10B(3), ALG12(2), ALG13(5), ALG14(1), ALG2(4), ALG3(3), ALG8(1), ALG9(2), B4GALT1(1), B4GALT2(2), B4GALT3(1), DHDDS(1), DOLPP1(3), DPAGT1(1), FUT8(4), GANAB(3), MAN1A2(8), MAN1C1(2), MAN2A1(7), MGAT1(1), MGAT3(3), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), RFT1(2), RPN2(4), STT3B(1)	8269803	76	40	76	28	15	25	21	6	9	0	0.821	1.000	1.000
408	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1D(2), ADRA2A(1), ADRA2C(1), ADRB3(1), CHRM1(1), CHRM2(4), CHRM3(4), CHRM4(2), DRD1(2), DRD2(7), DRD3(7), DRD5(3), HRH1(4), HRH2(2), HTR1A(8), HTR1B(2), HTR1E(4), HTR1F(3), HTR2A(2), HTR2C(5), HTR5A(6), HTR6(3)	4967274	76	40	76	36	5	31	27	8	5	0	0.880	1.000	1.000
409	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT2(1), AKT3(2), APC(6), AXIN1(2), AXIN2(2), CER1(1), CSNK1A1(1), CTNNB1(9), DACT1(6), DKK1(1), DKK2(3), DKK4(1), FSTL1(2), GSK3B(1), LRP1(17), MVP(1), NKD1(4), NKD2(2), PSEN1(1), PTPRA(2), SENP2(3)	7845135	68	40	67	22	9	20	17	10	12	0	0.729	1.000	1.000
410	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(4), BAX(1), BCL2(1), CASP1(2), CASP10(3), CASP2(2), CASP3(4), CASP4(1), CASP8(3), CASP9(2), CD40LG(4), DAXX(2), DFFA(3), FAS(2), FASLG(2), IKBKE(2), MCL1(1), NFKB1(2), NGFR(2), NR3C1(1), NTRK1(6), PTPN13(7), RIPK1(3), SFRS2IP(10), TNFRSF1B(1), TRAF3(1), TRAF6(3)	8549346	75	39	74	26	12	29	15	10	9	0	0.826	1.000	1.000
411	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(3), CCND1(2), CREBBP(2), EP300(1), ERCC3(4), GRIP1(5), GTF2A1(3), GTF2E1(2), GTF2F1(1), HDAC1(1), HDAC2(6), HDAC3(1), HDAC4(10), HDAC5(2), HDAC6(4), MEF2C(1), NCOR2(6), NR0B1(1), NRIP1(2), PELP1(2), POLR2A(6)	8937765	71	39	70	20	17	20	21	9	4	0	0.347	1.000	1.000
412	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(5), ABAT(1), ACAT1(1), ACSM1(3), AKR1B10(3), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), ALDH7A1(1), ALDH9A1(2), BDH2(1), DDHD1(3), EHHADH(3), GAD1(4), GAD2(5), HADH(2), HADHA(2), HMGCS1(2), HMGCS2(5), HSD3B7(2), OXCT1(4), PDHA1(1), PDHA2(8), PLA1A(4), PPME1(2), PRDX6(1)	7857777	78	39	78	23	14	28	15	10	9	2	0.358	1.000	1.000
413	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(3), ADCY3(2), ADCY9(1), ARF3(1), ARF4(2), ARF5(1), ARL4D(2), ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(1), ATP6V1G1(1), ATP6V1H(2), ERO1L(1), GNAS(3), PDIA4(2), PLCG1(4), PLCG2(4), PRKCA(7), SEC61A1(4), SEC61A2(3), SEC61G(1), TRIM23(1)	7158339	65	39	65	30	17	20	18	6	4	0	0.959	1.000	1.000
414	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN2(14), ACTN3(2), BCAR1(1), BCR(3), CRKL(2), FYN(2), GRB2(3), HRAS(1), ITGA1(5), ITGB1(2), MAP2K1(4), MAPK3(1), MAPK8(3), PPP1R12B(4), PTK2(7), RAF1(2), RAP1A(1), ROCK1(7), SHC1(2), SOS1(9), SRC(2), TLN1(9), VCL(2), ZYX(2)	9153066	90	39	90	37	22	27	10	22	9	0	0.925	1.000	1.000
415	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(3), ACAD8(1), ACAD9(1), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), AKR1B10(3), AKR1C4(1), AKR1D1(2), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), BAAT(3), CEL(3), CYP27A1(3), CYP7A1(4), HADHB(2), HSD3B7(2), LIPA(1), SLC27A5(1), SOAT1(3), SRD5A1(3)	6158331	79	38	79	31	8	37	17	7	9	1	0.858	1.000	1.000
416	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(2), AGXT2(6), AKR1B10(3), ALAS1(3), AMT(2), AOC2(3), AOC3(2), BHMT(4), CBS(1), CHKB(2), DAO(1), DLD(3), DMGDH(2), GARS(3), GATM(3), GCAT(2), GLDC(3), HSD3B7(2), PSAT1(1), PSPH(3), SARDH(2), SHMT1(2), SHMT2(1), TARS(3), TARS2(5)	8383710	68	38	68	25	14	24	17	9	4	0	0.730	1.000	1.000
417	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(2), ASS1(3), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(1), CPS1(23), DAO(1), EPRS(9), GATM(3), GLUD1(3), GLUD2(3), GOT1(2), GOT2(3), LAP3(1), NOS1(5), NOS3(1), OAT(1), OTC(2), P4HA1(2), P4HA3(1), RARS(4), RARS2(1)	6970386	76	38	76	34	13	26	21	7	9	0	0.979	1.000	1.000
418	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(1), ARRB2(1), CALM1(1), CALML3(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(4), CLCA4(5), CNGA3(5), CNGA4(3), CNGB1(1), GUCA1A(1), GUCA1B(1), GUCA1C(2), PDC(1), PDE1C(11), PRKACB(2), PRKACG(1), PRKG1(1), PRKG2(4), PRKX(3)	5913489	58	38	58	17	14	18	15	5	6	0	0.447	1.000	1.000
419	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(4), ATP4B(1), ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(2), ATP7A(11), ATP7B(6), COX4I1(1), COX5B(1), COX6B1(1), COX8A(1), NDUFA10(1), NDUFA11(1), NDUFA4(1), NDUFA8(2), NDUFB2(3), NDUFB4(1), NDUFB5(2), NDUFS1(4), NDUFS2(3), NDUFV1(2), SDHA(5), SHMT1(2), UQCRB(2), UQCRFS1(2)	7412211	82	38	82	37	22	25	15	8	12	0	0.965	1.000	1.000
420	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(1), CHN1(1), MAP3K1(3), MYL2(2), MYLK(10), NCF2(2), PAK1(5), PDGFRA(7), PIK3CA(5), PIK3R1(1), PLD1(7), PPP1R12B(4), RALBP1(1), TRIO(9), VAV1(1), WASF1(4)	6780885	64	38	62	20	9	19	19	5	12	0	0.605	1.000	1.000
421	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(13), CREB5(4), DUSP6(1), EEF2K(1), EIF4E(2), GRB2(3), MAP2K1(4), MAP3K8(1), MAPK3(1), MKNK1(1), NFKB1(2), RAP1A(1), RPS6KA2(2), RPS6KA3(1), SHC1(2), SOS1(9), SOS2(5), TRAF3(1)	5751078	54	38	50	17	7	15	13	12	7	0	0.584	1.000	1.000
422	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(2), CASP3(4), CASP8(3), DFFA(3), LMNB1(1), LMNB2(1), MADD(8), MAP2K4(2), MAP3K1(3), MAP3K7(3), MAPK8(3), PAK1(5), PAK2(3), PRKDC(14), RB1(5), RIPK1(3), SPTAN1(7)	7662600	70	38	70	18	20	14	17	6	13	0	0.295	1.000	1.000
423	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(2), MAP2K1(4), MAPK3(1), MYL2(2), MYLK(10), PIK3CA(5), PIK3R1(1), PTK2(7), RAF1(2), ROCK1(7), SHC1(2), SRC(2), TLN1(9)	7237803	71	37	69	22	15	20	11	16	9	0	0.619	1.000	1.000
424	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(8), ASAH1(2), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(5), ITGB3(2), MAPK3(1), PDGFA(6), PDGFRA(7), PIK3CA(5), PIK3R1(1), PLCB1(9), PRKCA(7), PTK2(7), SMPD1(1), SMPD2(1), SRC(2)	5309640	67	37	66	20	12	26	16	5	8	0	0.557	1.000	1.000
425	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(5), F2R(2), F3(4), F5(17), F7(2), FGA(2), FGB(10), FGG(2), PROC(2), PROS1(10), SERPINC1(5), TFPI(1)	3168627	63	37	63	19	8	22	16	6	10	1	0.706	1.000	1.000
426	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(1), GRB2(3), HRAS(1), INSR(1), IRS1(12), JAK2(2), MAP2K1(4), MAPK3(1), PIK3CA(5), PIK3R1(1), PLCG1(4), PRKCA(7), PTPN6(2), RAF1(2), SHC1(2), SOS1(9), STAT5A(2), STAT5B(3)	6398400	64	37	63	22	16	13	16	13	6	0	0.590	1.000	1.000
427	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA1(1), FUCA2(1), GBA(3), GUSB(2), HEXA(1), HGSNAT(2), HPSE2(4), HYAL1(1), IDS(2), IDUA(1), LCT(12), MAN2B1(1), MAN2B2(3), MAN2C1(3), MANBA(4), NAGLU(1), NEU3(1), NEU4(5), SPAM1(4)	6730833	54	37	54	22	8	18	16	6	6	0	0.856	1.000	1.000
428	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), AKT3(2), BCL2(1), GRB2(3), GSK3B(1), IL4R(5), IRS1(12), IRS2(2), JAK1(5), JAK3(3), MAP4K1(2), MAPK3(1), PDK1(2), PIK3CA(5), PIK3R1(1), PPP1R13B(2), RAF1(2), SHC1(2), SOS1(9), SOS2(5), STAT6(1)	7078875	67	37	66	23	12	13	20	14	8	0	0.613	1.000	1.000
429	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(2), ARSB(1), ARSD(2), CYP11B1(3), CYP11B2(6), HSD11B1(2), HSD11B2(1), HSD17B2(1), HSD3B1(7), HSD3B2(12), SRD5A1(3), STS(3), SULT2A1(1), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2B15(4), UGT2B4(6)	5322411	74	36	73	29	8	30	16	12	8	0	0.889	1.000	1.000
430	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(3), CASP3(4), CASP8(3), CFLAR(1), DAXX(2), DFFA(3), FAF1(2), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(3), MAPK8(3), PAK1(5), PAK2(3), PRKDC(14), PTPN13(7), RB1(5), SPTAN1(7)	8099523	72	36	72	22	20	16	18	5	13	0	0.599	1.000	1.000
431	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B2(3), AOC2(3), AOC3(2), DDC(6), EPX(3), ESCO1(5), ESCO2(2), GOT1(2), GOT2(3), HPD(2), LPO(2), MPO(2), MYST3(7), MYST4(6), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(2), TPO(9)	6629310	68	36	68	26	12	24	14	8	10	0	0.840	1.000	1.000
432	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALNT1(2), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(2), FUT3(1), FUT7(1), FUT9(1), GCNT2(1), PIGB(1), PIGC(1), PIGG(5), PIGM(4), PIGN(1), PIGO(4), PIGQ(1), PIGS(1), PIGT(1), PIGV(2), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1), ST3GAL6(1), ST6GALNAC3(8), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA5(2)	9415839	68	36	67	32	19	12	23	10	4	0	0.937	1.000	1.000
433	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(3), AASDHPPT(1), AASS(4), ACAT1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(6), EHHADH(3), EHMT1(4), EHMT2(1), GCDH(1), HADHA(2), PLOD1(2), PLOD2(2), PLOD3(2), SHMT1(2), SHMT2(1), TMLHE(2)	7226451	60	36	60	19	10	18	16	6	8	2	0.563	1.000	1.000
434	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(14), AR(2), ESR2(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(2), NR1D2(2), NR1H2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(4), NR2F2(2), NR3C1(1), NR4A1(1), NR4A2(2), NR5A2(3), PGR(5), PPARD(1), PPARG(2), RARA(2), ROR1(1), RORA(1), RORC(1), RXRG(6), THRA(1), THRB(4)	8128419	71	36	71	39	21	22	11	9	8	0	0.996	1.000	1.000
435	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT2(1), AKT3(2), DAG1(2), GNAQ(2), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), NFKB1(2), NFKB2(3), NFKBIE(1), PDK1(2), PHKA2(6), PIK3CB(2), PITX2(3), PLD1(7), PLD2(3)	8726334	68	36	67	19	15	18	22	6	7	0	0.267	1.000	1.000
436	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(4), EEF1B2(2), EEF1G(1), EEF2(1), EEF2K(1), EIF1AX(1), EIF2AK1(1), EIF2AK2(2), EIF2AK3(5), EIF2B2(2), EIF2B3(3), EIF2B4(2), EIF2B5(3), EIF2S3(1), EIF4A1(2), EIF4A2(3), EIF4E(2), EIF4G1(6), EIF4G3(4), EIF5B(7), GSPT2(2), PABPC1(1), PABPC3(6), PAIP1(4)	8529738	66	36	66	18	13	20	19	8	6	0	0.419	1.000	1.000
437	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGTR2(2), EDNRB(2), EGF(7), EGFR(24), HRAS(1), NFKB1(2), PLCG1(4), PRKCA(7)	3957462	54	35	44	17	9	11	13	14	7	0	0.699	1.000	1.000
438	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(3), B4GALT1(1), B4GALT2(2), G6PC(1), G6PC2(1), GAA(1), GALK2(1), GALT(1), GANC(1), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), HSD3B7(2), LCT(12), MGAM(15), PFKL(1), PFKM(2), PFKP(3), PGM1(2), PGM3(2), UGP2(1)	7565076	69	35	69	21	18	23	15	9	4	0	0.420	1.000	1.000
439	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(3), AOC3(2), ARG1(1), ASL(2), ASS1(3), CPS1(23), GATM(3), OTC(2), SAT1(1), SMS(1)	5743983	60	35	60	26	9	18	19	8	6	0	0.909	1.000	1.000
440	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(2), POLD1(1), POLD3(2), POLE(12), POLG(8), POLI(1), POLK(3), POLM(4), POLQ(10), PRIM1(2), PRIM2(7), REV1(2), REV3L(7)	7962009	62	35	62	19	18	10	21	7	6	0	0.556	1.000	1.000
441	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(3), CYP4F2(3), CYP4F3(7), EPX(3), GGT1(1), LPO(2), MPO(2), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PRDX2(1), PRDX5(1), PRDX6(1), PTGDS(2), PTGIS(1), PTGS1(3), PTGS2(4), TBXAS1(4), TPO(9)	5375817	65	35	65	21	9	16	19	12	9	0	0.552	1.000	1.000
442	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), ANGPTL2(2), DAG1(2), DGKA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(4), ITPR1(7), ITPR2(15), ITPR3(4), MAP2K1(4), MAPK3(1), NR1I3(1), PAK1(5), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(3), PIK3CA(5), PIK3R1(1), PSME1(1), RIPK3(1), SGCB(1)	9547161	73	35	71	18	17	21	18	8	9	0	0.241	1.000	1.000
443	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(3), ACADM(3), ACAT1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), AOX1(6), BCKDHB(4), EHHADH(3), HADHA(2), HADHB(2), HIBADH(1), MCCC1(2), MCCC2(2), MUT(4), OXCT1(4), PCCA(4), PCCB(1)	6972966	62	35	62	23	6	22	14	6	12	2	0.816	1.000	1.000
444	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(8), CAMK2A(1), CAMK2D(1), CAMK2G(2), GNAS(3), GRB2(3), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(5), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7), RPS6KA5(2), SOS1(9)	5624142	52	34	51	19	8	16	13	9	6	0	0.850	1.000	1.000
445	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(3), ALDOA(1), ALDOB(2), ALDOC(1), FPGT(1), FUK(2), GMDS(3), GMPPA(1), GMPPB(1), HK1(3), HK2(5), HK3(5), HSD3B7(2), KHK(1), MTMR1(2), MTMR2(1), MTMR6(3), PFKFB1(2), PFKFB2(3), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(2), PFKP(3), PGM2(5), PMM1(1), SORD(1), TPI1(3)	7318686	66	34	65	22	16	23	14	9	4	0	0.516	1.000	1.000
446	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(3), ABAT(1), ACY3(1), ADSSL1(1), AGXT(2), AGXT2(6), ASL(2), ASNS(2), ASPA(1), ASS1(3), CAD(9), DARS2(2), DDO(2), DLAT(3), DLD(3), GAD1(4), GAD2(5), GOT1(2), GOT2(3), GPT2(2), NARS(2), NARS2(2), PC(1), PDHA1(1), PDHA2(8)	7348356	72	34	72	23	19	21	20	7	5	0	0.422	1.000	1.000
447	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(8), ACACB(7), ACADM(3), ACAT1(1), ACSS1(1), ACSS2(3), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), EHHADH(3), HADHA(2), HIBCH(3), LDHA(3), LDHAL6A(3), LDHC(4), MLYCD(4), MUT(4), PCCA(4), PCCB(1), SUCLG1(1), SUCLG2(2)	7668276	72	34	72	30	18	24	12	6	11	1	0.922	1.000	1.000
448	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2B(1), GTF2E1(2), GTF2E2(1), GTF2F1(1), GTF2H1(4), GTF2I(3), GTF2IRD1(5), TAF1(3), TAF1L(17), TAF2(3), TAF4(2), TAF4B(3), TAF5L(3), TAF6(1), TAF9(1), TBPL2(2)	6979416	55	34	55	23	11	13	17	8	6	0	0.910	1.000	1.000
449	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(11), ITGAL(17), ITGAM(9), ITGB1(2), ITGB2(2), SELE(2), SELL(1), SELP(11)	3114060	56	34	56	22	8	18	15	9	6	0	0.923	1.000	1.000
450	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGTR1(1), AGTR2(2), CMA1(3), COL4A1(7), COL4A2(9), COL4A3(3), COL4A4(8), COL4A5(13), COL4A6(9)	4993461	58	33	58	29	4	27	11	8	8	0	0.995	1.000	1.000
451	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(4), CDT1(2), DIAPH2(3), GMNN(1), MCM10(1), MCM2(4), MCM3(3), MCM4(5), MCM5(1), MCM6(5), MCM7(1), NACA(1), ORC1L(2), ORC2L(1), ORC4L(1), ORC5L(3), POLD1(1), POLD3(2), POLE(12), PRIM1(2), RFC1(6), RFC3(1), RPA2(1), RPA4(3), UBC(7)	9871338	77	33	77	25	29	15	21	6	6	0	0.483	1.000	1.000
452	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), B4GALT2(2), G6PC(1), GAA(1), GALK2(1), GALT(1), GANAB(3), GCK(1), GLA(2), HK1(3), HK2(5), HK3(5), LCT(12), MGAM(15), PFKM(2), PFKP(3), PGM1(2), PGM3(2)	6365247	63	33	63	22	18	19	14	8	4	0	0.618	1.000	1.000
453	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), CALM1(1), CAMK1(2), HDAC5(2), IGF1(3), IGF1R(6), INSR(1), MAPK14(1), MAPK7(4), MEF2C(1), MEF2D(1), MYOD1(2), NFATC1(1), NFATC2(5), PIK3CA(5), PIK3R1(1), PPP3CA(2), PPP3CB(1), PPP3CC(1), SYT1(3)	6748506	45	33	44	16	5	19	11	5	5	0	0.680	1.000	1.000
454	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CA1(2), CA13(1), CA14(1), CA2(1), CA3(3), CA4(2), CA5A(1), CA8(2), CA9(1), CPS1(23), GLS(1), GLS2(2), GLUD1(3), GLUD2(3), HAL(1)	4122840	51	33	51	24	7	17	12	9	6	0	0.984	1.000	1.000
455	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(7), CFLAR(1), CRKL(2), GRB2(3), HRAS(1), IL2RA(3), IL2RB(4), IRS1(12), JAK1(5), JAK3(3), MAPK3(1), NMI(1), PIK3CA(5), PIK3R1(1), PTPN6(2), RAF1(2), SHC1(2), SOS1(9), STAT5A(2), STAT5B(3), SYK(1)	7001991	71	33	69	20	20	12	15	16	8	0	0.230	1.000	1.000
456	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(3), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH6(4), ADH7(3), ADHFE1(2), AKR1C4(1), AKR1D1(2), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), BAAT(3), CEL(3), CYP27A1(3), CYP7A1(4), HADHB(2), SRD5A1(3)	4500552	70	32	70	26	9	33	15	6	7	0	0.762	1.000	1.000
457	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(2), EIF4A2(3), EIF4E(2), EIF4G1(6), EIF4G3(4), GHR(1), IRS1(12), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(1), PIK3CA(5), PIK3R1(1), PRKCA(7), PTEN(3)	5435673	50	32	48	25	13	13	16	5	3	0	0.972	1.000	1.000
458	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(3), ANXA4(2), ANXA5(1), EDNRB(2), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(5), PTGDS(2), PTGER2(1), PTGER4(4), PTGFR(5), PTGIR(1), PTGIS(1), PTGS1(3), PTGS2(4), TBXAS1(4)	4008288	46	32	46	18	9	11	13	6	7	0	0.857	1.000	1.000
459	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(7), COL4A2(9), COL4A3(3), COL4A4(8), COL4A5(13), COL4A6(9), P4HB(2), SLC23A2(2), SLC2A3(4)	4969209	57	32	57	27	5	25	8	8	11	0	0.984	1.000	1.000
460	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), IL1A(2), IRAK1(2), MAP3K1(3), MAP3K14(1), MAP3K7(3), MYD88(2), NFKB1(2), RIPK1(3), TLR4(23), TNFRSF1B(1), TRAF6(3)	4735848	48	31	47	21	6	14	16	5	7	0	0.938	1.000	1.000
461	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CA1(2), CA14(1), CA2(1), CA3(3), CA4(2), CA5A(1), CA8(2), CA9(1), CPS1(23), GLS(1), GLS2(2), GLUD1(3), HAL(1)	3685401	47	31	47	23	7	13	12	9	6	0	0.986	1.000	1.000
462	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(2), ERCC3(4), GTF2B(1), GTF2E1(2), GTF2E2(1), GTF2H1(4), MNAT1(2), POLR1A(5), POLR1B(8), POLR2A(6), POLR2B(1), POLR2C(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR3B(10), POLR3D(2), POLR3E(1), POLR3H(1), TAF6(1), TAF9(1)	6778434	59	31	58	22	13	17	17	6	6	0	0.819	1.000	1.000
463	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(4), EPHB1(17), FYN(2), ITGA1(5), ITGB1(2), L1CAM(7), LYN(3), RAP1B(1), SELP(11)	3045303	52	30	52	18	9	13	13	13	4	0	0.799	1.000	1.000
464	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(7), F2(5), F2R(2), FGA(2), FGB(10), FGG(2), PLAT(4), PLG(8), SERPINB2(3), SERPINE1(3)	2592900	46	30	46	16	4	21	11	6	4	0	0.896	1.000	1.000
465	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO1(2), ACO2(1), CLYBL(2), CS(1), DLD(3), DLST(1), FH(1), IDH1(2), IDH2(2), IDH3A(2), IDH3G(1), MDH1(1), OGDHL(5), PC(1), PCK1(8), PCK2(1), SDHA(5), SDHD(1), SUCLG1(1), SUCLG2(2)	5748498	44	30	44	19	13	6	10	8	7	0	0.756	1.000	1.000
466	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(2), ALDOC(1), DERA(1), G6PD(2), GPI(3), H6PD(3), PFKL(1), PFKM(2), PFKP(3), PGD(1), PGM1(2), PGM3(2), PRPS1(3), PRPS1L1(2), PRPS2(1), RPE(1), RPIA(2), TKTL1(6), TKTL2(6)	4734945	45	30	45	16	10	11	12	9	3	0	0.631	1.000	1.000
467	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(5), CYP2C9(2), DHRS2(2), DHRS3(1), EHHADH(3), ESCO1(5), ESCO2(2), HADHA(2), MYST3(7), MYST4(6), PNPLA3(1), SH3GLB1(1), YOD1(1)	5986890	53	30	53	19	10	19	9	7	7	1	0.751	1.000	1.000
468	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCL4(1), CCR1(1), CCR2(5), CCR3(1), CCR4(1), CCR5(1), CD28(1), CD4(1), CXCR3(1), CXCR4(3), IFNG(3), IFNGR1(3), IFNGR2(2), IL12A(2), IL12RB1(2), IL12RB2(6), IL2(3), IL4R(5), TGFB1(2), TGFB2(5), TGFB3(1)	3868581	51	30	51	18	5	14	13	9	10	0	0.660	1.000	1.000
469	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B2(3), AOC2(3), AOC3(2), DDC(6), EPX(3), GOT1(2), GOT2(3), HPD(2), LPO(2), MPO(2), PRDX2(1), PRDX5(1), PRDX6(1), TAT(2), TPO(9)	4261902	48	30	48	20	8	16	12	6	6	0	0.849	1.000	1.000
470	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRB(1), CP(4), CPOX(3), EPRS(9), GUSB(2), HMBS(2), HMOX1(3), PPOX(2), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2B15(4), UGT2B4(6)	5315187	57	30	56	22	6	22	11	9	9	0	0.891	1.000	1.000
471	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), GRB2(3), HRAS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK3(1), MAPK8IP3(1), PAPPA(6), RPS6KA3(1), SHC1(2), SOS1(9), SYK(1), VAV1(1), VAV2(2), VAV3(9)	6224508	52	30	52	20	6	15	13	10	8	0	0.834	1.000	1.000
472	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), GNAQ(2), NFATC1(1), NFATC2(5), NFATC3(7), NFATC4(2), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(7), SP3(1), SYT1(3)	4049568	37	29	37	14	9	11	12	1	4	0	0.662	1.000	1.000
473	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(14), ACTN3(2), BCAR1(1), CTNNA1(2), CTNNA2(15), CTNNB1(9), PTK2(7), SRC(2), VCL(2)	3698559	54	29	53	18	9	17	12	12	4	0	0.591	1.000	1.000
474	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), BTG1(1), CBX3(2), CLOCK(2), CRY1(3), CRY2(2), DAZAP2(1), ETV6(3), GFRA1(2), GSTM3(1), GSTP1(2), HERPUD1(2), IDI1(1), MYF6(4), NCKAP1(2), NCOA4(4), NR1D2(2), PER1(2), PER2(4), PPP1R3C(1), PPP2CB(2), SF3A3(1), TOB1(1), UCP3(1), UGP2(1), ZFR(2)	7136409	51	29	51	25	12	19	9	3	8	0	0.992	1.000	1.000
475	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(3), AGPAT3(2), AGPAT4(1), AGPAT6(1), AGPS(2), ENPP2(6), ENPP6(2), PAFAH1B2(1), PAFAH2(1), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1), PLD1(7), PLD2(3), PPAP2B(1)	4508937	49	29	49	18	9	16	11	6	7	0	0.824	1.000	1.000
476	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(2), EIF4A2(3), EIF4B(3), EIF4E(2), EIF4G1(6), EIF4G3(4), MKNK1(1), PIK3CA(5), PIK3R1(1), PTEN(3), TSC1(7), TSC2(2)	5375817	39	29	37	19	4	13	14	5	3	0	0.961	1.000	1.000
477	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(8), ACADM(3), ACAT1(1), ALDH1A1(1), ALDH1A2(6), ALDH1A3(1), ALDH1B1(6), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(2), EHHADH(3), HADHA(2), LDHA(3), LDHC(4), MLYCD(4), MUT(4), PCCA(4), PCCB(1), SUCLG1(1), SUCLG2(2)	6391047	61	29	61	20	14	21	11	5	9	1	0.647	1.000	1.000
478	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	CDC42(2), CREB5(4), DUSP10(6), EEF2K(1), EIF4E(2), GADD45A(1), MAP2K3(3), MAP2K4(2), MAP3K10(1), MAP3K4(8), MAP3K5(8), MAP3K7(3), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MKNK1(1), MYEF2(3), NFKB1(2), NR2C2(1), TRAF6(3)	6449742	57	29	56	17	19	10	13	7	8	0	0.409	1.000	1.000
479	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(2), C1R(1), C1S(1), C2(1), C3(3), C5(1), C6(7), C7(14), C8A(2), C8B(7), C9(7), MASP1(2)	4066467	48	28	47	20	8	17	11	9	3	0	0.930	1.000	1.000
480	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(4), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP10(3), CASP3(4), CASP8(3), CASP9(2), CFLAR(1), CHUK(1), DFFA(3), GAS2(1), MAP3K14(1), NFKB1(2), RIPK1(3), SPTAN1(7), TNFRSF10B(1), TNFRSF25(1), TNFSF10(1)	6523788	44	28	44	22	10	12	11	5	6	0	0.981	1.000	1.000
481	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(7), EGFR(24), ERBB3(1), NRG1(6)	1997178	38	28	28	12	6	5	8	10	9	0	0.696	1.000	1.000
482	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(5), ADH1B(5), ADH1C(4), ADH4(3), ADH5(3), ADH6(4), ADH7(3), ADHFE1(2), DHRS2(2), DHRS3(1), ESCO1(5), ESCO2(2), MYST3(7), MYST4(6), PNPLA3(1), SH3GLB1(1)	4847304	56	28	56	21	7	32	4	5	8	0	0.897	1.000	1.000
483	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(3), IKBKB(2), IL1A(2), IL1RAP(2), IRAK1(2), IRAK3(2), MAP2K3(3), MAP3K1(3), MAP3K14(1), MAP3K7(3), MAPK14(1), MAPK8(3), MYD88(2), NFKB1(2), TGFB1(2), TGFB2(5), TGFB3(1), TRAF6(3)	5731728	43	28	42	23	8	7	10	10	8	0	0.987	1.000	1.000
484	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(1), EGR2(1), GNAQ(2), MAP3K1(3), NFATC1(1), NFATC2(5), NFKB1(2), PLCG1(4), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKACB(2), PRKACG(1), PRKAR1B(4), SYT1(3), VIP(1), VIPR2(2)	5403681	37	28	37	14	6	11	11	2	7	0	0.724	1.000	1.000
485	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(8), BAX(1), BCL2(1), CSF2RB(3), IGF1(3), IGF1R(6), IL3(1), IL3RA(4), KIT(3), PIK3CA(5), PIK3R1(1), PRKACB(2), PRKACG(1), PRKAR1B(4)	4230297	43	27	42	17	5	18	13	3	4	0	0.810	1.000	1.000
486	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACPP(6), ALPI(2), ALPL(2), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), DHRS2(2), DHRS3(1), PON1(1), PON3(5)	3501834	34	27	34	22	4	7	12	4	7	0	0.991	1.000	1.000
487	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(5), EXTL1(1), EXTL3(4), GLCE(3), HS3ST1(1), HS3ST3A1(1), HS3ST5(6), HS6ST1(1), HS6ST3(1), NDST1(1), NDST2(5), NDST3(6), NDST4(6)	4029831	42	27	41	24	4	17	13	5	3	0	0.992	1.000	1.000
488	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(8), POLR1D(1), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLR3A(7), POLR3B(10), POLR3H(1)	4557183	49	27	48	16	12	12	12	7	6	0	0.636	1.000	1.000
489	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(2), MAP2K7(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(3), MAPK8IP3(1), MAPK9(5), MAPKAPK5(3), NFKB1(2), NFKB2(3), NFKBIE(1), PIK3CA(5), PIK3R1(1), SYT1(3), TRAF3(1), TRAF5(1), TRAF6(3)	6540687	41	27	39	17	10	9	13	3	6	0	0.804	1.000	1.000
490	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(14), ACTN3(2), ITGA1(5), ITGB1(2), ITGB3(2), PTK2(7), SPTAN1(7), SRC(2), TLN1(9)	5531262	50	27	50	27	12	17	5	12	4	0	0.992	1.000	1.000
491	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD4(1), CREBBP(2), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(2), LCK(5), PRKACB(2), PRKACG(1), PRKAR1B(4), PTPRC(10), ZAP70(2)	4465335	43	26	43	13	5	16	13	2	7	0	0.622	1.000	1.000
492	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(8), CR2(4), FCGR2B(2), HLA-DRA(2), ITGAL(17), ITGB2(2), PTPRC(10)	2978739	45	26	45	14	8	16	10	3	8	0	0.683	1.000	1.000
493	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(2), C1R(1), C1S(1), C2(1), C3(3), C5(1), C6(7), C7(14), C8A(2), C9(7)	3430110	39	26	38	18	8	11	9	8	3	0	0.953	1.000	1.000
494	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(2), C1R(1), C1S(1), C2(1), C3(3), C5(1), C6(7), C7(14), C8A(2), C9(7), MASP1(2), MASP2(1)	4174956	42	26	41	23	8	13	10	8	3	0	0.992	1.000	1.000
495	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD4(1), CREBBP(2), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(2), LCK(5), PRKACB(2), PRKACG(1), PRKAR1B(4), PTPRC(10), ZAP70(2)	4465335	43	26	43	13	5	16	13	2	7	0	0.622	1.000	1.000
496	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(1), ALOX5(3), CYP1A2(1), CYP2C18(2), CYP2C19(5), CYP2C8(2), CYP2C9(2), CYP2E1(3), CYP2J2(8), CYP3A4(1), CYP3A43(1), CYP3A7(3), HSD3B7(2), PLA2G10(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(3), PLA2G2E(1), PLA2G2F(1), PLA2G3(4), PLA2G4A(5), PLA2G6(1)	4632261	55	26	55	24	13	20	10	6	5	1	0.881	1.000	1.000
497	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(1), ITGB1(2), KLRC1(1), KLRC2(2), KLRC3(3), KLRD1(1), LAT(3), MAP2K1(4), MAPK3(1), PAK1(5), PIK3CA(5), PIK3R1(1), PTK2B(6), PTPN6(2), SYK(1), VAV1(1)	3604776	39	26	38	12	10	6	10	7	6	0	0.439	1.000	1.000
498	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), GBA3(7), LPO(2), MPO(2), PRDX2(1), PRDX5(1), PRDX6(1), TPO(9), TYR(6)	1857600	32	26	32	12	4	10	7	6	5	0	0.849	1.000	1.000
499	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG1(1), ASL(2), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(1), CPS1(23), GATM(3), GLUD1(3), OAT(1), OTC(2), SMS(1)	3374511	40	26	40	19	6	12	12	4	6	0	0.966	1.000	1.000
500	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), CREM(1), FHL5(3), FSHB(1), FSHR(11), GNAS(3), XPO1(3)	1838508	30	25	30	12	3	11	7	4	5	0	0.939	1.000	1.000
501	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), BHMT(4), CBS(1), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MARS2(4), MAT1A(2), MAT2B(3), MTFMT(1), MTR(6), TAT(2)	4051374	39	25	39	13	12	9	11	4	2	1	0.518	1.000	1.000
502	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	BECN1(1), IFNA10(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNA7(3), IFNA8(1), IFNG(3), PIK3C3(4), PIK3R4(7), PRKAA1(1), ULK1(3), ULK3(1)	4109811	37	25	37	15	5	15	8	7	2	0	0.913	1.000	1.000
503	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(1), DLAT(3), DLD(3), DLST(1), FH(1), IDH2(2), IDH3A(2), IDH3G(1), MDH1(1), PC(1), PDHA1(1), PDHA2(8), PDHX(1), PDK1(2), PDK3(1), SDHA(5), SDHD(1), SUCLG1(1), SUCLG2(2)	5487015	39	25	39	21	11	8	11	4	5	0	0.934	1.000	1.000
504	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(1), GALNT3(2), GALNT4(3), GALNT6(2), GALNT7(4), GALNT8(6), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1), WBSCR17(8)	2789883	36	25	36	19	11	5	12	8	0	0	0.950	1.000	1.000
505	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(6), FYN(2), LRP8(1), RELN(28)	2722416	38	25	38	16	3	15	6	8	6	0	0.966	1.000	1.000
506	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(2), DDC(6), GAD1(4), GAD2(5), HDC(6), PAH(1), SLC18A3(5), TH(1), TPH1(10)	2815167	40	24	40	13	11	9	10	7	3	0	0.535	1.000	1.000
507	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCL4(1), CCR5(1), CXCR4(3), GNAQ(2), MAPK14(1), MAPK8(3), PLCG1(4), PRKCA(7), PTK2B(6), SYT1(3)	2654949	32	24	32	16	9	10	9	1	3	0	0.910	1.000	1.000
508	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(3), DPEP1(4), GGT1(1), PLA2G2A(3), PLA2G6(1), PTGDS(2), PTGIS(1), PTGS1(3), PTGS2(4), TBXAS1(4)	2915142	29	24	29	10	5	3	11	6	4	0	0.586	1.000	1.000
509	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), GRB2(3), HRAS(1), JAK2(2), MAP2K1(4), MAPK3(1), MAPK8(3), PLCG1(4), PTPN6(2), RAF1(2), SHC1(2), SOS1(9), STAT5A(2), STAT5B(3)	4164894	39	24	39	13	9	8	8	9	5	0	0.544	1.000	1.000
510	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(3), HRAS(1), IL3(1), IL3RA(4), JAK2(2), MAP2K1(4), MAPK3(1), PTPN6(2), RAF1(2), SHC1(2), SOS1(9), STAT5A(2), STAT5B(3)	3423531	39	24	39	13	6	11	7	9	6	0	0.621	1.000	1.000
511	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(11), ITGAL(17), ITGB1(2), ITGB2(2), SELE(2), SELL(1)	2364441	36	24	36	17	6	9	8	7	6	0	0.973	1.000	1.000
512	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(2), RPE(1), UGDH(3), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4), UGT2B15(4), UGT2B4(6)	3430626	37	24	36	19	4	13	7	6	7	0	0.967	1.000	1.000
513	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), APOA1(1), APOA4(3), APOC2(1), APOC3(2), APOE(1), CETP(1), CYP7A1(4), DGAT1(1), HMGCR(3), LCAT(1), LDLR(1), LIPC(5), LPL(2), LRP1(17), SOAT1(3)	5291967	53	24	53	21	15	14	11	9	3	1	0.835	1.000	1.000
514	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(1), C6(7), C7(14), C8A(2), C9(7)	2458224	34	23	33	12	8	11	7	5	3	0	0.804	1.000	1.000
515	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(1), CS(1), DLD(3), DLST(1), FH(1), IDH1(2), IDH2(2), IDH3A(2), IDH3G(1), MDH1(1), PC(1), PCK1(8), SDHA(5), SUCLG1(1), SUCLG2(2)	3963138	34	23	34	12	11	6	7	5	5	0	0.527	1.000	1.000
516	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(1), CD86(2), CTLA4(1), GRB2(3), HLA-DRA(2), IL2(3), ITK(4), LCK(5), PIK3CA(5), PIK3R1(1), PTPN11(1)	2466480	29	23	28	11	2	10	10	4	3	0	0.862	1.000	1.000
517	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(3), HRAS(1), MAPK3(1), MAPK7(4), MEF2C(1), MEF2D(1), NTRK1(6), PIK3CA(5), PIK3R1(1), PLCG1(4), SHC1(2)	3691335	29	23	28	11	5	6	10	6	2	0	0.743	1.000	1.000
518	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(8), CHST2(4), FUT8(4), ST3GAL1(2), ST3GAL2(2), ST3GAL3(1), ST3GAL4(1)	2417073	31	23	30	17	11	5	9	2	4	0	0.942	1.000	1.000
519	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), HEXA(1), LCT(12), SLC33A1(1), ST3GAL1(2), ST3GAL2(2), ST6GALNAC3(8), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA5(2)	3181269	32	23	32	10	5	6	12	5	4	0	0.576	1.000	1.000
520	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(3), GBA3(7), LPO(2), MPO(2), PRDX6(1), TPO(9)	1615596	27	23	27	10	2	11	6	3	5	0	0.840	1.000	1.000
521	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(3), AGTR1(1), AGTR2(2), ANPEP(3), CMA1(3), CPA3(4), CTSG(1), ENPEP(4), LNPEP(1), MAS1(2), MME(2), NLN(2), THOP1(2)	4118325	37	23	37	23	5	8	17	2	5	0	0.993	1.000	1.000
522	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CALM1(1), EP300(1), HDAC1(1), HDAC2(6), MEF2D(1), NFATC1(1), NFATC2(5), PPP3CA(2), PPP3CB(1), PPP3CC(1), PRKCA(7), SYT1(3)	4712370	32	23	32	12	6	14	8	1	3	0	0.728	1.000	1.000
523	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), CDKN1B(2), GRB2(3), ITGB1(2), MAPK3(1), PIK3CA(5), PIK3R1(1), PTEN(3), PTK2(7), SHC1(2), SOS1(9)	3745257	36	23	34	11	4	12	7	8	5	0	0.683	1.000	1.000
524	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(1), IFNG(3), IKBKB(2), IL2(3), MAP3K1(3), MAP3K5(8), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(2), TNFRSF9(2)	3754803	31	22	31	10	6	7	8	2	8	0	0.642	1.000	1.000
525	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), AGXT(2), AGXT2(6), ASL(2), ASNS(2), ASPA(1), CAD(9), DDO(2), GAD1(4), GAD2(5), GOT1(2), GOT2(3), GPT2(2), NARS(2), PC(1)	5067249	45	22	45	17	12	12	13	5	3	0	0.666	1.000	1.000
526	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(6), CYP17A1(2), HSD11B1(2), HSD11B2(1), HSD3B1(7), HSD3B2(12)	1831413	36	22	36	13	5	14	7	6	4	0	0.744	1.000	1.000
527	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), PRKAA1(1), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(4), PRKAR1B(4)	2964678	28	22	28	11	3	11	7	2	5	0	0.876	1.000	1.000
528	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(1), ALDOB(2), ALDOC(1), FPGT(1), GCK(1), GMDS(3), GMPPA(1), GMPPB(1), HK1(3), HK2(5), HK3(5), KHK(1), PFKFB1(2), PFKFB3(4), PFKFB4(3), PFKM(2), PFKP(3), PMM1(1), SORD(1), TPI1(3)	4683732	45	22	44	16	13	15	9	6	2	0	0.604	1.000	1.000
529	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(3), DHCR24(1), DHCR7(1), EBP(1), FDFT1(1), FDPS(1), GGCX(1), GGPS1(1), HMGCR(3), IDI1(1), LSS(3), MVD(1), NQO1(3), NSDHL(1), SC4MOL(1), SC5DL(2), TM7SF2(5), VKORC1(1)	3765897	33	22	33	12	5	11	10	4	3	0	0.715	1.000	1.000
530	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(6), CYP17A1(2), HSD11B1(2), HSD11B2(1), HSD3B1(7), HSD3B2(12)	1831413	36	22	36	13	5	14	7	6	4	0	0.744	1.000	1.000
531	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), BHMT(4), CBS(1), DNMT1(3), DNMT3A(6), DNMT3B(3), MARS(1), MARS2(4), MAT1A(2), MAT2B(3), MTR(6)	3391152	35	22	35	11	10	8	11	3	2	1	0.448	1.000	1.000
532	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(8), CCNB1(1), GNAI1(1), GNAS(3), GNB1(1), GNGT1(1), HRAS(1), MAPK3(1), MYT1(5), PRKACB(2), PRKACG(1), PRKAR1B(4), SRC(2)	3960558	31	22	31	15	6	10	7	3	5	0	0.960	1.000	1.000
533	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), AKT3(2), BPNT1(1), GRB2(3), MAPK3(1), PDK1(2), PIK3CA(5), PTEN(3), PTK2B(6), RBL2(1), SHC1(2), SOS1(9)	3945594	36	22	34	14	8	8	11	7	2	0	0.797	1.000	1.000
534	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(9), FARS2(1), GARS(3), HARS(2), IARS(3), KARS(3), LARS(3), LARS2(1), MARS(1), MARS2(4), NARS(2), QARS(2), RARS(4), TARS(3), WARS(2), WARS2(8), YARS(1)	6208254	54	21	54	16	11	23	9	8	3	0	0.608	1.000	1.000
535	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(3), DDX20(1), ETS1(1), ETS2(1), HDAC2(6), HDAC5(2), HRAS(1), NCOR2(6), RBL1(4), RBL2(1), SIN3A(4)	5041578	31	21	31	14	6	6	11	5	3	0	0.879	1.000	1.000
536	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE2(4), HYAL1(1), IDS(2), IDUA(1), LCT(12), NAGLU(1), SPAM1(4)	3972297	31	21	31	15	5	9	8	4	5	0	0.929	1.000	1.000
537	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST12(3), CHST13(2), CHST3(1), CHSY1(1), DSE(2), UST(1), XYLT1(13)	2657529	27	21	27	10	4	6	10	4	3	0	0.620	1.000	1.000
538	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(1), ACYP2(1), DHRS2(2), DHRS3(1), EHHADH(3), ESCO1(5), ESCO2(2), GCDH(1), HADHA(2), ITGB1BP3(2), MYST3(7), MYST4(6), PNPLA3(1), SH3GLB1(1), YOD1(1)	5027904	37	21	37	12	5	13	7	4	7	1	0.694	1.000	1.000
539	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(3), EPX(3), LPO(2), MPO(2), PRDX2(1), PRDX5(1), PRDX6(1), SHMT1(2), SHMT2(1), TPO(9)	2283300	28	21	28	11	3	12	5	4	4	0	0.836	1.000	1.000
540	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(17), ITGAM(9), ITGB2(2), SELE(2), SELL(1)	2037942	32	21	32	13	7	9	9	3	4	0	0.802	1.000	1.000
541	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), ALDOC(1), G6PD(2), GPI(3), H6PD(3), PFKM(2), PFKP(3), PGD(1), PGM1(2), PGM3(2), PRPS1(3), PRPS1L1(2), PRPS2(1), RPE(1), RPIA(2), TAL1(2)	3971523	33	21	33	13	9	7	8	8	1	0	0.749	1.000	1.000
542	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), AMT(2), ATIC(2), FTCD(2), GART(1), MTFMT(1), MTHFD1(1), MTHFD1L(4), MTHFR(1), MTR(6), SHMT1(2), SHMT2(1)	3685530	27	20	27	14	9	7	5	1	4	1	0.933	1.000	1.000
543	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(3), EPX(3), LPO(2), MPO(2), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(1), TPO(9)	2248728	27	20	27	11	3	11	6	3	4	0	0.852	1.000	1.000
544	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(6), CD38(1), ENPP1(3), ENPP3(5), NMNAT1(1), NNMT(3), NNT(4), NT5C1A(2), NT5C1B(1), NT5C3(1), NT5E(1), NT5M(1), NUDT12(1)	4187340	30	20	30	13	4	14	8	1	3	0	0.883	1.000	1.000
545	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CXCR3(1), ETV5(2), IFNG(3), IL12A(2), IL12RB1(2), IL12RB2(6), JAK2(2), MAPK14(1), MAPK8(3), STAT4(5), TYK2(2)	3610710	31	20	31	19	3	8	8	3	9	0	0.995	1.000	1.000
546	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(2), EP300(1), IKBKB(2), MAP2K3(3), MAP3K14(1), MAP3K7(3), MAPK14(1), MYD88(2), NFKB1(2), NR3C1(1), TGFBR1(2)	5732631	21	20	21	12	2	3	8	2	6	0	0.976	1.000	1.000
547	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(1), AP2M1(3), BTK(7), EEA1(2), GSK3B(1), LYN(3), PFKL(1), PFKM(2), PFKP(3), PLCG1(4), PRKCE(1), RAB5A(1), VAV2(2)	4836210	31	20	31	12	9	6	10	4	2	0	0.728	1.000	1.000
548	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(3), GTF2B(1), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(4), NCOA2(4), NCOA3(6), NCOR2(6), POLR2A(6), RARA(2)	4827567	40	20	40	14	12	13	7	7	1	0	0.674	1.000	1.000
549	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(2), CDC42(2), CHUK(1), HRAS(1), MAP2K1(4), MAPK3(1), NFKB1(2), PIK3CA(5), PIK3R1(1), RAF1(2), RALA(2), RALBP1(1), RHOA(1)	3694689	25	20	24	10	6	5	5	6	3	0	0.780	1.000	1.000
550	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(4), GLI3(6), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1B(4), SHH(3), SMO(4)	3271956	28	20	28	11	6	9	5	4	4	0	0.786	1.000	1.000
551	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), CNR2(1), DNMT1(3), MTNR1A(3), MTNR1B(5), PTAFR(2), PTGER2(1), PTGER4(4), PTGFR(5), PTGIR(1)	2194806	28	20	28	11	5	7	10	6	0	0	0.670	1.000	1.000
552	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(2), CHUK(1), IKBKB(2), MAP2K3(3), MAP2K4(2), MAP3K1(3), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(2), RIPK1(3), TANK(2)	4697019	25	20	25	12	3	8	7	1	6	0	0.937	1.000	1.000
553	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(2), HLA-DRA(2), IFNG(3), IFNGR1(3), IFNGR2(2), IL12A(2), IL12RB1(2), IL12RB2(6), IL2(3), IL2RA(3), IL4R(5)	2455902	34	20	33	14	7	6	11	4	6	0	0.799	1.000	1.000
554	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3D(1), CD4(1), ITGAL(17), ITGB2(2), PTPRC(10)	2190162	34	20	34	12	8	11	7	2	6	0	0.657	1.000	1.000
555	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(23), GLS(1), GLUD1(3), GOT1(2)	1508397	32	20	32	14	5	8	10	4	5	0	0.935	1.000	1.000
556	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(3), CHRNG(1), MUSK(4), PIK3CA(5), PIK3R1(1), PTK2(7), PTK2B(6), RAPSN(1), SRC(2), TERT(2)	3149793	32	19	31	13	8	8	8	5	3	0	0.756	1.000	1.000
557	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), ARPC3(1), NCK1(1), NCKAP1(2), NTRK1(6), PIR(2), WASF1(4), WASF3(2), WASL(4)	2968161	26	19	26	11	2	10	6	3	5	0	0.955	1.000	1.000
558	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), ARPC3(1), CDC42(2), PAK1(5), PDGFRA(7), PIK3CA(5), PIK3R1(1), WASL(4)	2592384	29	19	28	13	5	8	10	3	3	0	0.953	1.000	1.000
559	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(3), IL4R(5), IRS1(12), JAK1(5), JAK3(3), SHC1(2), STAT6(1)	2872314	31	19	31	11	8	6	7	9	1	0	0.617	1.000	1.000
560	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(5), ABCG2(3), BCHE(3), CES1(1), CYP3A4(1), UGT1A1(3), UGT1A10(3), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT1A9(4)	4405350	35	19	35	24	9	13	4	5	4	0	0.997	1.000	1.000
561	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3D(1), CD4(1), CXCR3(1), IFNG(3), IL12A(2), IL12RB1(2), IL12RB2(6), JAK2(2), STAT4(5), TYK2(2)	2852061	28	19	28	14	3	7	7	3	8	0	0.951	1.000	1.000
562	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(2), CASP3(4), CASP8(3), CFLAR(1), MAP2K4(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIE(1), NR2C2(1), RALBP1(1), RIPK1(3), TNFRSF1B(1)	5279712	31	19	31	10	8	7	7	3	6	0	0.551	1.000	1.000
563	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3D(1), CD8A(1), ITGAL(17), ITGB2(2), PTPRC(10)	2086962	34	19	34	12	8	10	8	2	6	0	0.647	1.000	1.000
564	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(5), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(1), NFATC2(5), PRKACB(2), PRKACG(1), PRKAR1B(4)	2368053	23	18	22	10	3	9	4	1	6	0	0.793	1.000	1.000
565	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(2), CALM1(1), GNAS(3), GNB1(1), GNGT1(1), NFKB1(2), NOS3(1), NPPA(1), NR3C1(1), PIK3CA(5), PIK3R1(1), SYT1(3)	3460554	22	18	21	12	3	8	7	2	2	0	0.970	1.000	1.000
566	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(7), FASN(1), OLAH(5), OXSM(5)	3092775	26	18	26	15	5	12	5	1	3	0	0.983	1.000	1.000
567	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(2), PIGB(1), PIGC(1), PIGG(5), PIGM(4), PIGN(1), PIGO(4), PIGQ(1), PIGS(1), PIGT(1), PIGV(2), PIGW(1), PIGX(1), PIGZ(1)	4649934	28	18	28	12	7	3	11	4	3	0	0.797	1.000	1.000
568	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACSL1(4), ACSL3(1), ACSL4(1), CPT1A(5), CPT2(2), DCI(2), EHHADH(3), HADHA(2), PECR(1), SCP2(3), SLC25A20(2)	3241641	29	18	29	13	4	11	4	6	3	1	0.914	1.000	1.000
569	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), AMT(2), ATIC(2), GART(1), MTHFD1(1), MTHFD1L(4), MTHFR(1), MTR(6), SHMT1(2), SHMT2(1)	3473712	24	18	24	13	8	6	4	1	4	1	0.946	1.000	1.000
570	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(2), FDXR(2), SHMT1(2)	3107610	29	18	29	10	9	6	8	4	2	0	0.623	1.000	1.000
571	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), GNAS(3), PLCE1(8), PRKACB(2), PRKACG(1), PRKAR1B(4)	2846127	26	18	26	11	2	12	6	3	3	0	0.906	1.000	1.000
572	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), CFTR(5), GNAS(3), PRKACB(2), PRKACG(1), PRKAR1B(4)	2522982	23	17	23	10	2	8	7	2	4	0	0.881	1.000	1.000
573	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), GOT1(2), GOT2(3), LDHA(3), LDHAL6A(3), LDHC(4), SULT1B1(4), SULT1C2(1), SULT1C4(1), SULT4A1(2)	2443260	25	17	25	14	6	9	8	1	1	0	0.980	1.000	1.000
574	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(3), GH1(2), GHR(1), HRAS(1), IGF1(3), IGF1R(6), PIK3CA(5), PIK3R1(1), SHC1(2), SOD2(1)	2548653	25	17	24	13	3	11	6	4	1	0	0.963	1.000	1.000
575	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(6), POLR2B(1), POLR2C(2), POLR2D(2), POLR2E(1), POLR2G(2), POLR2H(2), POLR2L(1), POLRMT(1)	2608896	26	17	25	12	6	5	8	3	4	0	0.900	1.000	1.000
576	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(3), IKBKB(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RIPK1(3), TANK(2), TNFRSF1B(1), TRAF3(1)	4338270	19	17	19	12	1	5	7	3	3	0	0.985	1.000	1.000
577	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	2919399	27	16	27	10	9	6	6	4	2	0	0.708	1.000	1.000
578	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	2919399	27	16	27	10	9	6	6	4	2	0	0.708	1.000	1.000
579	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAX(1), BCL10(1), BCL2(1), BCL2L11(2), BID(1), CASP8AP2(7), CASP9(2), CES1(1)	2207577	20	16	20	11	4	6	6	4	0	0	0.970	1.000	1.000
580	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(2), SHMT1(2)	2919399	27	16	27	10	9	6	6	4	2	0	0.708	1.000	1.000
581	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT1(3), B3GNT2(1), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(2), FUT3(1), FUT7(1), FUT9(1), GCNT2(1), ST3GAL6(1)	3121671	19	15	18	11	6	4	6	2	1	0	0.921	1.000	1.000
582	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(2), CRY1(3), CRY2(2), CSNK1D(1), CSNK1E(2), NR1D1(2), PER1(2), PER2(4), PER3(1)	3332973	21	15	21	11	7	8	3	0	3	0	0.947	1.000	1.000
583	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(4), BCL2(1), CASP3(4), CASP9(2), DAXX(2), FAS(2), FASLG(2), HSPB2(1), IL1A(2), MAPKAPK2(2), MAPKAPK3(1)	2192484	23	15	23	10	5	7	4	5	2	0	0.875	1.000	1.000
584	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(3), EIF2S3(1), EIF4E(2), GSK3B(1), IGF1(3), IGF1R(6), INPPL1(3), PIK3CA(5), PIK3R1(1), PTEN(3)	3817884	28	15	26	10	9	11	6	1	1	0	0.697	1.000	1.000
585	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(3), GNB1(1), GNGT1(1), PRKACB(2), PRKACG(1), PRKAR1B(4), PRKCA(7)	1854375	20	14	20	10	6	8	5	0	1	0	0.953	1.000	1.000
586	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(2), CHUK(1), GH1(2), GHR(1), NFKB1(2), PIK3CA(5), PIK3R1(1)	2704356	14	14	13	14	1	3	6	2	2	0	0.999	1.000	1.000
587	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA11(1), NDUFA4(1), NDUFA8(2), NDUFB2(3), NDUFB4(1), NDUFB5(2), NDUFS1(4), NDUFS2(3), NDUFV1(2)	1348695	20	14	20	10	4	5	3	1	7	0	0.922	1.000	1.000
588	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST3A1(1), XYLT1(13)	1297740	16	13	16	11	4	3	7	1	1	0	0.931	1.000	1.000
589	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST3A1(1), XYLT1(13)	1297740	16	13	16	11	4	3	7	1	1	0	0.931	1.000	1.000
590	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SEC22B(4), SNAP23(1), SNAP25(3), STX12(1), STX16(2), STX19(2), STX2(3), STX3(1), STX7(1), STX8(1), TSNARE1(1), VTI1A(1)	3273375	21	13	21	13	4	7	1	5	4	0	0.991	1.000	1.000
591	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(2), EP300(1), HDAC3(1), IKBKB(2), NFKB1(2), RIPK1(3), TNFRSF1B(1), TRAF6(3)	4346397	16	13	15	10	4	4	4	1	3	0	0.974	1.000	1.000
592	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(6), UBE2A(2), UBE2D2(1), UBE2D3(3), UBE2H(1), UBE2J1(1), UBE2J2(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE3A(2)	2037942	21	13	21	12	7	4	1	4	5	0	0.951	1.000	1.000
593	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(3), IKBKB(2), MAP3K1(3), MAP3K14(1), NFKB1(2), TRAF3(1), TRAF6(3)	3502092	16	12	15	13	3	3	6	1	3	0	0.997	1.000	1.000
594	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), FUT1(2), FUT9(1), GLA(2), HEXA(1), NAGA(2), ST3GAL1(2), ST3GAL2(2)	2066322	13	12	13	6	5	1	4	3	0	0	0.797	1.000	1.000
595	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(4)	1788069	16	12	16	8	1	3	9	3	0	0	0.863	1.000	1.000
596	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(1), CDK7(2), CHEK1(6), NEK1(3), WEE1(1)	1393329	15	12	15	6	0	7	4	4	0	0	0.872	1.000	1.000
597	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(2), FUT9(1), GLA(2), HEXA(1), NAGA(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(1)	1946739	13	11	13	6	5	1	4	3	0	0	0.777	1.000	1.000
598	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR109B(1), GPR18(1), GPR34(1), GPR39(2), GPR45(3), GPR65(2), GPR75(1)	1886238	12	11	12	10	1	1	6	3	1	0	0.986	1.000	1.000
599	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), COPS5(1), EP300(1), EPO(1), HIF1A(1), LDHA(3), NOS3(1), P4HB(2), VHL(1)	3323298	14	11	14	11	1	7	1	0	4	1	0.999	1.000	1.000
600	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL2(3), ELOVL6(1), FASN(1), HADHA(2), HSD17B12(1), PECR(1)	2790399	15	11	15	10	4	4	4	1	1	1	0.939	1.000	1.000
601	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(1), GOT1(2), GOT2(3), PAH(1), TAT(2), YARS(1), YARS2(2)	1687449	14	10	14	6	5	6	3	0	0	0	0.757	1.000	1.000
602	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(2), CDC25B(1), GRB2(3), PRKCA(7), PTPRA(2), SRC(2)	1779297	18	10	18	10	5	9	2	2	0	0	0.951	1.000	1.000
603	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(2), TNFRSF13B(1), TNFSF13B(1), TRAF3(1), TRAF5(1), TRAF6(3)	2818521	15	10	14	13	5	2	5	0	3	0	0.996	1.000	1.000
604	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGTR1(1), AGTR2(2), NOS3(1)	1945191	11	9	11	10	1	3	7	0	0	0	0.985	1.000	1.000
605	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), EPO(1), GRIN1(1), HIF1A(1), JAK2(2), NFKB1(2), SOD2(1)	2469447	10	9	10	10	2	2	2	1	3	0	0.998	1.000	1.000
606	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(2), SDHA(5), SDHD(1)	1278519	10	9	10	7	2	1	6	1	0	0	0.964	1.000	1.000
607	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT2A1(1), SUOX(4)	1178544	10	9	10	6	1	2	6	1	0	0	0.927	1.000	1.000
608	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(1), FARS2(1), GOT1(2), GOT2(3), PAH(1), TAT(2), YARS(1)	1602051	12	8	12	8	4	5	2	1	0	0	0.942	1.000	1.000
609	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(2), NR1H4(3)	1057284	6	5	6	5	1	0	4	1	0	0	0.949	1.000	1.000
610	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST3GAL2(2), ST3GAL4(1)	1098306	5	5	5	6	2	0	3	0	0	0	0.978	1.000	1.000
611	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(2), IL5RA(1)	1027743	5	5	5	4	0	1	1	3	0	0	0.975	1.000	1.000
612	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	354234	2	2	2	2	0	1	0	1	0	0	0.952	1.000	1.000
613	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB4A(1), RAB5A(1)	827793	2	2	2	3	0	1	1	0	0	0	0.989	1.000	1.000
614	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	139836	1	1	1	2	1	0	0	0	0	0	0.989	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		404544	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		327789	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000