Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.186 0.298 -9999.0 0.0 -0.702 15.0 15.0 IHH -0.199 0.302 -9999.0 0.0 -0.653 24.0 24.0 SHH Np/Cholesterol/GAS1 -0.109 0.184 -9999.0 0.0 -0.448 14.0 14.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.182 0.444 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.138 0.246 -9999.0 0.0 -0.647 10.0 10.0 SMO -0.152 0.26 -9999.0 0.0 -0.647 12.0 12.0 AKT1 -0.048 0.108 -9999.0 0.0 -0.339 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.114 -9999.0 0.0 -0.722 2.0 2.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.149 0.254 -9999.0 0.0 -0.592 15.0 15.0 STIL -0.153 0.246 -9999.0 0.0 -0.663 10.0 10.0 DHH N/PTCH2 -0.047 0.145 -9999.0 0.0 -0.48 8.0 8.0 DHH N/PTCH1 -0.136 0.204 -9999.0 0.0 -0.545 8.0 8.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.121 -9999.0 0.0 -0.625 3.0 3.0 PTHLH -0.238 0.389 -9999.0 0.0 -0.924 14.0 14.0 determination of left/right symmetry -0.149 0.254 -9999.0 0.0 -0.592 15.0 15.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.235 0.382 -9999.0 0.0 -0.907 14.0 14.0 IHH N/Hhip -0.255 0.296 -9999.0 0.0 -0.541 39.0 39.0 DHH N/Hhip -0.15 0.233 -9999.0 0.0 -0.507 24.0 24.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.149 0.254 -9999.0 0.0 -0.592 15.0 15.0 pancreas development -0.17 0.307 -9999.0 0.0 -0.686 21.0 21.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.054 0.198 -9999.0 0.0 -0.649 8.0 8.0 somite specification -0.149 0.254 -9999.0 0.0 -0.592 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.168 0.259 -9999.0 0.0 -0.662 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.096 0.169 -9999.0 0.0 -0.387 20.0 20.0 SHH Np/Cholesterol/Megalin -0.21 0.26 -9999.0 0.0 -0.533 26.0 26.0 SHH -0.077 0.204 -9999.0 0.0 -0.501 15.0 15.0 catabolic process -0.144 0.221 -9999.0 0.0 -0.51 15.0 15.0 SMO/Vitamin D3 -0.173 0.277 -9999.0 0.0 -0.732 11.0 11.0 SHH Np/Cholesterol/Hhip -0.175 0.225 -9999.0 0.0 -0.467 25.0 25.0 LRP2 -0.233 0.33 -9999.0 0.0 -0.672 29.0 29.0 receptor-mediated endocytosis -0.271 0.288 -9999.0 0.0 -0.71 19.0 19.0 SHH Np/Cholesterol/BOC -0.083 0.162 -9999.0 0.0 -0.426 12.0 12.0 SHH Np/Cholesterol/CDO -0.087 0.164 -9999.0 0.0 -0.426 12.0 12.0 mesenchymal cell differentiation 0.174 0.223 0.463 25.0 -9999.0 0.0 25.0 mol:Vitamin D3 -0.168 0.261 -9999.0 0.0 -0.664 12.0 12.0 IHH N/PTCH2 -0.147 0.218 -9999.0 0.0 -0.428 29.0 29.0 CDON -0.014 0.13 -9999.0 0.0 -0.673 3.0 3.0 IHH N/PTCH1 -0.146 0.223 -9999.0 0.0 -0.516 15.0 15.0 Megalin/LRPAP1 -0.179 0.242 -9999.0 0.0 -0.499 29.0 29.0 PTCH2 -0.03 0.163 -9999.0 0.0 -0.664 5.0 5.0 SHH Np/Cholesterol -0.073 0.156 -9999.0 0.0 -0.397 15.0 15.0 PTCH1 -0.144 0.221 -9999.0 0.0 -0.512 15.0 15.0 HHIP -0.17 0.308 -9999.0 0.0 -0.687 21.0 21.0