Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.074 0.196 -9999.0 0.0 -0.603 8.0 8.0 IHH -0.055 0.153 -9999.0 0.0 -0.444 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.019 0.086 -9999.0 0.0 -0.239 10.0 10.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.019 0.085 0.238 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.05 0.176 -9999.0 0.0 -0.505 6.0 6.0 SMO -0.072 0.172 -9999.0 0.0 -0.429 12.0 12.0 AKT1 -0.017 0.107 -9999.0 0.0 -0.455 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.071 -9999.0 0.0 -0.431 2.0 2.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.064 0.174 -9999.0 0.0 -0.423 12.0 12.0 STIL -0.051 0.14 -9999.0 0.0 -0.39 5.0 5.0 DHH N/PTCH2 0.016 0.078 -9999.0 0.0 -0.31 4.0 4.0 DHH N/PTCH1 -0.035 0.129 -9999.0 0.0 -0.289 14.0 14.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.018 0.054 -9999.0 0.0 -0.431 1.0 1.0 PTHLH -0.103 0.267 -9999.0 0.0 -0.774 9.0 9.0 determination of left/right symmetry -0.064 0.174 -9999.0 0.0 -0.423 12.0 12.0 PIK3R1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.102 0.264 -9999.0 0.0 -0.765 9.0 9.0 IHH N/Hhip -0.081 0.172 -9999.0 0.0 -0.34 23.0 23.0 DHH N/Hhip -0.043 0.14 -9999.0 0.0 -0.309 17.0 17.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.064 0.174 -9999.0 0.0 -0.423 12.0 12.0 pancreas development -0.071 0.181 -9999.0 0.0 -0.43 16.0 16.0 HHAT 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.003 0.101 -9999.0 0.0 -0.431 4.0 4.0 somite specification -0.064 0.174 -9999.0 0.0 -0.423 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.063 0.13 -9999.0 0.0 -0.321 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.017 0.085 -9999.0 0.0 -0.238 10.0 10.0 SHH Np/Cholesterol/Megalin -0.066 0.135 -9999.0 0.0 -0.286 20.0 20.0 SHH -0.043 0.089 -9999.0 0.0 -0.31 8.0 8.0 catabolic process -0.052 0.137 -9999.0 0.0 -0.314 16.0 16.0 SMO/Vitamin D3 -0.061 0.169 -9999.0 0.0 -0.467 6.0 6.0 SHH Np/Cholesterol/Hhip -0.058 0.122 -9999.0 0.0 -0.259 20.0 20.0 LRP2 -0.095 0.19 -9999.0 0.0 -0.431 19.0 19.0 receptor-mediated endocytosis -0.108 0.192 -9999.0 0.0 -0.468 12.0 12.0 SHH Np/Cholesterol/BOC -0.016 0.086 -9999.0 0.0 -0.238 10.0 10.0 SHH Np/Cholesterol/CDO -0.013 0.082 -9999.0 0.0 -0.238 9.0 9.0 mesenchymal cell differentiation 0.058 0.121 0.258 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 -0.043 0.15 -9999.0 0.0 -0.333 9.0 9.0 IHH N/PTCH2 -0.016 0.122 -9999.0 0.0 -0.303 11.0 11.0 CDON 0.014 0.072 -9999.0 0.0 -0.431 2.0 2.0 IHH N/PTCH1 -0.041 0.143 -9999.0 0.0 -0.316 16.0 16.0 Megalin/LRPAP1 -0.056 0.144 -9999.0 0.0 -0.309 19.0 19.0 PTCH2 0.007 0.088 -9999.0 0.0 -0.431 3.0 3.0 SHH Np/Cholesterol -0.016 0.074 -9999.0 0.0 -0.234 8.0 8.0 PTCH1 -0.052 0.137 -9999.0 0.0 -0.315 16.0 16.0 HHIP -0.071 0.181 -9999.0 0.0 -0.431 16.0 16.0