Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	11.0	1048.0	91.0	-0.633	0.583	1000.0	-1000.0	-0.129	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	545.0	46.0	-0.395	0.038	1000.0	-1000.0	-0.107	-1000.0
Signaling events mediated by the Hedgehog family	9.0	469.0	52.0	-0.108	0.058	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	435.0	44.0	-0.11	0.027	1000.0	-1000.0	-0.016	-1000.0
Syndecan-4-mediated signaling events	7.0	487.0	67.0	-0.126	0.031	1000.0	-1000.0	-0.041	-1000.0
Osteopontin-mediated events	6.0	265.0	38.0	-0.09	0.036	1000.0	-1000.0	-0.041	-1000.0
HIF-1-alpha transcription factor network	6.0	489.0	76.0	-0.246	0.035	1000.0	-1000.0	-0.114	-1000.0
Endothelins	6.0	636.0	96.0	-0.091	0.048	1000.0	-1000.0	-0.044	-1000.0
EGFR-dependent Endothelin signaling events	6.0	129.0	21.0	-0.052	0.036	1000.0	-1000.0	-0.037	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	200.0	34.0	-0.029	0.028	1000.0	-1000.0	-0.029	-1000.0
Syndecan-1-mediated signaling events	5.0	202.0	34.0	-0.065	0.027	1000.0	-1000.0	-0.035	-1000.0
Thromboxane A2 receptor signaling	5.0	546.0	105.0	-0.071	0.034	1000.0	-1000.0	-0.041	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	528.0	97.0	-0.096	0.027	1000.0	-1000.0	-0.052	-1000.0
TCGA08_p53	5.0	36.0	7.0	-0.017	0.021	1000.0	-1000.0	-0.012	-1000.0
TCGA08_retinoblastoma	5.0	45.0	8.0	-0.023	0.061	1000.0	-1000.0	-0.006	-1000.0
IL23-mediated signaling events	5.0	347.0	60.0	-0.241	0.027	1000.0	-1000.0	-0.114	-1000.0
Arf6 signaling events	4.0	281.0	62.0	-0.052	0.048	1000.0	-1000.0	-0.044	-1000.0
BMP receptor signaling	4.0	351.0	81.0	-0.107	0.051	1000.0	-1000.0	-0.032	-1000.0
amb2 Integrin signaling	4.0	394.0	82.0	-0.116	0.041	1000.0	-1000.0	-0.032	-1000.0
Nectin adhesion pathway	4.0	306.0	63.0	-0.09	0.058	1000.0	-1000.0	-0.051	-1000.0
Glucocorticoid receptor regulatory network	4.0	533.0	114.0	-0.293	0.103	1000.0	-1000.0	-0.062	-1000.0
Ephrin B reverse signaling	4.0	196.0	48.0	-0.053	0.03	1000.0	-1000.0	-0.024	-1000.0
S1P1 pathway	4.0	152.0	36.0	-0.13	0.027	1000.0	-1000.0	-0.039	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	464.0	93.0	-0.045	0.039	1000.0	-1000.0	-0.043	-1000.0
Effects of Botulinum toxin	4.0	107.0	26.0	-0.05	0.026	1000.0	-1000.0	-0.004	-1000.0
Glypican 2 network	4.0	16.0	4.0	0.005	0.009	1000.0	-1000.0	0.012	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	145.0	31.0	-0.129	0.027	1000.0	-1000.0	-0.047	-1000.0
IL6-mediated signaling events	4.0	305.0	75.0	-0.319	0.05	1000.0	-1000.0	-0.068	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	332.0	68.0	-0.18	0.042	1000.0	-1000.0	-0.086	-1000.0
Visual signal transduction: Rods	4.0	251.0	52.0	-0.096	0.038	1000.0	-1000.0	-0.031	-1000.0
IL12-mediated signaling events	3.0	335.0	87.0	-0.089	0.035	1000.0	-1000.0	-0.062	-1000.0
Noncanonical Wnt signaling pathway	3.0	81.0	26.0	-0.038	0.027	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PTP1B	3.0	295.0	76.0	-0.089	0.044	1000.0	-1000.0	-0.034	-1000.0
p75(NTR)-mediated signaling	3.0	499.0	125.0	-0.057	0.063	1000.0	-1000.0	-0.059	-1000.0
Reelin signaling pathway	3.0	194.0	56.0	-0.085	0.05	1000.0	-1000.0	-0.031	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	285.0	82.0	-0.035	0.038	1000.0	-1000.0	-0.044	-1000.0
Integrins in angiogenesis	3.0	325.0	84.0	-0.047	0.059	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	3.0	315.0	85.0	-0.071	0.052	1000.0	-1000.0	-0.058	-1000.0
IL27-mediated signaling events	3.0	178.0	51.0	-0.078	0.07	1000.0	-1000.0	-0.054	-1000.0
Wnt signaling	3.0	23.0	7.0	-0.024	0.026	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	3.0	354.0	102.0	-0.037	0.042	1000.0	-1000.0	-0.059	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	227.0	74.0	-0.067	0.054	1000.0	-1000.0	-0.05	-1000.0
BCR signaling pathway	3.0	373.0	99.0	-0.087	0.038	1000.0	-1000.0	-0.045	-1000.0
Plasma membrane estrogen receptor signaling	3.0	272.0	86.0	-0.08	0.076	1000.0	-1000.0	-0.041	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	460.0	120.0	-0.079	0.065	1000.0	-1000.0	-0.037	-1000.0
FOXM1 transcription factor network	3.0	180.0	51.0	-0.103	0.04	1000.0	-1000.0	-0.131	-1000.0
S1P4 pathway	3.0	77.0	25.0	-0.023	0.039	1000.0	-1000.0	-0.024	-1000.0
ErbB2/ErbB3 signaling events	2.0	176.0	65.0	-0.05	0.036	1000.0	-1000.0	-0.055	-1000.0
Caspase cascade in apoptosis	2.0	165.0	74.0	-0.038	0.061	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Cones	2.0	97.0	38.0	-0.038	0.042	1000.0	-1000.0	-0.027	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	133.0	54.0	-0.056	0.038	1000.0	-1000.0	-0.032	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	40.0	17.0	-0.018	0.043	1000.0	-1000.0	-0.027	-1000.0
Syndecan-2-mediated signaling events	2.0	150.0	69.0	-0.043	0.044	1000.0	-1000.0	-0.041	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	204.0	85.0	-0.031	0.041	1000.0	-1000.0	-0.038	-1000.0
Glypican 1 network	2.0	113.0	48.0	-0.056	0.049	1000.0	-1000.0	-0.026	-1000.0
mTOR signaling pathway	2.0	128.0	53.0	-0.083	0.029	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	2.0	201.0	76.0	-0.052	0.066	1000.0	-1000.0	-0.038	-1000.0
IL1-mediated signaling events	2.0	164.0	62.0	-0.051	0.056	1000.0	-1000.0	-0.037	-1000.0
S1P5 pathway	2.0	48.0	17.0	-0.016	0.027	1000.0	-1000.0	-0.01	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	135.0	52.0	-0.028	0.061	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	2.0	127.0	43.0	-0.047	0.049	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	2.0	112.0	47.0	-0.028	0.04	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	108.0	45.0	-0.026	0.065	1000.0	-1000.0	-0.053	-1000.0
Canonical Wnt signaling pathway	2.0	137.0	51.0	-0.081	0.054	1000.0	-1000.0	-0.04	-1000.0
Regulation of p38-alpha and p38-beta	2.0	114.0	54.0	-0.054	0.055	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	271.0	125.0	-0.024	0.057	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events	2.0	179.0	73.0	-0.072	0.049	1000.0	-1000.0	-0.033	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	212.0	88.0	-0.062	0.031	1000.0	-1000.0	-0.065	-1000.0
PDGFR-beta signaling pathway	2.0	231.0	97.0	-0.089	0.062	1000.0	-1000.0	-0.051	-1000.0
Aurora B signaling	2.0	153.0	67.0	-0.11	0.045	1000.0	-1000.0	-0.03	-1000.0
LPA4-mediated signaling events	1.0	16.0	12.0	-0.029	0.024	1000.0	-1000.0	-0.021	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	175.0	136.0	-0.184	0.07	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	1.0	104.0	76.0	-0.038	0.049	1000.0	-1000.0	-0.035	-1000.0
ErbB4 signaling events	1.0	125.0	69.0	-0.124	0.039	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	1.0	61.0	57.0	-0.05	0.063	1000.0	-1000.0	-0.034	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	54.0	28.0	-0.026	0.039	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	1.0	13.0	7.0	-0.0	0.02	1000.0	-1000.0	-0.004	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	0.016	0.03	1000.0	-1000.0	0.012	-1000.0
Cellular roles of Anthrax toxin	1.0	67.0	39.0	-0.041	0.033	1000.0	-1000.0	-0.019	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	100.0	65.0	-0.084	0.062	1000.0	-1000.0	-0.05	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	115.0	61.0	-0.081	0.058	1000.0	-1000.0	-0.037	-1000.0
Arf6 downstream pathway	1.0	64.0	43.0	-0.029	0.042	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	1.0	167.0	85.0	-0.016	0.045	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	1.0	50.0	44.0	-0.019	0.049	1000.0	-1000.0	-0.03	-1000.0
IFN-gamma pathway	1.0	110.0	68.0	-0.026	0.043	1000.0	-1000.0	-0.048	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	57.0	37.0	-0.028	0.058	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	1.0	60.0	48.0	-0.018	0.054	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	1.0	73.0	49.0	-0.006	0.035	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.012	0.026	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	1.0	84.0	58.0	-0.02	0.051	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	39.0	36.0	-0.045	0.047	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by PI3K	1.0	88.0	58.0	-0.021	0.045	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	1.0	77.0	52.0	-0.019	0.042	1000.0	-1000.0	-0.025	-1000.0
TCGA08_rtk_signaling	1.0	46.0	26.0	-0.015	0.056	1000.0	-1000.0	-0.008	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	105.0	76.0	-0.014	0.058	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	1.0	32.0	22.0	-0.057	0.032	1000.0	-1000.0	-0.043	-1000.0
Arf6 trafficking events	1.0	73.0	71.0	-0.04	0.047	1000.0	-1000.0	-0.028	-1000.0
Regulation of Telomerase	1.0	137.0	102.0	-0.076	0.062	1000.0	-1000.0	-0.045	-1000.0
IGF1 pathway	1.0	98.0	57.0	-0.019	0.053	1000.0	-1000.0	-0.038	-1000.0
Insulin Pathway	1.0	112.0	74.0	-0.062	0.062	1000.0	-1000.0	-0.049	-1000.0
VEGFR1 specific signals	1.0	69.0	56.0	-0.025	0.054	1000.0	-1000.0	-0.043	-1000.0
S1P3 pathway	1.0	61.0	42.0	-0.023	0.042	1000.0	-1000.0	-0.035	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	58.0	33.0	-0.017	0.07	1000.0	-1000.0	-0.025	-1000.0
E-cadherin signaling in keratinocytes	1.0	84.0	43.0	-0.027	0.045	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	144.0	78.0	-0.031	0.048	1000.0	-1000.0	-0.056	-1000.0
Regulation of Androgen receptor activity	1.0	126.0	70.0	-0.082	0.033	1000.0	-1000.0	-0.042	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	24.0	17.0	0.0	0.046	1000.0	-1000.0	-0.022	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.0	0.044	1000.0	-1000.0	-0.021	-1000.0
Canonical NF-kappaB pathway	0.0	15.0	39.0	-0.009	0.055	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class II	0.0	20.0	75.0	-0.028	0.068	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.015	0.028	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.007	0.047	1000.0	-1000.0	-0.031	-1000.0
Aurora A signaling	0.0	47.0	60.0	-0.018	0.048	1000.0	-1000.0	-0.022	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.008	-1000.0
EPO signaling pathway	0.0	35.0	55.0	-0.006	0.062	1000.0	-1000.0	-0.04	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.011	0.047	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	60.0	68.0	-0.036	0.056	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	0.0	28.0	40.0	-0.048	0.049	1000.0	-1000.0	-0.025	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	74.0	83.0	-0.008	0.053	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	59.0	104.0	-0.044	0.062	1000.0	-1000.0	-0.03	-1000.0
FoxO family signaling	0.0	57.0	64.0	-0.062	0.049	1000.0	-1000.0	-0.053	-1000.0
Atypical NF-kappaB pathway	0.0	19.0	31.0	-0.01	0.038	1000.0	-1000.0	-0.024	-1000.0
Syndecan-3-mediated signaling events	0.0	18.0	35.0	-0.015	0.058	1000.0	-1000.0	-0.022	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.01	0.052	1000.0	-1000.0	-0.032	-1000.0
Rapid glucocorticoid signaling	0.0	14.0	20.0	-0.005	0.034	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by PRL	0.0	22.0	34.0	-0.041	0.05	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.024	0.024	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling events	0.0	3.0	5.0	0.02	0.045	1000.0	-1000.0	0.015	-1000.0
p38 MAPK signaling pathway	0.0	33.0	44.0	-0.015	0.046	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	0.0	30.0	54.0	-0.003	0.04	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.066	1000.0	-1000.0	-0.0	-1000.0
Total	296	21587	7203	-8.07323860904	6.51763775259	131000	-131000	-4.88329710399	-131000