EPO signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 0.029 0.06 -9999.0 0.0 -9999.0 0.0 0.0 CRKL -0.022 0.067 -9999.0 0.0 -9999.0 0.0 0.0 mol:DAG 0.036 0.044 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.008 0.127 0.264 1.0 -0.269 1.0 2.0 MAPK8 -0.023 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A -0.022 0.067 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 -0.023 0.072 -9999.0 0.0 -9999.0 0.0 0.0 MAPK14 -0.021 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.033 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.036 0.045 -9999.0 0.0 -9999.0 0.0 0.0 EPOR/TRPC2/IP3 Receptors 0.036 0.024 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR (dimer)/SOCS3 0.059 0.079 -9999.0 0.0 -0.214 1.0 1.0 GAB1/SHC/GRB2/SOS1 0.006 0.095 -9999.0 0.0 -0.277 1.0 1.0 EPO/EPOR (dimer) 0.054 0.034 -9999.0 0.0 -9999.0 0.0 0.0 IRS2 -0.015 0.058 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 0.041 0.042 -9999.0 0.0 -9999.0 0.0 0.0 STAT5B 0.043 0.042 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.015 0.052 0.164 1.0 -9999.0 0.0 1.0 GAB1/SHIP/PIK3R1/SHP2/SHC 0.006 0.059 -9999.0 0.0 -9999.0 0.0 0.0 TEC -0.022 0.067 -9999.0 0.0 -9999.0 0.0 0.0 SOCS3 0.011 0.096 -9999.0 0.0 -0.332 1.0 1.0 STAT1 (dimer) 0.04 0.041 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.031 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR (dimer)/JAK2 0.06 0.093 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR 0.054 0.034 -9999.0 0.0 -9999.0 0.0 0.0 LYN 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TEC/VAV2 0.021 0.073 -9999.0 0.0 -9999.0 0.0 0.0 elevation of cytosolic calcium ion concentration 0.036 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.026 0.019 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR (dimer)/LYN 0.085 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.036 0.044 -9999.0 0.0 -9999.0 0.0 0.0 PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.015 0.067 -9999.0 0.0 -9999.0 0.0 0.0 SH2B3 0.009 0.098 -9999.0 0.0 -0.333 1.0 1.0 NFKB1 -0.023 0.019 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR (dimer)/JAK2/SOCS3 0.007 0.094 0.209 1.0 -0.188 2.0 3.0 PTPN6 -0.023 0.066 -9999.0 0.0 -9999.0 0.0 0.0 TEC/VAV2/GRB2 0.027 0.106 -9999.0 0.0 -0.28 1.0 1.0 EPOR 0.036 0.024 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.005 0.095 -9999.0 0.0 -0.278 1.0 1.0 SOS1 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG2 0.011 0.096 -9999.0 0.0 -0.332 1.0 1.0 CRKL/CBL/C3G 0.041 0.07 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 -0.013 0.059 -9999.0 0.0 -9999.0 0.0 0.0 CBL -0.011 0.059 -9999.0 0.0 -9999.0 0.0 0.0 SHC/Grb2/SOS1 0.01 0.1 -9999.0 0.0 -0.28 1.0 1.0 STAT5A 0.043 0.042 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.014 0.096 -9999.0 0.0 -0.332 1.0 1.0 STAT5 (dimer) 0.062 0.055 -9999.0 0.0 -9999.0 0.0 0.0 LYN/PLCgamma2 0.052 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BTK -0.042 0.108 -9999.0 0.0 -0.279 2.0 2.0 BCL2 0.044 0.035 -9999.0 0.0 -9999.0 0.0 0.0