Caspase cascade in apoptosis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TOP1 -0.005 0.115 -9999.0 0.0 -0.297 1.0 1.0 ACTA1 0.008 0.078 0.177 1.0 -9999.0 0.0 1.0 NUMA1 0.009 0.114 -9999.0 0.0 -0.348 1.0 1.0 SPTAN1 0.002 0.072 -9999.0 0.0 -9999.0 0.0 0.0 LIMK1 -0.005 0.076 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.024 0.127 -9999.0 0.0 -0.332 2.0 2.0 BIRC2 0.032 0.017 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CASP10 -0.016 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CRMA -0.0 0.0 -9999.0 0.0 -0.001 1.0 1.0 XIAP -0.0 0.001 -9999.0 0.0 -0.001 3.0 3.0 PTK2 0.007 0.114 -9999.0 0.0 -0.348 1.0 1.0 DIABLO 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 apoptotic nuclear changes -0.003 0.074 -9999.0 0.0 -9999.0 0.0 0.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GSN 0.002 0.072 -9999.0 0.0 -9999.0 0.0 0.0 MADD 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 TFAP2A 0.042 0.041 -9999.0 0.0 -9999.0 0.0 0.0 BID 0.003 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 -0.011 0.141 -9999.0 0.0 -0.501 1.0 1.0 TRADD 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 0.056 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:Activated DNA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIB -0.015 0.094 -9999.0 0.0 -0.234 1.0 1.0 CASP9 0.041 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DNA repair -0.015 0.072 -9999.0 0.0 -0.165 1.0 1.0 neuron apoptosis -0.006 0.168 -9999.0 0.0 -0.613 1.0 1.0 mol:NAD 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA fragmentation during apoptosis -0.0 0.106 -9999.0 0.0 -0.298 1.0 1.0 APAF1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 -0.027 0.238 -9999.0 0.0 -0.878 1.0 1.0 TRAF2 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ICAD/CAD -0.011 0.073 -9999.0 0.0 -9999.0 0.0 0.0 CASP7 -0.011 0.119 0.212 2.0 -9999.0 0.0 2.0 KRT18 -0.016 0.135 -9999.0 0.0 -0.48 1.0 1.0 apoptosis -0.04 0.14 -9999.0 0.0 -0.504 1.0 1.0 DFFA -0.005 0.076 -9999.0 0.0 -9999.0 0.0 0.0 DFFB -0.005 0.076 -9999.0 0.0 -9999.0 0.0 0.0 PARP1 0.015 0.072 0.166 1.0 -9999.0 0.0 1.0 actin filament polymerization -0.041 0.121 -9999.0 0.0 -0.346 1.0 1.0 TNF 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CYCS 0.033 0.049 0.141 1.0 -9999.0 0.0 1.0 SATB1 -0.041 0.219 -9999.0 0.0 -0.823 1.0 1.0 SLK -0.005 0.076 -9999.0 0.0 -9999.0 0.0 0.0 p15 BID/BAX 0.028 0.042 -9999.0 0.0 -9999.0 0.0 0.0 CASP2 0.005 0.072 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade 0.013 0.14 0.497 1.0 -9999.0 0.0 1.0 CASP3 0.003 0.081 0.195 1.0 -9999.0 0.0 1.0 LMNB2 -0.026 0.236 -9999.0 0.0 -0.865 1.0 1.0 RIPK1 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP4 0.008 0.095 -9999.0 0.0 -0.332 1.0 1.0 Mammalian IAPs/DIABLO 0.025 0.087 -9999.0 0.0 -0.174 2.0 2.0 negative regulation of DNA binding 0.042 0.04 -9999.0 0.0 -9999.0 0.0 0.0 stress fiber formation -0.004 0.075 -9999.0 0.0 -9999.0 0.0 0.0 GZMB -0.015 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CASP1 -0.024 0.144 -9999.0 0.0 -0.541 1.0 1.0 LMNB1 -0.048 0.247 -9999.0 0.0 -0.587 2.0 2.0 APP -0.007 0.17 -9999.0 0.0 -0.62 1.0 1.0 TNFRSF1A 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 response to stress 0.0 0.0 0.001 2.0 -9999.0 0.0 2.0 CASP8 -0.01 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VIM -0.034 0.145 -9999.0 0.0 -0.52 1.0 1.0 LMNA -0.02 0.132 -9999.0 0.0 -0.322 2.0 2.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD -0.001 0.067 -9999.0 0.0 -9999.0 0.0 0.0 LRDD 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SREBF1 0.009 0.066 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Caspase 9 0.044 0.038 -9999.0 0.0 -9999.0 0.0 0.0 nuclear fragmentation during apoptosis 0.009 0.113 -9999.0 0.0 -0.343 1.0 1.0 CFL2 0.036 0.122 0.347 1.0 -9999.0 0.0 1.0 GAS2 -0.005 0.081 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of apoptosis -0.042 0.24 -9999.0 0.0 -0.556 2.0 2.0 PRF1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0