Sphingosine 1-phosphate (S1P) pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SPHK1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GNAI2 0.011 0.096 -9999.0 0.0 -0.332 1.0 1.0 mol:S1P 0.002 0.062 -9999.0 0.0 -0.215 1.0 1.0 GNAO1 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:Sphinganine-1-P -0.015 0.02 -9999.0 0.0 -9999.0 0.0 0.0 growth factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1P/S1P2/G12/G13 0.037 0.074 -9999.0 0.0 -0.17 1.0 1.0 GNAI3 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/G13 0.056 0.016 -9999.0 0.0 -9999.0 0.0 0.0 S1PR3 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1PR2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P -0.011 0.055 -9999.0 0.0 -0.183 1.0 1.0 S1PR5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1PR4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.013 0.13 -9999.0 0.0 -0.332 2.0 2.0 S1P/S1P5/G12 0.019 0.067 -9999.0 0.0 -0.173 1.0 1.0 S1P/S1P3/Gq -0.015 0.114 -9999.0 0.0 -0.265 2.0 2.0 S1P/S1P4/Gi -0.022 0.11 -9999.0 0.0 -0.276 2.0 2.0 GNAQ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA14 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 GNA15 0.011 0.096 -9999.0 0.0 -0.332 1.0 1.0 GNA12 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ABCC1 0.008 0.095 -9999.0 0.0 -0.332 1.0 1.0