HIF-2-alpha transcription factor network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MMP14 0.032 0.032 -9999.0 0.0 -9999.0 0.0 0.0 oxygen homeostasis -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 TCEB2 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCEB1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 VHL/Elongin B/Elongin C/HIF2A 0.079 0.105 0.268 1.0 -9999.0 0.0 1.0 EPO 0.013 0.137 -9999.0 0.0 -0.349 1.0 1.0 FIH (dimer) 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0 APEX1 0.007 0.042 -9999.0 0.0 -9999.0 0.0 0.0 SERPINE1 0.031 0.213 0.444 1.0 -0.545 1.0 2.0 FLT1 -0.033 0.188 -9999.0 0.0 -0.689 1.0 1.0 ADORA2A 0.037 0.178 0.443 1.0 -0.363 1.0 2.0 germ cell development 0.023 0.165 0.44 1.0 -0.363 1.0 2.0 SLC11A2 0.044 0.182 0.444 1.0 -0.373 1.0 2.0 BHLHE40 -0.016 0.115 -9999.0 0.0 -0.368 1.0 1.0 HIF1AN 0.023 0.039 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT/SIRT1 0.024 0.105 -9999.0 0.0 -9999.0 0.0 0.0 ETS1 0.033 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CITED2 -0.169 0.342 -9999.0 0.0 -0.745 3.0 3.0 KDR -0.046 0.257 -9999.0 0.0 -0.962 1.0 1.0 PGK1 0.005 0.143 -9999.0 0.0 -0.373 1.0 1.0 SIRT1 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to hypoxia 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT 0.008 0.153 -9999.0 0.0 -0.41 1.0 1.0 EPAS1 0.012 0.103 0.255 1.0 -9999.0 0.0 1.0 SP1 0.045 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABCG2 -0.002 0.163 -9999.0 0.0 -0.36 1.0 1.0 EFNA1 0.008 0.144 -9999.0 0.0 -0.373 1.0 1.0 FXN 0.038 0.175 0.369 2.0 -0.349 1.0 3.0 POU5F1 0.022 0.168 0.444 1.0 -0.373 1.0 2.0 neuron apoptosis -0.007 0.15 0.402 1.0 -9999.0 0.0 1.0 EP300 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGLN3 -0.005 0.094 -9999.0 0.0 -0.327 1.0 1.0 EGLN2 0.025 0.036 -9999.0 0.0 -9999.0 0.0 0.0 EGLN1 0.023 0.036 -9999.0 0.0 -9999.0 0.0 0.0 VHL/Elongin B/Elongin C 0.076 0.021 -9999.0 0.0 -9999.0 0.0 0.0 VHL 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.007 0.036 -9999.0 0.0 -9999.0 0.0 0.0 SLC2A1 0.037 0.178 0.369 2.0 -0.363 1.0 3.0 TWIST1 0.005 0.137 -9999.0 0.0 -0.363 1.0 1.0 ELK1 0.014 0.058 -9999.0 0.0 -0.121 2.0 2.0 HIF2A/ARNT/Cbp/p300 0.031 0.115 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA 0.044 0.182 0.444 1.0 -0.373 1.0 2.0 CREBBP 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0