IL2 signaling events mediated by PI3K Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.041 0.145 -9999.0 0.0 -9999.0 0.0 0.0 UGCG -0.031 0.209 -9999.0 0.0 -0.773 1.0 1.0 AKT1/mTOR/p70S6K/Hsp90/TERT 0.026 0.132 -9999.0 0.0 -0.322 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:glucosylceramide -0.028 0.206 -9999.0 0.0 -0.761 1.0 1.0 mol:DAG 0.025 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CaM/Ca2+/Calcineurin A alpha-beta B1 -0.013 0.174 -9999.0 0.0 -0.408 2.0 2.0 FRAP1 -0.013 0.199 -9999.0 0.0 -0.46 2.0 2.0 FOXO3 -0.017 0.165 -9999.0 0.0 -0.385 2.0 2.0 AKT1 -0.007 0.176 -9999.0 0.0 -0.403 2.0 2.0 GAB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SMPD1 -0.031 0.208 -9999.0 0.0 -0.773 1.0 1.0 SGMS1 0.021 0.037 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of NF-kappaB transcription factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.013 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation 0.013 0.143 -9999.0 0.0 -0.437 1.0 1.0 EIF3A 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.055 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 0.033 0.02 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingomyelin 0.025 0.046 -9999.0 0.0 -9999.0 0.0 0.0 natural killer cell activation 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 JAK3 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JAK1 0.015 0.096 -9999.0 0.0 -0.331 1.0 1.0 NFKB1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYC 0.029 0.154 -9999.0 0.0 -9999.0 0.0 0.0 MYB 0.008 0.085 -9999.0 0.0 -9999.0 0.0 0.0 IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.012 0.172 -9999.0 0.0 -0.384 2.0 2.0 40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.078 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.169 -9999.0 0.0 -0.375 2.0 2.0 Rac1/GDP 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 T cell proliferation -0.011 0.158 -9999.0 0.0 -0.352 2.0 2.0 SHC1 0.026 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of cyclin-dependent protein kinase activity 0.003 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ -0.012 0.163 -9999.0 0.0 -0.365 2.0 2.0 NF kappa B1 p50/RelA 0.024 0.19 -9999.0 0.0 -0.401 2.0 2.0 IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.049 0.146 -9999.0 0.0 -0.354 2.0 2.0 HSP90AA1 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IL2RA 0.041 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL2RB 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 TERT 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E2F1 0.011 0.101 -9999.0 0.0 -0.352 1.0 1.0 SOS1 0.041 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RPS6 0.032 0.017 -9999.0 0.0 -9999.0 0.0 0.0 mol:cAMP -0.002 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IL2RG 0.009 0.095 -9999.0 0.0 -0.331 1.0 1.0 actin cytoskeleton organization -0.011 0.158 -9999.0 0.0 -0.352 2.0 2.0 GRB2 0.014 0.096 -9999.0 0.0 -0.331 1.0 1.0 IL2 0.013 0.096 -9999.0 0.0 -0.331 1.0 1.0 PIK3CA 0.039 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.064 0.036 -9999.0 0.0 -9999.0 0.0 0.0 LCK 0.015 0.096 -9999.0 0.0 -0.33 1.0 1.0 BCL2 -0.012 0.229 -9999.0 0.0 -0.808 1.0 1.0