rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(9) 237556 9 9 9 1 6 1 1 1 0 0 0.0730 0.0403 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 170466 3 3 3 1 3 0 0 0 0 0 0.612 0.494 1.000 3 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(4), TAT(12) 871759 19 16 18 4 12 2 2 1 2 0 0.0333 0.530 1.000 4 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(5), DCN(15), FMOD(4), KERA(13), LUM(10) 1162061 47 37 44 14 36 4 3 1 3 0 0.00242 0.659 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(4), FOSB(5), GRIA2(31), JUND(1), PPP1R1B(2) 1208725 43 38 40 14 26 3 2 5 7 0 0.0760 0.683 1.000 6 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(5), SNAP25(5), STX1A(2) 1083206 15 14 13 2 9 1 0 1 4 0 0.0134 0.886 1.000 7 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(6), HLA-DRA(10), HLA-DRB1(3) 777496 20 18 20 8 15 1 0 3 1 0 0.141 0.958 1.000 8 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(3), ALDOA(1), ALDOB(9), ALDOC(3) 1307091 16 14 13 4 11 2 0 1 2 0 0.0607 0.965 1.000 9 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(2) 512888 2 2 2 0 0 1 0 1 0 0 0.634 0.970 1.000 10 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), IL8(1), SLPI(5) 569288 9 9 9 4 4 1 0 4 0 0 0.617 0.973 1.000 11 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(3) 548910 3 3 2 1 2 0 0 1 0 0 0.552 0.978 1.000 12 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(4), NFKB1(7), NFKBIA(2), PLCB1(45), PRKCA(10), RELA(4) 2706318 72 53 68 21 55 3 2 7 5 0 0.00978 0.989 1.000 13 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(4), CD3G(1) 371843 5 5 5 4 4 0 0 0 1 0 0.819 0.991 1.000 14 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(6), SEC61A2(7), SRP19(5), SRP54(3), SRP68(6), SRP72(1), SRP9(1), SRPR(2) 2534869 31 27 28 6 12 0 3 10 6 0 0.149 0.991 1.000 15 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(3), MMP14(2), MMP2(6), MMP9(4), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6) 2455694 39 34 39 9 22 2 2 10 3 0 0.0202 0.993 1.000 16 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(14) 604439 16 11 15 8 11 2 1 2 0 0 0.481 0.994 1.000 17 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(4), DPM2(1), EGR1(4), HRAS(3), KLK2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), NGFR(6), RAF1(7) 2676053 45 40 39 14 22 4 2 10 7 0 0.0378 0.997 1.000 18 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(9), BCMO1(14), RDH5(2) 1292485 28 27 25 10 20 1 1 4 2 0 0.0881 0.999 1.000 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(3), NFYC(1), RB1(8), SP1(3) 2207129 16 14 16 4 2 1 2 5 4 2 0.292 0.999 1.000 20 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(1), EHHADH(5), HADHA(8), SDS(2) 1602491 19 18 17 7 11 2 0 5 1 0 0.260 0.999 1.000 21 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(1), CSF3(3), EPO(5), FLT3(28), IGF1(9), IL1A(4), IL3(2), IL6(2), IL9(1), KITLG(6), TGFB1(1), TGFB3(3) 2720654 65 48 62 22 41 4 4 10 6 0 0.0142 1.000 1.000 22 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(4) 1279473 8 8 8 9 3 0 1 0 4 0 0.985 1.000 1.000 23 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(7), CFL1(1), CFLAR(4), PDE6D(2) 1294332 18 16 18 7 7 1 2 6 2 0 0.599 1.000 1.000 24 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(13), CCND1(1), CCNE1(3), CCNE2(12), CDK4(5), CDKN1B(1), E2F1(4), E2F2(4), E2F4(1) 2559329 44 38 39 10 26 0 2 14 2 0 0.0195 1.000 1.000 25 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), DAG1(5), GNAQ(4), ITPKB(5) 1982765 15 15 15 4 10 0 1 1 3 0 0.110 1.000 1.000 26 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASDHPPT(3), AASS(3), KARS(4) 1538751 14 14 14 4 12 0 0 2 0 0 0.307 1.000 1.000 27 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(12), GOT1(3), GOT2(4), TAT(12), TYR(7) 1555309 38 29 37 14 26 4 3 1 4 0 0.0953 1.000 1.000 28 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD34(4), CD3D(4), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(3), IL3(2), IL6(2), IL8(1), KITLG(6) 1787812 32 29 32 13 22 1 2 5 2 0 0.140 1.000 1.000 29 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFV1(2) 2316834 15 15 15 2 11 0 1 3 0 0 0.0744 1.000 1.000 30 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(13), GAD1(12), HDC(16), PNMT(2), TH(7), TPH1(5) 1970359 55 45 52 22 45 2 1 2 5 0 0.0124 1.000 1.000 31 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), IDI1(1), SQLE(3) 1052305 7 7 7 3 3 1 1 2 0 0 0.583 1.000 1.000 32 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(1), EHHADH(5), GCDH(5), HADHA(8), SDHB(1), SDS(2) 2584097 23 20 22 7 15 3 0 4 1 0 0.131 1.000 1.000 33 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CFL1(1), E2F1(4), E2F2(4), MDM2(3), NXT1(1) 2102547 24 22 23 9 10 3 0 8 3 0 0.256 1.000 1.000 34 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12A(2), IL12B(1), IL18(2), IL2(2) 973416 10 8 10 6 7 1 0 1 1 0 0.620 1.000 1.000 35 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(3), PRKCA(10), TGM2(5) 1644743 20 16 19 9 15 2 0 0 3 0 0.0967 1.000 1.000 36 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(5), ACADS(4), ECHS1(1), HADHA(8) 1818817 22 20 22 7 13 2 1 6 0 0 0.313 1.000 1.000 37 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), FPGS(2), GGH(2), SPR(2) 2102059 38 29 35 14 30 4 2 1 1 0 0.0169 1.000 1.000 38 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(6), CD8A(2), CSF1(7), CSF2(1), CSF3(3), EPO(5), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL7(5), IL8(1), IL9(1) 1996913 40 33 40 18 28 2 1 4 5 0 0.0641 1.000 1.000 39 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(2), CBS(6), CTH(1), MUT(5) 1685619 16 16 16 6 10 2 1 2 1 0 0.356 1.000 1.000 40 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(5) 1024876 8 8 8 8 5 0 1 1 1 0 0.909 1.000 1.000 41 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(6), CD80(4), HLA-DRA(10), HLA-DRB1(3), IL10(3), IL2(2), IL4(1) 1302146 30 25 30 13 19 1 1 6 3 0 0.147 1.000 1.000 42 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(10), LPL(3), NR3C1(6), PPARG(11), RETN(2), RXRA(4), TNF(1) 1928268 37 31 35 14 24 2 0 6 5 0 0.118 1.000 1.000 43 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5) 1866390 97 69 81 31 74 7 5 9 2 0 0.00599 1.000 1.000 44 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(3), OXCT1(4) 1113816 8 8 8 5 5 1 0 1 1 0 0.790 1.000 1.000 45 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(4), ENO3(4), FARS2(4), GOT1(3), GOT2(4), PAH(9), TAT(12), YARS(1) 2762388 44 38 41 16 31 5 2 3 3 0 0.0281 1.000 1.000 46 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(11), IARS(8), LARS(9), LARS2(2), PDHA1(2), PDHA2(15), PDHB(1) 3332887 48 37 44 12 33 4 1 5 5 0 0.0316 1.000 1.000 47 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), WASF1(3), WASL(5) 2551150 22 21 22 7 12 2 1 3 4 0 0.284 1.000 1.000 48 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(1), GLUD2(3) 1503251 7 7 7 7 2 1 1 1 2 0 0.958 1.000 1.000 49 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSS(7), IL8(1), NFKB1(7), NOX1(10), RELA(4), TNF(1), XDH(44) 3259211 76 56 73 29 57 5 4 7 3 0 0.0129 1.000 1.000 50 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(4), DFFA(2), DFFB(3), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(8), TOP2B(7) 2962606 30 24 30 9 18 1 4 5 2 0 0.292 1.000 1.000 51 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(4), CD3G(1), CD4(6), FYN(5), HLA-DRA(10), HLA-DRB1(3), LCK(10), PTPRC(26), ZAP70(4) 2912348 69 52 66 27 45 7 1 9 7 0 0.0806 1.000 1.000 52 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(8), CSF2(1), HLA-DRA(10), HLA-DRB1(3), IL3(2), IL5(2) 1001088 27 25 27 15 22 0 0 3 2 0 0.209 1.000 1.000 53 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1) 1394598 10 9 10 5 7 1 1 1 0 0 0.549 1.000 1.000 54 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(6), FARSB(5), GOT1(3), GOT2(4), PAH(9), TAT(12), YARS(1), YARS2(2) 2882096 46 38 43 17 31 6 2 2 5 0 0.0420 1.000 1.000 55 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), NFS1(1), TPK1(9) 2115929 18 17 17 7 12 1 1 2 1 1 0.523 1.000 1.000 56 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(1), EHHADH(5), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT5(5), SIRT7(2), VNN2(13) 3917038 46 39 44 12 27 5 3 9 2 0 0.0358 1.000 1.000 57 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(2), ACP5(3), ACPP(6), ENPP1(10), ENPP3(14), FLAD1(7), TYR(7) 3193471 52 40 50 15 32 5 2 5 8 0 0.0408 1.000 1.000 58 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(3), CUL1(5), E2F1(4), FBXW7(10), RB1(8), TFDP1(2) 2689836 35 29 35 11 13 2 5 6 7 2 0.177 1.000 1.000 59 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(5), AASDHPPT(3), AASS(3), KARS(4) 2282739 19 17 19 6 16 0 0 2 1 0 0.327 1.000 1.000 60 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(5), BAX(3), BCL10(2), BCL2(2), BCL2L11(5), CASP8AP2(7), CASP9(2), CES1(16) 3567068 42 32 40 12 25 6 2 3 6 0 0.102 1.000 1.000 61 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(6), CASP8(7), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1) 2705266 24 24 24 9 16 0 2 3 3 0 0.283 1.000 1.000 62 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5) 2920311 27 21 27 9 14 2 2 6 3 0 0.342 1.000 1.000 63 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(1), GOT1(3), GOT2(4), LDHA(4), LDHB(2), LDHC(5), MPST(2) 2272151 30 25 28 11 21 1 5 2 1 0 0.150 1.000 1.000 64 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(13), CCNE1(3), CDC34(3), CUL1(5), E2F1(4), RB1(8), SKP2(2), TFDP1(2) 2813688 40 33 40 13 21 2 4 6 5 2 0.0968 1.000 1.000 65 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(1), ALAS2(5), CPOX(2), FECH(3), HMBS(1), PPOX(2), UROS(1) 2502665 19 19 19 8 13 1 1 1 3 0 0.333 1.000 1.000 66 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(7), CDC25B(4), CDKN1A(4), CHEK1(1), NEK1(6), WEE1(2) 2294556 24 21 24 7 11 5 1 4 3 0 0.299 1.000 1.000 67 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(2), MDH1(1), ME1(17), PC(12), PDHA1(2), SLC25A11(1) 3081479 44 32 43 17 26 4 2 9 3 0 0.0808 1.000 1.000 68 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(6), ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), CMBL(3), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), PON1(10), PON3(1) 5923184 141 81 135 42 102 10 6 10 13 0 8.95e-06 1.000 1.000 69 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(5), ATM(11), BAX(3), BCL2(2), CCND1(1), CCNE1(3), CDK4(5), CDKN1A(4), E2F1(4), MDM2(3), PCNA(2), RB1(8), TIMP3(5) 5680510 56 45 55 15 17 7 4 14 12 2 0.0923 1.000 1.000 70 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(1), HRAS(3), MAP2K1(11), MAP2K2(3), NGFR(6), NTRK1(12), PIK3CA(6), PIK3CD(7), SHC1(1), SOS1(7) 5258584 78 57 72 24 34 13 2 19 10 0 0.0499 1.000 1.000 71 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(3), BMPR2(4) 2077994 13 13 13 7 5 3 0 3 2 0 0.697 1.000 1.000 72 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), CREBBP(17), DFFA(2), DFFB(3), GZMA(10), GZMB(2), HMGB2(1), PRF1(7), SET(1) 3505672 45 34 43 13 23 3 5 10 4 0 0.119 1.000 1.000 73 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), ACO2(4), FH(3), IDH1(11), IDH2(2), MDH1(1), MDH2(3), SDHB(1) 2968905 30 23 21 11 22 0 2 3 3 0 0.135 1.000 1.000 74 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(1), GPD2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), UQCRC1(3) 2200969 11 11 11 5 7 0 1 1 2 0 0.554 1.000 1.000 75 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(7), PARK2(7), SNCA(2), SNCAIP(41), UBE2E2(2), UBE2F(3), UBE2G2(1), UBE2L6(2) 2127995 65 53 58 26 47 8 1 4 5 0 0.136 1.000 1.000 76 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(10), NR0B2(3), NR1H3(2), NR1H4(11), RXRA(4) 1797620 30 25 30 14 17 6 3 2 2 0 0.176 1.000 1.000 77 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(45), NRG2(5), NRG3(18), PRKCA(10), PSEN1(1) 2942174 80 60 73 29 61 4 2 5 8 0 0.0492 1.000 1.000 78 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(6), ENPP1(10), ENPP3(14), FLAD1(7), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), TYR(7) 4953964 71 49 68 18 44 6 5 7 9 0 0.00766 1.000 1.000 79 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(8), CD4(6), HLA-DRA(10), HLA-DRB1(3), IL1B(6), IL4(1), IL5(2), IL5RA(11), IL6(2) 1763611 50 44 48 25 37 1 1 5 6 0 0.0963 1.000 1.000 80 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADHA(8), HADHB(3), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(3), PPT2(8) 2807646 37 36 35 14 14 4 4 12 3 0 0.402 1.000 1.000 81 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), PAPSS2(5), SULT1A2(2), SULT1E1(10), SULT2A1(6), SUOX(3) 2016956 28 18 27 11 21 1 0 2 4 0 0.242 1.000 1.000 82 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(2), CDO1(5), CTH(1), GOT1(3), GOT2(4), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(10), SULT1C2(5), SULT1C4(9), SULT4A1(6) 4152462 80 58 76 27 53 2 9 7 9 0 0.0143 1.000 1.000 83 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1) 1876930 15 15 15 9 10 2 1 2 0 0 0.550 1.000 1.000 84 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(11), COASY(3), DPYD(53), DPYS(21), ENPP1(10), ENPP3(14), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(1), UPB1(6) 4590606 133 78 119 38 93 9 4 17 10 0 0.000894 1.000 1.000 85 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(1), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(10) 2923150 30 25 29 11 19 2 0 4 5 0 0.238 1.000 1.000 86 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2) 4416670 39 34 38 11 23 3 2 6 5 0 0.0342 1.000 1.000 87 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(10), E2F1(4), MDM2(3), MYC(4), PIK3CA(6), PIK3R1(3), POLR1A(11), POLR1B(8), RB1(8), TBX2(6), TWIST1(1) 6075112 64 45 64 17 36 7 2 9 7 3 0.0115 1.000 1.000 88 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(13), CHKA(2), PCYT1A(3), PDHA1(2), PDHA2(15), PEMT(2), SLC18A3(2) 2263430 42 35 39 20 33 5 0 1 3 0 0.122 1.000 1.000 89 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(1), IFRD1(2), IL18(2), IL1A(4), IL1R1(10), JUND(1), MYOG(2), NR4A3(6), WDR1(3) 3510892 44 36 43 16 26 5 2 4 7 0 0.194 1.000 1.000 90 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(5), CD3D(4), CD3G(1), GZMB(2), HLA-A(3), ICAM1(1), ITGAL(19), ITGB2(10), PRF1(7) 2870108 52 42 51 25 28 6 1 5 12 0 0.258 1.000 1.000 91 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(5), BAX(3), BCL2(2), BIK(2), BIRC2(3), BIRC3(6), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), DFFA(2), DFFB(3), DIABLO(1) 4461920 43 36 43 14 22 4 6 6 5 0 0.239 1.000 1.000 92 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MYC(4), SP1(3), WT1(4) 2074795 12 12 12 6 7 1 3 1 0 0 0.669 1.000 1.000 93 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(13), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNH(2), CDC25A(7), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), E2F1(4), RB1(8), RBL1(10), TFDP1(2) 5137617 68 49 67 21 36 3 6 14 7 2 0.0283 1.000 1.000 94 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(5), ACOX1(7), ACOX3(11), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(3), FASN(15), HADHA(8), HSD17B12(2), PECR(1), SCD(3) 4717329 60 48 60 22 38 4 2 9 7 0 0.0148 1.000 1.000 95 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDKN1B(1), CUL1(5), E2F1(4), NEDD8(1), RB1(8), SKP2(2), TFDP1(2), UBE2M(1) 2840634 27 26 27 11 9 2 4 4 6 2 0.366 1.000 1.000 96 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(1), ITGAL(19), ITGAM(17), ITGB2(10), SELE(28), SELL(7) 3385085 87 58 87 32 60 4 3 7 13 0 0.0139 1.000 1.000 97 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(4), CBS(6), CTH(1), DNMT1(16), DNMT3A(5), DNMT3B(8), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), MTR(7) 5836254 66 48 65 23 39 4 7 9 7 0 0.0384 1.000 1.000 98 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(7), FDPS(3), HMGCR(11), HMGCS1(1), IDI1(1), MVD(1), MVK(2), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(2), SQLE(3) 4350726 38 34 36 15 14 6 2 10 6 0 0.373 1.000 1.000 99 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(1), ITGA4(29), ITGAL(19), ITGAM(17), ITGB1(4), ITGB2(10), SELE(28), SELL(7), SELP(28) 5200616 148 83 141 45 109 4 4 13 18 0 0.000614 1.000 1.000 100 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(11), BCAT2(1), COASY(3), DPYD(53), DPYS(21), ENPP1(10), ENPP3(14), ILVBL(3), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(1), UPB1(6), VNN1(7) 5696693 144 80 130 43 102 9 4 18 11 0 0.000335 1.000 1.000 101 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(10), BCAR1(4), BCL2(2), BIRC2(3), BIRC3(6), CAPN2(7), CAV1(1), CCND1(1), CCND2(3), CCND3(2), CDC42(2), CHAD(3), COL11A1(49), COL11A2(27), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), COMP(4), CRK(2), CRKL(2), CTNNB1(11), DIAPH1(6), DOCK1(12), EGF(14), EGFR(17), ELK1(2), ERBB2(7), FARP2(5), FIGF(3), FLNA(14), FLNB(29), FLNC(47), FLT1(28), FN1(20), FYN(5), GRB2(1), GRLF1(10), GSK3B(2), HGF(22), HRAS(3), IBSP(7), IGF1(9), IGF1R(9), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAV(9), ITGB1(4), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), JUN(1), KDR(32), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), MAP2K1(11), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MET(19), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLK(35), MYLK2(9), MYLPF(1), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PARVB(3), PARVG(3), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(6), PDGFRA(23), PDGFRB(11), PDPK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP5K1C(6), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PRKCA(10), PRKCG(13), PTK2(8), PXN(3), RAC2(1), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF1(9), RELN(58), RHOA(1), ROCK1(4), ROCK2(13), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SPP1(6), SRC(1), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TLN1(11), TLN2(21), TNC(27), TNN(39), TNR(61), TNXB(115), VASP(3), VAV1(13), VAV2(2), VAV3(8), VCL(7), VEGFA(5), VEGFB(1), VTN(7), VWF(40), ZYX(6) 121092098 2500 206 2409 1078 1757 175 76 272 217 3 6.93e-07 1.000 1.000 102 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(15), ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), ADRA1A(7), ADRA1B(2), ADRA2A(1), ADRA2B(8), ADRA2C(1), ADRB1(4), ADRB2(2), AGTR1(9), AGTR2(10), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), C5AR1(9), CALCR(14), CALCRL(11), CCKAR(9), CCKBR(8), CGA(1), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CNR1(7), CNR2(4), CRHR1(6), CRHR2(2), CTSG(2), CYSLTR1(4), CYSLTR2(1), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), EDNRA(8), EDNRB(4), F2(9), F2R(5), F2RL1(14), F2RL2(5), F2RL3(3), FPR1(15), FSHB(4), FSHR(13), GABBR1(6), GABBR2(9), GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GABRB1(14), GABRB2(17), GABRB3(15), GABRD(3), GABRE(18), GABRG1(28), GABRG2(13), GABRG3(6), GABRP(8), GABRQ(8), GABRR1(6), GABRR2(1), GALR1(4), GALR3(2), GH1(3), GH2(9), GHR(20), GHRHR(3), GHSR(4), GIPR(1), GLP1R(11), GLP2R(13), GLRA1(11), GLRA2(5), GLRA3(11), GNRHR(1), GPR156(9), GPR35(1), GPR50(16), GPR63(6), GPR83(9), GRIA1(33), GRIA2(31), GRIA3(19), GRIA4(19), GRID1(18), GRID2(44), GRIK1(18), GRIK2(15), GRIK3(24), GRIK4(10), GRIK5(8), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), GRIN3A(30), GRIN3B(4), GRM1(14), GRM2(5), GRM3(45), GRM4(14), GRM5(10), GRM6(21), GRM7(28), GRM8(41), GRPR(4), GZMA(10), HCRTR1(2), HCRTR2(24), HRH1(9), HRH2(2), HRH3(3), HRH4(5), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), LEP(2), LEPR(19), LHCGR(21), LTB4R(1), LTB4R2(1), MAS1(3), MC2R(5), MC3R(6), MC4R(1), MC5R(7), MCHR1(1), MCHR2(14), MTNR1A(7), MTNR1B(5), NMBR(6), NMUR1(5), NMUR2(12), NPBWR1(1), NPBWR2(9), NPFFR1(1), NPFFR2(9), NPY1R(23), NPY2R(11), NPY5R(20), NR3C1(6), NTSR1(5), NTSR2(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(7), P2RX4(2), P2RX5(6), P2RX7(4), P2RY1(4), P2RY10(6), P2RY13(4), P2RY14(5), P2RY2(7), P2RY6(1), P2RY8(4), PARD3(14), PPYR1(10), PRL(1), PRLHR(1), PRLR(24), PRSS1(23), PRSS3(3), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(2), PTGFR(18), PTGIR(3), PTH2R(13), RXFP1(12), RXFP2(20), SCTR(6), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), SSTR5(3), TAAR1(2), TAAR2(8), TAAR5(3), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(6), TACR2(6), TACR3(21), TBXA2R(4), THRA(2), THRB(12), TRHR(17), TRPV1(2), TSHB(5), TSHR(6), UTS2R(1), VIPR1(2), VIPR2(5) 72035933 2053 205 1901 1259 1432 167 73 209 170 2 1.47e-07 1.000 1.000 103 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(6), ACTG1(6), CHAD(3), COL11A1(49), COL11A2(27), COL17A1(25), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), COMP(4), DES(7), DSC1(36), DSC2(28), DSC3(34), DSG2(17), DSG4(45), FN1(20), GJA1(6), GJA10(12), GJA4(4), GJA5(6), GJA8(17), GJA9(2), GJB1(1), GJB2(1), GJB3(3), GJB4(4), GJB5(5), GJB6(5), GJB7(1), GJC1(6), GJD2(5), IBSP(7), INA(3), ITGA6(6), ITGB4(20), KRT1(16), KRT10(14), KRT12(10), KRT13(10), KRT14(2), KRT15(10), KRT16(10), KRT17(7), KRT18(2), KRT2(14), KRT20(7), KRT23(7), KRT24(7), KRT25(10), KRT27(4), KRT28(10), KRT3(12), KRT31(8), KRT32(9), KRT33A(5), KRT33B(2), KRT34(9), KRT35(8), KRT36(14), KRT37(10), KRT38(7), KRT39(9), KRT4(14), KRT40(6), KRT5(14), KRT6A(13), KRT6B(8), KRT6C(12), KRT7(5), KRT71(14), KRT72(11), KRT73(10), KRT74(11), KRT75(11), KRT76(10), KRT77(11), KRT78(17), KRT79(6), KRT8(5), KRT81(2), KRT82(6), KRT83(12), KRT84(10), KRT85(7), KRT86(3), KRT9(16), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), LMNA(8), LMNB1(2), LMNB2(4), NES(16), PRPH(1), RELN(58), SPP1(6), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNC(27), TNN(39), TNR(61), TNXB(115), VIM(5), VTN(7), VWF(40) 80894081 2168 201 2087 942 1590 161 58 191 167 1 2.67e-07 1.000 1.000 104 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(13), CD36(4), CD44(5), CD47(1), CHAD(3), COL11A1(49), COL11A2(27), COL1A1(36), COL1A2(30), COL2A1(27), COL3A1(55), COL4A1(43), COL4A2(21), COL4A4(82), COL4A6(31), COL5A1(54), COL5A2(35), COL5A3(52), COL6A1(5), COL6A2(19), COL6A3(49), COL6A6(44), DAG1(5), FN1(20), FNDC1(28), FNDC3A(7), FNDC4(3), FNDC5(3), GP5(3), GP6(4), GP9(4), HMMR(4), HSPG2(23), IBSP(7), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAV(9), ITGB1(4), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), LAMA1(30), LAMA2(51), LAMA3(50), LAMA4(11), LAMA5(21), LAMB1(8), LAMB2(11), LAMB3(17), LAMB4(29), LAMC1(9), LAMC2(17), LAMC3(5), RELN(58), SDC1(3), SDC2(2), SDC3(5), SDC4(2), SPP1(6), SV2A(12), SV2B(25), SV2C(13), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNC(27), TNN(39), TNR(61), TNXB(115), VTN(7), VWF(40) 73862106 1755 199 1695 729 1284 102 57 160 151 1 0.000326 1.000 1.000 105 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(2), ACVR2A(4), ACVR2B(3), AMHR2(14), BMP2(3), BMP7(1), BMPR1A(1), BMPR1B(3), BMPR2(4), CCL1(1), CCL11(1), CCL14(2), CCL15(2), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL24(3), CCL26(1), CCL27(2), CCL7(4), CCL8(2), CCR1(7), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CD27(2), CD40(4), CD40LG(1), CNTF(1), CSF1(7), CSF1R(10), CSF2(1), CSF2RA(17), CSF2RB(14), CSF3(3), CSF3R(2), CX3CL1(4), CX3CR1(11), CXCL10(2), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(1), CXCR3(3), CXCR4(3), CXCR6(4), EDA(2), EDA2R(3), EDAR(5), EGF(14), EGFR(17), EPO(5), EPOR(1), FAS(5), FASLG(12), FLT1(28), FLT3(28), FLT3LG(2), FLT4(17), GDF5(11), GH1(3), GH2(9), GHR(20), HGF(22), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(4), IL10(3), IL10RA(6), IL10RB(5), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL13RA1(3), IL15(3), IL15RA(5), IL17A(8), IL17B(3), IL17RA(3), IL17RB(2), IL18(2), IL18R1(16), IL18RAP(18), IL19(2), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), IL1RAP(4), IL2(2), IL20(4), IL20RA(9), IL21(6), IL21R(15), IL22(1), IL22RA1(8), IL23A(1), IL23R(7), IL25(2), IL26(2), IL28B(3), IL28RA(3), IL29(1), IL2RA(3), IL2RB(7), IL2RG(2), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(24), IL8(1), IL9(1), IL9R(4), INHBA(12), INHBB(4), INHBC(10), INHBE(3), KDR(32), KIT(8), KITLG(6), LEP(2), LEPR(19), LIF(2), LIFR(28), LTA(1), LTB(2), MET(19), MPL(7), NGFR(6), OSM(5), OSMR(34), PDGFB(2), PDGFC(14), PDGFRA(23), PDGFRB(11), PLEKHO2(4), PPBP(4), PRL(1), PRLR(24), RELT(2), TGFB1(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFRSF11A(3), TNFRSF11B(8), TNFRSF12A(1), TNFRSF13B(6), TNFRSF14(2), TNFRSF17(5), TNFRSF18(2), TNFRSF19(2), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(8), TNFRSF25(4), TNFRSF4(2), TNFRSF6B(2), TNFRSF8(16), TNFRSF9(3), TNFSF10(7), TNFSF11(3), TNFSF12(1), TNFSF13B(1), TNFSF14(7), TNFSF15(4), TNFSF18(6), TNFSF4(2), TNFSF8(3), TNFSF9(1), TPO(33), TSLP(1), VEGFA(5), VEGFB(1), XCL1(1), XCL2(1), XCR1(4) 57913468 1233 198 1195 675 857 85 38 128 125 0 0.0853 1.000 1.000 106 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(2), ACVR1C(7), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(4), ATF4(7), BDNF(3), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1F(18), CACNA1G(26), CACNA1H(21), CACNA1I(27), CACNA1S(41), CACNA2D1(9), CACNA2D2(12), CACNA2D3(41), CACNA2D4(14), CACNB1(4), CACNB2(12), CACNB3(2), CACNB4(9), CACNG1(3), CACNG2(9), CACNG3(17), CACNG4(2), CACNG5(7), CACNG6(5), CACNG7(4), CACNG8(1), CASP3(2), CD14(4), CDC25B(4), CDC42(2), CHP(3), CHUK(2), CRK(2), CRKL(2), DAXX(8), DDIT3(2), DUSP10(5), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(14), EGFR(17), ELK1(2), ELK4(6), FAS(5), FASLG(12), FGF1(1), FGF10(2), FGF11(2), FGF12(9), FGF13(6), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF2(2), FGF21(3), FGF23(8), FGF3(3), FGF4(2), FGF5(5), FGF6(4), FGF7(6), FGF8(1), FGF9(4), FGFR1(11), FGFR2(26), FGFR3(7), FGFR4(7), FLNA(14), FLNB(29), FLNC(47), FOS(2), GADD45B(2), GNA12(3), GRB2(1), HRAS(3), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), JUN(1), JUND(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K6(4), MAP3K7(1), MAP4K1(8), MAP4K2(4), MAP4K3(7), MAP4K4(6), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MAPT(9), MEF2C(2), MKNK1(3), MKNK2(1), MOS(3), MRAS(1), MYC(4), NF1(38), NFATC2(6), NFATC4(11), NFKB1(7), NFKB2(4), NLK(5), NR4A1(2), NTF3(4), NTRK1(12), NTRK2(8), PAK1(4), PAK2(8), PDGFA(1), PDGFB(2), PDGFRA(23), PDGFRB(11), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PPM1A(3), PPM1B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PPP5C(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PTPN5(10), PTPN7(1), PTPRR(16), RAC2(1), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF2(7), RASA1(4), RASA2(12), RASGRF1(15), RASGRF2(17), RASGRP1(6), RASGRP2(6), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(3), RPS6KA6(15), RRAS(1), SOS1(7), SOS2(11), SRF(3), STK4(1), STMN1(3), TAOK1(10), TAOK2(22), TAOK3(3), TGFB1(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF1A(2), TRAF2(1), TRAF6(4), ZAK(6) 91841157 1596 197 1540 928 1030 148 59 188 167 4 0.450 1.000 1.000 107 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY7(9), ADCY8(40), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRB1(4), ADRB2(2), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(13), ATP2B1(6), ATP2B2(22), ATP2B3(7), ATP2B4(11), AVPR1A(3), AVPR1B(6), BDKRB1(3), BDKRB2(9), BST1(1), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1F(18), CACNA1G(26), CACNA1H(21), CACNA1I(27), CACNA1S(41), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CCKAR(9), CCKBR(8), CD38(2), CHP(3), CHRM1(3), CHRM2(17), CHRM3(17), CHRM5(4), CHRNA7(2), CYSLTR1(4), CYSLTR2(1), DRD1(6), EDNRA(8), EDNRB(4), EGFR(17), ERBB2(7), ERBB3(4), ERBB4(45), F2R(5), GNA11(6), GNA14(4), GNA15(5), GNAL(2), GNAQ(4), GNAS(17), GRIN1(5), GRIN2A(74), GRIN2C(4), GRIN2D(6), GRM1(14), GRM5(10), GRPR(4), HRH1(9), HRH2(2), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), LHCGR(21), LTB4R2(1), MYLK(35), MYLK2(9), NOS1(48), NOS3(14), NTSR1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(7), P2RX4(2), P2RX5(6), P2RX7(4), PDE1B(10), PDE1C(37), PDGFRA(23), PDGFRB(11), PHKA1(17), PHKA2(7), PHKB(6), PHKG1(1), PHKG2(2), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(18), PTK2B(8), RYR1(72), RYR2(77), RYR3(66), SLC25A6(2), SLC8A1(26), SLC8A2(7), SLC8A3(26), SPHK1(1), SPHK2(6), TACR1(6), TACR2(6), TACR3(21), TBXA2R(4), TNNC1(2), TNNC2(4), TRHR(17), TRPC1(5), VDAC1(1), VDAC2(1), VDAC3(1) 87235255 1931 197 1836 1245 1364 142 72 179 172 2 0.0238 1.000 1.000 108 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), APC(17), APC2(8), ARAF(3), ARHGEF1(1), ARHGEF12(10), ARHGEF4(4), ARHGEF6(10), ARHGEF7(3), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(4), BDKRB1(3), BDKRB2(9), CD14(4), CDC42(2), CFL1(1), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CRK(2), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(19), DIAPH1(6), DIAPH2(6), DIAPH3(10), DOCK1(12), EGF(14), EGFR(17), EZR(1), F2(9), F2R(5), FGD1(3), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(9), FGF13(6), FGF14(4), FGF17(1), FGF18(2), FGF19(2), FGF2(2), FGF21(3), FGF23(8), FGF3(3), FGF4(2), FGF5(5), FGF6(4), FGF7(6), FGF8(1), FGF9(4), FGFR1(11), FGFR2(26), FGFR3(7), FGFR4(7), FN1(20), GIT1(3), GNA12(3), GNA13(1), GRLF1(10), GSN(3), HRAS(3), IQGAP1(8), IQGAP2(17), IQGAP3(11), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAD(17), ITGAE(12), ITGAL(19), ITGAM(17), ITGAV(9), ITGAX(15), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), KRAS(4), LIMK1(2), LIMK2(9), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MOS(3), MRAS(1), MSN(1), MYH10(13), MYH14(13), MYH9(11), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLK(35), MYLK2(9), MYLPF(1), NCKAP1(5), NCKAP1L(20), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDGFA(1), PDGFB(2), PDGFRA(23), PDGFRB(11), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PPP1R12B(7), PTK2(8), PXN(3), RAC2(1), RAF1(7), RDX(1), RHOA(1), ROCK1(4), ROCK2(13), RRAS(1), SCIN(6), SLC9A1(3), SOS1(7), SOS2(11), SSH1(13), SSH2(7), SSH3(3), TIAM1(17), TIAM2(20), TMSL3(1), VAV1(13), VAV2(2), VAV3(8), VCL(7), WAS(6), WASF1(3), WASF2(3), WASL(5) 89700269 1380 196 1337 706 883 94 53 201 146 3 0.0187 1.000 1.000 109 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(10), ABLIM1(9), ABLIM2(5), ABLIM3(6), ARHGEF12(10), CDC42(2), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(3), DCC(71), DPYSL2(3), DPYSL5(7), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(2), EPHA1(12), EPHA2(12), EPHA3(24), EPHA4(16), EPHA5(6), EPHA6(58), EPHA7(36), EPHA8(13), EPHB1(22), EPHB2(21), EPHB3(12), EPHB4(10), EPHB6(19), FES(4), FYN(5), GNAI1(1), GNAI2(4), GNAI3(2), GSK3B(2), HRAS(3), ITGB1(4), KRAS(4), L1CAM(8), LIMK1(2), LIMK2(9), LRRC4C(37), MAPK1(4), MAPK3(1), MET(19), NCK1(1), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NGEF(12), NRP1(16), NTN4(13), NTNG1(13), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PLXNA1(13), PLXNA2(5), PLXNA3(9), PLXNB1(16), PLXNB2(16), PLXNB3(5), PLXNC1(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PTK2(8), RAC2(1), RASA1(4), RGS3(9), RHOA(1), RHOD(1), RND1(6), ROBO1(21), ROBO2(31), ROBO3(12), ROCK1(4), ROCK2(13), SEMA3A(8), SEMA3B(2), SEMA3C(3), SEMA3D(10), SEMA3E(19), SEMA3F(9), SEMA3G(11), SEMA4A(7), SEMA4B(3), SEMA4C(5), SEMA4D(7), SEMA4F(6), SEMA4G(7), SEMA5A(16), SEMA5B(12), SEMA6A(5), SEMA6B(6), SEMA6C(5), SEMA6D(4), SEMA7A(3), SLIT1(14), SLIT2(47), SLIT3(36), SRGAP1(6), SRGAP2(7), SRGAP3(28), UNC5A(6), UNC5B(9), UNC5C(12), UNC5D(20) 63889944 1224 191 1167 631 830 96 37 151 110 0 0.0180 1.000 1.000 110 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRB1(4), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(9), ATP1B3(1), ATP2A2(12), ATP2A3(13), ATP2B1(6), ATP2B2(22), ATP2B3(7), CACNA1A(25), CACNA1B(21), CACNA1C(32), CACNA1D(23), CACNA1E(83), CACNA1S(41), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CASQ1(8), CASQ2(3), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), GJA1(6), GJA4(4), GJA5(6), GJB1(1), GJB2(1), GJB3(3), GJB4(4), GJB5(5), GJB6(5), GNA11(6), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAZ(5), GNB3(5), GNB4(3), GNB5(2), GNG2(3), GNG4(1), GNG7(1), GRK4(7), GRK5(3), GRK6(3), ITPR1(21), ITPR2(15), ITPR3(6), KCNB1(30), KCNJ3(16), KCNJ5(11), MIB1(5), NME7(4), PKIA(2), PKIB(1), PKIG(1), PLCB3(3), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), RGS1(1), RGS11(2), RGS14(1), RGS16(2), RGS18(8), RGS20(2), RGS3(9), RGS4(1), RGS5(1), RGS6(13), RGS7(34), RGS9(9), RYR1(72), RYR2(77), RYR3(66), SFN(1), SLC8A1(26), SLC8A3(26), USP5(3), YWHAB(1), YWHAQ(3) 61247073 1167 187 1112 818 793 113 50 112 98 1 0.790 1.000 1.000 111 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(8), AKT3(4), CBL(8), CBLB(14), CBLC(10), CCND1(1), CCND2(3), CCND3(2), CISH(2), CNTF(1), CREBBP(17), CSF2(1), CSF2RA(17), CSF2RB(14), CSF3(3), CSF3R(2), EP300(13), EPO(5), EPOR(1), GH1(3), GH2(9), GHR(20), GRB2(1), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(4), IL10(3), IL10RA(6), IL10RB(5), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(5), IL19(2), IL2(2), IL20(4), IL20RA(9), IL21(6), IL21R(15), IL22(1), IL22RA1(8), IL23A(1), IL23R(7), IL26(2), IL28B(3), IL28RA(3), IL29(1), IL2RA(3), IL2RB(7), IL2RG(2), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(24), IL9(1), IL9R(4), IRF9(1), JAK1(5), JAK2(7), JAK3(4), LEP(2), LEPR(19), LIF(2), LIFR(28), MPL(7), MYC(4), OSM(5), OSMR(34), PIAS1(4), PIAS2(4), PIAS3(5), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIM1(1), PRL(1), PRLR(24), PTPN11(9), PTPN6(2), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(4), SOCS7(4), SOS1(7), SOS2(11), SPRED1(4), SPRED2(1), SPRY1(6), SPRY2(3), SPRY3(11), SPRY4(1), STAM(4), STAM2(1), STAT1(3), STAT2(5), STAT3(10), STAT4(20), STAT5A(2), STAT5B(4), STAT6(7), TPO(33), TSLP(1), TYK2(7) 47919524 832 187 804 387 534 63 35 115 84 1 0.0407 1.000 1.000 112 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(3), ACTN2(16), ACTN3(7), ACTN4(5), DES(7), DMD(29), FAM48A(1), MYBPC1(16), MYBPC2(16), MYBPC3(14), MYH3(17), MYH6(30), MYH7(35), MYH8(48), MYL1(8), MYL2(4), MYL3(1), MYL4(3), MYL9(1), MYOM1(21), NEB(94), TCAP(1), TNNC2(4), TNNI2(2), TNNI3(1), TNNT1(1), TNNT2(3), TNNT3(3), TPM1(3), TPM2(2), TPM3(2), TPM4(2), TTN(914), VIM(5) 43726082 1321 185 1239 556 960 97 48 133 74 9 1.20e-06 1.000 1.000 113 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(21), CASK(4), CDC42(2), CDK4(5), CGN(7), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(1), CSDA(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTTN(1), EPB41(8), EPB41L1(7), EPB41L2(17), EPB41L3(6), EXOC3(2), EXOC4(8), F11R(4), GNAI1(1), GNAI2(4), GNAI3(2), HCLS1(5), HRAS(3), IGSF5(7), INADL(32), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(11), MAGI1(23), MAGI2(19), MAGI3(10), MLLT4(10), MPDZ(9), MPP5(1), MRAS(1), MYH1(79), MYH10(13), MYH11(24), MYH13(30), MYH14(13), MYH15(45), MYH2(72), MYH3(17), MYH4(71), MYH6(30), MYH7(35), MYH7B(19), MYH8(48), MYH9(11), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLPF(1), OCLN(3), PARD3(14), PARD6A(1), PARD6B(1), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PPP2R3A(6), PPP2R3B(4), PPP2R4(1), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(7), SRC(1), SYMPK(4), TJAP1(4), TJP1(9), TJP2(8), TJP3(15), VAPA(1), YES1(5), ZAK(6) 63261093 1132 184 1081 689 765 99 40 128 98 2 0.414 1.000 1.000 114 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(3), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(4), ATF2(4), ATF4(7), ATF5(7), ATP2A2(12), ATP2A3(13), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CNN1(4), CNN2(1), CORIN(22), CREB3(1), CRH(3), CRHR1(6), DGKZ(6), ETS2(7), FOS(2), GABPB2(7), GBA2(2), GJA1(6), GNAQ(4), GNB3(5), GNB4(3), GNB5(2), GNG2(3), GNG4(1), GNG7(1), GRK4(7), GRK5(3), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(24), IGFBP1(3), IGFBP2(1), IGFBP3(2), IGFBP6(2), IL1B(6), IL6(2), ITPR1(21), ITPR2(15), ITPR3(6), JUN(1), MIB1(5), MYL2(4), MYL4(3), MYLK2(9), NFKB1(7), NOS1(48), NOS3(14), OXTR(5), PDE4B(7), PDE4D(7), PKIA(2), PKIB(1), PKIG(1), PLCB3(3), PLCD1(3), PLCG1(7), PLCG2(22), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), RAMP2(1), RAMP3(2), RGS1(1), RGS11(2), RGS14(1), RGS16(2), RGS18(8), RGS20(2), RGS3(9), RGS4(1), RGS5(1), RGS6(13), RGS7(34), RGS9(9), RLN1(1), RYR1(72), RYR2(77), RYR3(66), SFN(1), SLC8A1(26), SP1(3), TNXB(115), USP5(3), YWHAB(1), YWHAQ(3) 57243026 1046 184 999 608 726 92 40 108 79 1 0.0438 1.000 1.000 115 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(4), ADRB2(2), AGTR1(9), AGTR2(10), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), CCBP2(8), CCKAR(9), CCKBR(8), CCR1(7), CCR10(2), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CCRL2(5), CHML(4), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), CMKLR1(12), CNR1(7), CNR2(4), CX3CR1(11), CXCR3(3), CXCR4(3), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), EDNRA(8), EDNRB(4), F2R(5), F2RL1(14), F2RL2(5), F2RL3(3), FPR1(15), FSHR(13), GALR1(4), GALR3(2), GALT(2), GHSR(4), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(1), GPR3(2), GPR35(1), GPR37(7), GPR37L1(6), GPR4(3), GPR50(16), GPR6(5), GPR63(6), GPR77(5), GPR83(9), GPR85(5), GPR87(4), GRPR(4), HCRTR1(2), HCRTR2(24), HRH1(9), HRH2(2), HRH3(3), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8), LHCGR(21), LTB4R(1), MAS1(3), MC3R(6), MC4R(1), MC5R(7), MTNR1A(7), MTNR1B(5), NMBR(6), NMUR1(5), NMUR2(12), NPY1R(23), NPY2R(11), NPY5R(20), NTSR1(5), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OR10A5(5), OR11A1(6), OR12D3(4), OR1C1(7), OR1F1(4), OR1Q1(6), OR2H1(6), OR5V1(8), OR7A5(2), OR7C1(1), OR8B8(9), OXTR(5), P2RY1(4), P2RY10(6), P2RY12(2), P2RY13(4), P2RY14(5), P2RY2(7), P2RY6(1), PPYR1(10), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), RGR(5), RHO(1), RRH(1), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), SUCNR1(7), TBXA2R(4), TRHR(17) 39855752 970 181 921 712 645 96 34 127 68 0 0.00368 1.000 1.000 116 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(17), APC2(8), AXIN1(9), AXIN2(3), BTRC(4), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CCND1(1), CCND2(3), CCND3(2), CER1(12), CHD8(16), CHP(3), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(11), CTNNBIP1(1), CUL1(5), CXXC4(1), DAAM1(5), DAAM2(5), DKK1(2), DKK2(12), DKK4(2), DVL1(1), DVL2(4), DVL3(6), EP300(13), FBXW11(4), FZD1(4), FZD10(1), FZD2(5), FZD4(1), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(17), LRP6(19), MAP3K7(1), MAPK10(8), MAPK8(1), MAPK9(5), MMP7(4), MYC(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NKD1(6), NKD2(5), NLK(5), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PORCN(4), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRICKLE1(7), PRICKLE2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(4), ROCK2(13), RUVBL1(1), SENP2(10), SFRP1(2), SFRP2(9), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(4), TBL1X(5), TBL1XR1(1), TBL1Y(5), TCF7(1), TCF7L1(3), TCF7L2(6), VANGL1(2), VANGL2(8), WIF1(7), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3) 52457830 726 180 704 359 447 63 35 106 74 1 0.157 1.000 1.000 117 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(4), CADM1(3), CADM3(16), CD22(17), CD226(6), CD274(1), CD276(5), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(1), CD58(1), CD6(5), CD80(4), CD86(18), CD8A(2), CD8B(5), CD99(1), CDH1(4), CDH15(6), CDH2(10), CDH4(27), CDH5(8), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(19), CNTN2(12), CNTNAP1(11), CNTNAP2(69), CTLA4(2), F11R(4), GLG1(5), HLA-A(3), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(5), HLA-G(2), ICAM1(1), ICAM2(3), ICOS(3), ICOSLG(1), ITGA4(29), ITGA6(6), ITGA8(27), ITGA9(8), ITGAL(19), ITGAM(17), ITGAV(9), ITGB1(4), ITGB2(10), ITGB7(5), ITGB8(16), JAM2(10), JAM3(2), L1CAM(8), MADCAM1(1), MAG(7), MPZ(3), MPZL1(1), NCAM1(10), NCAM2(7), NEGR1(6), NEO1(12), NFASC(26), NLGN1(10), NLGN2(4), NLGN3(6), NRCAM(7), NRXN1(35), NRXN2(12), NRXN3(23), OCLN(3), PDCD1(3), PDCD1LG2(3), PTPRC(26), PTPRF(25), PTPRM(6), PVR(3), PVRL1(4), PVRL2(5), PVRL3(5), SDC1(3), SDC2(2), SDC3(5), SDC4(2), SELE(28), SELL(7), SELP(28), SELPLG(8), SIGLEC1(14), SPN(3), VCAM1(13), VCAN(28) 47920830 981 180 940 451 659 78 41 122 81 0 0.000101 1.000 1.000 118 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADK(4), ADSL(3), ADSS(2), ADSSL1(7), AK2(3), AK5(5), AK7(18), ALLC(7), AMPD1(24), AMPD2(5), AMPD3(20), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(10), ENPP3(14), ENTPD1(7), ENTPD2(2), ENTPD3(5), ENTPD4(3), ENTPD5(1), ENTPD6(4), ENTPD8(2), FHIT(2), GART(9), GDA(10), GMPR2(1), GMPS(1), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(2), NME7(4), NPR1(11), NPR2(9), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(5), PDE10A(10), PDE11A(14), PDE1C(37), PDE2A(11), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE5A(7), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(19), PDE9A(8), PFAS(7), PKLR(8), PKM2(3), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(12), PRPS1(2), PRPS1L1(11), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2), RRM2B(2), XDH(44) 53471666 853 173 824 432 573 64 48 95 73 0 0.0119 1.000 1.000 119 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ADRB1(4), CSNK1D(1), DRD1(6), DRD2(13), EGF(14), EGFR(17), GJA1(6), GJD2(5), GNA11(6), GNAI1(1), GNAI2(4), GNAI3(2), GNAQ(4), GNAS(17), GRB2(1), GRM1(14), GRM5(10), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), HRAS(3), HTR2A(8), HTR2B(2), HTR2C(10), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K5(2), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(3), NPR1(11), NPR2(9), PDGFA(1), PDGFB(2), PDGFC(14), PDGFD(6), PDGFRA(23), PDGFRB(11), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKG1(10), PRKG2(13), PRKX(3), RAF1(7), SOS1(7), SOS2(11), SRC(1), TJP1(9), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10) 42895894 808 173 763 458 541 64 38 96 68 1 0.0753 1.000 1.000 120 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 64 A2M(18), BDKRB1(3), BDKRB2(9), C1QA(3), C1QB(3), C1QC(6), C1R(8), C1S(11), C2(12), C3(36), C3AR1(4), C4BPA(14), C4BPB(5), C5(9), C5AR1(9), C6(50), C7(44), C8B(34), C8G(1), CD55(4), CD59(1), CFB(26), CFH(41), CFI(12), CPB2(1), CR1(47), CR2(26), F10(7), F11(9), F12(1), F13A1(21), F13B(19), F2(9), F2R(5), F5(24), F7(7), F8(40), F9(11), FGA(32), FGB(6), FGG(7), KLKB1(19), KNG1(8), MASP1(6), MASP2(6), MBL2(10), PLAT(3), PLAU(1), PLAUR(2), PLG(25), PROC(4), PROS1(12), SERPINA1(5), SERPINA5(10), SERPINC1(6), SERPIND1(3), SERPINE1(5), SERPINF2(5), SERPING1(10), TFPI(7), THBD(3), VWF(40) 28952129 825 173 785 352 564 62 38 90 70 1 0.00131 1.000 1.000 121 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(18), ACACB(15), AKT1(3), AKT2(8), AKT3(4), ARAF(3), CALM1(1), CALM2(1), CALML3(5), CBL(8), CBLB(14), CBLC(10), CRK(2), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(15), FBP1(2), FBP2(2), FLOT1(2), FOXO1(5), G6PC(4), G6PC2(3), GCK(15), GRB2(1), GSK3B(2), GYS1(3), GYS2(13), HRAS(3), IKBKB(3), INPP5D(24), INSR(19), IRS1(5), IRS2(2), IRS4(9), KRAS(4), LIPE(8), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MKNK1(3), MKNK2(1), PCK1(16), PCK2(4), PDE3A(17), PDE3B(6), PDPK1(4), PFKL(4), PFKM(1), PHKA1(17), PHKA2(7), PHKB(6), PHKG1(1), PHKG2(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PKLR(8), PKM2(3), PPARGC1A(12), PPP1CB(5), PPP1CC(2), PPP1R3A(45), PPP1R3B(5), PPP1R3C(2), PPP1R3D(3), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKACA(3), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCI(7), PRKCZ(4), PRKX(3), PTPN1(4), PTPRF(25), PYGB(2), PYGL(6), PYGM(9), RAF1(7), RAPGEF1(9), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(3), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SLC2A4(7), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(10), SOS1(7), SOS2(11), SREBF1(5), TRIP10(4), TSC1(5), TSC2(11) 52003391 768 173 742 351 489 58 36 110 73 2 0.00570 1.000 1.000 122 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), ARHGAP5(10), BCAR1(4), CD99(1), CDC42(2), CDH5(8), CLDN1(5), CLDN10(4), CLDN11(4), CLDN14(3), CLDN16(7), CLDN17(4), CLDN18(4), CLDN19(1), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(9), CLDN6(6), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(7), EZR(1), F11R(4), GNAI1(1), GNAI2(4), GNAI3(2), GRLF1(10), ICAM1(1), ITGA4(29), ITGAL(19), ITGAM(17), ITGB1(4), ITGB2(10), ITK(19), JAM2(10), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MLLT4(10), MMP2(6), MMP9(4), MSN(1), MYL2(4), MYL5(1), MYL7(2), MYL9(1), MYLPF(1), NCF1(1), NCF2(7), NCF4(4), NOX1(10), NOX3(4), OCLN(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PRKCA(10), PRKCG(13), PTK2(8), PTK2B(8), PTPN11(9), PXN(3), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(10), RAPGEF4(10), RASSF5(5), RHOA(1), RHOH(4), ROCK1(4), ROCK2(13), SIPA1(7), THY1(1), TXK(8), VASP(3), VAV1(13), VAV2(2), VAV3(8), VCAM1(13), VCL(7) 40535732 672 170 647 316 431 48 23 100 68 2 0.00282 1.000 1.000 123 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(16), AMY2A(4), AMY2B(10), ASCC3(10), ATP13A2(8), DDX18(4), DDX19A(1), DDX23(5), DDX4(10), DDX41(5), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(2), DDX56(3), DHX58(4), ENPP1(10), ENPP3(14), ENTPD7(2), EP400(18), ERCC2(2), ERCC3(1), G6PC(4), G6PC2(3), GAA(6), GANC(5), GBA(3), GBA3(14), GBE1(7), GCK(15), GPI(3), GUSB(3), GYS1(3), GYS2(13), HK1(3), HK2(11), HK3(12), IFIH1(13), MGAM(124), MOV10L1(23), NUDT5(2), NUDT8(1), PGM1(4), PGM3(1), PYGB(2), PYGL(6), PYGM(9), RAD54B(5), RUVBL2(4), SETX(13), SI(67), SKIV2L2(5), SMARCA2(10), SMARCA5(5), TREH(2), UGDH(1), UGP2(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), UXS1(4) 40454669 786 168 741 332 527 65 37 76 80 1 0.000132 1.000 1.000 124 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1C1(1), AKR1C2(5), AKR1C3(7), AKR1C4(7), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), CYP1A1(8), CYP1A2(10), CYP1B1(2), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2F1(9), CYP2S1(8), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), DHDH(3), EPHX1(2), GSTA1(5), GSTA2(2), GSTA5(3), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15) 18838459 636 167 585 272 461 44 36 44 50 1 1.95e-07 1.000 1.000 125 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(15), CD14(4), CD19(7), CD1A(8), CD1B(11), CD1C(23), CD1D(5), CD1E(16), CD22(17), CD33(15), CD34(4), CD36(4), CD37(3), CD38(2), CD3D(4), CD3G(1), CD4(6), CD44(5), CD5(5), CD55(4), CD59(1), CD8A(2), CD8B(5), CR1(47), CR2(26), CSF1(7), CSF1R(10), CSF2(1), CSF2RA(17), CSF3(3), CSF3R(2), DNTT(7), EPO(5), EPOR(1), FCER2(3), FCGR1A(5), FLT3(28), FLT3LG(2), GP5(3), GP9(4), GYPA(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), IL11RA(2), IL1A(4), IL1B(6), IL1R1(10), IL1R2(5), IL2RA(3), IL3(2), IL3RA(5), IL4(1), IL4R(12), IL5(2), IL5RA(11), IL6(2), IL6R(4), IL7(5), IL7R(24), IL9R(4), ITGA1(16), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGAM(17), ITGB3(9), KIT(8), KITLG(6), MME(17), MS4A1(7), TFRC(4), THPO(6), TNF(1), TPO(33) 26528247 657 167 629 299 469 32 27 52 77 0 0.00203 1.000 1.000 126 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(3), C7orf16(1), CACNA1A(25), CRH(3), CRHR1(6), GNA11(6), GNA12(3), GNA13(1), GNAI1(1), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(17), GNAZ(5), GRIA1(33), GRIA2(31), GRIA3(19), GRID2(44), GRM1(14), GRM5(10), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), HRAS(3), IGF1(9), IGF1R(9), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), LYN(5), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), NOS1(48), NOS3(14), NPR1(11), NPR2(9), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), PRKCA(10), PRKCG(13), PRKG1(10), PRKG2(13), RAF1(7), RYR1(72) 35345370 801 167 746 448 565 52 26 89 68 1 0.0361 1.000 1.000 127 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(10), ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(5), ATM(11), ATR(18), BUB1(3), BUB1B(8), CCNA1(13), CCNB2(3), CCNB3(26), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDC14A(4), CDC16(1), CDC20(1), CDC23(3), CDC25A(7), CDC25B(4), CDC25C(2), CDC27(9), CDC6(1), CDC7(2), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(17), CUL1(5), DBF4(5), E2F1(4), E2F2(4), E2F3(5), EP300(13), ESPL1(9), FZR1(6), GADD45B(2), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(16), PTTG2(5), RB1(8), RBL1(10), RBL2(4), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(18), TFDP1(2), TGFB1(1), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 44574017 424 163 414 164 229 34 32 87 40 2 0.0204 1.000 1.000 128 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(24), ADCY8(40), ARAF(3), ATF4(7), CACNA1C(32), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CHP(3), CREBBP(17), EP300(13), GNAQ(4), GRIA1(33), GRIA2(31), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), GRM1(14), GRM5(10), HRAS(3), ITPR1(21), ITPR2(15), ITPR3(6), KRAS(4), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PPP1CB(5), PPP1CC(2), PPP1R12A(3), PPP1R1A(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), RAF1(7), RAP1A(2), RAP1B(1), RAPGEF3(10), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15) 31767069 692 163 646 405 470 55 28 84 54 1 0.276 1.000 1.000 129 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(10), ABCA10(18), ABCA12(48), ABCA13(51), ABCA2(7), ABCA3(15), ABCA4(43), ABCA5(7), ABCA6(20), ABCA7(9), ABCA8(26), ABCA9(15), ABCB1(28), ABCB10(5), ABCB11(37), ABCB4(13), ABCB5(33), ABCB6(2), ABCB7(4), ABCB8(2), ABCB9(6), ABCC1(10), ABCC10(10), ABCC11(15), ABCC12(20), ABCC2(7), ABCC3(19), ABCC4(11), ABCC5(8), ABCC6(21), ABCC8(31), ABCC9(47), ABCD2(16), ABCD3(8), ABCD4(1), ABCG1(7), ABCG2(5), ABCG4(5), ABCG5(6), ABCG8(14), CFTR(38), TAP1(1), TAP2(11) 38824639 710 161 681 409 460 59 29 84 78 0 0.0576 1.000 1.000 130 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(5), CDS1(6), CDS2(4), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPP5B(5), INPP5D(24), INPPL1(14), ITPK1(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), OCRL(4), PI4KA(18), PI4KB(5), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3C3(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), PRKCA(10), PRKCG(13), SYNJ1(18), SYNJ2(13) 40507548 679 161 641 309 456 37 27 94 63 2 0.000640 1.000 1.000 131 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), AKT2(8), AKT3(4), CASP8(7), CD14(4), CD40(4), CD80(4), CD86(18), CHUK(2), CXCL10(2), CXCL9(1), FOS(2), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(3), IKBKE(8), IL12A(2), IL12B(1), IL1B(6), IL6(2), IL8(1), IRAK1(4), IRAK4(3), IRF3(3), IRF5(4), IRF7(7), JUN(1), LBP(6), LY96(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MYD88(4), NFKB1(7), NFKB2(4), NFKBIA(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), RELA(4), RIPK1(1), SPP1(6), STAT1(3), TBK1(4), TICAM1(7), TIRAP(1), TLR1(10), TLR2(13), TLR3(8), TLR4(25), TLR5(16), TLR6(5), TLR7(15), TLR8(8), TLR9(12), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 29350983 467 161 451 201 283 30 24 83 46 1 0.00270 1.000 1.000 132 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(3), AKT3(4), BCAR1(4), CAPN1(4), CAPN10(5), CAPN11(8), CAPN2(7), CAPN3(7), CAPN5(5), CAPN6(11), CAPN7(1), CAPN9(10), CAPNS1(1), CAV1(1), CDC42(2), CRK(2), CSK(1), DOCK1(12), FYN(5), GIT2(7), GRB2(1), ITGA10(7), ITGA11(12), ITGA2(7), ITGA2B(9), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGAD(17), ITGAE(12), ITGAL(19), ITGAM(17), ITGAV(9), ITGAX(15), ITGB1(4), ITGB2(10), ITGB3(9), ITGB4(20), ITGB5(5), ITGB6(9), ITGB7(5), ITGB8(16), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAPK10(8), MAPK12(1), MAPK4(14), MAPK6(4), MAPK7(3), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC2(1), RAP1B(1), RAPGEF1(9), RHO(1), ROCK1(4), ROCK2(13), SDCCAG8(2), SHC1(1), SHC3(8), SORBS1(10), SOS1(7), SRC(1), TLN1(11), TNS1(7), VASP(3), VAV2(2), VAV3(8), VCL(7), ZYX(6) 43601691 622 161 605 289 401 48 23 90 59 1 0.00928 1.000 1.000 133 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ATF4(7), CACNA1C(32), CACNA1D(23), CACNA1F(18), CACNA1S(41), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CDC42(2), CGA(1), EGFR(17), ELK1(2), FSHB(4), GNA11(6), GNAQ(4), GNAS(17), GNRH2(2), GNRHR(1), GRB2(1), HBEGF(1), HRAS(3), ITPR1(21), ITPR2(15), ITPR3(6), JUN(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(5), MMP14(2), MMP2(6), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLD1(9), PLD2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCD(4), PRKX(3), PTK2B(8), RAF1(7), SOS1(7), SOS2(11), SRC(1) 41341024 697 160 660 439 454 65 35 79 63 1 0.589 1.000 1.000 134 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(6), ALG14(2), ALG2(4), ALG3(4), ALG6(2), ALG8(5), ALG9(4), B3GNT1(2), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(5), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(5), CHST12(3), CHST13(2), CHST14(2), CHST2(3), CHST3(1), CHST4(8), CHST6(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(1), EXT2(6), EXTL1(2), EXTL3(9), FUT11(3), FUT8(7), GALNT1(4), GALNT10(6), GALNT11(1), GALNT12(6), GALNT13(23), GALNT14(23), GALNT2(5), GALNT3(3), GALNT4(3), GALNT5(8), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GALNTL1(4), GALNTL2(17), GALNTL4(6), GALNTL5(12), GANAB(3), GCNT1(6), GCNT3(5), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(4), HS6ST1(3), HS6ST2(2), HS6ST3(9), MAN1A1(13), MAN1A2(4), MAN1B1(3), MAN1C1(4), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), NDST1(4), NDST2(2), NDST3(22), NDST4(41), OGT(9), RPN2(2), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(3), STT3B(5), WBSCR17(36), XYLT1(8), XYLT2(3) 35984285 578 158 556 297 382 43 27 69 57 0 0.0603 1.000 1.000 135 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(3), CASP3(2), CD244(6), CD247(2), CD48(3), CHP(3), CSF2(1), FAS(5), FASLG(12), FCGR3A(6), FCGR3B(2), FYN(5), GRB2(1), GZMB(2), HLA-A(3), HLA-B(4), HLA-C(1), HLA-E(1), HLA-G(2), HRAS(3), ICAM1(1), ICAM2(3), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(1), IFNGR1(4), IFNGR2(4), ITGAL(19), ITGB2(10), KIR2DL3(6), KIR2DL4(3), KIR3DL1(12), KIR3DL2(2), KLRC1(3), KLRC2(1), KLRC3(11), KLRD1(3), KLRK1(5), KRAS(4), LAT(1), LCK(10), LCP2(9), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MICA(3), MICB(1), NCR1(12), NCR2(11), NCR3(2), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PAK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRF1(7), PRKCA(10), PRKCG(13), PTK2B(8), PTPN11(9), PTPN6(2), RAC2(1), RAF1(7), SH2D1A(2), SH2D1B(2), SH3BP2(2), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SYK(12), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFSF10(7), TYROBP(5), ULBP1(2), ULBP3(5), VAV1(13), VAV2(2), VAV3(8), ZAP70(4) 36194051 616 157 590 307 394 41 26 97 57 1 0.173 1.000 1.000 136 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(8), AKT3(4), BCL10(2), CARD11(29), CBL(8), CBLB(14), CBLC(10), CD247(2), CD28(1), CD3D(4), CD3G(1), CD4(6), CD40LG(1), CD8A(2), CD8B(5), CDC42(2), CDK4(5), CHP(3), CHUK(2), CSF2(1), CTLA4(2), FOS(2), FYN(5), GRAP2(4), GRB2(1), HRAS(3), ICOS(3), IFNG(1), IKBKB(3), IL10(3), IL2(2), IL4(1), IL5(2), ITK(19), JUN(1), KRAS(4), LAT(1), LCK(10), LCP2(9), MALT1(6), MAP3K14(3), NCK1(1), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDCD1(3), PDK1(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKCQ(13), PTPN6(2), PTPRC(26), RASGRP1(6), RHOA(1), SOS1(7), SOS2(11), TEC(9), TNF(1), VAV1(13), VAV2(2), VAV3(8), ZAP70(4) 33277939 539 156 518 243 333 42 26 90 47 1 0.0663 1.000 1.000 137 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(10), ACTN1(5), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(1), ARHGEF6(10), ARHGEF7(3), BCAR1(4), CAV1(1), CDC42(2), CRK(2), CSE1L(4), DOCK1(12), EPHB2(21), FYN(5), GRB2(1), GRB7(4), GRLF1(10), ITGA1(16), ITGA10(7), ITGA11(12), ITGA2(7), ITGA3(7), ITGA4(29), ITGA5(16), ITGA6(6), ITGA7(15), ITGA8(27), ITGA9(8), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MRAS(1), MYLK(35), MYLK2(9), P4HB(2), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PIK3CA(6), PIK3CB(21), PKLR(8), PLCG1(7), PLCG2(22), PTK2(8), RAF1(7), RALA(1), RHO(1), ROCK1(4), ROCK2(13), SHC1(1), SOS1(7), SOS2(11), SRC(1), TERF2IP(1), TLN1(11), TLN2(21), VASP(3), WAS(6), ZYX(6) 39128913 597 156 573 268 373 48 24 93 59 0 0.00750 1.000 1.000 138 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), ASIP(1), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CREB3(1), CREB3L1(3), CREB3L2(6), CREB3L3(9), CREB3L4(5), CREBBP(17), CTNNB1(11), DCT(2), DVL1(1), DVL2(4), DVL3(6), EDN1(7), EDNRB(4), EP300(13), FZD1(4), FZD10(1), FZD2(5), FZD4(1), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GNAI1(1), GNAI2(4), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(17), GSK3B(2), HRAS(3), KIT(8), KITLG(6), KRAS(4), LEF1(3), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MITF(4), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), POMC(1), PRKACA(3), PRKACB(4), PRKACG(7), PRKCA(10), PRKCG(13), PRKX(3), RAF1(7), TCF7(1), TCF7L1(3), TCF7L2(6), TYR(7), TYRP1(8), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3) 35393314 590 155 560 331 369 55 30 72 63 1 0.154 1.000 1.000 139 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(16), AMY2A(4), AMY2B(10), ENPP1(10), ENPP3(14), G6PC(4), GAA(6), GANAB(3), GBA3(14), GBE1(7), GCK(15), GPI(3), GUSB(3), GYS1(3), GYS2(13), HK1(3), HK2(11), HK3(12), MGAM(124), PGM1(4), PGM3(1), PYGB(2), PYGL(6), PYGM(9), SI(67), UCHL1(3), UCHL3(2), UGDH(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27), UXS1(4) 18681871 490 155 457 207 337 49 22 41 40 1 0.000577 1.000 1.000 140 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(21), ASH2L(3), CARM1(6), CTCFL(16), DOT1L(7), EED(1), EHMT1(7), EHMT2(9), EZH1(4), EZH2(10), FBXO11(6), HCFC1(14), JMJD4(4), JMJD6(1), KDM6A(3), MEN1(2), MLL(34), MLL2(42), MLL3(53), MLL4(28), MLL5(11), NSD1(14), OGT(9), PAXIP1(2), PPP1CB(5), PPP1CC(2), PRDM2(11), PRDM7(5), PRDM9(41), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(3), SATB1(11), SETD1A(22), SETD2(12), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(3), SMYD3(2), STK38(4), SUV39H1(1), SUV39H2(1), SUV420H1(7), SUV420H2(1), SUZ12(2), WHSC1(8), WHSC1L1(6) 38938961 487 154 471 165 307 46 22 66 46 0 0.00130 1.000 1.000 141 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADCY9(9), AKAP1(7), AKAP10(3), AKAP11(11), AKAP12(3), AKAP3(16), AKAP4(12), AKAP6(26), AKAP7(3), AKAP8(6), AKAP9(26), ARHGEF1(1), CALM1(1), CALM2(1), GNA11(6), GNA12(3), GNA13(1), GNA14(4), GNA15(5), GNAI2(4), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(4), GNAZ(5), GNB3(5), GNB5(2), GNG4(1), GNG7(1), GNGT2(3), HRAS(3), ITPR1(21), KCNJ3(16), KRAS(4), PDE1B(10), PDE1C(37), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(19), PLCB3(3), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(3), USP5(3) 37969523 555 153 542 337 371 47 30 65 42 0 0.701 1.000 1.000 142 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(10), ABL2(10), AKT1(3), AKT2(8), AKT3(4), ARAF(3), AREG(4), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CBL(8), CBLB(14), CBLC(10), CDKN1A(4), CDKN1B(1), CRK(2), CRKL(2), EGF(14), EGFR(17), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(4), ERBB4(45), EREG(4), GAB1(2), GRB2(1), GSK3B(2), HBEGF(1), HRAS(3), JUN(1), KRAS(4), MAP2K1(11), MAP2K2(3), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MYC(4), NCK1(1), NCK2(4), NRG1(15), NRG2(5), NRG3(18), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG1(7), PLCG2(22), PRKCA(10), PRKCG(13), PTK2(8), RAF1(7), RPS6KB1(2), RPS6KB2(2), SHC1(1), SHC2(5), SHC3(8), SHC4(2), SOS1(7), SOS2(11), SRC(1), STAT5A(2), STAT5B(4), TGFA(2) 33158408 558 152 529 237 348 41 27 90 51 1 0.0108 1.000 1.000 143 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(3), ACTB(6), ACTG1(6), ACTN1(5), ACTN2(16), ACTN3(7), ACTN4(5), ACVR1B(2), ACVR1C(7), BAIAP2(5), CDC42(2), CDH1(4), CREBBP(17), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(19), CTNNA3(25), CTNNB1(11), CTNND1(9), EGFR(17), EP300(13), ERBB2(7), FARP2(5), FER(2), FGFR1(11), FYN(5), IGF1R(9), INSR(19), IQGAP1(8), LEF1(3), LMO7(18), MAP3K7(1), MAPK1(4), MAPK3(1), MET(19), MLLT4(10), NLK(5), PARD3(14), PTPN1(4), PTPN6(2), PTPRB(64), PTPRF(25), PTPRJ(7), PTPRM(6), PVRL1(4), PVRL2(5), PVRL3(5), PVRL4(6), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(1), SNAI2(4), SORBS1(10), SRC(1), SSX2IP(5), TCF7(1), TCF7L1(3), TCF7L2(6), TGFBR2(7), TJP1(9), VCL(7), WAS(6), WASF1(3), WASF2(3), WASF3(11), WASL(5), YES1(5) 39491282 549 152 528 268 352 44 25 67 60 1 0.255 1.000 1.000 144 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(9), AGTR2(10), ATP8A1(19), AVPR1A(3), AVPR1B(6), AVPR2(1), BDKRB1(3), BDKRB2(9), BRS3(4), C3AR1(4), CCKAR(9), CCKBR(8), CCR1(7), CCR10(2), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR6(2), CCR7(3), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(3), CXCR6(4), EDNRA(8), EDNRB(4), FPR1(15), FSHR(13), GALR1(4), GALR3(2), GALT(2), GHSR(4), GNB2L1(3), GNRHR(1), GPR77(5), GRPR(4), LHCGR(21), MC2R(5), MC3R(6), MC4R(1), MC5R(7), NMBR(6), NPY1R(23), NPY2R(11), NPY5R(20), NTSR1(5), NTSR2(3), OPRD1(2), OPRK1(19), OPRL1(5), OPRM1(4), OXTR(5), PPYR1(10), SSTR1(10), SSTR2(5), SSTR3(7), SSTR4(3), TACR1(6), TACR2(6), TACR3(21), TRHR(17), TSHR(6) 17248969 461 152 436 304 316 40 18 54 33 0 0.00172 1.000 1.000 145 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY1(24), ADCY2(8), ADCY3(2), ADCY4(4), ADCY5(11), ADCY6(5), ADCY7(9), ADCY8(40), ADK(4), ADSL(3), ADSS(2), AK2(3), AK5(5), ALLC(7), AMPD1(24), AMPD2(5), AMPD3(20), APRT(3), ATIC(5), ATP5B(1), ATP5C1(2), ATP5F1(5), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(10), ENPP3(14), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(10), GMPS(1), GUCY1A2(16), GUCY1A3(24), GUCY1B3(6), GUCY2C(27), GUCY2D(8), GUCY2F(14), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(11), NPR2(9), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(5), PDE4A(9), PDE4B(7), PDE4C(13), PDE4D(7), PDE5A(7), PDE6B(10), PDE6C(20), PDE6G(2), PDE7B(16), PDE8A(2), PDE9A(8), PFAS(7), PKLR(8), PKM2(3), POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(11), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2) 41743625 634 152 608 332 431 49 26 69 59 0 0.0323 1.000 1.000 146 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(2), ACVRL1(8), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(4), BUB1(3), CDKL1(4), CDKL2(1), CDS1(6), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(2), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPPL1(14), ITPKB(5), MAP3K10(7), MOS(3), NEK1(6), NEK3(2), OCRL(4), PAK4(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3CA(6), PIK3CB(21), PIK3CG(21), PIM2(4), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCG1(7), PLCG2(22), PLK3(2), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), PRKCZ(4), PRKD1(3), PRKG1(10), RAF1(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(3) 36998017 559 149 530 298 375 28 21 77 57 1 0.533 1.000 1.000 147 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(10), ATM(11), BUB1(3), BUB1B(8), CCNA1(13), CCNB2(3), CCNB3(26), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDAN1(4), CDC14A(4), CDC20(1), CDC25A(7), CDC25B(4), CDC25C(2), CDC6(1), CDC7(2), CDH1(4), CDK4(5), CDKN1A(4), CHEK1(1), CHEK2(2), DTX4(4), E2F1(4), E2F2(4), E2F3(5), E2F4(1), E2F5(1), EP300(13), ESPL1(9), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(8), HDAC5(6), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), MPEG1(5), MPL(7), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(16), PTPRA(6), PTTG2(5), RB1(8), RBL1(10), SKP2(2), SMAD4(2), TBC1D8(8), TFDP1(2), TGFB1(1), WEE1(2) 35732722 338 148 332 144 195 31 17 64 29 2 0.0529 1.000 1.000 148 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(2), ACVR1C(7), ACVR2A(4), ACVR2B(3), ACVRL1(8), AMHR2(14), BMP2(3), BMP4(2), BMP5(21), BMP6(7), BMP7(1), BMP8A(2), BMP8B(1), BMPR1A(1), BMPR1B(3), BMPR2(4), CHRD(10), COMP(4), CREBBP(17), CUL1(5), DCN(15), E2F4(1), E2F5(1), EP300(13), FST(4), GDF5(11), GDF6(2), GDF7(2), ID2(2), IFNG(1), INHBA(12), INHBB(4), INHBC(10), INHBE(3), LEFTY1(6), LEFTY2(3), LTBP1(33), MAPK1(4), MAPK3(1), MYC(4), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(3), PPP2R2A(2), PPP2R2B(4), PPP2R2C(6), RBL1(10), RBL2(4), RHOA(1), ROCK1(4), ROCK2(13), RPS6KB1(2), RPS6KB2(2), SMAD1(5), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(2), SMAD6(6), SMAD7(2), SMAD9(9), SMURF1(1), SMURF2(9), SP1(3), TFDP1(2), TGFB1(1), TGFB3(3), TGFBR2(7), THBS1(21), THBS2(9), THBS3(10), THBS4(9), TNF(1), ZFYVE16(3), ZFYVE9(7) 32712263 432 148 421 203 275 39 19 56 43 0 0.239 1.000 1.000 149 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), F10(7), F11(9), F12(1), F2(9), F2R(5), F5(24), F8(40), F9(11), FGA(32), FGB(6), FGG(7), KLKB1(19), PROC(4), PROS1(12), SERPINC1(6), SERPING1(10) 14637957 460 147 440 140 345 32 19 43 21 0 0.0557 1.000 1.000 150 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(7), AKR1D1(17), ARSD(3), ARSE(5), CARM1(6), CYP11B1(11), CYP11B2(11), CYP19A1(9), HEMK1(4), HSD11B1(10), HSD11B2(2), HSD17B12(2), HSD17B2(7), HSD17B3(3), HSD17B7(1), HSD3B1(10), HSD3B2(7), LCMT1(3), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(2), SRD5A2(5), STS(6), SULT1E1(10), SULT2A1(6), SULT2B1(5), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), WBSCR22(1) 16431976 418 146 394 178 282 40 23 30 42 1 0.000120 1.000 1.000 151 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(3), AKT2(8), AKT3(4), BTK(15), CSF2(1), FCER1A(12), FYN(5), GAB2(3), GRB2(1), HRAS(3), IL3(2), IL4(1), IL5(2), INPP5D(24), KRAS(4), LAT(1), LCP2(9), LYN(5), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MS4A2(9), PDK1(2), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCG1(7), PLCG2(22), PRKCA(10), PRKCD(4), PRKCE(5), RAC2(1), RAF1(7), SOS1(7), SOS2(11), SYK(12), TNF(1), VAV1(13), VAV2(2), VAV3(8) 23503893 407 145 390 163 248 26 18 70 44 1 0.00165 1.000 1.000 152 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(15), ACAT2(1), ACMSD(9), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(18), ASMT(5), CAT(5), CYP19A1(9), CYP1A1(8), CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2D6(1), CYP2E1(12), CYP2F1(9), CYP2J2(3), CYP3A4(16), CYP3A5(10), CYP3A7(12), CYP4B1(17), CYP4F8(11), DDC(12), ECHS1(1), EHHADH(5), GCDH(5), HAAO(3), HADHA(8), KMO(7), KYNU(10), MAOA(2), MAOB(11), SDS(2), TDO2(4), TPH1(5), WARS(4), WARS2(4) 18076614 457 145 435 257 339 30 19 38 31 0 0.0694 1.000 1.000 153 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(6), EGFR(17), ERBB2(7), ERBB4(45), ETS1(3), ETS2(7), ETV6(10), ETV7(2), FMN2(56), GRB2(1), KRAS(4), MAP2K1(11), MAPK1(4), MAPK3(1), NOTCH1(5), NOTCH2(34), NOTCH3(21), NOTCH4(48), PIWIL1(17), PIWIL2(11), PIWIL3(9), PIWIL4(4), RAF1(7), SOS1(7), SOS2(11), SPIRE1(2), SPIRE2(6) 16803127 356 144 340 139 233 20 14 63 26 0 0.0268 1.000 1.000 154 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), AKT2(8), AKT3(4), BCL10(2), BLNK(8), BTK(15), CARD11(29), CD19(7), CD22(17), CD72(4), CD79A(2), CD79B(1), CHP(3), CHUK(2), CR2(26), FCGR2B(2), FOS(2), GSK3B(2), HRAS(3), IKBKB(3), INPP5D(24), JUN(1), KRAS(4), LILRB3(5), LYN(5), MALT1(6), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PTPN6(2), RAC2(1), RASGRP3(11), SYK(12), VAV1(13), VAV2(2), VAV3(8) 24284676 412 143 403 168 252 24 25 67 43 1 0.00216 1.000 1.000 155 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(5), ATM(11), BAX(3), BCL2(2), BIRC2(3), BIRC3(6), CAPN1(4), CAPN2(7), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHP(3), CHUK(2), CSF2RB(14), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(12), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1RAP(4), IL3(2), IL3RA(5), IRAK1(4), IRAK2(9), IRAK3(5), IRAK4(3), MAP3K14(3), MYD88(4), NFKB1(7), NFKB2(4), NFKBIA(2), NTRK1(12), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(4), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(7), TNFRSF1A(2), TNFSF10(7), TRAF2(1) 27122791 356 142 349 182 209 24 17 67 38 1 0.549 1.000 1.000 156 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(2), CDC40(4), CLK2(6), CLK3(2), COL2A1(27), CPSF1(6), CPSF2(2), CPSF3(4), CSTF1(4), CSTF2(4), CSTF2T(2), CSTF3(4), DDIT3(2), DDX1(2), DDX20(7), DHX15(4), DHX16(7), DHX38(7), DHX8(9), DHX9(8), DICER1(16), DNAJC8(2), GIPC1(3), LOC440563(17), LSM2(2), LSM7(1), METTL3(1), NCBP1(1), NONO(8), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(10), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(1), PRPF4B(5), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(6), RBM17(1), RBM5(6), RNGTT(1), RNMT(5), RNPS1(1), SF3A1(6), SF3A2(5), SF3A3(4), SF3B1(14), SF3B2(9), SF3B4(4), SF4(8), SFRS12(2), SFRS14(9), SFRS16(3), SFRS4(2), SFRS5(2), SFRS6(1), SFRS7(2), SFRS8(6), SFRS9(2), SNRPA(2), SNRPA1(1), SNRPB(4), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(4), SNURF(2), SPOP(2), SRPK1(7), SRPK2(2), SRRM1(6), SUPT5H(5), TXNL4A(1), U2AF2(3), XRN2(4) 35101502 359 142 354 155 212 29 22 49 47 0 0.455 1.000 1.000 157 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(11), ALG6(2), CCKBR(8), CCR2(15), CCR3(8), CCR5(6), CELSR1(20), CELSR2(22), CELSR3(31), CHRM2(17), CHRM3(17), CXCR3(3), DRD4(1), EDNRA(8), EMR2(4), EMR3(15), F2R(5), FSHR(13), GHRHR(3), GNRHR(1), GPR116(28), GPR132(3), GPR133(12), GPR143(3), GPR17(1), GPR18(5), GPR55(2), GPR56(4), GPR61(8), GPR77(5), GPR84(7), GRM1(14), GRPR(4), HRH4(5), LGR6(15), LPHN2(30), LPHN3(17), LTB4R2(1), NTSR1(5), OR2M4(10), OR8G2(13), P2RY13(4), PTGFR(18), SMO(10), SSTR2(5), TAAR5(3), TSHR(6) 21917759 448 141 431 293 288 40 20 63 36 1 0.281 1.000 1.000 158 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(6), BCL2(2), CABIN1(9), CALM1(1), CALM2(1), CAMK2B(4), CAMK4(8), CD3G(1), CD69(3), CDKN1A(4), CNR1(7), CREBBP(17), CSF2(1), CSNK2A1(1), CSNK2B(1), CTLA4(2), EGR2(3), EGR3(2), EP300(13), FCER1A(12), FCGR3A(6), FOS(2), GATA3(5), GATA4(2), GRLF1(10), GSK3B(2), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL1B(6), IL2(2), IL2RA(3), IL3(2), IL4(1), IL6(2), IL8(1), ITK(19), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(1), MAPK9(5), MEF2A(4), MEF2B(2), MEF2D(4), MYF5(11), NCK2(4), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB2(4), NFKBIB(1), NPPB(3), NUP214(11), OPRD1(2), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(26), RELA(4), RPL13A(1), SFN(1), SLA(2), SP1(3), TGFB1(1), TNF(1), TRAF2(1), TRPV6(25), VAV1(13), VAV2(2), VAV3(8), XPO5(7) 30019156 395 140 381 194 262 23 21 47 42 0 0.180 1.000 1.000 159 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AGK(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AKR1A1(3), AKR1B1(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CEL(11), DAK(3), DGAT1(1), DGAT2(4), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), GK(6), GLA(1), GLB1(7), GPAM(2), LCT(29), LIPA(4), LIPC(8), LIPF(14), LIPG(5), LPL(3), MGLL(6), PNLIP(3), PNLIPRP1(7), PNLIPRP2(2), PNPLA3(2), PPAP2B(5), PPAP2C(6) 19038385 376 140 347 175 248 39 16 48 25 0 0.0107 1.000 1.000 160 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPP5B(5), INPPL1(14), IPMK(1), ITPK1(4), ITPKB(5), MINPP1(1), MIOX(2), OCRL(4), PI4KA(18), PI4KB(5), PIK3C3(3), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(13), PIP5K1C(6), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(41), PLCG1(7), PLCG2(22), PLCZ1(18), SYNJ1(18), SYNJ2(13) 24048182 406 138 385 175 263 23 19 66 34 1 0.00254 1.000 1.000 161 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(5), ACADL(4), ACADM(5), ACOX1(7), ACOX2(5), ACOX3(11), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADIPOQ(3), ANGPTL4(4), APOA1(1), APOA5(4), AQP7(2), CD36(4), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), CYP27A1(3), CYP4A11(19), CYP4A22(16), CYP7A1(6), CYP8B1(9), DBI(1), EHHADH(5), FABP1(6), FABP2(5), FABP4(1), FADS2(3), GK(6), HMGCS2(16), LPL(3), ME1(17), MMP1(10), NR1H3(2), OLR1(2), PCK1(16), PCK2(4), PDPK1(4), PLTP(1), PPARA(6), PPARD(2), PPARG(11), RXRA(4), RXRB(4), RXRG(4), SCD(3), SCP2(2), SLC27A1(3), SLC27A2(11), SLC27A4(2), SLC27A5(6), SLC27A6(24), SORBS1(10), UBC(4), UCP1(3) 21276979 380 137 365 202 264 33 15 37 31 0 0.164 1.000 1.000 162 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH7A1(8), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), G6PC2(3), GALM(2), GAPDH(1), GAPDHS(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(22), PGM1(4), PGM3(1), PKLR(8), PKM2(3) 19194694 323 135 292 150 218 29 18 37 21 0 0.00209 1.000 1.000 163 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(3), AKT2(8), AKT3(4), CASP9(2), CDC42(2), CHP(3), HRAS(3), KDR(32), KRAS(4), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPKAPK2(5), MAPKAPK3(3), NFAT5(6), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NOS3(14), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCG1(7), PLCG2(22), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(5), PRKCA(10), PRKCG(13), PTGS2(9), PTK2(8), PXN(3), RAC2(1), RAF1(7), SH2D2A(2), SHC2(5), SPHK1(1), SPHK2(6), SRC(1), VEGFA(5) 23473905 395 135 379 167 245 20 13 73 43 1 0.00607 1.000 1.000 164 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(11), CCNA1(13), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNH(2), CDC25A(7), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2C(1), CREB3(1), CREB3L1(3), CREB3L3(9), CREB3L4(5), E2F1(4), E2F2(4), E2F3(5), E2F4(1), E2F5(1), GBA2(2), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), MDM2(3), MNAT1(2), MYC(4), MYT1(19), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLE(14), POLE2(3), PRIM1(3), RB1(8), RBL1(10), RPA1(3), RPA2(2), RPA3(1), TFDP1(2), TFDP2(4), TNXB(115), WEE1(2) 25617602 348 133 335 145 209 24 12 69 32 2 0.0252 1.000 1.000 165 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(15), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), AOX1(18), CARM1(6), COMT(3), DBH(13), DCT(2), DDC(12), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(3), GOT2(4), HEMK1(4), HGD(10), HPD(4), LCMT1(3), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), MYST3(12), MYST4(9), NAT6(1), PNMT(2), PNPLA3(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(12), TH(7), TPO(33), TYR(7), TYRP1(8), WBSCR22(1) 19582692 370 133 351 190 258 33 20 39 20 0 0.138 1.000 1.000 166 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(10), ADCY4(4), ADCY6(5), ADCY8(40), CACNA1A(25), CACNA1B(21), GNAS(17), GNAT3(2), GNB3(5), GRM4(14), ITPR3(6), KCNB1(30), PLCB2(6), PRKACA(3), PRKACB(4), PRKACG(7), PRKX(3), SCNN1A(6), SCNN1B(11), SCNN1G(21), TAS1R1(10), TAS1R2(20), TAS1R3(1), TAS2R1(7), TAS2R10(6), TAS2R13(2), TAS2R14(1), TAS2R16(8), TAS2R3(1), TAS2R38(13), TAS2R39(8), TAS2R4(3), TAS2R40(2), TAS2R41(11), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R60(15), TAS2R7(3), TAS2R8(3), TAS2R9(5), TRPM5(11) 18263511 378 133 361 322 246 32 18 46 36 0 0.976 1.000 1.000 167 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(7), AGT(5), AGTR1(9), AGTR2(10), CMA1(5), COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), REN(8) 8315500 302 132 286 86 242 16 8 24 12 0 0.370 1.000 1.000 168 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(4), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(11), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), CYP4A11(19), CYP4A22(16), DCI(2), ECHS1(1), EHHADH(5), GCDH(5), HADHA(8), HADHB(3), HSD17B10(2), HSD17B4(6), PECI(1) 16232626 310 132 287 131 215 27 18 27 23 0 0.00316 1.000 1.000 169 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(8), AKT3(4), DAG1(5), DRD2(13), EGFR(17), EPHB2(21), GRB2(1), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), PI3(5), PIK3CB(21), PITX2(4), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), RAF1(7), RGS20(2), SHC1(1), SOS1(7), SOS2(11), SRC(1), STAT3(10), TERF2IP(1) 18776680 336 132 314 165 210 28 21 46 30 1 0.0575 1.000 1.000 170 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(2), CREBBP(17), CTBP2(1), DLL1(2), DLL3(4), DLL4(6), DTX1(8), DTX2(3), DTX3(4), DTX3L(5), DTX4(4), DVL1(1), DVL2(4), DVL3(6), EP300(13), HDAC1(1), HDAC2(1), HES1(2), JAG1(8), JAG2(7), LFNG(3), MAML1(3), MAML2(6), MAML3(6), MFNG(7), NCOR2(22), NCSTN(4), NOTCH1(5), NOTCH2(34), NOTCH3(21), NOTCH4(48), NUMB(4), NUMBL(3), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(3), RBPJL(3), SNW1(2) 22644022 280 130 276 139 160 26 12 60 22 0 0.619 1.000 1.000 171 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(4), CHUK(2), DAXX(8), ELK1(2), FOS(2), GRB2(1), HRAS(3), IKBKB(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(2), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K6(4), MAP3K7(1), MAP3K9(20), MAP4K1(8), MAP4K2(4), MAP4K3(7), MAP4K4(6), MAP4K5(2), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK4(14), MAPK6(4), MAPK7(3), MAPK8(1), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(3), MKNK2(1), MYC(4), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAF1(7), RELA(4), RIPK1(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(3), RPS6KB1(2), RPS6KB2(2), SHC1(1), SP1(3), STAT1(3), TGFB1(1), TGFB3(3), TRAF2(1) 30490517 332 130 321 170 193 36 16 55 32 0 0.652 1.000 1.000 172 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(2), ACP5(3), ACPP(6), ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), CYP19A1(9), CYP1A1(8), CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2D6(1), CYP2E1(12), CYP2F1(9), CYP2J2(3), CYP3A4(16), CYP3A5(10), CYP3A7(12), CYP4B1(17), CYP4F8(11), PON1(10) 9583676 329 129 306 182 255 20 11 18 25 0 0.00512 1.000 1.000 173 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), CEL(11), DGAT1(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), GK(6), GLA(1), GLB1(7), LCT(29), LIPC(8), LIPF(14), LIPG(5), LPL(3), PNLIP(3), PNLIPRP1(7), PNLIPRP2(2), PPAP2B(5), PPAP2C(6) 15923554 328 129 303 157 229 32 13 37 17 0 0.0193 1.000 1.000 174 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(15), ACSL1(4), ACSL3(5), ACSL4(2), ACSL5(18), ACSL6(13), ADIPOQ(3), ADIPOR1(4), ADIPOR2(1), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(2), CAMKK2(6), CD36(4), CHUK(2), CPT1A(9), CPT1B(10), CPT1C(9), CPT2(1), G6PC(4), G6PC2(3), IKBKB(3), IRS1(5), IRS2(2), IRS4(9), JAK1(5), JAK2(7), JAK3(4), LEP(2), LEPR(19), MAPK10(8), MAPK8(1), MAPK9(5), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(16), PCK2(4), POMC(1), PPARA(6), PPARGC1A(12), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKCQ(13), PTPN11(9), RELA(4), RXRA(4), RXRB(4), RXRG(4), SLC2A1(4), SLC2A4(7), SOCS3(2), STAT3(10), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1), TYK2(7) 27377337 378 129 368 212 225 38 21 47 47 0 0.645 1.000 1.000 175 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(3), AKT2(8), AKT3(4), CDC42(2), CDKN1B(1), CREB3(1), CREB5(7), ERBB4(45), F2RL2(5), GAB1(2), GRB2(1), GSK3B(2), IGF1(9), IGFBP1(3), INPPL1(14), IRS1(5), IRS2(2), IRS4(9), MET(19), MYC(4), NOLC1(3), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PARD3(14), PARD6A(1), PDK1(2), PIK3CA(6), PIK3CD(7), PPP1R13B(6), PREX1(7), PTK2(8), PTPN1(4), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(7), SOS1(7), SOS2(11), TSC1(5), TSC2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 25021271 337 128 325 161 197 35 17 51 36 1 0.228 1.000 1.000 176 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(5), CAD(12), CANT1(9), CDA(1), CTPS(2), CTPS2(3), DCTD(2), DHODH(2), DPYD(53), DPYS(21), ENTPD1(7), ENTPD3(5), ENTPD4(3), ENTPD5(1), ENTPD6(4), ENTPD8(2), NME6(2), NME7(4), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(12), RRM1(3), RRM2(2), RRM2B(2), TK2(1), TXNRD1(4), TXNRD2(3), TYMS(1), UCK1(1), UMPS(1), UPB1(6), UPP2(2), UPRT(1) 26729841 319 127 302 163 203 24 17 49 26 0 0.331 1.000 1.000 177 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), AGT(5), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(2), CAMK1G(6), CAMK4(8), CREBBP(17), CSNK1A1(2), EDN1(7), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(2), GSK3B(2), HAND1(2), HAND2(5), HRAS(3), IGF1(9), LIF(2), MAP2K1(11), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(72), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NKX2-5(1), NPPA(2), PIK3CA(6), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RAF1(7), RPS6KB1(2), SYT1(17) 16757309 298 127 278 159 202 25 15 32 23 1 0.441 1.000 1.000 178 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(3), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(3), CHRNA1(5), FLT1(28), FLT4(17), KDR(32), NOS3(14), PDE2A(11), PDE3A(17), PDE3B(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKG1(10), PRKG2(13), RYR2(77), SLC7A1(3), SYT1(17) 13428312 289 127 274 173 198 22 9 31 29 0 0.544 1.000 1.000 179 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(10), ACTB(6), ACTG1(6), ARHGEF2(17), ARPC5(1), CD14(4), CDC42(2), CDH1(4), CLDN1(5), CTNNB1(11), CTTN(1), EZR(1), FYN(5), HCLS1(5), ITGB1(4), KRT18(2), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(3), PRKCA(10), RHOA(1), ROCK1(4), ROCK2(13), TLR4(25), TLR5(16), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10), WAS(6), WASL(5), YWHAQ(3) 17033985 275 126 265 111 172 29 11 33 30 0 0.00182 1.000 1.000 180 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(10), ACTB(6), ACTG1(6), ARHGEF2(17), ARPC5(1), CD14(4), CDC42(2), CDH1(4), CLDN1(5), CTNNB1(11), CTTN(1), EZR(1), FYN(5), HCLS1(5), ITGB1(4), KRT18(2), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(3), PRKCA(10), RHOA(1), ROCK1(4), ROCK2(13), TLR4(25), TLR5(16), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(20), TUBA3D(10), TUBA3E(2), TUBA4A(5), TUBA8(3), TUBAL3(10), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(3), TUBB4(3), TUBB4Q(9), TUBB6(10), WAS(6), WASL(5), YWHAQ(3) 17033985 275 126 265 111 172 29 11 33 30 0 0.00182 1.000 1.000 181 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(2), BMP5(21), BMP6(7), BMP7(1), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1A1L(5), CSNK1D(1), CSNK1E(2), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(4), GLI1(9), GLI2(32), GLI3(15), GSK3B(2), HHIP(17), IHH(2), LRP2(68), PRKACA(3), PRKACB(4), PRKACG(7), PRKX(3), PTCH1(7), PTCH2(15), RAB23(1), SHH(4), SMO(10), STK36(12), SUFU(2), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT3A(6), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4), WNT8A(6), WNT8B(6), WNT9A(2), WNT9B(3), ZIC2(2) 19851691 358 125 343 170 240 32 18 37 31 0 0.0280 1.000 1.000 182 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(10), BLNK(8), BTK(15), CD19(7), CD22(17), CR2(26), CSK(1), DAG1(5), FLOT1(2), GRB2(1), GSK3B(2), INPP5D(24), ITPR1(21), ITPR2(15), ITPR3(6), LYN(5), MAP4K1(8), MAPK1(4), MAPK3(1), NFATC1(13), NFATC2(6), NR0B2(3), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PLCG2(22), PPP1R13B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(26), RAF1(7), SHC1(1), SOS1(7), SOS2(11), SYK(12), VAV1(13) 24341275 351 125 343 161 222 24 24 43 37 1 0.0203 1.000 1.000 183 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(8), PKM2(3) 16111702 273 124 248 120 188 27 14 28 16 0 0.000822 1.000 1.000 184 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1A1(3), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), ALDOA(1), ALDOB(9), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GCK(15), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHB(2), LDHC(5), PDHA1(2), PDHA2(15), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(8), PKM2(3) 16111702 273 124 248 120 188 27 14 28 16 0 0.000822 1.000 1.000 185 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(1), ALAS2(5), BLVRA(2), COX10(4), COX15(4), CP(9), CPOX(2), EPRS(9), FECH(3), FTH1(3), FTMT(5), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(1), PPOX(2), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), UROS(1) 13884039 298 124 281 118 200 24 18 19 36 1 0.00150 1.000 1.000 186 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(5), ATM(11), ATR(18), BAI1(13), BAX(3), CASP3(2), CASP8(7), CASP9(2), CCNB2(3), CCNB3(26), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(12), CCNG1(1), CDK4(5), CDK6(2), CDKN1A(4), CHEK1(1), CHEK2(2), CYCS(1), DDB2(1), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(9), IGFBP3(2), LRDD(4), MDM2(3), MDM4(2), PERP(2), RFWD2(4), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(7), SERPINE1(5), SESN2(4), SESN3(1), SFN(1), STEAP3(6), THBS1(21), TNFRSF10B(1), TP53I3(2), TP73(5), TSC2(11), ZMAT3(1) 20649326 242 123 235 110 135 22 17 44 23 1 0.263 1.000 1.000 187 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(8), AKT3(4), BCR(10), BTK(15), CD19(7), DAPP1(4), FLOT1(2), GAB1(2), ITPR1(21), ITPR2(15), ITPR3(6), LYN(5), NR0B2(3), PDK1(2), PIK3CA(6), PITX2(4), PLCG2(22), PPP1R13B(6), PREX1(7), PTPRC(26), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(12), TEC(9), VAV1(13) 17674286 237 122 224 136 154 16 16 28 23 0 0.386 1.000 1.000 188 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(43), COL4A2(21), COL4A3(33), COL4A4(82), COL4A5(48), COL4A6(31), P4HB(2), SLC23A1(2), SLC23A2(4), SLC2A1(4), SLC2A3(7) 8219316 277 122 263 73 223 14 9 20 11 0 0.0938 1.000 1.000 189 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(1), ARHGAP1(2), ARHGAP4(1), ARHGEF11(15), BTK(15), CDC42(2), CFL1(1), GDI1(1), GDI2(2), INPPL1(14), ITPR1(21), ITPR2(15), ITPR3(6), LIMK1(2), MYLK(35), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3CG(21), PIK3R1(3), PITX2(4), PPP1R13B(6), RACGAP1(3), RHO(1), ROCK1(4), ROCK2(13), SAG(9), WASF1(3), WASL(5) 22779565 316 121 299 138 203 27 11 47 27 1 0.00661 1.000 1.000 190 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(6), ACTG2(3), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(1), CDC42(2), CFL1(1), FLNA(14), FLNC(47), FSCN1(4), FSCN2(2), FSCN3(8), GDI1(1), GDI2(2), LIMK1(2), MYH2(72), MYLK(35), MYLK2(9), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), RHO(1), ROCK1(4), ROCK2(13), VASP(3), WASF1(3), WASL(5) 15719931 313 121 291 162 210 40 9 32 22 0 0.0326 1.000 1.000 191 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(17), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(2), CTNNB1(11), DVL1(1), DVL2(4), DVL3(6), FBXW2(1), FZD1(4), FZD10(1), FZD2(5), FZD5(2), FZD6(1), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LDLR(10), MAPK10(8), MAPK9(5), MYC(4), PAFAH1B1(4), PLAU(1), PPP2R5C(4), PPP2R5E(4), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCI(7), PRKCQ(13), PRKCZ(4), PRKD1(3), RHOA(1), SFRP4(6), TCF7(1), WNT1(1), WNT10A(7), WNT10B(4), WNT11(3), WNT16(1), WNT2(5), WNT2B(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(5), WNT7A(13), WNT7B(4) 19499073 253 121 248 137 152 28 8 30 35 0 0.345 1.000 1.000 192 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(5), CALR(1), CANX(1), CD4(6), CD74(5), CD8A(2), CD8B(5), CIITA(14), CTSL1(1), CTSS(6), HLA-A(3), HLA-B(4), HLA-C(1), HLA-DMA(3), HLA-DMB(7), HLA-DOA(5), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(10), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(5), HLA-G(2), HSP90AA1(2), HSP90AB1(5), HSPA5(4), IFI30(2), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), KIR2DL3(6), KIR2DL4(3), KIR2DS4(13), KIR3DL1(12), KIR3DL2(2), KIR3DL3(6), KLRC1(3), KLRC2(1), KLRC3(11), KLRC4(4), KLRD1(3), LGMN(5), LTA(1), NFYA(1), NFYB(3), NFYC(1), PDIA3(3), PSME2(3), RFX5(5), RFXANK(1), RFXAP(1), TAP1(1), TAP2(11), TAPBP(1) 14962656 259 120 251 140 164 25 12 33 25 0 0.266 1.000 1.000 193 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(4), BAX(3), BTK(15), CAD(12), CASP10(2), CASP3(2), CASP8(7), CASP8AP2(7), CDK2AP1(1), CSNK1A1(2), DAXX(8), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EGFR(17), EPHB2(21), FAF1(7), FAIM2(4), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAP3K5(15), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MET(19), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(3), PTPN13(11), RALBP1(2), RIPK1(1), ROCK1(4), SMPD1(3), TNFRSF6B(2), TPX2(5), TRAF2(1), TUFM(4) 23658864 268 120 261 146 152 21 17 42 36 0 0.789 1.000 1.000 194 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(7), ALOX12(5), ALOX12B(11), ALOX15(8), ALOX15B(8), ALOX5(7), CBR3(1), CYP2B6(16), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2J2(3), CYP2U1(1), CYP4A11(19), CYP4A22(16), CYP4F2(11), CYP4F3(15), EPHX2(4), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GPX6(15), LTA4H(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PTGDS(1), PTGES2(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9) 12737054 377 119 357 227 298 24 6 21 28 0 0.0667 1.000 1.000 195 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(15), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), AOX1(18), COMT(3), DBH(13), DCT(2), DDC(12), FAH(2), GOT1(3), GOT2(4), HGD(10), HPD(4), MAOA(2), MAOB(11), PNMT(2), TAT(12), TH(7), TPO(33), TYR(7) 10415268 285 119 266 142 212 23 15 21 14 0 0.0120 1.000 1.000 196 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2A1(17), UGT2A3(19), UGT2B10(30), UGT2B11(15), UGT2B15(21), UGT2B28(23), UGT2B4(27), UGT2B7(15), XYLB(4) 8962706 246 118 230 105 170 19 14 15 27 1 0.0155 1.000 1.000 197 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(1), CD3D(4), CSK(1), CTLA4(2), DAG1(5), EPHB2(21), FBXW7(10), GRAP2(4), GRB2(1), ITK(19), ITPKB(5), LAT(1), LCK(10), LCP2(9), MAPK1(4), NCK1(1), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(8), PAK4(4), PAK6(3), PAK7(41), PLCG1(7), PTPRC(26), RAF1(7), RASGRP1(6), RASGRP2(6), RASGRP3(11), RASGRP4(9), SOS1(7), SOS2(11), VAV1(13), ZAP70(4) 18261628 308 118 295 140 190 27 17 42 32 0 0.0787 1.000 1.000 198 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(3), INPP4B(2), INPP5A(4), INPPL1(14), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(39), PIK3CA(6), PIK3CB(21), PIK3CG(21), PLCB1(45), PLCB2(6), PLCB3(3), PLCB4(58), PLCD1(3), PLCG1(7), PLCG2(22) 14699678 287 117 264 122 192 14 12 39 29 1 0.00947 1.000 1.000 199 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(8), AKT3(4), BCR(10), BLNK(8), BTK(15), CD19(7), CSK(1), DAG1(5), EPHB2(21), GRB2(1), ITPKB(5), LYN(5), MAP2K1(11), MAP2K2(3), MAPK1(4), NFAT5(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(5), PIK3CA(6), PIK3CD(7), PIK3R1(3), PLCG2(22), PPP1R13B(6), RAF1(7), SERPINA4(12), SHC1(1), SOS1(7), SOS2(11), SYK(12), VAV1(13) 17415013 250 117 239 125 150 20 15 39 25 1 0.288 1.000 1.000 200 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(1), ABP1(15), ACAT2(1), ACMSD(9), AFMID(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(18), ASMT(5), CARM1(6), CAT(5), CYP1A1(8), CYP1A2(10), CYP1B1(2), DDC(12), ECHS1(1), EHHADH(5), GCDH(5), HAAO(3), HADHA(8), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(8), KMO(7), KYNU(10), LCMT1(3), LNX1(13), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), NFX1(5), OGDH(10), OGDHL(31), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(4), TPH1(5), TPH2(11), WARS(4), WARS2(4), WBSCR22(1) 19949334 334 116 323 165 226 27 18 42 21 0 0.0687 1.000 1.000 201 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(7), ADAM17(1), ATP6AP1(1), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(17), F11R(4), GIT1(3), HBEGF(1), IGSF5(7), IKBKB(3), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(5), MAP2K4(4), MAP3K14(3), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK8(1), MAPK9(5), MET(19), NFKB1(7), NFKB2(4), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(7), PLCG2(22), PTPN11(9), PTPRZ1(19), RELA(4), SRC(1), TCIRG1(3), TJP1(9) 23086985 289 115 285 169 175 27 16 46 25 0 0.822 1.000 1.000 202 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(38), B3GALT4(2), CDR1(11), DGKI(21), IL6ST(10), MRPL19(1), PIGK(5), RPL10(4), RPL11(2), RPL13A(1), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(4), RPL5(5), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS27(1), RPS29(1), RPS3A(1), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(5), TBC1D10C(5), TSPAN9(3), UBB(1), UBC(4) 17108004 207 115 197 119 123 19 13 32 20 0 0.747 1.000 1.000 203 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(4), AKT1(3), APC(17), CAMP(1), DAG1(5), DLG4(4), EPHB2(21), GNAI1(1), GNAQ(4), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RHO(1), RYR1(72) 14863262 215 115 208 131 145 20 12 17 21 0 0.384 1.000 1.000 204 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(15), AGMAT(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH4A1(5), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(5), CKM(2), CKMT2(4), CPS1(17), DAO(9), GAMT(3), GATM(4), GLUD1(1), GOT1(3), GOT2(4), MAOA(2), MAOB(11), NOS1(48), NOS3(14), OAT(2), ODC1(3), OTC(2), P4HA1(8), P4HA2(4), P4HA3(10), P4HB(2), PYCR1(1), RARS(7), SMS(5) 14511719 242 114 236 142 154 28 13 22 25 0 0.438 1.000 1.000 205 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(7), F11(9), F12(1), F13B(19), F2(9), F5(24), F7(7), F8(40), F9(11), FGA(32), FGB(6), FGG(7), LPA(41), PLAT(3), PLAU(1), PLG(25), SERPINB2(16), SERPINE1(5), SERPINF2(5), VWF(40) 11571113 308 114 297 120 218 20 19 23 27 1 0.00854 1.000 1.000 206 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), ELK1(2), FPR1(15), GNA15(5), HRAS(3), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(39), PLCB1(45), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(7), RELA(4), SYT1(17) 12407622 251 114 229 100 175 13 9 27 27 0 0.0105 1.000 1.000 207 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(4), GRIN1(5), GRIN2A(74), GRIN2B(42), GRIN2C(4), GRIN2D(6), NOS1(48), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), SYT1(17) 8389358 242 113 226 155 175 26 5 17 19 0 0.415 1.000 1.000 208 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(8), AKT3(4), CAB39(1), EIF4B(3), EIF4EBP1(1), FIGF(3), HIF1A(5), IGF1(9), MAPK1(4), MAPK3(1), PDPK1(4), PIK3CA(6), PIK3CB(21), PIK3CD(7), PIK3CG(21), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(15), PRKAA1(1), PRKAA2(19), RHEB(1), RICTOR(9), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(2), STK11(3), TSC1(5), TSC2(11), ULK1(7), ULK2(6), ULK3(1), VEGFA(5), VEGFB(1) 16596826 228 112 216 96 130 16 10 47 23 2 0.101 1.000 1.000 209 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(11), BMPR1B(3), CCND2(3), CDK4(5), CDKN1B(1), DAZL(4), DMC1(8), EGR1(4), ESR2(6), FSHR(13), GJA4(4), INHA(4), LHCGR(21), MLH1(5), MSH5(12), NCOR1(17), NR5A1(5), NRIP1(6), PGR(12), PRLR(24), PTGER2(6), SMPD1(3), VDR(2), ZP2(7) 11502202 186 112 171 97 124 15 4 24 19 0 0.662 1.000 1.000 210 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(4), CDC42(2), DLD(2), DUSP10(5), DUSP8(3), GAB1(2), GCK(15), IL1R1(10), JUN(1), MAP2K4(4), MAP2K5(2), MAP2K7(4), MAP3K1(2), MAP3K10(7), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K2(6), MAP3K3(4), MAP3K4(15), MAP3K5(15), MAP3K7(1), MAP3K9(20), MAPK10(8), MAPK7(3), MAPK8(1), MAPK9(5), MYEF2(4), NFATC3(7), NR2C2(2), PAPPA(44), SHC1(1), TRAF6(4), ZAK(6) 16307012 231 112 224 101 159 20 7 26 19 0 0.264 1.000 1.000 211 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(7), ABP1(15), ACADL(4), ACADM(5), ACADSB(4), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(7), DPYD(53), DPYS(21), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), MLYCD(1), SDS(2), SMS(5), UPB1(6) 9595855 210 111 197 103 136 19 11 30 14 0 0.168 1.000 1.000 212 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(9), ALDOC(3), DLAT(2), DLD(2), ENO1(3), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(4), GAPDH(1), GAPDHS(1), GCK(15), GOT1(3), GOT2(4), GPI(3), HK1(3), HK2(11), HK3(12), LDHA(4), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(3), PC(12), PCK1(16), PDHA1(2), PDHA2(15), PDHB(1), PDHX(2), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(22), PKLR(8), PKM2(3), TNFAIP1(1) 14031082 205 110 193 104 142 17 12 19 15 0 0.0197 1.000 1.000 213 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), C1GALT1(5), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(1), GALNT12(6), GALNT13(23), GALNT14(23), GALNT2(5), GALNT3(3), GALNT4(3), GALNT5(8), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GALNTL1(4), GALNTL2(17), GALNTL4(6), GALNTL5(12), GCNT1(6), GCNT3(5), GCNT4(4), OGT(9), ST3GAL1(5), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(36) 10652859 238 110 224 109 177 10 6 23 22 0 0.0824 1.000 1.000 214 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(36), C5(9), C6(50), C7(44), ICAM1(1), IL1A(4), IL6(2), IL8(1), ITGA4(29), ITGAL(19), ITGB1(4), ITGB2(10), SELP(28), SELPLG(8), TNF(1), VCAM1(13) 8118657 259 110 235 104 184 9 13 24 29 0 0.00228 1.000 1.000 215 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(5), BAX(3), BCL2(2), BCL2L11(5), BIRC2(3), BIRC3(6), BIRC5(1), BNIP3L(2), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(12), GZMB(2), HELLS(5), IKBKB(3), IRF1(1), IRF2(5), IRF3(3), IRF4(3), IRF5(4), IRF6(11), IRF7(7), JUN(1), LTA(1), MAP2K4(4), MAP3K1(2), MAPK10(8), MDM2(3), MYC(4), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(9), PRF1(7), RELA(4), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF21(8), TNFRSF25(4), TNFSF10(7), TP73(5), TRAF1(5), TRAF2(1), TRAF3(5) 18571978 212 109 210 111 135 23 13 22 19 0 0.483 1.000 1.000 216 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(3), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), CDS1(6), CDS2(4), CHAT(13), CHKA(2), CHKB(1), CHPT1(1), CRLS1(1), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKI(21), DGKQ(6), DGKZ(6), ESCO1(1), ESCO2(2), ETNK1(4), GNPAT(2), GPAM(2), GPD1(6), GPD1L(2), GPD2(2), LYPLA1(1), MYST3(12), MYST4(9), NAT6(1), PCYT1A(3), PCYT1B(6), PEMT(2), PISD(1), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLD1(9), PLD2(5), PNPLA3(2), PPAP2B(5), PPAP2C(6), PTDSS2(1), SH3GLB1(2) 21532695 269 109 259 157 162 26 8 41 32 0 0.820 1.000 1.000 217 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(4), G6PC2(3), GAA(6), GALK1(1), GALK2(2), GALT(2), GANC(5), GCK(15), GLA(1), GLB1(7), HK1(3), HK2(11), HK3(12), HSD3B7(3), LALBA(6), LCT(29), MGAM(124), PFKL(4), PFKM(1), PGM1(4), PGM3(1), RDH11(2), RDH12(2), RDH13(3), UGP2(1) 12703662 266 108 253 150 192 24 7 28 15 0 0.150 1.000 1.000 218 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(5), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), AKR1B10(8), AKR1C4(7), AKR1D1(17), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), BAAT(9), CEL(11), CYP27A1(3), CYP7A1(6), HADHB(3), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(6), SOAT1(3), SOAT2(4), SRD5A1(2), SRD5A2(5) 10484346 234 108 212 110 152 27 19 22 14 0 0.0242 1.000 1.000 219 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(7), ABP1(15), ACADM(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(7), DPYD(53), DPYS(21), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HIBCH(1), MLYCD(1), SMS(5), UPB1(6) 8925225 197 108 183 100 125 19 12 28 13 0 0.243 1.000 1.000 220 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(8), ALOX15(8), ALOX5(7), CYP1A2(10), CYP2C18(25), CYP2C19(31), CYP2C8(26), CYP2C9(30), CYP2E1(12), CYP2J2(3), CYP3A4(16), CYP3A43(15), CYP3A5(10), CYP3A7(12), HSD3B7(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), RDH11(2), RDH12(2), RDH13(3) 7869382 266 108 250 150 208 11 8 14 25 0 0.0680 1.000 1.000 221 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(12), CANT1(9), CDA(1), CTPS(2), CTPS2(3), DCTD(2), DHODH(2), DPYD(53), DPYS(21), ENTPD1(7), NT5E(3), NT5M(1), POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(4), TYMS(1), UCK1(1), UMPS(1), UNG(2), UPB1(6) 18923449 232 108 216 100 148 16 11 36 21 0 0.0278 1.000 1.000 222 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(15), CALM1(1), CALM2(1), ELK1(2), FCER1A(12), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PAK2(8), PIK3CA(6), PIK3R1(3), PLA2G4A(10), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(7), SHC1(1), SOS1(7), SYK(12), SYT1(17), VAV1(13) 14147534 209 107 198 94 133 11 12 33 19 1 0.354 1.000 1.000 223 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(7), AKR1D1(17), ARSB(1), ARSD(3), ARSE(5), CYP11B1(11), CYP11B2(11), HSD11B1(10), HSD11B2(2), HSD17B2(7), HSD17B3(3), HSD3B1(10), HSD3B2(7), SRD5A1(2), SRD5A2(5), STS(6), SULT1E1(10), SULT2A1(6), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27) 8980020 239 106 223 111 159 26 16 14 23 1 0.00917 1.000 1.000 224 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(5), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CDK5(4), F2(9), FYN(5), GNA11(6), GNAI1(1), GRB2(1), HRAS(3), JAK2(7), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPT(9), MYLK(35), PLCG1(7), PRKCA(10), PTK2B(8), RAF1(7), SHC1(1), SOS1(7), STAT1(3), STAT3(10), STAT5A(2), SYT1(17) 13666459 210 106 194 114 125 20 10 33 22 0 0.557 1.000 1.000 225 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(4), GAA(6), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(15), GLA(1), GLB1(7), HK1(3), HK2(11), HK3(12), LALBA(6), LCT(29), MGAM(124), PFKM(1), PGM1(4), PGM3(1) 10712335 240 106 227 132 173 24 7 24 12 0 0.119 1.000 1.000 226 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(3), CDS1(6), CDS2(4), CHAT(13), CHKA(2), CHKB(1), CLC(2), CPT1B(10), DGKA(3), DGKB(19), DGKD(9), DGKE(5), DGKG(12), DGKH(8), DGKQ(6), DGKZ(6), ETNK1(4), GNPAT(2), GPD1(6), GPD2(2), LGALS13(3), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(6), PEMT(2), PISD(1), PLA2G1B(1), PLA2G2A(2), PLA2G2E(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLCB2(6), PLCG1(7), PLCG2(22), PPAP2B(5), PPAP2C(6) 16466078 248 106 240 130 163 18 7 36 24 0 0.145 1.000 1.000 227 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(8), AKT3(4), ARHGEF11(15), BCL2(2), CDC42(2), DLG4(4), GNA13(1), LPA(41), MAP2K4(4), MAP3K1(2), MAP3K5(15), MAPK8(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(5), PIK3CB(21), PLD1(9), PLD2(5), PLD3(1), PTK2(8), RDX(1), ROCK1(4), ROCK2(13), SERPINA4(12), SRF(3), TBXA2R(4) 16163640 218 106 209 106 116 18 10 45 29 0 0.520 1.000 1.000 228 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(17), AR(3), CAMP(1), CCL15(2), CCL16(1), DAG1(5), EGFR(17), GNA11(6), GNA15(5), GNAI1(1), GNAQ(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), KCNJ3(16), KCNJ5(11), KCNJ9(4), MAPK1(4), MAPK10(8), MAPK14(5), PHKA2(7), PIK3CA(6), PIK3CD(7), PIK3R1(3), PITX2(4), PTX3(1), RAF1(7), SRC(1) 16996958 196 105 191 109 115 17 13 27 23 1 0.577 1.000 1.000 229 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(8), CFL1(1), GNAQ(4), GNAS(17), HRAS(3), LIMK1(2), MAP2K1(11), MAPK1(4), MAPK3(1), MYL2(4), NOX1(10), PIK3C2G(39), PLCB1(45), PPP1R12B(7), PRKCA(10), PTK2(8), RAF1(7), ROCK2(13) 8255848 195 104 178 71 136 6 5 31 17 0 0.0172 1.000 1.000 230 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(8), AKT3(4), ANKRD6(2), APC(17), AXIN1(9), AXIN2(3), CER1(12), CSNK1A1(2), CTNNB1(11), DACT1(9), DKK1(2), DKK2(12), DKK3(4), DKK4(2), DVL1(1), FSTL1(2), GSK3B(2), LRP1(28), MVP(8), NKD1(6), NKD2(5), PIN1(1), PSEN1(1), PTPRA(6), SENP2(10), SFRP1(2), TSHB(5), WIF1(7) 13169699 184 104 181 93 104 21 8 26 25 0 0.471 1.000 1.000 231 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(5), ACAA2(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH6(7), ADH7(11), ADHFE1(5), AKR1C4(7), AKR1D1(17), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BAAT(9), CEL(11), CYP27A1(3), CYP7A1(6), HADHB(3), SOAT2(4), SRD5A1(2), SRD5A2(5) 7699701 202 103 182 86 133 22 14 21 12 0 0.00828 1.000 1.000 232 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 11 C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44), C8B(34), MASP1(6) 6028498 216 103 192 103 157 12 8 24 15 0 0.0918 1.000 1.000 233 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), AKT2(8), AKT3(4), BRD4(14), CAP1(1), CBL(8), CDC42(2), F2RL2(5), FLOT1(2), GRB2(1), GSK3B(2), IGFBP1(3), INPPL1(14), IRS1(5), IRS2(2), IRS4(9), LNPEP(9), MAPK1(4), MAPK3(1), PARD3(14), PARD6A(1), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PPYR1(10), PTPN1(4), RAF1(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(1), SLC2A4(7), SORBS1(10), SOS1(7), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 19220999 214 103 213 101 115 25 13 38 22 1 0.412 1.000 1.000 234 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(8), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), BBOX1(3), DOT1L(7), ECHS1(1), EHHADH(5), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(14), OGDH(10), OGDHL(31), PIPOX(5), PLOD1(5), PLOD2(5), PLOD3(4), RDH11(2), RDH12(2), RDH13(3), SETD1A(22), SETD7(2), SETDB1(10), SHMT1(1), SHMT2(2), SUV39H1(1), SUV39H2(1), TMLHE(1) 19071286 224 102 215 102 140 20 15 33 16 0 0.0935 1.000 1.000 235 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(1), CD36(4), CPT1B(10), CREBBP(17), EHHADH(5), EP300(13), FABP1(6), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(17), MYC(4), NCOA1(7), NCOR1(17), NCOR2(22), NFKBIA(2), NR0B2(3), NR1H3(2), NR2F1(6), NRIP1(6), PDGFA(1), PIK3CA(6), PIK3R1(3), PPARA(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), PTGS2(9), RB1(8), RELA(4), RXRA(4), SP1(3), STAT5A(2), STAT5B(4), TNF(1) 20921014 244 102 238 109 154 19 17 31 20 3 0.154 1.000 1.000 236 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 12 C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44), MASP1(6), MASP2(6), MBL2(10) 6198028 198 101 178 97 144 10 5 22 17 0 0.144 1.000 1.000 237 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(48), GABBR1(6), GPRC5A(4), GPRC5B(5), GPRC5C(7), GPRC5D(2), GRM1(14), GRM2(5), GRM3(45), GRM4(14), GRM5(10), GRM7(28), GRM8(41) 6886701 229 101 214 151 166 18 12 19 14 0 0.113 1.000 1.000 238 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(5), AADAC(13), ABAT(7), ACADS(4), ACAT2(1), ACSM1(22), AKR1B10(8), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH5A1(8), ALDH7A1(8), ALDH9A1(2), BDH1(3), DDHD1(6), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HMGCL(3), HMGCS1(1), HMGCS2(16), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(3), L2HGDH(3), OXCT1(4), OXCT2(2), PDHA1(2), PDHA2(15), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3) 13417181 220 101 211 108 144 24 13 21 18 0 0.116 1.000 1.000 239 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(2), CRK(2), CRKL(2), DOCK1(12), ELK1(2), FOS(2), GAB1(2), GRB2(1), HGF(22), HRAS(3), ITGA1(16), ITGB1(4), JUN(1), MAP2K1(11), MAP2K2(3), MAP4K1(8), MAPK1(4), MAPK3(1), MAPK8(1), MET(19), PAK1(4), PIK3CA(6), PIK3R1(3), PTK2(8), PTK2B(8), PTPN11(9), PXN(3), RAF1(7), RAP1A(2), RAP1B(1), RASA1(4), SOS1(7), SRC(1), STAT3(10) 14144245 191 101 181 91 112 16 7 34 21 1 0.639 1.000 1.000 240 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(3), ATF1(4), CAMP(1), CREB3(1), CREB5(7), CREBBP(17), CRKL(2), DAG1(5), EGR1(4), EGR2(3), EGR3(2), EGR4(5), ELK1(2), FRS2(4), GNAQ(4), JUN(1), MAP1B(18), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), NTRK1(12), OPN1LW(3), PIK3C2G(39), PIK3CA(6), PIK3CD(7), PIK3R1(3), PTPN11(9), RPS6KA3(2), SHC1(1), SRC(1), TERF2IP(1), TH(7) 16345537 219 101 210 99 141 17 8 30 22 1 0.152 1.000 1.000 241 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(18), ACACB(15), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PC(12), PCK1(16), PCK2(4), PDHA1(2), PDHA2(15), PDHB(1), PKLR(8), PKM2(3) 15459865 204 100 197 109 127 17 15 31 14 0 0.338 1.000 1.000 242 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(1), CD3D(4), CD3G(1), ELK1(2), FOS(2), FYN(5), GRB2(1), HRAS(3), JUN(1), LAT(1), LCK(10), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), NFKB1(7), NFKBIA(2), PIK3CA(6), PIK3R1(3), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), PTPN7(1), RAF1(7), RASA1(4), RELA(4), SHC1(1), SOS1(7), SYT1(17), VAV1(13), ZAP70(4) 15584908 192 100 182 86 119 18 8 29 17 1 0.331 1.000 1.000 243 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(15), AGXT(7), AGXT2(16), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(4), CBS(6), CHDH(5), CHKA(2), CHKB(1), CPT1B(10), CTH(1), DAO(9), DLD(2), DMGDH(8), GAMT(3), GARS(5), GATM(4), GCAT(4), GLDC(4), MAOA(2), MAOB(11), PEMT(2), PISD(1), PLCB2(6), PLCG1(7), PLCG2(22), PSPH(2), SARDH(16), SARS(10), SHMT1(1), SHMT2(2), TARS(1) 13878751 211 99 205 114 142 14 12 23 20 0 0.172 1.000 1.000 244 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(6), APAF1(5), ARHGDIB(3), BAG4(3), BCL2(2), BIRC2(3), BIRC3(6), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(8), DFFA(2), DFFB(3), GSN(3), LMNA(8), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(15), MAPK8(1), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(16), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(4), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF1(5), TRAF2(1) 22825930 202 99 199 90 94 23 14 44 25 2 0.290 1.000 1.000 245 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(5), ABO(4), B3GALNT1(5), B3GALT1(9), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(1), B3GNT3(5), B3GNT4(3), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(4), FUT6(4), FUT7(2), GBGT1(1), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(7), PIGH(1), PIGK(5), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(7), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(6), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(6), UGCG(1) 15727745 178 99 176 96 100 20 11 27 20 0 0.316 1.000 1.000 246 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(7), ADRA1B(2), ADRA1D(3), ADRA2A(1), ADRA2C(1), ADRB1(4), ADRB2(2), CHRM1(3), CHRM2(17), CHRM3(17), CHRM4(5), CHRM5(4), DRD1(6), DRD2(13), DRD3(5), DRD4(1), DRD5(19), HRH1(9), HRH2(2), HTR1A(6), HTR1B(2), HTR1D(3), HTR1E(4), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(8), HTR5A(15), HTR6(1), HTR7(8) 8300971 195 99 182 148 124 21 8 25 17 0 0.149 1.000 1.000 247 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(1), DAG1(5), DGKA(3), ETFA(2), GCA(2), ITGA9(8), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), MAP2K1(11), MAPK1(4), MAPK3(1), NR1I3(6), PAK1(4), PDE3A(17), PDE3B(6), PI3(5), PIK3C2G(39), PIK3CA(6), PIK3CD(7), PIK3R1(3), RIPK3(8), VASP(3) 15979795 195 99 181 71 127 14 10 23 20 1 0.000576 1.000 1.000 248 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(16), ATP4A(12), ATP4B(1), ATP5B(1), ATP5C1(2), ATP5F1(5), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), COX10(4), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(3), NDUFA12(1), NDUFA13(6), NDUFA4(1), NDUFA6(1), NDUFA9(1), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFS3(2), NDUFS4(2), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(2), UQCRFS1(2) 18505279 200 98 196 85 117 16 14 34 19 0 0.0360 1.000 1.000 249 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(15), AGXT(7), AGXT2(16), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(4), CBS(6), CHDH(5), CHKA(2), CHKB(1), CTH(1), DAO(9), DLD(2), DMGDH(8), GAMT(3), GARS(5), GATM(4), GCAT(4), GLDC(4), GNMT(1), HSD3B7(3), MAOA(2), MAOB(11), PEMT(2), PHGDH(12), PIPOX(5), PISD(1), PSAT1(1), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(16), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(7) 14107189 215 98 205 116 140 14 10 25 26 0 0.252 1.000 1.000 250 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(15), ACY3(2), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH7A1(8), ALDH9A1(2), AMDHD1(3), AOC2(7), AOC3(8), ASPA(3), CARM1(6), CNDP1(7), DDC(12), FTCD(2), HAL(11), HARS(7), HARS2(3), HDC(16), HEMK1(4), HNMT(1), LCMT1(3), MAOA(2), MAOB(11), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(3), UROC1(10), WBSCR22(1) 13031688 205 98 201 125 128 23 13 22 19 0 0.539 1.000 1.000 251 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(7), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(28), FLT4(17), HIF1A(5), HRAS(3), KDR(32), NOS3(14), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTK2(8), PXN(3), SHC1(1), VHL(4) 11265656 165 98 154 86 100 13 3 25 23 1 0.585 1.000 1.000 252 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(8), BTK(15), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP3K1(2), MAPK14(5), MAPK3(1), MAPK8(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), RAF1(7), SHC1(1), SOS1(7), SYK(12), SYT1(17), VAV1(13) 12462142 184 97 173 83 119 9 10 28 18 0 0.303 1.000 1.000 253 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(2), ABAT(7), ACY3(2), ADSL(3), ADSS(2), ADSSL1(7), AGXT(7), AGXT2(16), ASL(5), ASNS(8), ASPA(3), ASRGL1(2), ASS1(6), CAD(12), CRAT(5), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(12), GAD2(7), GOT1(3), GOT2(4), GPT(3), GPT2(1), NARS(2), NARS2(4), PC(12), PDHA1(2), PDHA2(15), PDHB(1) 12519163 175 97 166 83 119 16 9 20 11 0 0.0712 1.000 1.000 254 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(2), DAXX(8), EGF(14), EGFR(17), ETS1(3), ETS2(7), FOS(2), HOXA7(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(11), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(15), MAPK1(4), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(10), PRKCD(4), PRKCE(5), PRKCG(13), PRKCH(9), PRKCQ(13), RAF1(7), RELA(4), RIPK1(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1) 16133073 213 97 204 125 131 19 9 35 19 0 0.843 1.000 1.000 255 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 9 C1QA(3), C1QB(3), C1R(8), C1S(11), C2(12), C3(36), C5(9), C6(50), C7(44) 4941052 176 96 156 83 127 8 5 21 15 0 0.119 1.000 1.000 256 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(5), ARG1(1), ARG2(1), ASL(5), ASS1(6), CKM(2), CKMT2(4), CPS1(17), DAO(9), EPRS(9), GAMT(3), GATM(4), GLUD1(1), GLUD2(3), GOT1(3), GOT2(4), LAP3(1), NOS1(48), NOS3(14), OAT(2), OTC(2), P4HA1(8), P4HA2(4), P4HA3(10), PRODH(1), PYCR1(1), RARS(7), RARS2(2) 11807859 177 96 172 105 116 19 7 15 20 0 0.562 1.000 1.000 257 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(8), ALPL(7), ALPP(7), ALPPL2(10), ASCC3(10), ATP13A2(8), DDX18(4), DDX19A(1), DDX23(5), DDX4(10), DDX41(5), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(2), DDX56(3), DHX58(4), ENTPD7(2), EP400(18), ERCC2(2), ERCC3(1), FPGS(2), GGH(2), IFIH1(13), MOV10L1(23), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(5), RUVBL2(4), SETX(13), SKIV2L2(5), SMARCA2(10), SMARCA5(5), SPR(2) 20580993 212 96 202 99 133 14 13 27 25 0 0.176 1.000 1.000 258 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(2), CARS(9), CARS2(2), DARS(4), DARS2(3), EPRS(9), FARS2(4), FARSA(6), FARSB(5), GARS(5), HARS(7), HARS2(3), IARS(8), IARS2(12), KARS(4), LARS(9), LARS2(2), MARS(5), MARS2(3), MTFMT(1), NARS(2), NARS2(4), QARS(5), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(1), TARS2(7), VARS(18), VARS2(5), WARS(4), WARS2(4), YARS(1), YARS2(2) 18075180 182 96 170 90 109 18 9 26 20 0 0.413 1.000 1.000 259 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(7), ALOX12(5), ALOX15(8), ALOX5(7), CBR3(1), CYP4F2(11), CYP4F3(15), EPX(5), GGT1(4), LPO(15), LTA4H(3), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(1), PTGES2(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9), TPO(33) 9191724 213 96 210 112 159 18 3 17 16 0 0.0193 1.000 1.000 260 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(4), CHUK(2), ELK1(2), FOS(2), IKBKB(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(4), NFKB1(7), NFKBIA(2), PPARA(6), RELA(4), TIRAP(1), TLR10(8), TLR2(13), TLR3(8), TLR4(25), TLR6(5), TLR7(15), TLR9(12), TOLLIP(1), TRAF6(4) 11951023 162 96 160 76 101 16 9 24 12 0 0.194 1.000 1.000 261 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(3), ARRB2(6), CALM1(1), CALM2(1), CALML3(5), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CLCA1(3), CLCA2(7), CLCA4(17), CNGA3(22), CNGA4(11), CNGB1(17), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(6), PDC(5), PDE1C(37), PRKACA(3), PRKACB(4), PRKACG(7), PRKG1(10), PRKG2(13), PRKX(3) 9944606 208 95 197 119 142 14 6 28 18 0 0.393 1.000 1.000 262 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(21), AR(3), ESR1(5), ESR2(6), ESRRA(2), HNF4A(13), NPM1(3), NR0B1(1), NR1D2(9), NR1H2(3), NR1H3(2), NR1I2(2), NR1I3(6), NR2C2(2), NR2E1(3), NR2F1(6), NR2F2(1), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(2), NR5A1(5), NR5A2(16), PGR(12), PPARA(6), PPARD(2), PPARG(11), RARA(3), RARB(4), RARG(1), ROR1(10), RORA(3), RORC(6), RXRA(4), RXRB(4), RXRG(4), THRA(2), THRB(12), VDR(2) 13734019 206 95 199 102 149 13 4 22 18 0 0.0945 1.000 1.000 263 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(7), ACAA1(5), ACAA2(1), ACADM(5), ACADS(4), ACAT2(1), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH7A1(8), ALDH9A1(2), AOX1(18), AUH(3), BCAT1(11), BCAT2(1), BCKDHA(1), BCKDHB(2), DLD(2), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), HIBADH(7), HIBCH(1), HMGCL(3), HMGCS1(1), HMGCS2(16), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(3), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), OXCT2(2), PCCA(3), PCCB(2) 14257130 172 94 165 88 100 19 12 29 12 0 0.619 1.000 1.000 264 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(5), ACTN2(16), ACTN3(7), BCAR1(4), BCR(10), CAPN1(4), CAPNS1(1), CAV1(1), CRKL(2), CSK(1), FYN(5), GRB2(1), HRAS(3), ITGA1(16), ITGB1(4), JUN(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MAPK8(1), PPP1R12B(7), PTK2(8), PXN(3), RAF1(7), RAP1A(2), ROCK1(4), SHC1(1), SOS1(7), SRC(1), TLN1(11), VCL(7), ZYX(6) 15384738 167 94 159 76 89 20 8 29 20 1 0.149 1.000 1.000 265 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(5), F2RL3(3), GNAI1(1), HRAS(3), ITGA1(16), ITGB1(4), MAP2K1(11), MAPK1(4), MAPK3(1), PLA2G4A(10), PLCB1(45), PRKCA(10), PTGS1(14), PTK2(8), RAF1(7), SRC(1), SYK(12), TBXAS1(9) 8028622 173 93 162 68 117 13 5 20 18 0 0.0170 1.000 1.000 266 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(18), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(4), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PC(12), PCK1(16), PDHA1(2), PDHA2(15), PDHB(1), PKLR(8), PKM2(3) 12220662 164 92 159 93 108 14 10 23 9 0 0.602 1.000 1.000 267 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(4), BCR(10), BLNK(8), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), LYN(5), MAP2K1(11), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8IP3(8), PAPPA(44), RPS6KA1(6), RPS6KA3(2), SHC1(1), SOS1(7), SYK(12), VAV1(13), VAV2(2), VAV3(8) 10350438 157 92 146 99 110 11 3 19 14 0 0.902 1.000 1.000 268 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(15), DLG4(4), EPHB2(21), F2(9), F2RL1(14), F2RL2(5), F2RL3(3), JUN(1), MAP2K5(2), MAPK1(4), MAPK7(3), MAPK8(1), MYEF2(4), PLD1(9), PLD2(5), PLD3(1), PTK2(8), RAF1(7), RASAL1(13), SRC(1), TEC(9), VAV1(13) 9027412 152 92 145 96 83 16 6 32 15 0 0.901 1.000 1.000 269 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), AOX1(18), BCAT1(11), BCKDHA(1), BCKDHB(2), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), HIBADH(7), HMGCL(3), IVD(4), MCCC1(3), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), PCCA(3), PCCB(2), SDS(2) 11937056 145 92 140 76 88 14 8 23 12 0 0.654 1.000 1.000 270 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(3), ENPP7(6), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(7), LCT(29), NEU1(6), NEU2(10), NEU3(3), NEU4(8), PPAP2B(5), PPAP2C(6), SGMS1(12), SGMS2(1), SGPP2(5), SMPD1(3), SMPD2(1), SMPD3(6), SMPD4(4), SPHK1(1), SPHK2(6), SPTLC1(2), SPTLC2(5), UGCG(1), UGT8(6) 11676586 162 91 157 103 108 12 5 23 14 0 0.788 1.000 1.000 271 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CDK5(4), CFL1(1), CHN1(5), LIMK1(2), MAP3K1(2), MYL2(4), MYLK(35), NCF2(7), PAK1(4), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLD1(9), PPP1R12B(7), RALBP1(2), RPS6KB1(2), TRIO(15), VAV1(13), WASF1(3) 11419067 148 91 144 87 94 8 9 21 15 1 0.862 1.000 1.000 272 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(2), ARHGAP4(1), ARHGAP5(10), ARHGAP6(10), ARHGEF1(1), ARHGEF11(15), ARHGEF5(14), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(6), GSN(3), LIMK1(2), MYL2(4), MYLK(35), OPHN1(3), PIP5K1A(6), PIP5K1B(13), PPP1R12B(7), ROCK1(4), SRC(1), TLN1(11), VCL(7) 14841732 171 91 165 80 117 10 7 22 15 0 0.0807 1.000 1.000 273 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(47), CR2(26), FCGR2B(2), HLA-DRA(10), HLA-DRB1(3), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26) 4955144 148 90 144 58 96 12 5 14 21 0 0.0713 1.000 1.000 274 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(17), ELK1(2), GNAS(17), GRB2(1), HRAS(3), IGF1R(9), ITGB1(4), KLK2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(3), MKNK2(1), MYC(4), NGFR(6), PDGFRA(23), PPP2CA(1), PTPRR(16), RAF1(7), RPS6KA1(6), RPS6KA5(3), SHC1(1), SOS1(7), SRC(1), STAT3(10) 10837865 163 90 154 82 98 16 9 28 12 0 0.470 1.000 1.000 275 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(17), AXIN1(9), CCND1(1), CD14(4), CTNNB1(11), DVL1(1), FZD1(4), GJA1(6), GNAI1(1), GSK3B(2), IRAK1(4), LBP(6), LEF1(3), LY96(4), MYD88(4), NFKB1(7), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(25), TOLLIP(1), WNT1(1) 10013730 133 90 130 63 77 11 9 18 17 1 0.453 1.000 1.000 276 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(15), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), DDC(12), EPX(5), ESCO1(1), ESCO2(2), GOT1(3), GOT2(4), HPD(4), LPO(15), MAOA(2), MAOB(11), MPO(11), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(12), TPO(33) 11305879 188 90 185 118 132 17 9 18 12 0 0.732 1.000 1.000 277 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(6), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(2), ALG8(5), ALG9(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(2), DPAGT1(2), DPM1(1), FUT8(7), GANAB(3), MAN1A1(13), MAN1A2(4), MAN1B1(3), MAN1C1(4), MAN2A1(7), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), RFT1(3), RPN2(2), ST6GAL1(4), STT3B(5) 13966640 144 90 141 77 84 14 11 18 17 0 0.440 1.000 1.000 278 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(4), ANXA2(2), ANXA3(3), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(11), EDN1(7), EDNRA(8), EDNRB(4), HPGD(1), HSD11B1(10), HSD11B2(2), PLA2G4A(10), PRL(1), PTGDR(9), PTGDS(1), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), PTGIS(10), PTGS1(14), PTGS2(9), S100A6(1), SCGB1A1(1), TBXAS1(9) 6745101 155 90 150 58 106 16 3 15 15 0 0.000290 1.000 1.000 279 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(17), ATF2(4), AXIN1(9), BMP10(13), BMP2(3), BMP4(2), BMP5(21), BMP7(1), BMPR1A(1), BMPR2(4), CHRD(10), CTNNB1(11), DVL1(1), FZD1(4), GATA4(2), GSK3B(2), MAP3K7(1), MEF2C(2), MYL2(4), NKX2-5(1), NOG(1), NPPA(2), NPPB(3), RFC1(3), TGFB1(1), TGFB3(3), TGFBR2(7), TGFBR3(6), WNT1(1) 11918674 142 89 135 68 92 13 6 14 17 0 0.500 1.000 1.000 280 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(24), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(4), GNAS(17), HRAS(3), JUN(1), MAP2K1(11), MAPK3(1), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), RAF1(7), RPS6KA3(2), SYT1(17) 11447355 178 88 167 101 114 14 10 22 18 0 0.769 1.000 1.000 281 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(14), EGFR(17), GRB2(1), HRAS(3), MAP2K1(11), MAPK1(4), MAPK3(1), PTPRB(64), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SPRY1(6), SPRY2(3), SPRY3(11), SPRY4(1), SRC(1) 8236574 164 88 149 69 113 14 6 19 12 0 0.194 1.000 1.000 282 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(5), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CD40(4), CD40LG(1), CRADD(1), CYCS(1), DAXX(8), DFFA(2), DFFB(3), FAS(5), FASLG(12), IKBKE(8), LTA(1), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(6), NR3C1(6), NTRK1(12), PTPN13(11), RIPK1(1), SFRS2IP(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF1(5), TRAF2(1), TRAF3(5), TRAF6(4) 14288881 155 87 154 84 91 14 9 21 20 0 0.764 1.000 1.000 283 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(4), CRK(2), CXCL12(2), CXCR4(3), GNAI1(1), GNAQ(4), HRAS(3), MAP2K1(11), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(39), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTK2(8), PTK2B(8), PXN(3), RAF1(7), RELA(4) 9057765 137 87 125 64 87 9 3 24 13 1 0.327 1.000 1.000 284 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(3), ADCY3(2), ADCY9(9), ARF4(3), ARF5(1), ARL4D(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(17), ATP6V0D2(7), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), ERO1L(4), GNAS(17), PDIA4(3), PLCG1(7), PLCG2(22), PRKCA(10), SEC61A1(2), SEC61A2(7), TRIM23(2) 12242971 163 87 158 101 105 8 9 24 17 0 0.653 1.000 1.000 285 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(15), ALDH1A3(1), ALDH3A1(4), ALDH3B1(2), ALDH3B2(6), AOC2(7), AOC3(8), DDC(12), EPX(5), GOT1(3), GOT2(4), HPD(4), LPO(15), MAOA(2), MAOB(11), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(12), TPO(33) 7225532 163 87 160 94 120 14 8 11 10 0 0.119 1.000 1.000 286 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(2), CP(9), CPOX(2), EPRS(9), FECH(3), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(2), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27), UROS(1) 9124512 156 87 148 75 100 16 12 9 18 1 0.184 1.000 1.000 287 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(20), GRB2(1), HRAS(3), INSR(19), IRS1(5), JAK2(7), MAP2K1(11), MAPK1(4), MAPK3(1), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), PTPN6(2), RAF1(7), RPS6KA1(6), SHC1(1), SLC2A4(7), SOS1(7), SRF(3), STAT5A(2), STAT5B(4) 10942545 139 86 130 73 79 13 6 27 13 1 0.665 1.000 1.000 288 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(3), AKT2(8), AKT3(4), DAG1(5), GNAQ(4), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(21), PITX2(4), PLD1(9), PLD2(5), PLD3(1) 14763656 145 86 140 86 66 15 13 32 19 0 0.719 1.000 1.000 289 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 4 C3(36), C5(9), C6(50), C7(44) 3337038 139 85 123 62 103 4 4 14 14 0 0.102 1.000 1.000 290 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(5), AGTR1(9), ATF2(4), CALM1(1), CALM2(1), EGFR(17), ELK1(2), GNAQ(4), GRB2(1), HRAS(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), PAK1(4), PRKCA(10), PTK2(8), PTK2B(8), RAF1(7), SHC1(1), SOS1(7), SRC(1), SYT1(17) 10881547 149 85 136 79 95 12 7 21 14 0 0.748 1.000 1.000 291 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(24), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(9), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLCB1(45), PRKCA(10), PTK2(8), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1) 8947925 153 85 149 67 104 8 6 19 15 1 0.0685 1.000 1.000 292 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2) 8280553 148 85 132 68 102 13 6 21 6 0 0.351 1.000 1.000 293 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(27), ACE2(7), AGT(5), AGTR1(9), AGTR2(10), ANPEP(15), CMA1(5), CPA3(14), CTSA(4), CTSG(2), ENPEP(25), LNPEP(9), MAS1(3), MME(17), NLN(4), REN(8), THOP1(6) 6944195 170 85 163 89 118 12 12 11 17 0 0.125 1.000 1.000 294 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(4), CAPN2(7), CAPNS1(1), CXCR3(3), EGF(14), EGFR(17), HRAS(3), ITGA1(16), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(4), MYLK(35), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTK2(8), PXN(3), TLN1(11) 10701633 156 85 151 91 103 11 8 20 14 0 0.542 1.000 1.000 295 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), DAG1(5), ITPKB(5), ITPR1(21), ITPR2(15), ITPR3(6), NFAT5(6), PDE6A(9), PDE6B(10), PDE6C(20), PDE6D(2), PDE6G(2), SLC6A13(21), TF(10) 11749943 148 85 142 86 103 8 6 13 18 0 0.249 1.000 1.000 296 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(10), DIAPH1(6), FYN(5), GSN(3), HRAS(3), ITGA1(16), ITGB1(4), MAP2K1(11), MAPK1(4), MAPK3(1), MYL2(4), MYLK(35), PIK3CA(6), PIK3R1(3), PTK2(8), PXN(3), RAF1(7), ROCK1(4), SHC1(1), SRC(1), TLN1(11) 12309796 146 84 135 63 91 12 5 23 14 1 0.176 1.000 1.000 297 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(15), CALCR(14), CALCRL(11), CD97(5), CRHR1(6), CRHR2(2), ELTD1(22), EMR1(23), EMR2(4), GHRHR(3), GIPR(1), GLP1R(11), GLP2R(13), GPR64(5), LPHN1(6), LPHN2(30), LPHN3(17), SCTR(6), VIPR1(2), VIPR2(5) 8680779 201 84 186 123 147 11 11 14 18 0 0.206 1.000 1.000 298 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(12), ADH1B(27), ADH1C(24), ADH4(11), ADH5(3), ADH6(7), ADH7(11), ADHFE1(5), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2) 4367728 128 84 110 49 88 13 9 13 5 0 0.00776 1.000 1.000 299 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(6), EXTL1(2), EXTL3(9), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(4), HS6ST1(3), HS6ST2(2), HS6ST3(9), NDST1(4), NDST2(2), NDST3(22), NDST4(41) 6701009 136 83 133 71 86 10 5 19 16 0 0.264 1.000 1.000 300 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(6), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), CYP2C19(31), CYP2C9(30), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(1), EHHADH(5), ESCO1(1), ESCO2(2), HADHA(8), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2), YOD1(1) 10242521 156 83 145 103 97 17 9 20 13 0 0.957 1.000 1.000 301 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(4), ARSB(1), FUCA1(2), GALNS(4), GBA(3), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), HGSNAT(4), HPSE(9), HPSE2(4), HYAL1(2), IDS(9), IDUA(4), LCT(29), MAN2B1(5), MAN2B2(8), MAN2C1(3), MANBA(6), NAGLU(4), NEU1(6), NEU2(10), NEU3(3), NEU4(8), SPAM1(18) 11251155 165 83 164 84 113 14 5 19 14 0 0.240 1.000 1.000 302 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(8), AKT3(4), CISH(2), GRB2(1), IARS(8), IL13RA1(3), IL2RG(2), IL4(1), IL4R(12), INPP5D(24), JAK1(5), JAK2(7), JAK3(4), NR0B2(3), PI3(5), PIK3CA(6), PPP1R13B(6), RPS6KB1(2), SERPINA4(12), SHC1(1), SOS1(7), SOS2(11), SRC(1), STAT6(7), TYK2(7) 12142110 152 83 149 71 92 11 8 24 17 0 0.404 1.000 1.000 303 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(3), AKT2(8), AKT3(4), BTK(15), DAPP1(4), GRB2(1), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(24), PDK1(2), PIK3CA(6), PPP1R13B(6), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SOS1(7), SOS2(11), TEC(9), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 11424194 138 83 133 51 83 9 11 21 14 0 0.0733 1.000 1.000 304 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(5), BAX(3), BCL2(2), BIRC2(3), BIRC3(6), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), FAS(5), FASLG(12), GZMB(2), JUN(1), MAP2K4(4), MAP3K1(2), MAP3K14(3), MAPK10(8), MCL1(3), MDM2(3), MYC(4), NFKB1(7), NFKBIA(2), PARP1(6), PRF1(7), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TNFSF10(7), TRAF1(5), TRAF2(1) 12008981 129 82 129 56 73 14 11 16 15 0 0.212 1.000 1.000 305 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(8), CARM1(6), CCND1(1), CREBBP(17), EP300(13), ERCC3(1), ESR1(5), GRIP1(8), GTF2A1(2), GTF2E1(2), GTF2F1(4), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(8), HDAC5(6), HDAC6(2), MEF2C(2), NCOR2(22), NR0B1(1), NRIP1(6), PELP1(9), POLR2A(10), TBP(4) 14978305 144 82 144 70 95 6 11 23 9 0 0.498 1.000 1.000 306 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(4), CRY1(5), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(10), GFRA1(7), GSTM3(3), GSTP1(2), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(5), NCOA4(4), NR1D2(9), PER1(7), PER2(8), PIGF(2), PPP1R3C(2), PPP2CB(2), PSMA4(1), PURA(3), SF3A3(4), TOB1(2), TUBB3(3), UCP3(4), UGP2(1), VAPA(1), ZFR(8) 12043292 139 82 137 58 63 13 12 31 20 0 0.541 1.000 1.000 307 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(15), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH3B1(2), ALDH3B2(6), ALDH9A1(2), AOC2(7), AOC3(8), ASPA(3), CNDP1(7), DDC(12), HAL(11), HARS(7), HDC(16), HNMT(1), MAOA(2), MAOB(11), PRPS1(2), PRPS2(3) 8018441 145 82 142 89 94 13 9 15 14 0 0.525 1.000 1.000 308 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(15), ACY1(1), ADC(5), AGMAT(2), ALDH18A1(7), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(5), ASS1(6), CPS1(17), GATM(4), MAOA(2), MAOB(11), NAGS(1), ODC1(3), OTC(2), SAT2(1), SMS(5) 9621249 132 82 130 81 77 13 11 15 16 0 0.633 1.000 1.000 309 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(7), ADC(5), ALDH4A1(5), ALDH5A1(8), CAD(12), CPS1(17), EPRS(9), GAD1(12), GAD2(7), GCLC(4), GCLM(2), GFPT1(4), GFPT2(6), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(2), GMPS(1), GOT1(3), GOT2(4), GPT(3), GPT2(1), GSS(7), NADSYN1(4), NAGK(1), QARS(5) 13046566 136 82 132 72 73 15 11 24 13 0 0.483 1.000 1.000 310 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(3), IL1A(4), IL1B(6), IL1R1(10), IL1RAP(4), IL1RN(5), IL6(2), IRAK1(4), IRAK2(9), IRAK3(5), JUN(1), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(4), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 9719883 110 82 107 57 66 10 4 18 12 0 0.475 1.000 1.000 311 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(4), CDC42(2), CREB3(1), CREB5(7), DUSP10(5), EEF2K(5), ELK1(2), HSPB1(2), IL1R1(10), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K10(7), MAP3K4(15), MAP3K5(15), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(3), MKNK2(1), MYEF2(4), NFKB1(7), NR2C2(2), SRF(3), TRAF6(4) 10976258 137 82 133 71 86 11 3 23 14 0 0.509 1.000 1.000 312 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(9), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(5), EIF1AX(2), EIF2AK1(3), EIF2AK2(3), EIF2AK3(17), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(12), EIF4G3(15), EIF5(2), EIF5B(2), ETF1(2), GSPT2(6), KIAA0664(4), PABPC1(4), PABPC3(6), PAIP1(7), SLC35A4(4) 14403080 131 82 122 67 62 12 8 21 28 0 0.856 1.000 1.000 313 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(7), ACACA(18), ACACB(15), ACADM(5), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH7A1(8), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), HIBCH(1), LDHA(4), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(1), MUT(5), PCCA(3), PCCB(2), SUCLG1(1), SUCLG2(2) 13153760 135 81 129 70 74 13 14 25 9 0 0.526 1.000 1.000 314 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(17), AXIN1(9), CREBBP(17), CTNNB1(11), DVL1(1), EP300(13), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(38), WNT1(1) 10973086 123 81 119 68 65 10 10 20 18 0 0.901 1.000 1.000 315 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(11), ATR(18), BRCA1(8), CDC25A(7), CDC25B(4), CDC25C(2), CDC34(3), CDKN1A(4), CHEK1(1), CHEK2(2), EP300(13), MDM2(3), MYT1(19), PRKDC(16), RPS6KA1(6), WEE1(2), YWHAQ(3) 13617055 122 80 120 53 68 12 7 21 14 0 0.543 1.000 1.000 316 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(9), CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), HDAC5(6), IGF1(9), IGF1R(9), INSR(19), MAP2K6(2), MAPK14(5), MAPK7(3), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1), NFATC1(13), NFATC2(6), PIK3CA(6), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(17) 11492139 144 80 138 77 92 14 5 22 10 1 0.447 1.000 1.000 317 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(4), GTF2F2(1), GTF2H1(3), GTF2H4(1), GTF2I(2), GTF2IRD1(8), TAF1(10), TAF13(2), TAF1L(46), TAF2(5), TAF4(8), TAF4B(2), TAF5L(3), TAF6(3), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(3) 11969233 140 80 136 58 92 11 6 22 9 0 0.283 1.000 1.000 318 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(3), UCHL1(3), UCHL3(2), UGDH(1), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10), UGT2B15(21), UGT2B4(27) 5851326 127 80 116 69 86 12 10 5 13 1 0.297 1.000 1.000 319 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(15), CD33(15), CD5(5), CSF2(1), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL3(2), IL4(1), IL5(2), ITGAX(15), TLR2(13), TLR4(25), TLR7(15), TLR9(12) 5878542 135 79 133 79 94 8 8 11 14 0 0.0813 1.000 1.000 320 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(5), BCL2(2), BIRC2(3), BIRC3(6), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(11), LMNA(8), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), SPTAN1(7), TNFRSF10A(5), TNFRSF10B(1), TNFRSF25(4), TNFSF10(7), TNFSF12(1), TRAF2(1) 11028556 107 79 107 66 57 13 10 19 8 0 0.918 1.000 1.000 321 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(5), BTRC(4), CDC16(1), CDC20(1), CDC23(3), CDC27(9), CUL1(5), CUL2(4), CUL3(4), FBXW11(4), FBXW7(10), FZR1(6), ITCH(6), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(2), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E2(2), UBE2E3(1), VHL(4), WWP1(3), WWP2(6) 13161270 129 79 123 57 77 4 10 22 15 1 0.638 1.000 1.000 322 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(7), ADSL(3), ADSS(2), AGXT(7), AGXT2(16), ASL(5), ASNS(8), ASPA(3), CAD(12), CRAT(5), DARS(4), DDO(7), GAD1(12), GAD2(7), GOT1(3), GOT2(4), GPT(3), GPT2(1), NARS(2), PC(12) 8637212 127 78 121 62 85 12 8 14 8 0 0.0930 1.000 1.000 323 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(7), F2(9), F2R(5), F5(24), F7(7), FGA(32), FGB(6), FGG(7), PROC(4), PROS1(12), SERPINC1(6), TFPI(7) 5420987 126 78 120 49 82 16 8 13 7 0 0.0893 1.000 1.000 324 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(21), F2(9), F2R(5), FGA(32), FGB(6), FGG(7), PLAT(3), PLAU(1), PLG(25), SERPINB2(16), SERPINE1(5) 4407342 131 78 126 44 99 7 7 12 6 0 0.0123 1.000 1.000 325 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(7), ACACA(18), ACADL(4), ACADM(5), ACADSB(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), LDHA(4), LDHB(2), LDHC(5), MCEE(2), MLYCD(1), MUT(5), PCCA(3), PCCB(2), SDS(2), SUCLG1(1), SUCLG2(2) 10979176 117 78 113 59 69 10 10 22 6 0 0.584 1.000 1.000 326 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(4), CALM1(1), CALM2(1), CRKL(2), GNAQ(4), GRB2(1), HRAS(3), JUN(1), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), PAK1(4), PLCG1(7), PRKCA(10), PTK2B(8), RAF1(7), SHC1(1), SOS1(7), SRC(1), SYT1(17) 9242576 117 78 106 62 70 11 5 19 12 0 0.697 1.000 1.000 327 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(24), AKT1(3), BAX(3), BCL2(2), CSF2RB(14), IGF1(9), IGF1R(9), IL3(2), IL3RA(5), KIT(8), KITLG(6), PIK3CA(6), PIK3R1(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 7219664 113 77 112 71 68 13 7 11 13 1 0.718 1.000 1.000 328 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(14), EGFR(17), ELK1(2), FOS(2), GRB2(1), HRAS(3), JAK1(5), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(3), STAT3(10), STAT5A(2) 12345828 128 77 122 70 68 14 7 26 12 1 0.928 1.000 1.000 329 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(9), ACO1(5), ACO2(4), CLYBL(5), CS(2), DLD(2), FH(3), IDH1(11), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), OGDH(10), OGDHL(31), PC(12), PCK1(16), PCK2(4), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(1), SUCLG2(2) 9907559 134 77 122 59 93 3 7 18 13 0 0.0487 1.000 1.000 330 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BCL2(2), CBL(8), CFLAR(4), CRKL(2), E2F1(4), FOS(2), GRB2(1), HRAS(3), IL2RA(3), IL2RB(7), IL2RG(2), IRS1(5), JAK1(5), JAK3(4), MAPK1(4), MAPK3(1), MYC(4), NMI(1), PIK3CA(6), PIK3R1(3), PPIA(1), PTPN6(2), RAF1(7), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(7), STAT5A(2), STAT5B(4), SYK(12) 11864684 114 77 113 61 60 12 11 16 14 1 0.746 1.000 1.000 331 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(10), ABCC2(7), ABCG2(5), BCHE(5), CES1(16), CES2(3), CYP3A4(16), CYP3A5(10), UGT1A1(3), UGT1A10(12), UGT1A3(9), UGT1A4(8), UGT1A5(8), UGT1A6(4), UGT1A7(9), UGT1A8(5), UGT1A9(10) 7564108 140 77 132 66 92 12 11 9 16 0 0.0266 1.000 1.000 332 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(16), ATP4B(1), ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), ATP7A(9), ATP7B(13), COX10(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(3), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(1), NDUFV1(2), PPA2(2), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2) 12673105 135 77 134 79 80 6 17 20 12 0 0.749 1.000 1.000 333 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(24), ARHGEF1(1), F2(9), F2R(5), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(4), MAP3K7(1), PIK3CA(6), PIK3R1(3), PLCB1(45), PPP1R12B(7), PRKCA(10), PTK2B(8), ROCK1(4) 8525737 135 77 131 68 91 10 5 17 11 1 0.345 1.000 1.000 334 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(17), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(7), DAG1(5), EPHB2(21), FOS(2), GNAQ(4), ITPKB(5), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5) 9373915 111 77 109 58 66 7 5 14 19 0 0.631 1.000 1.000 335 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(24), CD3D(4), CD3G(1), CD4(6), CREBBP(17), CSK(1), GNAS(17), HLA-DRA(10), HLA-DRB1(3), LCK(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(26), ZAP70(4) 7464576 142 76 138 82 92 13 7 17 13 0 0.678 1.000 1.000 336 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(5), ABAT(7), ACADS(4), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH5A1(8), ALDH9A1(2), ECHS1(1), EHHADH(5), GAD1(12), GAD2(7), HADHA(8), HMGCL(3), L2HGDH(3), OXCT1(4), PDHA1(2), PDHA2(15), PDHB(1), SDHB(1), SDS(2) 8563701 121 76 116 56 75 14 4 17 11 0 0.133 1.000 1.000 337 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(12), FOS(2), HRAS(3), JUN(1), MAP2K1(11), MAPK1(4), MAPK3(1), MYC(4), NFKB1(7), NFKBIA(2), PLCB1(45), PRKCA(10), RAF1(7), RELA(4), TNF(1) 5141821 114 76 104 40 78 7 5 14 10 0 0.00504 1.000 1.000 338 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(24), CD3D(4), CD3G(1), CD4(6), CREBBP(17), CSK(1), GNAS(17), HLA-DRA(10), HLA-DRB1(3), LCK(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PTPRC(26), ZAP70(4) 7464576 142 76 138 82 92 13 7 17 13 0 0.678 1.000 1.000 339 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(4), CDC42(2), DAXX(8), DDIT3(2), ELK1(2), GRB2(1), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K5(15), MAP3K7(1), MAP3K9(20), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(3), MYC(4), PLA2G4A(10), RIPK1(1), RPS6KA5(3), SHC1(1), STAT1(3), TGFB1(1), TGFB3(3), TRAF2(1) 11840725 124 76 121 54 73 11 3 20 17 0 0.449 1.000 1.000 340 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JAK1(5), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(23), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(3), STAT3(10), STAT5A(2) 11495188 121 76 115 54 61 14 6 25 14 1 0.530 1.000 1.000 341 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(6), MAPK8IP3(8), MAPK9(5), MAPKAPK5(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(6), PIK3CD(7), PIK3R1(3), SYT1(17), TRAF2(1), TRAF3(5), TRAF5(6), TRAF6(4) 11016197 127 76 122 66 79 9 6 23 9 1 0.333 1.000 1.000 342 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(13), ABP1(15), AOC2(7), AOC3(8), CES1(16), CES7(12), DDHD1(6), ESCO1(1), ESCO2(2), LIPA(4), MYST3(12), MYST4(9), NAT6(1), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2) 8377781 124 75 121 68 88 7 7 11 11 0 0.726 1.000 1.000 343 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), BBOX1(3), DOT1L(7), ECHS1(1), EHHADH(5), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(5), PLOD3(4), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1) 12140939 113 75 109 65 68 13 4 20 8 0 0.610 1.000 1.000 344 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(7), CCR2(15), CCR3(8), CCR4(7), CCR5(6), CCR7(3), CD28(1), CD4(6), CSF2(1), CXCR3(3), CXCR4(3), IFNG(1), IFNGR1(4), IFNGR2(4), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18R1(16), IL2(2), IL4(1), IL4R(12), IL5(2), TGFB1(1), TGFB3(3) 6586153 124 75 118 65 87 9 1 15 12 0 0.0817 1.000 1.000 345 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), DIAPH2(6), MCM10(5), MCM2(9), MCM3(10), MCM4(5), MCM5(3), MCM6(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), PRIM1(3), RFC1(3), RFC2(2), RPA1(3), RPA2(2), RPA3(1), RPA4(2), UBB(1), UBC(4) 16711072 118 74 118 71 68 8 5 22 15 0 0.905 1.000 1.000 346 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CFLAR(4), DAXX(8), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(16), PTPN13(11), RB1(8), RIPK2(2), SPTAN1(7) 13548412 121 74 121 57 52 11 10 32 14 2 0.771 1.000 1.000 347 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(7), ALDH4A1(5), ALDH5A1(8), CAD(12), CPS1(17), EPRS(9), GAD1(12), GAD2(7), GCLC(4), GCLM(2), GFPT1(4), GLS(1), GLS2(2), GLUD1(1), GLUL(2), GMPS(1), GOT1(3), GOT2(4), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(5) 10971763 121 74 117 59 67 11 10 22 11 0 0.361 1.000 1.000 348 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), GOT1(3), GOT2(4), GPT(3), GPT2(1), MDH1(1), MDH2(3), ME1(17), ME3(8), PGK1(4), PGK2(22), PKLR(8), PKM2(3), TKT(5), TKTL2(20) 6689457 119 74 109 69 82 13 5 13 6 0 0.238 1.000 1.000 349 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(4), MYL2(4), MYLK(35), PLCB1(45), PPP1R12B(7), PRKCA(10), ROCK1(4) 6864952 124 74 115 51 94 4 5 13 8 0 0.0779 1.000 1.000 350 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(8), ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(1), GMPPB(2), HK1(3), HK2(11), HK3(12), HSD3B7(3), LHPP(1), MPI(1), MTMR1(4), MTMR2(1), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB3(1), PFKFB4(3), PFKL(4), PFKM(1), PGM2(5), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2) 12174626 114 73 110 82 76 13 8 11 6 0 0.732 1.000 1.000 351 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(14), POLE2(3), POLG(6), POLG2(4), POLH(2), POLI(1), POLK(6), POLL(6), POLM(2), POLQ(22), PRIM1(3), PRIM2(12), REV1(2), REV3L(11) 13368725 116 73 114 49 64 4 7 27 14 0 0.487 1.000 1.000 352 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(5), CASP1(2), CASP3(2), CASP7(4), CASP8(7), GAPDH(1), INSR(19), ITCH(6), MAGI1(23), MAGI2(19), RERE(19), WWP1(3), WWP2(6) 7955726 121 73 119 55 79 9 3 19 10 1 0.456 1.000 1.000 353 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(5), HLA-A(3), IL18(2), ITGB1(4), KLRC1(3), KLRC2(1), KLRC3(11), KLRC4(4), KLRD1(3), LAT(1), MAP2K1(11), MAPK3(1), PAK1(4), PIK3CA(6), PIK3R1(3), PTK2B(8), PTPN6(2), SYK(12), VAV1(13) 5979931 97 72 89 55 66 4 2 13 11 1 0.779 1.000 1.000 354 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(17), EP300(13), IKBKB(3), IL1B(6), IL8(1), MAP2K3(7), MAP2K6(2), MAP3K14(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(4), NFKB1(7), NFKBIA(2), NR3C1(6), RELA(4), TGFBR2(7), TLR2(13), TNF(1) 9806381 105 72 104 58 60 14 5 20 6 0 0.856 1.000 1.000 355 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(1), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(1), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(13), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(3), TAF7(2), TAF9(2), TBP(4) 11608240 99 72 98 36 57 8 8 18 8 0 0.0871 1.000 1.000 356 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(3), CHAT(13), COMT(3), DBH(13), DDC(12), GAD1(12), GAD2(7), HDC(16), MAOA(2), PAH(9), PNMT(2), SLC18A3(2), TH(7), TPH1(5) 4656696 107 71 102 60 85 8 3 3 8 0 0.115 1.000 1.000 357 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(9), AGT(5), AGTR2(10), EDN1(7), EDNRA(8), EDNRB(4), EGF(14), EGFR(17), FOS(2), HRAS(3), JUN(1), MYC(4), NFKB1(7), PLCG1(7), PRKCA(10), RELA(4) 6777078 112 71 109 57 75 10 5 16 6 0 0.342 1.000 1.000 358 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(10), EGF(14), EGFR(17), GRB2(1), MET(19), PDGFRA(23), PRKCA(10), SH3GLB1(2), SH3GLB2(1), SH3KBP1(5), SRC(1) 6434888 111 71 110 67 70 10 6 13 12 0 0.853 1.000 1.000 359 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(12), EIF4G2(5), EIF4G3(15), GHR(20), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(3), PABPC1(4), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PRKCA(10), RPS6KB1(2) 9084936 111 71 106 40 62 15 7 12 14 1 0.0934 1.000 1.000 360 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(7), CSF1R(10), DDX20(7), E2F1(4), E2F4(1), ETS1(3), ETS2(7), ETV3(4), FOS(2), HDAC2(1), HDAC5(6), HRAS(3), JUN(1), NCOR2(22), RBL1(10), RBL2(4), SIN3A(8), SIN3B(6) 8574607 106 71 106 50 66 7 2 20 11 0 0.251 1.000 1.000 361 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(10), ATM(11), ATR(18), CCNA1(13), CCND1(1), CCNE1(3), CDC25A(7), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(4), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(2), TGFB1(1), TGFB3(3) 9482194 98 71 97 37 51 7 8 16 14 2 0.154 1.000 1.000 362 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(3), ARSE(5), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(7), LCT(29), NEU1(6), NEU2(10), NEU3(3), NEU4(8), PPAP2B(5), PPAP2C(6), SMPD1(3), SMPD2(1), SPTLC1(2), SPTLC2(5), UGCG(1) 7898645 110 71 107 69 73 12 2 16 7 0 0.785 1.000 1.000 363 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(1), ITGA4(29), ITGAL(19), ITGB1(4), ITGB2(10), SELE(28), SELL(7) 3955279 103 70 101 33 74 4 3 8 14 0 0.0140 1.000 1.000 364 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(6), GALNT2(5), GALNT3(3), GALNT4(3), GALNT6(13), GALNT7(4), GALNT8(17), GALNT9(5), GCNT1(6), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), WBSCR17(36) 4784390 109 70 102 46 81 7 4 9 8 0 0.0568 1.000 1.000 365 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), BCL2(2), EGFR(17), IGF1R(9), MYC(4), POLR2A(10), PPP2CA(1), PRKCA(10), RB1(8), TEP1(27), TERF1(2), TERT(5), TNKS(5), XRCC5(2) 9004197 105 70 103 59 66 8 8 12 9 2 0.566 1.000 1.000 366 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(4), CSNK1D(1), DRD1(6), DRD2(13), GRM1(14), PLCB1(45), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 5256480 110 69 105 69 83 2 6 10 9 0 0.599 1.000 1.000 367 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(24), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), GNAS(17), GRB2(1), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(6), PIK3R1(3), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10), RPS6KA1(6), RPS6KA5(3), SOS1(7) 9391625 128 69 125 81 83 10 6 13 15 1 0.920 1.000 1.000 368 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(15), G6PD(4), GCLC(4), GCLM(2), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GPX6(15), GSS(7), GSTA1(5), GSTA2(2), GSTA5(3), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), IDH1(11), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(5), TXNDC12(1) 7201664 115 69 105 62 78 7 6 16 8 0 0.131 1.000 1.000 369 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(17), EP300(13), FYN(5), IL2RG(2), IL7(5), IL7R(24), JAK1(5), JAK3(4), LCK(10), NMI(1), PIK3CA(6), PIK3R1(3), PTK2B(8), STAT5A(2), STAT5B(4) 9200062 111 69 109 59 65 12 5 19 9 1 0.744 1.000 1.000 370 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(28), ABCB11(37), ABCB4(13), ABCC1(10), ABCC3(19), GSTP1(2) 4690518 109 69 104 58 68 13 5 9 14 0 0.0532 1.000 1.000 371 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(1), GSK3B(2), IL4R(12), IRS1(5), IRS2(2), JAK1(5), JAK3(4), MAP4K1(8), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(6), PIK3CD(7), PIK3R1(3), PPP1R13B(6), RAF1(7), SHC1(1), SOS1(7), SOS2(11), STAT6(7) 12046344 118 69 118 48 63 16 5 20 13 1 0.150 1.000 1.000 372 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(4), CREB3(1), CREB5(7), DUSP6(1), DUSP9(3), EEF2K(5), GRB2(1), MAP2K1(11), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(3), MKNK2(1), MOS(3), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(6), RPS6KA3(2), SHC1(1), SOS1(7), SOS2(11), TRAF3(5) 9204542 95 69 88 56 62 6 4 15 8 0 0.875 1.000 1.000 373 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), GBA3(14), LPO(15), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(33), TYR(7) 3190336 93 69 89 45 71 7 1 6 8 0 0.0902 1.000 1.000 374 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(11), ATR(18), BRCA1(8), BRCA2(17), CHEK1(1), CHEK2(2), FANCA(7), FANCC(3), FANCD2(9), FANCE(2), FANCF(1), FANCG(3), HUS1(1), MRE11A(4), RAD1(2), RAD17(5), RAD50(3), RAD9A(4) 14303332 101 68 100 51 63 4 5 17 12 0 0.889 1.000 1.000 375 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(4), DAB1(33), FYN(5), LRP8(3), RELN(58), VLDLR(4) 4612440 107 68 103 57 74 6 2 12 13 0 0.811 1.000 1.000 376 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(3), EGR3(2), GNAQ(4), MAP3K1(2), MYC(4), NFATC1(13), NFATC2(6), NFKB1(7), NFKBIA(2), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RELA(4), SYT1(17), VIP(3), VIPR2(5) 9196673 113 68 109 74 75 9 7 14 8 0 0.931 1.000 1.000 377 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(17), AXIN1(9), BTRC(4), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(11), DVL1(1), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(4), NLK(5), PPARD(2), PPP2CA(1), TLE1(4), WIF1(7), WNT1(1) 9629208 96 68 95 50 50 6 8 14 18 0 0.846 1.000 1.000 378 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(27), AGT(5), AGTR1(9), AGTR2(10), BDKRB2(9), KNG1(8), NOS3(14), REN(8) 3263245 90 67 86 50 58 5 6 12 9 0 0.162 1.000 1.000 379 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(4), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), HGSNAT(4), HPSE(9), HPSE2(4), HYAL1(2), IDS(9), IDUA(4), LCT(29), NAGLU(4), SPAM1(18) 6705179 107 67 106 60 77 6 2 12 10 0 0.543 1.000 1.000 380 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(7), AKR1D1(17), CYP11A1(11), CYP11B1(11), CYP11B2(11), CYP17A1(6), CYP21A2(14), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7) 3233793 106 66 97 49 73 10 5 11 7 0 0.00540 1.000 1.000 381 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(14), EGFR(17), MAP2K1(11), MAP3K1(2), MAPK14(5), NCOR2(22), RARA(3), RXRA(4), THRA(2), THRB(12) 5658383 92 66 87 46 64 6 3 14 5 0 0.456 1.000 1.000 382 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(15), G6PD(4), GCLC(4), GCLM(2), GGT1(4), GPX1(2), GPX3(1), GPX5(9), GSS(7), GSTA1(5), GSTA2(2), GSTM1(1), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(5), GSTP1(2), GSTT1(1), IDH1(11), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(7) 5953366 96 66 87 40 65 5 6 13 7 0 0.0124 1.000 1.000 383 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(7), AKR1D1(17), CYP11A1(11), CYP11B1(11), CYP11B2(11), CYP17A1(6), CYP21A2(14), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7) 3233793 106 66 97 49 73 10 5 11 7 0 0.00540 1.000 1.000 384 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(7), CHIT1(9), CMAS(1), CTBS(5), CYB5R1(1), GFPT1(4), GFPT2(6), GNE(3), HEXA(4), HEXB(3), HK1(3), HK2(11), HK3(12), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(3), UAP1(2) 9455743 88 66 87 45 54 8 4 13 9 0 0.415 1.000 1.000 385 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(15), PGAP1(5), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(7), PIGH(1), PIGK(5), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(7), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGW(2), PIGX(2), PIGZ(3) 7902652 92 66 91 36 50 7 8 20 7 0 0.0661 1.000 1.000 386 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(7), PAFAH1B1(4), PAFAH1B2(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8), PLD1(9), PLD2(5), PPAP2B(5), PPAP2C(6) 7702810 108 66 105 60 63 10 4 17 14 0 0.630 1.000 1.000 387 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(24), CAP1(1), CDC25C(2), GNAI1(1), GNAS(17), HRAS(3), MAPK1(4), MAPK3(1), MYT1(19), PIN1(1), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RPS6KA1(6), SRC(1) 6756155 101 66 98 75 68 8 4 8 13 0 0.929 1.000 1.000 388 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(6), CBS(6), CTH(1), GGT1(4), HEMK1(4), LCMT1(3), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), METTL2B(7), METTL6(2), PAPSS1(2), PAPSS2(5), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1) 8283870 90 65 90 41 51 11 5 15 8 0 0.162 1.000 1.000 389 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAPK3(1), MPL(7), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), RAF1(7), RASA1(4), SHC1(1), SOS1(7), STAT1(3), STAT3(10), STAT5A(2), STAT5B(4), THPO(6) 9854658 104 65 98 46 54 11 6 22 10 1 0.578 1.000 1.000 390 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(16), EPHB1(22), FYN(5), ITGA1(16), ITGB1(4), L1CAM(8), LYN(5), RAP1B(1), SELP(28) 5208273 107 64 97 54 77 4 2 16 8 0 0.387 1.000 1.000 391 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GPHN(7), NSF(1), SRC(1), UBQLN1(5) 3868805 95 64 85 49 70 3 5 10 6 1 0.340 1.000 1.000 392 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(2), BCR(10), CRKL(2), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(4), PIK3CA(6), PIK3R1(3), RAF1(7), SOS1(7), STAT1(3), STAT5A(2), STAT5B(4) 9219474 86 64 81 41 43 8 5 18 11 1 0.699 1.000 1.000 393 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(9), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(5), PFKL(4), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(11), PRPS2(3), RBKS(4), TALDO1(2), TKT(5), TKTL2(20) 7994574 96 64 90 69 61 10 5 9 11 0 0.730 1.000 1.000 394 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(24), ADRB2(2), GNAS(17), PLCE1(41), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 4810738 103 64 99 62 67 9 7 10 10 0 0.721 1.000 1.000 395 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(3), BAG4(3), CASP2(1), CASP3(2), CASP8(7), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MADD(14), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(16), RB1(8), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(2), TRAF2(1) 12862505 107 64 106 48 48 9 9 25 14 2 0.440 1.000 1.000 396 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(24), ADRB2(2), CFTR(38), GNAS(17), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SLC9A3R1(3) 4266158 103 63 98 70 68 8 6 10 11 0 0.875 1.000 1.000 397 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(17), NFKB1(7), NOS3(14), NPPA(2), NR3C1(6), PIK3CA(6), PIK3R1(3), RELA(4), SYT1(17) 5858698 87 63 82 46 62 6 2 13 3 1 0.682 1.000 1.000 398 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), GBA(3), GBA3(14), LPO(15), MPO(11), PRDX6(4), TPO(33) 2769796 85 63 81 43 66 6 1 6 6 0 0.0841 1.000 1.000 399 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IL2(2), IL2RA(3), IL2RB(7), IL2RG(2), JAK1(5), JAK3(4), JUN(1), LCK(10), MAP2K1(11), MAPK3(1), MAPK8(1), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4), SYK(12) 7585475 89 63 83 42 52 8 5 16 8 0 0.369 1.000 1.000 400 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), ESRRA(2), HDAC5(6), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), PPARA(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(7), SYT1(17) 6614951 95 63 89 53 68 6 3 10 8 0 0.420 1.000 1.000 401 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(2), GLI2(32), GLI3(15), GSK3B(2), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), SHH(4), SMO(10), SUFU(2) 5468723 88 63 87 53 55 10 7 8 8 0 0.664 1.000 1.000 402 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(2), ACTN1(5), ACTN2(16), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(16), ITGB1(4), ITGB3(9), PTK2(8), PXN(3), SPTAN1(7), SRC(1), TLN1(11) 9148788 94 63 92 47 56 9 5 12 11 1 0.106 1.000 1.000 403 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(18), BST1(1), CD38(2), ENPP1(10), ENPP3(14), NADK(3), NADSYN1(4), NMNAT2(2), NMNAT3(7), NNMT(7), NNT(4), NT5C1A(3), NT5C1B(19), NT5C2(3), NT5C3(2), NT5E(3), NT5M(1), NUDT12(1), QPRT(5) 7118470 109 62 106 61 70 8 6 12 13 0 0.665 1.000 1.000 404 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3D(4), CD3G(1), CXCR3(3), ETV5(6), IFNG(1), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18(2), IL18R1(16), JAK2(7), JUN(1), MAP2K6(2), MAPK14(5), MAPK8(1), STAT4(20), TYK2(7) 6122777 100 62 97 50 65 6 3 15 11 0 0.525 1.000 1.000 405 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(3), IL1A(4), IL1R1(10), IRAK1(4), MAP3K1(2), MAP3K14(3), MAP3K7(1), MYD88(4), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TLR4(25), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(3), TRAF6(4) 7903842 83 62 81 48 56 5 5 11 6 0 0.725 1.000 1.000 406 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(6), PIK3R1(3), PLCB1(45), PLCG1(7), PRKCA(10), VAV1(13) 4245758 87 62 83 41 68 3 2 8 5 1 0.271 1.000 1.000 407 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(27), CD44(5), CSF1(7), FCGR3A(6), IL1B(6), IL6R(4), SELL(7), SPN(3), TGFB1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TNFRSF8(16), TNFSF8(3) 4266233 91 62 86 39 66 2 6 5 12 0 0.0514 1.000 1.000 408 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(7), CNR2(4), DNMT1(16), MTNR1A(7), MTNR1B(5), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(2), PTGFR(18), PTGIR(3), TBXA2R(4) 3679888 85 62 81 60 56 10 5 7 7 0 0.307 1.000 1.000 409 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(9), DARS(4), EPRS(9), FARS2(4), GARS(5), HARS(7), IARS(8), KARS(4), LARS(9), LARS2(2), MARS(5), MARS2(3), NARS(2), QARS(5), RARS(7), SARS(10), TARS(1), WARS(4), WARS2(4), YARS(1) 10653299 107 61 102 41 65 10 6 17 9 0 0.0966 1.000 1.000 410 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(11), BCAT2(1), IARS(8), IARS2(12), ILVBL(3), LARS(9), LARS2(2), PDHA1(2), PDHA2(15), PDHB(1), VARS(18), VARS2(5) 6240861 87 61 77 39 56 8 3 11 9 0 0.290 1.000 1.000 411 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(4), FUCA1(2), GLB1(7), HEXA(4), HEXB(3), LCT(29), MAN2B1(5), MAN2B2(8), MAN2C1(3), MANBA(6), NEU1(6), NEU2(10), NEU3(3), NEU4(8) 6689304 98 61 98 50 69 10 3 12 4 0 0.288 1.000 1.000 412 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(8), ASRGL1(2), CA1(8), CA12(3), CA13(4), CA2(7), CA3(5), CA4(3), CA5A(1), CA5B(1), CA6(2), CA7(1), CA8(4), CA9(6), CPS1(17), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(2), HAL(11) 6953356 94 61 94 46 64 5 4 12 9 0 0.347 1.000 1.000 413 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IGF1(9), IGF1R(9), IRS1(5), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PTPN11(9), RAF1(7), RASA1(4), SHC1(1), SOS1(7), SRF(3) 8169999 86 61 78 38 39 16 2 20 8 1 0.614 1.000 1.000 414 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), INSR(19), IRS1(5), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PIK3CA(6), PIK3R1(3), PTPN11(9), RAF1(7), RASA1(4), SHC1(1), SLC2A4(7), SOS1(7), SRF(3) 8451789 94 61 87 42 40 14 3 26 10 1 0.669 1.000 1.000 415 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(5), EPX(5), LPO(15), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(2), TPO(33) 3908637 83 61 81 44 64 6 1 8 4 0 0.155 1.000 1.000 416 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(3), EIF4EBP1(1), EIF4G1(12), EIF4G2(5), EIF4G3(15), FKBP1A(2), MKNK1(3), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(11) 8880277 85 61 83 31 41 11 8 12 11 2 0.177 1.000 1.000 417 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(4), HDAC3(5), NCOA1(7), NCOA2(10), NCOA3(12), NCOR2(22), POLR2A(10), RARA(3), RXRA(4), TBP(4) 8198530 89 61 89 35 65 3 5 9 7 0 0.0920 1.000 1.000 418 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(24), GNAS(17), PPP2CA(1), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAG2(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 5033685 93 60 90 57 62 8 7 4 12 0 0.800 1.000 1.000 419 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(15), GMDS(5), GMPPA(1), GMPPB(2), HK1(3), HK2(11), HK3(12), MPI(1), PFKFB1(4), PFKFB3(1), PFKFB4(3), PFKM(1), PMM1(2), PMM2(1), SORD(2) 7856145 85 60 81 64 61 11 5 4 4 0 0.643 1.000 1.000 420 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(10), CYP2A13(10), CYP2A6(10), CYP2A7(7), NAT1(2), NAT2(8), XDH(44) 2655301 91 60 86 49 70 4 8 4 5 0 0.0308 1.000 1.000 421 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), OGDH(10), PC(12), PDHA1(2), PDHA2(15), PDHB(1), PDHX(2), PDK1(2), PDK2(2), PDK3(4), PDK4(6), PDP2(5), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(1), SUCLG2(2) 9400274 94 60 90 39 61 5 6 10 12 0 0.110 1.000 1.000 422 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(1), CALM2(1), CDKN1A(4), GNAQ(4), NFATC1(13), NFATC2(6), NFATC3(7), NFATC4(11), PLCG1(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SP1(3), SYT1(17) 6848766 95 59 90 40 64 8 6 9 8 0 0.181 1.000 1.000 423 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(11), MAP2K2(3), MAP2K3(7), MAP2K6(2), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(6), PIK3R1(3), RB1(8), RELA(4), SP1(3) 6376852 69 59 63 32 33 7 3 13 10 3 0.638 1.000 1.000 424 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG5(2), ATG7(8), BECN1(3), GABARAPL1(1), IFNA1(1), IFNA10(1), IFNA14(3), IFNA16(6), IFNA17(1), IFNA2(1), IFNA21(5), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(4), IFNA8(3), IFNG(1), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(19), ULK1(7), ULK2(6), ULK3(1) 6883722 91 59 88 49 59 7 6 13 6 0 0.542 1.000 1.000 425 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), IL6(2), IL6R(4), IL6ST(10), JAK1(5), JAK2(7), JAK3(4), JUN(1), MAP2K1(11), MAPK3(1), PTPN11(9), RAF1(7), SHC1(1), SOS1(7), SRF(3), STAT3(10) 7845842 91 59 84 43 38 12 3 26 12 0 0.773 1.000 1.000 426 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(17), CDH1(4), CREBBP(17), EP300(13), MAP2K1(11), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB3(3), TGFBR2(7) 8496455 77 59 72 41 41 8 3 14 11 0 0.938 1.000 1.000 427 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(5), ACTN2(16), ACTN3(7), BCAR1(4), CSK(1), CTNNA1(2), CTNNA2(19), CTNNB1(11), PTK2(8), PXN(3), SRC(1), VCL(7) 6221168 84 58 81 41 50 7 4 12 10 1 0.155 1.000 1.000 428 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(13), GABRA2(13), GABRA3(18), GABRA4(9), GABRA5(1), GABRA6(22), GPX1(2), PRKCE(5) 2546725 83 58 72 42 63 3 3 9 4 1 0.283 1.000 1.000 429 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(9), CALM1(1), CALM2(1), CAPN2(7), CAPNS1(1), EP300(13), HDAC1(1), HDAC2(1), MEF2D(4), NFATC1(13), NFATC2(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SYT1(17) 8100312 95 58 90 41 65 6 7 10 7 0 0.197 1.000 1.000 430 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(8), CA1(8), CA12(3), CA2(7), CA3(5), CA4(3), CA5A(1), CA5B(1), CA6(2), CA7(1), CA8(4), CA9(6), CPS1(17), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUL(2), HAL(11) 6216027 85 58 85 41 58 4 3 12 8 0 0.332 1.000 1.000 431 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(5), EPX(5), LPO(15), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(2), TPO(33) 3861764 80 57 78 44 62 6 1 8 3 0 0.189 1.000 1.000 432 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(18), CPT1A(9), LEP(2), LEPR(19), PRKAA1(1), PRKAA2(19), PRKAB1(2), PRKAB2(1), PRKAG1(2), PRKAG2(7) 4825885 80 57 76 45 55 3 4 6 12 0 0.802 1.000 1.000 433 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(14), FOS(2), GRB2(1), HRAS(3), IL3(2), IL3RA(5), JAK2(7), MAP2K1(11), MAPK3(1), PTPN6(2), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4) 5790304 69 56 64 36 39 4 3 13 10 0 0.687 1.000 1.000 434 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(4), FUCA1(2), GLB1(7), HEXA(4), HEXB(3), LCT(29), MAN2C1(3), MANBA(6), NEU1(6), NEU2(10), NEU3(3), NEU4(8) 5430311 85 56 85 44 60 8 2 11 4 0 0.433 1.000 1.000 435 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(12), AP2A1(1), AP2M1(3), BIN1(4), CALM1(1), CALM2(1), DNM1(5), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(18), SYNJ2(13), SYT1(17) 7055500 96 56 92 46 66 9 2 15 4 0 0.364 1.000 1.000 436 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(5), ESR2(6), PDE1B(10), PLCB1(45), PLCB2(6), PRL(1), TRH(3), VIP(3) 3245908 79 56 74 43 64 1 2 6 6 0 0.245 1.000 1.000 437 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(10), ATM(11), BRCA1(8), CDKN1A(4), CHEK1(1), CHEK2(2), JUN(1), MAPK8(1), MDM2(3), MRE11A(4), NFKB1(7), NFKBIA(2), RAD50(3), RBBP8(3), RELA(4), TP73(5) 9525262 69 55 69 32 28 12 3 17 9 0 0.801 1.000 1.000 438 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(5), ATM(11), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(10), PTK2(8), PXN(3), STAT1(3), TLN1(11) 8740922 69 55 68 30 34 10 4 12 9 0 0.386 1.000 1.000 439 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), ACO2(4), CS(2), DLD(2), FH(3), IDH1(11), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(3), PC(12), PCK1(16), SDHA(1), SDHB(1), SUCLG1(1), SUCLG2(2) 6851708 72 55 63 38 51 1 6 8 6 0 0.375 1.000 1.000 440 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(4), CD3G(1), CD80(4), CD86(18), CTLA4(2), GRB2(1), HLA-DRA(10), HLA-DRB1(3), ICOS(3), IL2(2), ITK(19), LCK(10), PIK3CA(6), PIK3R1(3), PTPN11(9) 4218793 96 55 92 34 62 7 1 15 10 1 0.121 1.000 1.000 441 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15(8), ALOX15B(8), ALOX5(7), DPEP1(4), GGT1(4), LTA4H(3), PLA2G2A(2), PLA2G6(8), PTGDS(1), PTGIS(10), PTGS1(14), PTGS2(9), TBXAS1(9) 4919856 92 55 91 50 64 8 2 10 8 0 0.0818 1.000 1.000 442 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), BHMT(4), CBS(6), CTH(1), DNMT1(16), DNMT3A(5), DNMT3B(8), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), MTAP(2), MTFMT(1), MTR(7), TAT(12) 6930499 81 55 79 34 48 5 8 11 9 0 0.139 1.000 1.000 443 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), G6PD(4), GPI(3), H6PD(5), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(11), PRPS2(3), RBKS(4), TAL1(5), TALDO1(2), TKT(5) 6735422 75 55 72 55 47 6 5 7 10 0 0.788 1.000 1.000 444 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(5), BIRC2(3), BIRC3(6), CASP10(2), CASP3(2), CASP7(4), CASP8(7), CASP9(2), DFFA(2), DFFB(3), GZMB(2), PRF1(7), SCAP(8), SREBF1(5), SREBF2(7) 6010138 65 55 63 33 36 5 7 10 7 0 0.585 1.000 1.000 445 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(10), APOA1(1), APOA4(4), APOC1(2), APOC2(1), APOE(1), CETP(5), CYP7A1(6), DGAT1(1), HMGCR(11), LDLR(10), LIPC(8), LPL(3), LRP1(28), SCARB1(3), SOAT1(3) 9134284 97 55 95 57 52 12 6 16 11 0 0.607 1.000 1.000 446 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(9), ALDOC(3), FBP1(2), FBP2(2), GOT1(3), GOT2(4), GPT(3), GPT2(1), MDH1(1), MDH2(3), ME1(17), ME2(1), ME3(8), PGK1(4), PKLR(8), PKM2(3), TKT(5) 5976452 78 54 75 41 52 8 5 7 6 0 0.194 1.000 1.000 447 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(11), POLR1B(8), POLR2A(10), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(2), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(13), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1) 7760432 69 54 68 27 38 6 6 12 7 0 0.164 1.000 1.000 448 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(3), BIRC3(6), CASP3(2), CASP8(7), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(4), MAP3K7(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(3), TRAF2(1) 8914772 69 54 69 44 35 4 9 16 5 0 0.938 1.000 1.000 449 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(18), HLA-DRA(10), HLA-DRB1(3), IFNG(1), IFNGR1(4), IFNGR2(4), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), IL18(2), IL18R1(16), IL2(2), IL2RA(3), IL4(1), IL4R(12) 4177465 95 54 91 40 69 4 0 9 13 0 0.125 1.000 1.000 450 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(3), CCND1(1), CCNE1(3), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(4), HRAS(3), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(6), PIK3R1(3), RAF1(7), RB1(8), RELA(4), TFDP1(2) 6503722 74 53 73 29 30 7 6 16 12 3 0.221 1.000 1.000 451 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), CASP9(2), CDC42(2), CHUK(2), ELK1(2), H2AFX(2), HRAS(3), MAP2K1(11), MAPK3(1), NFKB1(7), PIK3CA(6), PIK3R1(3), RAF1(7), RALA(1), RALBP1(2), RALGDS(8), RELA(4), RHOA(1) 6089578 67 53 62 35 35 10 2 15 4 1 0.700 1.000 1.000 452 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(4), CYSLTR2(1), GPR109B(5), GPR161(5), GPR171(8), GPR18(5), GPR34(2), GPR39(10), GPR45(6), GPR65(7), GPR68(3), GPR75(5), GPR81(2) 3226252 63 52 62 32 44 2 4 6 7 0 0.0202 1.000 1.000 453 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(3), GLB1(7), HEXA(4), HEXB(3), LCT(29), SLC33A1(5), ST3GAL1(5), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(6), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(6) 5442361 82 52 82 54 56 8 1 13 4 0 0.773 1.000 1.000 454 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(7), MAN1A1(13), MAN1B1(3), MGAT1(2), MGAT2(2), MGAT3(8), MGAT4A(8), MGAT4B(1), MGAT5(4), RPN2(2), ST6GAL1(4) 6599775 73 52 73 44 45 8 3 10 7 0 0.659 1.000 1.000 455 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(18), CD38(2), ENPP1(10), ENPP3(14), NADSYN1(4), NMNAT2(2), NNMT(7), NNT(4), NT5E(3), NT5M(1), QPRT(5) 4815433 70 52 67 35 42 7 4 9 8 0 0.478 1.000 1.000 456 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(6), CD3D(4), CD3G(1), CD4(6), CXCR3(3), IFNG(1), IL12A(2), IL12B(1), IL12RB1(13), IL12RB2(2), JAK2(7), STAT4(20), TYK2(7) 4557504 73 52 71 39 43 7 3 11 9 0 0.516 1.000 1.000 457 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(4), IFNG(1), IFNGR1(4), IFNGR2(4), IKBKB(3), JAK2(7), NFKB1(7), NFKBIA(2), RB1(8), RELA(4), TNF(1), TNFRSF1A(2), TNFRSF1B(3), USH1C(15), WT1(4) 5547991 69 52 66 28 29 5 3 13 17 2 0.375 1.000 1.000 458 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), CHRNB1(1), CHRNG(1), MUSK(28), PIK3CA(6), PIK3R1(3), PTK2(8), PTK2B(8), RAPSN(1), SRC(1), TERT(5) 5362469 65 51 62 50 43 4 1 12 4 1 0.923 1.000 1.000 459 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(6), CREBBP(17), EP300(13), NCOA3(12), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), RARA(3), RXRA(4) 6838162 74 51 74 41 44 4 4 14 8 0 0.868 1.000 1.000 460 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(5), ARHGDIB(3), BIRC2(3), BIRC3(6), CASP1(2), CASP10(2), CASP2(1), CASP3(2), CASP7(4), CASP8(7), CASP9(2), CYCS(1), DFFA(2), DFFB(3), GZMB(2), LMNA(8), LMNB1(2), LMNB2(4), PRF1(7) 6465148 66 51 66 33 32 9 6 13 6 0 0.696 1.000 1.000 461 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(4), CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(1), MAP2K3(7), MAP2K4(4), MAP2K6(2), MAP3K1(2), MAP3K14(3), MAP4K2(4), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TRAF2(1) 7840716 59 51 59 38 32 9 2 10 6 0 0.859 1.000 1.000 462 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(5), EPOR(1), FOS(2), GRB2(1), HRAS(3), JAK2(7), JUN(1), MAP2K1(11), MAPK3(1), MAPK8(1), PLCG1(7), PTPN6(2), RAF1(7), SHC1(1), SOS1(7), STAT5A(2), STAT5B(4) 7028000 66 50 61 35 32 5 5 16 8 0 0.791 1.000 1.000 463 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(7), ASPH(3), COPS5(3), EDN1(7), EP300(13), EPO(5), HIF1A(5), JUN(1), LDHA(4), NOS3(14), P4HB(2), VHL(4) 5648847 68 50 67 31 40 3 5 10 10 0 0.547 1.000 1.000 464 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF2B5(1), EIF2S1(1), EIF4EBP1(1), GSK3B(2), IGF1(9), IGF1R(9), INPPL1(14), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2) 6224181 59 50 57 28 32 8 5 8 5 1 0.494 1.000 1.000 465 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), GRB2(1), HRAS(3), IGF1R(9), IRS1(5), MAP2K1(11), MAPK1(4), MAPK3(1), PIK3CA(6), PIK3R1(3), RAF1(7), SHC1(1), SOS1(7) 6280733 61 50 56 26 31 8 2 12 7 1 0.447 1.000 1.000 466 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(17), EP300(13), LPL(3), NCOA1(7), NCOA2(10), PPARG(11), RXRA(4) 6146339 65 50 64 27 41 4 3 11 6 0 0.516 1.000 1.000 467 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(24), FHL5(10), FSHB(4), FSHR(13), GNAS(17), XPO1(2) 3121658 70 49 68 44 51 5 4 5 5 0 0.821 1.000 1.000 468 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(6), POLD2(2), POLE(14), POLG(6), POLL(6), POLQ(22) 5520439 56 49 55 22 31 3 2 12 8 0 0.181 1.000 1.000 469 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(11), CDC25A(7), CDC25B(4), CDC25C(2), CDK4(5), CHEK1(1), MYT1(19), RB1(8), WEE1(2) 5538796 59 49 57 22 28 5 2 11 11 2 0.319 1.000 1.000 470 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD28(1), CD3D(4), CD3G(1), CD8A(2), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26), THY1(1) 3261789 65 49 62 37 43 5 2 5 10 0 0.439 1.000 1.000 471 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD28(1), CD3D(4), CD3G(1), CD4(6), ICAM1(1), ITGAL(19), ITGB2(10), PTPRC(26), THY1(1) 3430877 69 49 66 39 45 6 2 6 10 0 0.408 1.000 1.000 472 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNAQ(4), HTR2C(10), PLCB1(45), TUB(8) 2360005 70 49 66 30 56 1 1 7 5 0 0.0721 1.000 1.000 473 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(7), ARG1(1), ARG2(1), ASL(5), CKM(2), CKMT2(4), CPS1(17), GAMT(3), GATM(4), GLUD1(1), NAGS(1), OAT(2), ODC1(3), OTC(2), PYCR1(1), SMS(5) 5700389 60 49 60 29 34 6 2 9 9 0 0.328 1.000 1.000 474 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(2), CASP8(7), CYCS(1), MAP2K1(11), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFKB1(7), NSMAF(4), RAF1(7), RELA(4), RIPK1(1), SMPD1(3), TNFRSF1A(2), TRAF2(1) 6724325 65 48 60 25 36 5 3 13 8 0 0.267 1.000 1.000 475 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(11), CYP11A1(11), CYP11B2(11), CYP17A1(6), HSD11B1(10), HSD11B2(2), HSD3B1(10), HSD3B2(7) 2277073 68 48 64 41 50 6 1 5 6 0 0.0671 1.000 1.000 476 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(6), B3GAT2(2), B3GAT3(4), CHPF(3), CHST11(5), CHST12(3), CHST13(2), CHST14(2), CHST3(1), CHSY1(9), DSE(17), XYLT1(8), XYLT2(3) 4375846 65 48 65 37 42 9 3 7 4 0 0.241 1.000 1.000 477 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(6), CSF1(7), CSF2(1), CSF3(3), HLA-DRA(10), HLA-DRB1(3), IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL15(3), IL1A(4), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL7(5), IL8(1), LTA(1), PDGFA(1), TGFB1(1), TGFB3(3), TNF(1) 4337184 73 48 73 36 47 3 3 9 11 0 0.0600 1.000 1.000 478 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(5), GH1(3), GHR(20), HRAS(3), IGF1(9), IGF1R(9), PIK3CA(6), PIK3R1(3), SHC1(1) 4379468 62 48 59 33 41 9 0 8 3 1 0.609 1.000 1.000 479 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(28), AKT1(3), ATM(11), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(3), NFKBIB(1), NQO1(1) 6595760 67 48 63 34 35 8 2 12 10 0 0.781 1.000 1.000 480 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(17), AXIN1(9), BTRC(4), CTNNB1(11), DLL1(2), DVL1(1), FZD1(4), GSK3B(2), NOTCH1(5), PSEN1(1), WNT1(1) 6953227 58 48 58 35 28 7 4 5 14 0 0.882 1.000 1.000 481 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(2), IL6R(4), JAK1(5), JAK2(7), JAK3(4), PIAS3(5), PTPRU(13), REG1A(6), SRC(1), STAT3(10) 5011621 59 48 59 37 31 6 2 11 9 0 0.779 1.000 1.000 482 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(12), PIR(1), WASF1(3), WASF2(3), WASF3(11), WASL(5) 4920084 53 47 52 24 31 5 2 8 7 0 0.639 1.000 1.000 483 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(11), FADS2(3), PLA2G12B(1), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(3), PLA2G2F(3), PLA2G3(10), PLA2G4A(10), PLA2G5(2), PLA2G6(8) 3343640 64 47 64 33 44 4 1 5 10 0 0.244 1.000 1.000 484 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(4), LCMT1(3), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 4982218 61 47 61 28 34 9 2 12 4 0 0.265 1.000 1.000 485 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(1), HRAS(3), JUN(1), KLK2(1), MAP2K1(11), MAPK3(1), MAPK8(1), NGFR(6), PIK3CA(6), PIK3R1(3), PLCG1(7), RAF1(7), SHC1(1), SOS1(7) 6276583 62 47 57 27 32 7 2 15 5 1 0.560 1.000 1.000 486 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(3), AP2A1(1), AP2M1(3), BTK(15), EEA1(2), GRASP(1), GSK3B(2), LYN(5), PDPK1(4), PFKL(4), PFKM(1), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(1), RPS6KB1(2), VAV2(2) 8014511 62 47 60 41 34 5 5 10 8 0 0.752 1.000 1.000 487 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(18), ACACB(15), FASN(15), MCAT(2), OLAH(8), OXSM(1) 5215892 59 46 58 32 34 5 3 9 8 0 0.416 1.000 1.000 488 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(6), IL22(1), IL22RA1(8), JAK1(5), JAK2(7), JAK3(4), SOCS3(2), STAT1(3), STAT3(10), STAT5A(2), STAT5B(4), TYK2(7) 6006878 59 46 59 40 26 6 6 14 7 0 0.941 1.000 1.000 489 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(4), CHUK(2), IFNG(1), IKBKB(3), IL2(2), IL4(1), JUN(1), MAP3K1(2), MAP3K5(15), MAP4K5(2), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(3), TNFSF9(1), TRAF2(1) 6320955 57 45 54 30 32 4 1 12 8 0 0.734 1.000 1.000 490 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(15), GFPT1(4), GNE(3), HEXA(4), HEXB(3), HK1(3), HK2(11), HK3(12), PGM3(1), RENBP(3), UAP1(2) 5607415 62 45 61 31 40 5 2 8 7 0 0.360 1.000 1.000 491 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(1), CCR5(6), CXCL12(2), CXCR4(3), FOS(2), GNAQ(4), JUN(1), MAPK14(5), MAPK8(1), PLCG1(7), PRKCA(10), PTK2B(8), SYT1(17) 4570191 69 45 64 46 44 6 4 10 5 0 0.743 1.000 1.000 492 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(1), HRAS(3), MAPK1(4), MAPK3(1), MAPK7(3), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), NTRK1(12), PIK3CA(6), PIK3R1(3), PLCG1(7), RPS6KA1(6), SHC1(1) 6232179 62 45 60 45 35 10 2 7 7 1 0.963 1.000 1.000 493 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(5), ACADS(4), ACADVL(1), ACSL1(4), ACSL3(5), ACSL4(2), CPT1A(9), CPT2(1), DCI(2), EHHADH(5), HADHA(8), PECR(1), SCP2(2), SLC25A20(1) 5612162 54 45 53 24 35 3 3 7 6 0 0.464 1.000 1.000 494 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), FDXR(7), SHMT1(1) 5299552 69 45 68 38 37 4 6 13 9 0 0.486 1.000 1.000 495 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(4), GRB2(1), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(6), PIK3CD(7), PTK2B(8), RBL2(4), SHC1(1), SOS1(7) 6518280 56 45 56 29 30 6 0 14 6 0 0.727 1.000 1.000 496 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(5), JAK2(7), JAK3(4), PIAS1(4), PIAS3(5), PTPRU(13), REG1A(6), SOAT1(3) 4508699 49 45 49 27 30 4 1 7 7 0 0.613 1.000 1.000 497 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), CASP9(2), CHUK(2), GH1(3), GHR(20), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PPP2CA(1), RELA(4) 4615538 57 44 54 33 36 6 3 8 3 1 0.824 1.000 1.000 498 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(6), GBF1(10), GPLD1(15), KDELR3(1) 5418590 56 44 56 35 29 4 4 13 6 0 0.880 1.000 1.000 499 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1) 4981708 62 44 61 35 33 3 6 12 8 0 0.560 1.000 1.000 500 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1) 4981708 62 44 61 35 33 3 6 12 8 0 0.560 1.000 1.000 501 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(4), GLB1(7), GNS(2), GUSB(3), HEXA(4), HEXB(3), IDS(9), IDUA(4), LCT(29), NAGLU(4) 4719648 70 44 70 40 54 4 0 8 4 0 0.540 1.000 1.000 502 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(6), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(1), EHHADH(5), ESCO1(1), ESCO2(2), GCDH(5), HADHA(8), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2), YOD1(1) 8625866 73 44 72 45 40 9 3 16 5 0 0.934 1.000 1.000 503 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(31), CYP2C9(30) 666729 61 44 53 44 50 3 2 1 5 0 0.795 1.000 1.000 504 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(5), BCL2(2), CASP3(2), CASP9(2), CYCS(1), DAXX(8), FAS(5), FASLG(12), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(5), MAPKAPK3(3), TNF(1) 3762030 55 44 55 26 32 4 3 8 8 0 0.325 1.000 1.000 505 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(17), DAXX(8), HRAS(3), PAX3(3), PML(3), RARA(3), RB1(8), SP100(7), TNF(1), TNFRSF1A(2), TNFRSF1B(3) 5931263 58 44 58 24 25 6 6 11 8 2 0.385 1.000 1.000 506 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(6), F13B(19), HSD17B2(7), HSD17B3(3), HSD17B4(6), HSD17B7(1), HSD3B1(10), HSD3B2(7) 2642634 59 44 54 28 40 4 4 4 6 1 0.206 1.000 1.000 507 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(1), ATP6V0A1(9), ATP6V0A4(17), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(5), ATP6V1H(4), SHMT1(1) 4981708 62 44 61 35 33 3 6 12 8 0 0.560 1.000 1.000 508 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(26), MAP2(11), PPP2CA(1), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4), PRKCE(5) 5974126 61 43 60 38 36 6 4 7 8 0 0.955 1.000 1.000 509 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(2), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(6), CAMK2G(3), CAMK4(8), CAMKK1(2), CAMKK2(6), SYT1(17) 3837996 59 43 54 48 42 6 2 5 4 0 0.920 1.000 1.000 510 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(2), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(23), PIK3CA(6), PIK3R1(3), WASL(5) 4305231 53 43 53 20 31 3 2 8 8 1 0.344 1.000 1.000 511 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(29), MPI(1), PGM1(4), PYGL(6), PYGM(9), TREH(2) 4354958 54 43 54 44 41 5 1 5 2 0 0.801 1.000 1.000 512 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(14), EGFR(17), ERBB3(4), NRG1(15), UBE2D1(1) 3416290 51 42 51 35 37 1 3 7 3 0 0.972 1.000 1.000 513 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10L(4), RPL11(2), RPL13A(1), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS27(1), RPS29(1), RPS3A(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1) 7437620 56 42 56 38 29 4 7 10 6 0 0.882 1.000 1.000 514 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(11), CDC25A(7), CDC25B(4), CDC25C(2), CHEK1(1), MYT1(19), WEE1(2) 4552047 46 41 45 21 27 5 1 6 7 0 0.588 1.000 1.000 515 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(1), HEMK1(4), LCMT1(3), METTL2B(7), METTL6(2), PCYT1A(3), PCYT1B(6), PRMT2(2), PRMT3(4), PRMT5(4), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 4641616 54 41 54 22 29 7 4 10 4 0 0.181 1.000 1.000 516 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(7), CHST2(3), CHST4(8), CHST6(3), FUT8(7), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1) 4108493 51 41 50 34 32 11 4 2 2 0 0.588 1.000 1.000 517 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(11), AMT(1), ATIC(5), FTCD(2), GART(9), MTFMT(1), MTHFD1(9), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(1), SHMT2(2), TYMS(1) 6263966 52 41 51 30 36 4 3 6 3 0 0.640 1.000 1.000 518 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(6), CLOCK(4), CRY1(5), CRY2(3), CSNK1D(1), CSNK1E(2), NPAS2(4), PER1(7), PER2(8), PER3(9) 5616530 49 41 46 37 31 5 1 4 8 0 0.974 1.000 1.000 519 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2), ECHS1(1), EHHADH(5), HADHA(8), SDS(2) 4003888 48 41 46 25 25 8 2 9 4 0 0.391 1.000 1.000 520 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(17), EP300(13), HDAC3(5), IKBKB(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(2), TNFRSF1B(3), TRAF6(4) 7363190 64 41 64 30 37 6 5 12 4 0 0.551 1.000 1.000 521 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(6), JAK1(5), PTPRU(13), REG1A(6), STAT1(3), STAT2(5), TYK2(7) 4141969 47 41 47 24 25 3 2 9 8 0 0.463 1.000 1.000 522 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(3), MAPK14(5), MAPK8(1), NFKB1(7), RELA(4), TNFRSF13B(6), TNFRSF17(5), TNFSF13B(1), TRAF2(1), TRAF3(5), TRAF5(6), TRAF6(4) 4743145 50 41 49 21 31 6 0 11 2 0 0.297 1.000 1.000 523 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(15), AOC2(7), AOC3(8), CES1(16), ESD(1) 1987022 47 40 45 30 38 2 3 2 2 0 0.551 1.000 1.000 524 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(5), IL4(1), IL5(2), MAF(1), MAP2K3(7), MAPK14(5), NFATC1(13), NFATC2(6), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 3978166 59 40 58 41 40 5 3 5 6 0 0.767 1.000 1.000 525 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), BCAR1(4), CDKN1B(1), GRB2(1), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(2), PDPK1(4), PIK3CA(6), PIK3R1(3), PTK2(8), SHC1(1), SOS1(7) 6063672 49 40 48 24 28 5 0 10 5 1 0.734 1.000 1.000 526 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(1), GRB2(1), HRAS(3), KLK2(1), NTRK1(12), PIK3CA(6), PIK3R1(3), PLCG1(7), PRKCA(10), SHC1(1), SOS1(7) 5131802 55 40 54 26 30 8 2 9 5 1 0.593 1.000 1.000 527 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(4), B3GNT1(2), B3GNT2(1), B3GNT3(5), B3GNT4(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(4), FUT6(4), FUT7(2), ST3GAL6(2), ST8SIA1(1) 5034775 49 39 48 28 29 7 3 3 7 0 0.373 1.000 1.000 528 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(1), IL10(3), IL12A(2), IL12B(1), IL15(3), IL16(10), IL18(2), IL1A(4), IL2(2), IL3(2), IL4(1), IL5(2), IL6(2), IL8(1), IL9(1), LTA(1), TNF(1) 3260886 46 38 46 28 30 1 3 4 8 0 0.387 1.000 1.000 529 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(5), ARHGAP5(10), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP8(7), CASP9(2), CYCS(1), GZMB(2), JUN(1), PRF1(7) 4275626 44 38 43 25 25 5 3 8 3 0 0.854 1.000 1.000 530 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(14), EGFR(17), HGS(3), RAB5A(1), TF(10), TFRC(4) 4240903 51 38 51 35 35 2 4 7 3 0 0.951 1.000 1.000 531 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(7), CDKN1A(4), EPO(5), EPOR(1), GRIN1(5), HIF1A(5), JAK2(7), NFKB1(7), NFKBIA(2), RELA(4) 4136534 47 38 47 21 19 5 4 10 9 0 0.568 1.000 1.000 532 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(7), FDPS(3), GGCX(3), GGPS1(1), HMGCR(11), HSD17B7(1), IDI1(1), IDI2(1), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(1), SC4MOL(3), SC5DL(2), SQLE(3), TM7SF2(3) 6367089 48 38 46 23 18 9 4 10 7 0 0.443 1.000 1.000 533 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(6), HDAC9(32), MEF2A(4), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1) 2443516 53 38 46 27 40 5 0 3 5 0 0.437 1.000 1.000 534 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(11), AMT(1), ATIC(5), GART(9), MTHFD1(9), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(1), SHMT2(2), TYMS(1) 5914775 49 38 48 25 34 4 3 6 2 0 0.411 1.000 1.000 535 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(6), CTH(1), GGT1(4), MARS(5), MARS2(3), MAT1A(5), MAT2B(2), PAPSS1(2), PAPSS2(5), SCLY(3), SEPHS1(4) 4124862 44 38 44 19 25 4 3 7 5 0 0.184 1.000 1.000 536 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(10), CYP2E1(12), NR1I3(6), PTGS1(14), PTGS2(9) 1783044 51 37 50 27 36 4 1 4 6 0 0.201 1.000 1.000 537 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(17), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4), PRKCA(10) 3121026 49 37 47 34 37 4 2 2 4 0 0.917 1.000 1.000 538 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(1), IL10(3), IL10RA(6), IL10RB(5), IL1A(4), IL6(2), JAK1(5), STAT1(3), STAT3(10), STAT5A(2), TNF(1) 4034884 44 37 43 23 18 5 6 7 8 0 0.485 1.000 1.000 539 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(17), EP300(13), ESR1(5), MAPK1(4), MAPK3(1), PELP1(9), SRC(1) 4842523 50 37 50 25 32 3 3 9 3 0 0.644 1.000 1.000 540 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(5), IKBKB(3), LTA(1), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNFAIP3(1), TNFRSF1B(3), TRAF1(5), TRAF2(1), TRAF3(5) 7357740 45 37 45 40 28 6 1 6 4 0 0.995 1.000 1.000 541 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(1), OPRK1(19), POLR2A(10), PRKACB(4), PRKACG(7), PRKAR1A(1), PRKAR1B(2), PRKAR2A(1), PRKAR2B(4) 4235756 52 36 52 46 39 3 3 3 4 0 0.969 1.000 1.000 542 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(8), DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(10), PON3(1), RDH11(2), RDH12(2), RDH13(3) 2989709 46 36 45 24 31 4 1 6 4 0 0.323 1.000 1.000 543 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(4), AFMID(2), CS(2), GRHPR(2), HAO1(5), HAO2(9), HYI(1), MDH1(1), MDH2(3), MTHFD1(9), MTHFD1L(1), MTHFD2(1) 4429226 45 36 42 23 25 4 4 6 6 0 0.387 1.000 1.000 544 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(1), GOSR1(1), GOSR2(1), SEC22B(4), SNAP25(5), SNAP29(1), STX10(1), STX11(1), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(2), STX5(4), STX6(1), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(4), VAMP8(1), VTI1A(1), VTI1B(1) 5464208 48 36 46 22 25 5 2 9 7 0 0.354 1.000 1.000 545 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(1), IL2RG(2), IL4(1), IL4R(12), IRS1(5), JAK1(5), JAK3(4), RPS6KB1(2), SHC1(1), STAT6(7) 4870795 43 36 43 24 22 6 3 5 7 0 0.628 1.000 1.000 546 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(9), CDO1(5), CSAD(3), GAD1(12), GAD2(7), GGT1(4) 1868778 40 35 39 22 26 4 4 4 2 0 0.442 1.000 1.000 547 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(15), HK1(3), HK2(11), HK3(12), IMPA1(1), IMPA2(2), PGM1(4), PGM3(1), TGDS(1) 3847850 50 35 49 31 36 5 1 3 5 0 0.502 1.000 1.000 548 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(3), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(1), NFKB1(7), RELA(4), TNFRSF11A(3), TNFSF11(3), TRAF6(4) 3658339 42 35 42 23 27 3 0 8 4 0 0.729 1.000 1.000 549 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(10), MBTPS1(8), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(7) 3916090 40 35 38 20 23 2 3 8 4 0 0.457 1.000 1.000 550 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(5), IKBKB(3), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(1), TRAF3(5), TRAF6(4) 5959104 38 34 38 31 23 6 1 6 2 0 0.985 1.000 1.000 551 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(4), CS(2), GRHPR(2), HAO1(5), HAO2(9), HYI(1), MDH1(1), MDH2(3), MTHFD1(9), MTHFD1L(1), MTHFD2(1) 4228787 43 34 40 19 24 4 3 6 6 0 0.234 1.000 1.000 552 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(5), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(5), SULT1A1(8), SULT1A2(2), SULT1E1(10), SULT2A1(6), SULT2B1(5), SUOX(3) 3008192 51 34 49 30 40 2 0 4 5 0 0.482 1.000 1.000 553 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(15), CKM(2), FBL(1), GPT(3), LDHA(4), LDHB(2), LDHC(5), MAPK14(5), NCL(6) 2969921 43 34 42 20 30 2 4 4 3 0 0.329 1.000 1.000 554 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(3), IL4R(12), JAK1(5), JAK2(7), TYK2(7) 3455250 37 34 37 17 22 1 1 8 5 0 0.583 1.000 1.000 555 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(1), IFNGR1(4), JAK1(5), JAK2(7), PLA2G2A(2), PTPRU(13), REG1A(6), STAT1(3) 3771205 43 34 43 21 24 2 0 8 9 0 0.606 1.000 1.000 556 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(3), IL4R(12), JAK1(5), JAK2(7), TYK2(7) 3455250 37 34 37 17 22 1 1 8 5 0 0.583 1.000 1.000 557 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), XYLT1(8), XYLT2(3) 2093810 37 33 37 31 23 5 1 5 3 0 0.824 1.000 1.000 558 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(6), HS3ST3A1(4), HS3ST3B1(2), XYLT1(8), XYLT2(3) 2093810 37 33 37 31 23 5 1 5 3 0 0.824 1.000 1.000 559 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(15), HK1(3), HK2(11), HK3(12), IMPA1(1), PGM1(4), PGM3(1), TGDS(1) 3382328 48 33 47 26 35 5 1 3 4 0 0.337 1.000 1.000 560 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(4), FOS(2), FYN(5), JUN(1), MAPK14(5), THBS1(21) 2446867 40 32 40 20 23 1 2 6 8 0 0.610 1.000 1.000 561 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(24), GNAS(17), PRKACA(3), PRKAR1A(1) 2142082 45 31 44 23 28 5 3 4 5 0 0.368 1.000 1.000 562 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(5), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(12), MYST4(9), NAT6(1), PNPLA3(2), SH3GLB1(2) 5506878 46 31 46 34 24 6 1 11 4 0 0.991 1.000 1.000 563 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(11), ATR(18), CDC25C(2), CHEK1(1), CHEK2(2) 5013553 34 31 34 18 20 2 2 5 5 0 0.867 1.000 1.000 564 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(17), GNA12(3), PRKACB(4), PRKACG(7), PRKAG1(2), PRKAR2A(1), PRKAR2B(4) 3333743 38 30 38 20 26 3 1 5 3 0 0.575 1.000 1.000 565 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(5), B3GALNT1(5), B3GALT5(1), FUT1(3), FUT2(3), GBGT1(1), GLA(1), HEXA(4), HEXB(3), NAGA(3), ST3GAL1(5), ST3GAL2(1), ST8SIA1(1) 3321145 36 30 36 25 21 4 2 5 4 0 0.747 1.000 1.000 566 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3) 5340030 39 30 38 18 22 4 2 8 3 0 0.620 1.000 1.000 567 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(5), STAT1(3), STAT2(5), TYK2(7) 3561135 36 30 36 16 18 2 2 9 5 0 0.471 1.000 1.000 568 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(8), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(9), PPP2CA(1) 2969661 32 29 32 15 20 2 2 3 5 0 0.367 1.000 1.000 569 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2) 2625032 32 28 31 19 16 6 2 5 3 0 0.553 1.000 1.000 570 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(9), ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH9A1(2) 2625032 32 28 31 19 16 6 2 5 3 0 0.553 1.000 1.000 571 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(7), FDPS(3), HMGCR(11), IDI1(1), MVD(1), MVK(2), NQO1(1), PMVK(1), SC5DL(2), SQLE(3) 3640106 32 28 30 14 11 4 2 10 5 0 0.515 1.000 1.000 572 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(17), EIF2AK4(10), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(2) 3849317 33 28 29 14 12 1 1 12 7 0 0.843 1.000 1.000 573 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(9), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(3), IDH1(11), IDH2(2), MDH1(1), MDH2(3) 4423490 43 28 34 19 30 0 2 7 4 0 0.184 1.000 1.000 574 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(2), ADORA2B(1), ADORA3(11), LTB4R(1), P2RY1(4), P2RY2(7), P2RY6(1) 1968108 32 28 32 23 19 5 0 5 3 0 0.245 1.000 1.000 575 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(5), JAK2(7), JAK3(4), MAPK1(4), MAPK3(1), STAT3(10), TYK2(7) 3841492 38 28 38 26 16 5 2 8 7 0 0.903 1.000 1.000 576 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(4), CD3G(1), IFNG(1), IL2(2), IL2RA(3), IL4(1), TGFB1(1), TGFB3(3), TGFBR2(7), TGFBR3(6), TOB1(2), TOB2(1) 3477736 33 28 33 23 25 2 0 1 5 0 0.791 1.000 1.000 577 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(3), NRF1(4), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2J2(4), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(5) 3499172 32 28 32 16 19 5 1 5 2 0 0.675 1.000 1.000 578 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(7), ALDH2(4), ALDH3A1(4), ALDH3A2(2), ALDH7A1(8), ALDH9A1(2), MIOX(2), UGDH(1) 2795171 31 27 29 21 14 7 4 3 3 0 0.739 1.000 1.000 579 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(2), ESR1(5), GREB1(13), HSPB1(2), HSPB2(1), MTA1(1), MTA3(2), PDZK1(3), TUBA8(3) 3518573 33 27 33 22 25 0 3 4 1 0 0.654 1.000 1.000 580 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(7), CDC25B(4), CDC25C(2), CSK(1), GRB2(1), PRKCA(10), PTPRA(6), SRC(1) 3074133 32 27 31 20 19 6 1 4 2 0 0.734 1.000 1.000 581 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(9), ENO1(3), GPI(3), HK1(3), PFKL(4), PGK1(4), PKLR(8) 3029886 34 26 31 16 21 4 1 4 4 0 0.123 1.000 1.000 582 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(5), CPS1(17), GLS(1), GLUD1(1), GOT1(3) 2523415 28 26 28 16 17 1 2 6 2 0 0.709 1.000 1.000 583 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(5), FUT1(3), FUT2(3), GBGT1(1), GLA(1), HEXA(4), HEXB(3), NAGA(3), ST3GAL1(5), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 3113601 31 25 31 20 18 4 0 5 4 0 0.636 1.000 1.000 584 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(5) 4299016 33 25 33 14 17 4 1 8 3 0 0.548 1.000 1.000 585 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(6), CLOCK(4), CRY1(5), CRY2(3), CSNK1E(2), PER1(7) 2789603 27 24 26 14 15 3 1 3 5 0 0.735 1.000 1.000 586 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(5), ACAA2(1), ACAT2(1), ECHS1(1), EHHADH(5), HADHA(8), HADHB(3), SDS(2) 2765943 26 24 25 13 15 3 1 4 3 0 0.609 1.000 1.000 587 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(3), GBA3(14), GGT1(4), SHMT1(1), SHMT2(2) 1769501 26 24 24 15 19 1 0 3 3 0 0.408 1.000 1.000 588 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT1(9), B3GALT2(1), B3GALT5(1), FUT1(3), FUT2(3), FUT3(4), ST3GAL3(1), ST3GAL4(1) 2368254 27 24 27 20 20 3 0 3 1 0 0.740 1.000 1.000 589 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(7), PLCG1(7), PRKCA(10), PTK2B(8) 2234632 32 24 31 21 23 3 1 2 3 0 0.498 1.000 1.000 590 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(22), RANGAP1(3) 2819019 26 24 26 11 17 2 1 3 3 0 0.651 1.000 1.000 591 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), ADSS(2), IMPDH1(2), MTHFD2(1), POLD1(6), POLG(6), PRPS2(3), RRM1(3) 4101930 26 23 26 23 16 0 1 5 4 0 0.979 1.000 1.000 592 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(7), ST3GAL1(5), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1) 2594733 25 22 25 15 13 6 3 2 1 0 0.687 1.000 1.000 593 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(7), CDC25B(4), CDC25C(2), MNAT1(2), SHH(4), XPO1(2) 2888586 23 22 23 11 12 3 2 5 1 0 0.674 1.000 1.000 594 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(4), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(1), HBB(4), HMBS(1), UROS(1) 2522927 22 21 22 17 17 1 0 1 3 0 0.807 1.000 1.000 595 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(14), GGT1(4), SHMT1(1), SHMT2(2) 1340428 21 21 19 14 15 1 0 3 2 0 0.518 1.000 1.000 596 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(3), HMGCL(3), HMGCS1(1), HMGCS2(16), OXCT1(4), OXCT2(2) 2361155 30 21 29 20 18 5 0 5 2 0 0.879 1.000 1.000 597 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT1(3), FUT2(3), FUT3(4), FUT5(4), FUT6(4), ST3GAL3(1) 1648452 23 20 23 16 13 3 1 2 4 0 0.507 1.000 1.000 598 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(1), EIF2S1(1), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4) 2929174 20 20 20 11 10 4 1 4 1 0 0.729 1.000 1.000 599 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 CAMP(1), CREB3(1), CREB5(7), MAPK1(4), RAF1(7), SNX13(1), SRC(1), TERF2IP(1) 3204135 23 20 23 23 13 3 1 3 3 0 0.993 1.000 1.000 600 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HBXIP(1), HRAS(3), PTK2B(8), SHC1(1), SOS1(7), SRC(1) 2908172 22 19 22 20 14 2 0 4 2 0 0.991 1.000 1.000 601 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3) 1594295 22 19 22 17 15 1 2 1 3 0 0.763 1.000 1.000 602 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(10), SDHA(1) 3134522 23 19 22 15 14 0 2 3 4 0 0.806 1.000 1.000 603 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(7), IL1B(6), MST1(1), MST1R(5), TNF(1) 2162875 21 19 20 20 15 2 1 0 3 0 0.947 1.000 1.000 604 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(18), PNPO(1), PSAT1(1) 1609765 20 18 20 18 16 1 1 2 0 0 0.948 1.000 1.000 605 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(4), IFNGR2(4), JAK1(5), JAK2(7), STAT1(3) 2697873 24 18 22 10 7 1 0 7 9 0 0.900 1.000 1.000 606 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), CSF1(7), IL6(2), LDLR(10), LPL(3) 1772401 23 18 23 13 14 3 2 3 1 0 0.519 1.000 1.000 607 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(1), APOBEC3C(2), APOBEC3F(3), APOBEC3G(2) 2445919 18 17 18 24 12 2 3 1 0 0 0.998 1.000 1.000 608 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(1), CD3D(4), CD3G(1), CD4(6) 1059590 18 15 18 14 11 3 0 3 1 0 0.728 1.000 1.000 609 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ5(2), COQ6(1), COQ7(2), NDUFA12(1), NDUFA13(6) 1316053 13 13 12 9 11 1 1 0 0 0 0.831 1.000 1.000 610 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(2), FURIN(5), NOTCH1(5), PSEN1(1) 3036240 14 13 14 16 7 3 1 3 0 0 0.972 1.000 1.000 611 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 ABO(4), B3GNT1(2), FUT1(3), FUT2(3), ST8SIA1(1) 1752739 13 12 13 11 10 1 1 1 0 0 0.763 1.000 1.000 612 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), HGD(10) 743976 12 12 12 16 8 2 2 0 0 0 0.987 1.000 1.000 613 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(5), ARG1(1), GLS(1), GLUD1(1), OAT(2), PRODH(1) 1797831 11 10 11 12 3 4 1 2 1 0 0.984 1.000 1.000 614 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4) 1631058 9 9 9 10 4 0 1 0 4 0 0.987 1.000 1.000 615 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(3) 1406766 9 9 9 5 5 1 1 2 0 0 0.672 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3) 703495 3 3 3 4 2 0 0 1 0 0 0.951 1.000 1.000