E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.094 0.188 -9999.0 0.0 -0.384 68.0 68.0 KLHL20 -0.019 0.081 -9999.0 0.0 -0.211 10.0 10.0 CYFIP2 -0.01 0.095 -9999.0 0.0 -0.38 14.0 14.0 Rac1/GDP -0.035 0.117 -9999.0 0.0 -0.213 65.0 65.0 ENAH -0.098 0.191 -9999.0 0.0 -0.39 68.0 68.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.018 -9999.0 0.0 -0.257 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.042 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.033 0.046 -9999.0 0.0 -0.152 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.057 0.122 -9999.0 0.0 -0.218 77.0 77.0 RAPGEF1 -0.072 0.166 -9999.0 0.0 -0.33 68.0 68.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.101 0.193 -9999.0 0.0 -0.4 68.0 68.0 CRK -0.083 0.178 -9999.0 0.0 -0.359 68.0 68.0 E-cadherin/gamma catenin/alpha catenin -0.061 0.123 -9999.0 0.0 -0.24 68.0 68.0 alphaE/beta7 Integrin 0.001 0.073 -9999.0 0.0 -0.276 15.0 15.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.023 0.025 -9999.0 0.0 -0.208 2.0 2.0 DLG1 -0.093 0.188 -9999.0 0.0 -0.384 68.0 68.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.046 -9999.0 0.0 -0.179 1.0 1.0 MLLT4 0.009 0.043 -9999.0 0.0 -0.361 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.011 0.058 -9999.0 0.0 -0.208 15.0 15.0 PI3K -0.04 0.057 -9999.0 0.0 -0.229 1.0 1.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.084 0.144 -9999.0 0.0 -0.293 68.0 68.0 TIAM1 -0.015 0.106 -9999.0 0.0 -0.404 16.0 16.0 E-cadherin(dimer)/Ca2+ -0.04 0.101 -9999.0 0.0 -0.19 68.0 68.0 AKT1 -0.023 0.034 -9999.0 0.0 -0.131 1.0 1.0 PIK3R1 0.01 0.039 -9999.0 0.0 -0.414 2.0 2.0 CDH1 -0.127 0.195 -9999.0 0.0 -0.388 81.0 81.0 RhoA/GDP -0.035 0.117 -9999.0 0.0 -0.213 65.0 65.0 actin cytoskeleton organization -0.013 0.062 -9999.0 0.0 -0.154 10.0 10.0 CDC42/GDP -0.035 0.117 -9999.0 0.0 -0.213 65.0 65.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.052 0.106 -9999.0 0.0 -0.21 68.0 68.0 ITGB7 -0.013 0.103 -9999.0 0.0 -0.403 15.0 15.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.043 0.108 -9999.0 0.0 -0.203 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.047 0.1 -9999.0 0.0 -0.195 68.0 68.0 mol:GDP -0.048 0.131 -9999.0 0.0 -0.248 65.0 65.0 CDC42/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.053 -9999.0 0.0 -0.309 6.0 6.0 p120 catenin/RhoA/GDP -0.035 0.118 -9999.0 0.0 -0.242 3.0 3.0 RAC1/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.047 -9999.0 0.0 -0.128 11.0 11.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.098 0.189 -9999.0 0.0 -0.387 68.0 68.0 regulation of cell-cell adhesion -0.038 0.055 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.017 0.025 -9999.0 0.0 -0.106 2.0 2.0 Rap1/GTP -0.022 0.088 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.051 0.12 -9999.0 0.0 -0.206 77.0 77.0 CCND1 -0.009 0.057 -9999.0 0.0 -0.157 11.0 11.0 VAV2 -0.093 0.202 -9999.0 0.0 -0.381 72.0 72.0 RAP1/GDP -0.027 0.098 -9999.0 0.0 -0.208 1.0 1.0 adherens junction assembly -0.094 0.184 -9999.0 0.0 -0.376 68.0 68.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.044 0.114 -9999.0 0.0 -0.349 9.0 9.0 E-cadherin/beta catenin -0.084 0.142 -9999.0 0.0 -0.303 68.0 68.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.093 0.188 -9999.0 0.0 -0.384 68.0 68.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.414 2.0 2.0 Rac1/GTP -0.068 0.098 -9999.0 0.0 -0.342 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.057 0.118 -9999.0 0.0 -0.232 68.0 68.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.103 0.197 -9999.0 0.0 -0.408 68.0 68.0