Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.18 -9999.0 0.0 -0.534 21.0 21.0 IHH -0.004 0.058 -9999.0 0.0 -0.274 5.0 5.0 SHH Np/Cholesterol/GAS1 0.007 0.043 -9999.0 0.0 -0.203 9.0 9.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.007 0.042 0.202 9.0 -9999.0 0.0 9.0 SMO/beta Arrestin2 -0.03 0.142 -9999.0 0.0 -0.448 13.0 13.0 SMO -0.038 0.148 -9999.0 0.0 -0.463 14.0 14.0 AKT1 -0.003 0.078 -9999.0 0.0 -0.271 2.0 2.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.09 -9999.0 0.0 -0.307 19.0 19.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.146 -9999.0 0.0 -0.456 14.0 14.0 STIL -0.007 0.096 -9999.0 0.0 -0.354 9.0 9.0 DHH N/PTCH2 -0.021 0.092 -9999.0 0.0 -0.21 42.0 42.0 DHH N/PTCH1 -0.03 0.131 -9999.0 0.0 -0.342 21.0 21.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.414 2.0 2.0 DHH -0.032 0.112 -9999.0 0.0 -0.294 34.0 34.0 PTHLH -0.05 0.236 -9999.0 0.0 -0.787 18.0 18.0 determination of left/right symmetry -0.037 0.146 -9999.0 0.0 -0.456 14.0 14.0 PIK3R1 0.01 0.039 -9999.0 0.0 -0.414 2.0 2.0 skeletal system development -0.049 0.234 -9999.0 0.0 -0.778 18.0 18.0 IHH N/Hhip -0.005 0.065 -9999.0 0.0 -0.218 16.0 16.0 DHH N/Hhip -0.026 0.089 -9999.0 0.0 -0.196 47.0 47.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.146 -9999.0 0.0 -0.456 14.0 14.0 pancreas development -0.009 0.068 -9999.0 0.0 -0.257 16.0 16.0 HHAT 0.004 0.062 -9999.0 0.0 -0.414 5.0 5.0 PI3K 0.015 0.046 -9999.0 0.0 -0.367 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.007 0.051 -9999.0 0.0 -0.374 4.0 4.0 somite specification -0.037 0.146 -9999.0 0.0 -0.456 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.01 0.101 -9999.0 0.0 -0.289 19.0 19.0 SHH Np/Cholesterol/PTCH2 0.003 0.049 -9999.0 0.0 -0.214 9.0 9.0 SHH Np/Cholesterol/Megalin -0.089 0.103 -9999.0 0.0 -0.168 132.0 132.0 SHH 0.003 0.044 -9999.0 0.0 -0.291 5.0 5.0 catabolic process -0.016 0.123 -9999.0 0.0 -0.373 18.0 18.0 SMO/Vitamin D3 -0.021 0.119 -9999.0 0.0 -0.389 14.0 14.0 SHH Np/Cholesterol/Hhip -0.001 0.049 -9999.0 0.0 -0.239 5.0 5.0 LRP2 -0.179 0.177 -9999.0 0.0 -0.325 132.0 132.0 receptor-mediated endocytosis -0.084 0.144 -9999.0 0.0 -0.471 17.0 17.0 SHH Np/Cholesterol/BOC -0.003 0.056 -9999.0 0.0 -0.163 24.0 24.0 SHH Np/Cholesterol/CDO 0.008 0.046 -9999.0 0.0 -0.244 7.0 7.0 mesenchymal cell differentiation 0.001 0.048 0.237 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.008 0.103 -9999.0 0.0 -0.29 19.0 19.0 IHH N/PTCH2 0.0 0.067 -9999.0 0.0 -0.267 11.0 11.0 CDON 0.008 0.048 -9999.0 0.0 -0.414 3.0 3.0 IHH N/PTCH1 -0.014 0.125 -9999.0 0.0 -0.375 18.0 18.0 Megalin/LRPAP1 -0.114 0.125 -9999.0 0.0 -0.216 132.0 132.0 PTCH2 -0.002 0.072 -9999.0 0.0 -0.314 11.0 11.0 SHH Np/Cholesterol 0.004 0.033 -9999.0 0.0 -0.219 5.0 5.0 PTCH1 -0.016 0.123 -9999.0 0.0 -0.374 18.0 18.0 HHIP -0.009 0.068 -9999.0 0.0 -0.257 16.0 16.0