Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.043 0.1 -9999.0 0.0 -0.196 68.0 68.0 epithelial cell differentiation -0.042 0.099 -9999.0 0.0 -0.189 68.0 68.0 CYFIP2 -0.01 0.095 -9999.0 0.0 -0.38 14.0 14.0 ENAH -0.016 0.078 -9999.0 0.0 -0.224 6.0 6.0 EGFR -0.019 0.099 -9999.0 0.0 -0.303 24.0 24.0 EPHA2 -0.0 0.071 -9999.0 0.0 -0.344 9.0 9.0 MYO6 -0.045 0.098 -9999.0 0.0 -0.216 8.0 8.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.013 0.057 -9999.0 0.0 -0.232 11.0 11.0 AQP5 -0.044 0.103 -9999.0 0.0 -0.495 4.0 4.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.037 0.092 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.05 0.103 -9999.0 0.0 -0.191 72.0 72.0 EGF -0.091 0.173 -9999.0 0.0 -0.365 64.0 64.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.138 -9999.0 0.0 -0.472 15.0 15.0 cortical microtubule organization -0.042 0.099 -9999.0 0.0 -0.189 68.0 68.0 GO:0000145 -0.037 0.087 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.101 -9999.0 0.0 -0.19 68.0 68.0 MLLT4 0.009 0.043 -9999.0 0.0 -0.361 3.0 3.0 ARF6/GDP -0.048 0.066 -9999.0 0.0 -0.238 3.0 3.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.039 -9999.0 0.0 -0.203 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.03 0.089 -9999.0 0.0 -0.207 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.039 0.095 -9999.0 0.0 -0.179 68.0 68.0 ARF6/GTP 0.032 0.036 -9999.0 0.0 -0.183 5.0 5.0 CDH1 -0.127 0.195 -9999.0 0.0 -0.388 81.0 81.0 EGFR/EGFR/EGF/EGF -0.107 0.121 -9999.0 0.0 -0.341 34.0 34.0 RhoA/GDP -0.036 0.093 -9999.0 0.0 -0.174 68.0 68.0 actin cytoskeleton organization -0.04 0.096 -9999.0 0.0 -0.306 2.0 2.0 IGF-1R heterotetramer 0.009 0.043 -9999.0 0.0 -0.361 3.0 3.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.043 -9999.0 0.0 -0.361 3.0 3.0 IGF1 -0.024 0.117 -9999.0 0.0 -0.378 22.0 22.0 DIAPH1 -0.021 0.126 -9999.0 0.0 -0.584 11.0 11.0 Wnt receptor signaling pathway 0.042 0.099 0.189 68.0 -9999.0 0.0 68.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.066 -9999.0 0.0 -0.238 3.0 3.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.097 -9999.0 0.0 -0.313 2.0 2.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.035 0.09 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.058 0.079 -9999.0 0.0 -0.275 3.0 3.0 SEC6/SEC8 -0.049 0.067 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.05 0.105 -9999.0 0.0 -0.193 72.0 72.0 HGF/MET -0.09 0.109 -9999.0 0.0 -0.308 29.0 29.0 HGF -0.026 0.112 -9999.0 0.0 -0.327 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.043 0.1 -9999.0 0.0 -0.197 68.0 68.0 actin cable formation -0.005 0.078 -9999.0 0.0 -0.25 3.0 3.0 KIAA1543 -0.072 0.115 -9999.0 0.0 -0.299 24.0 24.0 KIFC3 -0.039 0.093 -9999.0 0.0 -0.175 69.0 69.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.018 -9999.0 0.0 -0.257 1.0 1.0 ACTN1 -0.041 0.094 -9999.0 0.0 -0.175 72.0 72.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.042 0.099 -9999.0 0.0 -0.189 68.0 68.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.093 -9999.0 0.0 -0.175 68.0 68.0 PIP5K1C -0.038 0.093 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.019 0.08 -9999.0 0.0 -0.21 3.0 3.0 adherens junction assembly -0.056 0.114 -9999.0 0.0 -0.337 13.0 13.0 IGF-1R heterotetramer/IGF1 -0.07 0.092 -9999.0 0.0 -0.337 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.031 -9999.0 0.0 -0.244 3.0 3.0 MET -0.039 0.133 -9999.0 0.0 -0.365 32.0 32.0 PLEKHA7 -0.05 0.105 -9999.0 0.0 -0.191 75.0 75.0 mol:GTP 0.026 0.039 -9999.0 0.0 -0.202 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.018 0.084 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.043 0.1 -9999.0 0.0 -0.196 68.0 68.0 regulation of cell-cell adhesion -0.04 0.096 -9999.0 0.0 -0.306 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.043 0.1 -9999.0 0.0 -0.197 68.0 68.0