E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.1 0.186 0.224 1.0 -0.368 73.0 74.0 KLHL20 -0.031 0.093 0.189 4.0 -0.221 18.0 22.0 CYFIP2 0.015 0.068 -9999.0 0.0 -0.321 9.0 9.0 Rac1/GDP -0.047 0.117 0.239 1.0 -0.228 53.0 54.0 ENAH -0.096 0.182 0.219 1.0 -0.377 64.0 65.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.083 -9999.0 0.0 -0.164 2.0 2.0 ABI1/Sra1/Nap1 -0.041 0.054 -9999.0 0.0 -0.145 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.009 0.116 -9999.0 0.0 -0.178 71.0 71.0 RAPGEF1 -0.082 0.167 0.227 2.0 -0.338 62.0 64.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.097 0.195 -9999.0 0.0 -0.375 75.0 75.0 CRK -0.088 0.176 0.211 1.0 -0.351 67.0 68.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.114 -9999.0 0.0 -0.194 63.0 63.0 alphaE/beta7 Integrin 0.026 0.059 -9999.0 0.0 -0.219 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.029 -9999.0 0.0 -0.158 2.0 2.0 DLG1 -0.099 0.186 -9999.0 0.0 -0.367 74.0 74.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.047 -9999.0 0.0 -0.148 2.0 2.0 MLLT4 0.022 0.034 -9999.0 0.0 -0.321 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.051 -9999.0 0.0 -0.168 12.0 12.0 PI3K -0.051 0.06 -9999.0 0.0 -0.188 2.0 2.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.031 0.124 -9999.0 0.0 -0.229 63.0 63.0 TIAM1 0.01 0.078 -9999.0 0.0 -0.321 12.0 12.0 E-cadherin(dimer)/Ca2+ 0.002 0.103 -9999.0 0.0 -0.162 63.0 63.0 AKT1 -0.025 0.05 0.127 3.0 -0.126 1.0 4.0 PIK3R1 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 CDH1 -0.063 0.159 -9999.0 0.0 -0.321 63.0 63.0 RhoA/GDP -0.045 0.128 0.273 3.0 -0.227 58.0 61.0 actin cytoskeleton organization -0.021 0.072 0.162 5.0 -0.161 18.0 23.0 CDC42/GDP -0.045 0.127 0.273 3.0 -0.227 58.0 61.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.095 -9999.0 0.0 -0.19 63.0 63.0 ITGB7 0.011 0.078 -9999.0 0.0 -0.321 12.0 12.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.11 -9999.0 0.0 -0.173 63.0 63.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.094 -9999.0 0.0 -0.158 63.0 63.0 mol:GDP -0.063 0.135 0.278 3.0 -0.257 58.0 61.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.035 -9999.0 0.0 -0.321 2.0 2.0 p120 catenin/RhoA/GDP -0.041 0.131 0.239 3.0 -0.233 55.0 58.0 RAC1/GTP/IQGAP1 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.011 0.056 0.135 8.0 -0.109 19.0 27.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.104 0.187 -9999.0 0.0 -0.37 75.0 75.0 regulation of cell-cell adhesion -0.026 0.066 -9999.0 0.0 -0.139 46.0 46.0 WASF2 -0.014 0.04 0.093 3.0 -0.09 10.0 13.0 Rap1/GTP -0.019 0.095 0.253 3.0 -0.178 2.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.001 0.12 -9999.0 0.0 -0.174 70.0 70.0 CCND1 -0.014 0.066 0.16 7.0 -0.132 19.0 26.0 VAV2 -0.122 0.248 0.356 1.0 -0.638 23.0 24.0 RAP1/GDP -0.026 0.107 0.301 2.0 -0.219 4.0 6.0 adherens junction assembly -0.1 0.182 -9999.0 0.0 -0.359 75.0 75.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.011 0.11 0.24 1.0 -0.17 70.0 71.0 E-cadherin/beta catenin -0.065 0.129 -9999.0 0.0 -0.278 62.0 62.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.097 0.182 0.22 1.0 -0.365 70.0 71.0 PIK3CA 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 Rac1/GTP -0.076 0.124 -9999.0 0.0 -0.335 24.0 24.0 E-cadherin/beta catenin/alpha catenin -0.012 0.111 -9999.0 0.0 -0.189 63.0 63.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.199 -9999.0 0.0 -0.383 75.0 75.0