Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.119 -9999.0 0.0 -0.452 12.0 12.0 IHH 0.032 0.052 0.134 6.0 -0.137 16.0 22.0 SHH Np/Cholesterol/GAS1 0.014 0.033 -9999.0 0.0 -0.166 7.0 7.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.014 0.033 0.165 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 0.009 0.128 -9999.0 0.0 -0.354 13.0 13.0 SMO -0.012 0.12 -9999.0 0.0 -0.371 14.0 14.0 AKT1 -0.001 0.102 -9999.0 0.0 -0.365 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.06 -9999.0 0.0 -0.321 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.012 0.118 -9999.0 0.0 -0.367 14.0 14.0 STIL 0.012 0.081 0.19 15.0 -0.231 14.0 29.0 DHH N/PTCH2 0.036 0.066 0.165 3.0 -0.224 12.0 15.0 DHH N/PTCH1 0.024 0.108 -9999.0 0.0 -0.34 15.0 15.0 PIK3CA 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 DHH 0.025 0.071 -9999.0 0.0 -0.321 8.0 8.0 PTHLH -0.002 0.176 -9999.0 0.0 -0.627 15.0 15.0 determination of left/right symmetry -0.012 0.118 -9999.0 0.0 -0.367 14.0 14.0 PIK3R1 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 skeletal system development -0.001 0.174 -9999.0 0.0 -0.621 15.0 15.0 IHH N/Hhip 0.044 0.042 0.174 3.0 -9999.0 0.0 3.0 DHH N/Hhip 0.041 0.057 0.165 3.0 -0.224 8.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.012 0.118 -9999.0 0.0 -0.367 14.0 14.0 pancreas development 0.031 0.023 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.018 0.051 -9999.0 0.0 -0.321 5.0 5.0 PI3K 0.036 0.039 -9999.0 0.0 -0.285 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.034 -9999.0 0.0 -0.321 2.0 2.0 somite specification -0.012 0.118 -9999.0 0.0 -0.367 14.0 14.0 SHH Np/Cholesterol/PTCH1 0.009 0.071 -9999.0 0.0 -0.238 14.0 14.0 SHH Np/Cholesterol/PTCH2 0.016 0.037 -9999.0 0.0 -0.166 8.0 8.0 SHH Np/Cholesterol/Megalin -0.007 0.096 -9999.0 0.0 -0.177 51.0 51.0 SHH 0.001 0.033 -9999.0 0.0 -0.219 5.0 5.0 catabolic process 0.01 0.104 -9999.0 0.0 -0.359 16.0 16.0 SMO/Vitamin D3 0.009 0.099 0.215 12.0 -0.275 15.0 27.0 SHH Np/Cholesterol/Hhip 0.018 0.031 -9999.0 0.0 -0.165 5.0 5.0 LRP2 -0.031 0.17 -9999.0 0.0 -0.321 57.0 57.0 receptor-mediated endocytosis -0.029 0.12 0.204 3.0 -0.297 25.0 28.0 SHH Np/Cholesterol/BOC 0.016 0.042 -9999.0 0.0 -0.166 10.0 10.0 SHH Np/Cholesterol/CDO 0.013 0.038 -9999.0 0.0 -0.187 7.0 7.0 mesenchymal cell differentiation -0.018 0.031 0.164 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.026 0.089 0.216 16.0 -0.239 14.0 30.0 IHH N/PTCH2 0.038 0.053 0.186 1.0 -0.135 12.0 13.0 CDON 0.021 0.04 -9999.0 0.0 -0.321 3.0 3.0 IHH N/PTCH1 0.021 0.109 0.209 1.0 -0.361 16.0 17.0 Megalin/LRPAP1 -0.006 0.128 -9999.0 0.0 -0.223 57.0 57.0 PTCH2 0.025 0.048 0.113 7.0 -0.321 4.0 11.0 SHH Np/Cholesterol 0.013 0.027 -9999.0 0.0 -0.162 5.0 5.0 PTCH1 0.01 0.104 -9999.0 0.0 -0.36 16.0 16.0 HHIP 0.031 0.023 -9999.0 0.0 -9999.0 0.0 0.0