Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.033 0.092 -9999.0 0.0 -0.181 64.0 64.0 epithelial cell differentiation -0.002 0.099 -9999.0 0.0 -0.161 63.0 63.0 CYFIP2 0.015 0.068 -9999.0 0.0 -0.321 9.0 9.0 ENAH -0.046 0.066 0.266 1.0 -0.238 3.0 4.0 EGFR 0.023 0.061 -9999.0 0.0 -0.321 6.0 6.0 EPHA2 0.022 0.052 -9999.0 0.0 -0.321 5.0 5.0 MYO6 -0.048 0.078 0.209 5.0 -0.16 63.0 68.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.05 -9999.0 0.0 -0.184 9.0 9.0 AQP5 -0.027 0.092 0.422 1.0 -0.435 4.0 5.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.046 0.075 0.208 5.0 -0.155 61.0 66.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.08 0.219 5.0 -0.16 55.0 60.0 EGF -0.028 0.14 -9999.0 0.0 -0.321 42.0 42.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.116 0.384 1.0 -0.342 20.0 21.0 cortical microtubule organization -0.002 0.099 -9999.0 0.0 -0.161 63.0 63.0 GO:0000145 -0.045 0.07 0.196 5.0 -0.149 61.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.103 -9999.0 0.0 -0.162 63.0 63.0 MLLT4 0.022 0.034 -9999.0 0.0 -0.321 2.0 2.0 ARF6/GDP -0.055 0.058 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.045 -9999.0 0.0 -0.169 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.069 0.21 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.043 0.073 0.215 4.0 -0.157 55.0 59.0 ARF6/GTP 0.062 0.047 -9999.0 0.0 -0.16 5.0 5.0 CDH1 -0.063 0.159 -9999.0 0.0 -0.321 63.0 63.0 EGFR/EGFR/EGF/EGF -0.039 0.114 -9999.0 0.0 -0.174 90.0 90.0 RhoA/GDP -0.0 0.097 -9999.0 0.0 -0.156 63.0 63.0 actin cytoskeleton organization -0.053 0.077 0.193 5.0 -0.163 55.0 60.0 IGF-1R heterotetramer 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.033 -9999.0 0.0 -0.321 2.0 2.0 IGF1 0.008 0.087 -9999.0 0.0 -0.321 15.0 15.0 DIAPH1 -0.03 0.213 -9999.0 0.0 -0.562 23.0 23.0 Wnt receptor signaling pathway 0.002 0.099 0.161 63.0 -9999.0 0.0 63.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.059 -9999.0 0.0 -0.153 55.0 55.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.054 0.078 0.195 5.0 -0.166 55.0 60.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.051 0.073 0.201 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 -0.009 0.09 -9999.0 0.0 -0.155 61.0 61.0 SEC6/SEC8 -0.049 0.06 -9999.0 0.0 -0.154 50.0 50.0 MGAT3 -0.045 0.081 0.221 5.0 -0.162 55.0 60.0 HGF/MET -0.024 0.107 -9999.0 0.0 -0.173 72.0 72.0 HGF 0.014 0.078 -9999.0 0.0 -0.321 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.033 0.093 -9999.0 0.0 -0.182 64.0 64.0 actin cable formation -0.017 0.107 0.269 13.0 -0.252 5.0 18.0 KIAA1543 -0.049 0.075 0.198 5.0 -0.281 2.0 7.0 KIFC3 -0.049 0.073 0.235 3.0 -0.159 1.0 4.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.049 0.077 0.209 5.0 -9999.0 0.0 5.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.099 -9999.0 0.0 -0.161 63.0 63.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.047 0.076 0.209 5.0 -0.157 62.0 67.0 PIP5K1C -0.046 0.076 0.209 5.0 -0.157 61.0 66.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.096 0.445 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.047 0.09 0.275 3.0 -0.308 8.0 11.0 IGF-1R heterotetramer/IGF1 -0.018 0.103 -9999.0 0.0 -0.164 73.0 73.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.029 -9999.0 0.0 -0.224 2.0 2.0 MET -0.0 0.097 -9999.0 0.0 -0.321 19.0 19.0 PLEKHA7 -0.049 0.08 0.209 5.0 -0.294 2.0 7.0 mol:GTP 0.055 0.044 -9999.0 0.0 -0.168 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.019 0.109 0.303 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization -0.033 0.092 -9999.0 0.0 -0.181 64.0 64.0 regulation of cell-cell adhesion -0.053 0.077 0.193 5.0 -0.163 55.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.033 0.093 -9999.0 0.0 -0.182 64.0 64.0