Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.179 -9999.0 0.0 -0.528 22.0 22.0 IHH -0.003 0.057 -9999.0 0.0 -0.234 8.0 8.0 SHH Np/Cholesterol/GAS1 0.002 0.051 -9999.0 0.0 -0.21 10.0 10.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.051 0.209 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.032 0.144 -9999.0 0.0 -0.43 16.0 16.0 SMO -0.04 0.15 -9999.0 0.0 -0.406 22.0 22.0 AKT1 -0.004 0.078 -9999.0 0.0 -0.247 8.0 8.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.088 -9999.0 0.0 -0.306 19.0 19.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.04 0.148 -9999.0 0.0 -0.4 22.0 22.0 STIL -0.009 0.097 -9999.0 0.0 -0.34 10.0 10.0 DHH N/PTCH2 -0.023 0.093 -9999.0 0.0 -0.208 45.0 45.0 DHH N/PTCH1 -0.031 0.131 -9999.0 0.0 -0.317 28.0 28.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 DHH -0.035 0.116 -9999.0 0.0 -0.299 37.0 37.0 PTHLH -0.05 0.237 -9999.0 0.0 -0.787 19.0 19.0 determination of left/right symmetry -0.04 0.148 -9999.0 0.0 -0.4 22.0 22.0 PIK3R1 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 skeletal system development -0.049 0.234 -9999.0 0.0 -0.778 19.0 19.0 IHH N/Hhip -0.006 0.066 -9999.0 0.0 -0.212 19.0 19.0 DHH N/Hhip -0.029 0.093 -9999.0 0.0 -0.201 51.0 51.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.04 0.148 -9999.0 0.0 -0.4 22.0 22.0 pancreas development -0.011 0.071 -9999.0 0.0 -0.258 18.0 18.0 HHAT 0.005 0.06 -9999.0 0.0 -0.41 5.0 5.0 PI3K 0.015 0.044 -9999.0 0.0 -0.363 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.063 -9999.0 0.0 -0.385 6.0 6.0 somite specification -0.04 0.148 -9999.0 0.0 -0.4 22.0 22.0 SHH Np/Cholesterol/PTCH1 -0.013 0.102 -9999.0 0.0 -0.289 19.0 19.0 SHH Np/Cholesterol/PTCH2 0.0 0.054 -9999.0 0.0 -0.214 10.0 10.0 SHH Np/Cholesterol/Megalin -0.094 0.106 -9999.0 0.0 -0.233 63.0 63.0 SHH -0.001 0.054 -9999.0 0.0 -0.209 14.0 14.0 catabolic process -0.015 0.122 -9999.0 0.0 -0.367 19.0 19.0 SMO/Vitamin D3 -0.024 0.121 -9999.0 0.0 -0.342 21.0 21.0 SHH Np/Cholesterol/Hhip -0.005 0.057 -9999.0 0.0 -0.238 8.0 8.0 LRP2 -0.182 0.176 -9999.0 0.0 -0.325 139.0 139.0 receptor-mediated endocytosis -0.087 0.146 -9999.0 0.0 -0.423 24.0 24.0 SHH Np/Cholesterol/BOC -0.006 0.059 -9999.0 0.0 -0.211 11.0 11.0 SHH Np/Cholesterol/CDO 0.005 0.051 -9999.0 0.0 -0.24 7.0 7.0 mesenchymal cell differentiation 0.005 0.057 0.237 8.0 -9999.0 0.0 8.0 mol:Vitamin D3 -0.011 0.103 -9999.0 0.0 -0.29 19.0 19.0 IHH N/PTCH2 0.002 0.065 -9999.0 0.0 -0.275 10.0 10.0 CDON 0.008 0.047 -9999.0 0.0 -0.41 3.0 3.0 IHH N/PTCH1 -0.013 0.123 -9999.0 0.0 -0.369 19.0 19.0 Megalin/LRPAP1 -0.116 0.124 -9999.0 0.0 -0.216 139.0 139.0 PTCH2 -0.0 0.068 -9999.0 0.0 -0.319 10.0 10.0 SHH Np/Cholesterol 0.001 0.04 -9999.0 0.0 -0.217 5.0 5.0 PTCH1 -0.015 0.122 -9999.0 0.0 -0.368 19.0 19.0 HHIP -0.011 0.071 -9999.0 0.0 -0.259 18.0 18.0