E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.1 0.187 0.229 1.0 -0.378 70.0 71.0 KLHL20 -0.03 0.094 0.192 5.0 -0.22 20.0 25.0 CYFIP2 0.016 0.067 0.124 3.0 -0.316 9.0 12.0 Rac1/GDP -0.047 0.119 0.219 2.0 -0.229 55.0 57.0 ENAH -0.096 0.183 0.224 1.0 -0.376 67.0 68.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.083 -9999.0 0.0 -0.21 2.0 2.0 ABI1/Sra1/Nap1 -0.04 0.055 -9999.0 0.0 -0.146 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.115 -9999.0 0.0 -0.174 74.0 74.0 RAPGEF1 -0.082 0.169 0.228 2.0 -0.338 65.0 67.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.096 0.196 -9999.0 0.0 -0.377 77.0 77.0 CRK -0.088 0.178 0.216 1.0 -0.363 64.0 65.0 E-cadherin/gamma catenin/alpha catenin -0.012 0.113 -9999.0 0.0 -0.19 66.0 66.0 alphaE/beta7 Integrin 0.027 0.057 -9999.0 0.0 -0.215 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.029 -9999.0 0.0 -0.155 2.0 2.0 DLG1 -0.099 0.186 -9999.0 0.0 -0.369 76.0 76.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.048 -9999.0 0.0 -0.153 4.0 4.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.316 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.05 -9999.0 0.0 -0.165 12.0 12.0 PI3K -0.051 0.06 -9999.0 0.0 -0.194 4.0 4.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.029 0.123 -9999.0 0.0 -0.225 66.0 66.0 TIAM1 0.011 0.075 -9999.0 0.0 -0.316 12.0 12.0 E-cadherin(dimer)/Ca2+ 0.003 0.102 -9999.0 0.0 -0.159 66.0 66.0 AKT1 -0.024 0.051 0.128 3.0 -0.129 2.0 5.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 CDH1 -0.062 0.157 -9999.0 0.0 -0.316 66.0 66.0 RhoA/GDP -0.044 0.129 0.254 4.0 -0.229 59.0 63.0 actin cytoskeleton organization -0.02 0.073 0.157 7.0 -0.161 20.0 27.0 CDC42/GDP -0.044 0.129 0.254 4.0 -0.23 57.0 61.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.038 0.096 -9999.0 0.0 -0.19 66.0 66.0 ITGB7 0.012 0.075 0.124 1.0 -0.316 12.0 13.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.11 -9999.0 0.0 -0.17 66.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.093 -9999.0 0.0 -0.155 66.0 66.0 mol:GDP -0.062 0.137 0.244 5.0 -0.259 60.0 65.0 CDC42/GTP/IQGAP1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.034 0.124 4.0 -0.316 2.0 6.0 p120 catenin/RhoA/GDP -0.039 0.133 0.24 3.0 -0.234 57.0 60.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.057 0.135 9.0 -0.111 18.0 27.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.102 0.187 -9999.0 0.0 -0.38 71.0 71.0 regulation of cell-cell adhesion -0.026 0.066 -9999.0 0.0 -0.187 2.0 2.0 WASF2 -0.014 0.04 0.093 3.0 -0.1 3.0 6.0 Rap1/GTP -0.019 0.096 0.254 3.0 -0.231 2.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.001 0.119 -9999.0 0.0 -0.171 72.0 72.0 CCND1 -0.013 0.067 0.154 9.0 -0.135 18.0 27.0 VAV2 -0.121 0.25 0.355 1.0 -0.649 24.0 25.0 RAP1/GDP -0.025 0.109 0.264 3.0 -0.244 5.0 8.0 adherens junction assembly -0.1 0.183 -9999.0 0.0 -0.368 72.0 72.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.109 0.218 2.0 -0.167 72.0 74.0 E-cadherin/beta catenin -0.065 0.129 -9999.0 0.0 -0.276 65.0 65.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.098 0.183 0.224 1.0 -0.372 70.0 71.0 PIK3CA 0.026 0.032 -9999.0 0.0 -0.316 2.0 2.0 Rac1/GTP -0.076 0.125 -9999.0 0.0 -0.339 25.0 25.0 E-cadherin/beta catenin/alpha catenin -0.011 0.11 -9999.0 0.0 -0.185 66.0 66.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.199 -9999.0 0.0 -0.384 77.0 77.0