Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.119 -9999.0 0.0 -0.46 12.0 12.0 IHH 0.033 0.053 0.145 6.0 -0.134 17.0 23.0 SHH Np/Cholesterol/GAS1 0.015 0.03 -9999.0 0.0 -0.169 5.0 5.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.015 0.03 0.168 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 0.011 0.133 -9999.0 0.0 -0.365 13.0 13.0 SMO -0.013 0.121 -9999.0 0.0 -0.384 14.0 14.0 AKT1 -0.0 0.101 -9999.0 0.0 -0.365 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.059 -9999.0 0.0 -0.316 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 STIL 0.023 0.088 0.188 31.0 -0.23 13.0 44.0 DHH N/PTCH2 0.035 0.069 0.181 2.0 -0.22 14.0 16.0 DHH N/PTCH1 0.025 0.11 -9999.0 0.0 -0.336 16.0 16.0 PIK3CA 0.026 0.032 -9999.0 0.0 -0.316 2.0 2.0 DHH 0.024 0.077 -9999.0 0.0 -0.316 10.0 10.0 PTHLH -0.002 0.178 -9999.0 0.0 -0.63 16.0 16.0 determination of left/right symmetry -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 skeletal system development -0.002 0.177 -9999.0 0.0 -0.624 16.0 16.0 IHH N/Hhip 0.045 0.044 0.191 3.0 -0.088 1.0 4.0 DHH N/Hhip 0.041 0.063 0.181 4.0 -0.22 10.0 14.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 pancreas development 0.032 0.027 0.124 18.0 -9999.0 0.0 18.0 HHAT 0.019 0.05 -9999.0 0.0 -0.316 5.0 5.0 PI3K 0.036 0.038 -9999.0 0.0 -0.28 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.023 0.039 0.124 1.0 -0.316 3.0 4.0 somite specification -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 SHH Np/Cholesterol/PTCH1 0.01 0.068 -9999.0 0.0 -0.238 13.0 13.0 SHH Np/Cholesterol/PTCH2 0.018 0.036 0.158 2.0 -0.169 6.0 8.0 SHH Np/Cholesterol/Megalin 0.003 0.104 0.195 13.0 -0.172 52.0 65.0 SHH -0.013 0.027 -9999.0 0.0 -0.224 3.0 3.0 catabolic process 0.011 0.102 -9999.0 0.0 -0.357 16.0 16.0 SMO/Vitamin D3 0.007 0.099 0.229 7.0 -0.283 15.0 22.0 SHH Np/Cholesterol/Hhip 0.016 0.039 0.158 6.0 -0.168 3.0 9.0 LRP2 -0.028 0.173 0.124 77.0 -0.316 61.0 138.0 receptor-mediated endocytosis -0.028 0.121 0.205 3.0 -0.343 17.0 20.0 SHH Np/Cholesterol/BOC 0.019 0.039 0.203 1.0 -0.169 7.0 8.0 SHH Np/Cholesterol/CDO 0.014 0.034 -9999.0 0.0 -0.198 5.0 5.0 mesenchymal cell differentiation -0.016 0.039 0.167 3.0 -0.156 6.0 9.0 mol:Vitamin D3 0.037 0.098 0.214 32.0 -0.239 13.0 45.0 IHH N/PTCH2 0.039 0.053 0.204 1.0 -0.237 4.0 5.0 CDON 0.022 0.039 -9999.0 0.0 -0.316 3.0 3.0 IHH N/PTCH1 0.022 0.108 0.229 1.0 -0.359 16.0 17.0 Megalin/LRPAP1 -0.004 0.13 -9999.0 0.0 -0.22 61.0 61.0 PTCH2 0.025 0.047 0.124 6.0 -0.316 4.0 10.0 SHH Np/Cholesterol 0.01 0.021 -9999.0 0.0 -0.166 3.0 3.0 PTCH1 0.011 0.102 -9999.0 0.0 -0.358 16.0 16.0 HHIP 0.032 0.027 0.124 18.0 -9999.0 0.0 18.0