Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.033 0.093 -9999.0 0.0 -0.182 67.0 67.0 epithelial cell differentiation -0.001 0.099 -9999.0 0.0 -0.158 66.0 66.0 CYFIP2 0.016 0.067 0.124 3.0 -0.316 9.0 12.0 ENAH -0.046 0.069 0.418 1.0 -0.226 4.0 5.0 EGFR 0.026 0.056 -9999.0 0.0 -0.316 5.0 5.0 EPHA2 0.019 0.059 -9999.0 0.0 -0.316 7.0 7.0 MYO6 -0.047 0.078 0.204 6.0 -0.289 1.0 7.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.049 -9999.0 0.0 -0.181 9.0 9.0 AQP5 -0.027 0.093 0.427 1.0 -0.426 5.0 6.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.075 0.202 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.079 0.221 5.0 -0.285 2.0 7.0 EGF -0.029 0.14 0.124 19.0 -0.316 45.0 64.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.118 0.384 1.0 -0.352 21.0 22.0 cortical microtubule organization -0.001 0.099 -9999.0 0.0 -0.158 66.0 66.0 GO:0000145 -0.044 0.07 0.19 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.102 -9999.0 0.0 -0.159 66.0 66.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.316 2.0 2.0 ARF6/GDP -0.055 0.058 -9999.0 0.0 -0.151 58.0 58.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.048 -9999.0 0.0 -0.167 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.068 0.21 4.0 -9999.0 0.0 4.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.042 0.072 0.216 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.061 0.05 -9999.0 0.0 -0.158 7.0 7.0 CDH1 -0.062 0.157 -9999.0 0.0 -0.316 66.0 66.0 EGFR/EGFR/EGF/EGF -0.038 0.114 -9999.0 0.0 -0.174 90.0 90.0 RhoA/GDP 0.001 0.097 -9999.0 0.0 -0.153 66.0 66.0 actin cytoskeleton organization -0.051 0.077 0.188 6.0 -0.284 1.0 7.0 IGF-1R heterotetramer 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 IGF1 0.008 0.088 0.124 5.0 -0.316 16.0 21.0 DIAPH1 -0.029 0.212 -9999.0 0.0 -0.54 31.0 31.0 Wnt receptor signaling pathway 0.001 0.099 0.158 66.0 -9999.0 0.0 66.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.059 -9999.0 0.0 -0.152 61.0 61.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.077 0.19 6.0 -0.29 1.0 7.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.049 0.073 0.195 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 -0.01 0.091 -9999.0 0.0 -0.154 65.0 65.0 SEC6/SEC8 -0.048 0.059 -9999.0 0.0 -0.152 51.0 51.0 MGAT3 -0.044 0.08 0.222 5.0 -0.289 2.0 7.0 HGF/MET -0.023 0.107 -9999.0 0.0 -0.171 75.0 75.0 HGF 0.016 0.076 0.124 13.0 -0.316 11.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.034 0.094 -9999.0 0.0 -0.183 67.0 67.0 actin cable formation -0.017 0.108 0.281 13.0 -0.267 5.0 18.0 KIAA1543 -0.047 0.074 0.191 6.0 -0.276 2.0 8.0 KIFC3 -0.048 0.073 0.219 4.0 -9999.0 0.0 4.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.077 0.204 6.0 -9999.0 0.0 6.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.099 -9999.0 0.0 -0.158 66.0 66.0 EXOC4 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.045 0.076 0.204 6.0 -9999.0 0.0 6.0 PIP5K1C -0.045 0.076 0.204 6.0 -9999.0 0.0 6.0 LIMA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.098 0.367 5.0 -0.228 1.0 6.0 adherens junction assembly -0.045 0.09 0.32 2.0 -0.304 8.0 10.0 IGF-1R heterotetramer/IGF1 -0.018 0.102 -9999.0 0.0 -0.16 77.0 77.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.028 -9999.0 0.0 -0.22 2.0 2.0 MET 0.0 0.097 0.124 8.0 -0.316 20.0 28.0 PLEKHA7 -0.047 0.08 0.204 6.0 -0.289 2.0 8.0 mol:GTP 0.054 0.047 -9999.0 0.0 -0.167 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.016 0.11 0.257 14.0 -9999.0 0.0 14.0 cortical actin cytoskeleton stabilization -0.033 0.093 -9999.0 0.0 -0.182 67.0 67.0 regulation of cell-cell adhesion -0.051 0.077 0.188 6.0 -0.284 1.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.034 0.094 -9999.0 0.0 -0.183 67.0 67.0