(All_Primary cohort)
This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 8 different clustering approaches and 7 clinical features across 31 patients, no significant finding detected with P value < 0.05 and Q value < 0.25.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes do not correlate to any clinical features.
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5 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes do not correlate to any clinical features.
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CNMF clustering analysis on RPPA data identified 2 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on RPPA data identified 2 subtypes that do not correlate to any clinical features.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 2 subtypes that do not correlate to any clinical features.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 2 subtypes that do not correlate to any clinical features.
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2 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes do not correlate to any clinical features.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes do not correlate to any clinical features.
Clinical Features |
Time to Death |
AGE |
PRIMARY SITE OF DISEASE |
GENDER |
LYMPH NODE METASTASIS |
TUMOR STAGECODE |
NEOPLASM DISEASESTAGE |
Statistical Tests | logrank test | ANOVA | Chi-square test | Fisher's exact test | Chi-square test | ANOVA | Chi-square test |
Copy Number Ratio CNMF subtypes |
0.646 (1.00) |
0.589 (1.00) |
0.23 (1.00) |
0.278 (1.00) |
0.595 (1.00) |
0.602 (1.00) |
|
METHLYATION CNMF |
0.365 (1.00) |
0.839 (1.00) |
0.203 (1.00) |
0.115 (1.00) |
0.576 (1.00) |
0.644 (1.00) |
|
RPPA CNMF subtypes |
0.841 (1.00) |
0.679 (1.00) |
1 (1.00) |
0.109 (1.00) |
0.443 (1.00) |
||
RPPA cHierClus subtypes |
0.841 (1.00) |
0.679 (1.00) |
1 (1.00) |
0.109 (1.00) |
0.443 (1.00) |
||
RNAseq CNMF subtypes |
0.918 (1.00) |
0.303 (1.00) |
0.468 (1.00) |
0.231 (1.00) |
0.517 (1.00) |
0.325 (1.00) |
|
RNAseq cHierClus subtypes |
0.918 (1.00) |
0.215 (1.00) |
0.492 (1.00) |
0.399 (1.00) |
0.366 (1.00) |
0.212 (1.00) |
|
MIRSEQ CNMF |
0.302 (1.00) |
0.776 (1.00) |
0.132 (1.00) |
1 (1.00) |
0.485 (1.00) |
0.586 (1.00) |
|
MIRSEQ CHIERARCHICAL |
0.336 (1.00) |
0.201 (1.00) |
0.617 (1.00) |
1 (1.00) |
0.708 (1.00) |
0.523 (1.00) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 10 | 8 | 11 |
P value = 0.646 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 22 | 5 | 0.0 - 27.0 (1.2) |
subtype1 | 6 | 1 | 0.1 - 12.1 (0.9) |
subtype2 | 8 | 1 | 0.0 - 24.0 (0.5) |
subtype3 | 8 | 3 | 0.3 - 27.0 (7.8) |
P value = 0.589 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 26 | 61.1 (15.3) |
subtype1 | 8 | 61.9 (14.1) |
subtype2 | 8 | 56.5 (10.9) |
subtype3 | 10 | 64.1 (19.4) |
P value = 0.23 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 25 | 2 |
subtype1 | 2 | 7 | 1 |
subtype2 | 0 | 7 | 1 |
subtype3 | 0 | 11 | 0 |
P value = 0.278 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 9 | 20 |
subtype1 | 5 | 5 |
subtype2 | 2 | 6 |
subtype3 | 2 | 9 |
P value = 0.595 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|
ALL | 15 | 1 | 1 | 1 | 3 | 1 | 3 | 3 |
subtype1 | 6 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
subtype2 | 4 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
subtype3 | 5 | 0 | 0 | 0 | 1 | 1 | 2 | 2 |
P value = 0.602 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 15 | 1 | 3 | 4 | 1 |
subtype1 | 1 | 0 | 1 | 5 | 0 | 1 | 0 | 0 |
subtype2 | 0 | 0 | 0 | 4 | 1 | 1 | 2 | 0 |
subtype3 | 0 | 1 | 0 | 6 | 0 | 1 | 2 | 1 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 4 | 7 | 11 | 5 | 4 |
P value = 0.365 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 24 | 5 | 0.0 - 27.0 (1.2) |
subtype1 | 4 | 0 | 0.1 - 3.9 (0.9) |
subtype2 | 7 | 1 | 0.0 - 24.0 (7.8) |
subtype3 | 6 | 3 | 0.5 - 27.0 (3.6) |
subtype4 | 4 | 0 | 0.1 - 1.3 (0.3) |
subtype5 | 3 | 1 | 0.4 - 12.1 (0.4) |
P value = 0.839 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 28 | 59.4 (16.0) |
subtype1 | 4 | 64.5 (11.1) |
subtype2 | 7 | 63.9 (15.8) |
subtype3 | 8 | 56.9 (21.2) |
subtype4 | 5 | 56.0 (14.0) |
subtype5 | 4 | 56.0 (15.1) |
P value = 0.203 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 27 | 2 |
subtype1 | 0 | 4 | 0 |
subtype2 | 0 | 5 | 2 |
subtype3 | 2 | 9 | 0 |
subtype4 | 0 | 5 | 0 |
subtype5 | 0 | 4 | 0 |
P value = 0.115 (Chi-square test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 10 | 21 |
subtype1 | 2 | 2 |
subtype2 | 1 | 6 |
subtype3 | 4 | 7 |
subtype4 | 0 | 5 |
subtype5 | 3 | 1 |
P value = 0.576 (Chi-square test), Q value = 1
nPatients | N0 | N1 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|---|
ALL | 16 | 1 | 1 | 1 | 1 | 3 | 1 | 3 | 3 |
subtype1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
subtype2 | 5 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
subtype3 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 2 | 2 |
subtype4 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
subtype5 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
P value = 0.644 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 16 | 1 | 4 | 4 | 1 |
subtype1 | 0 | 0 | 0 | 2 | 0 | 1 | 1 | 0 |
subtype2 | 0 | 0 | 0 | 5 | 1 | 0 | 0 | 0 |
subtype3 | 0 | 1 | 0 | 4 | 0 | 2 | 2 | 1 |
subtype4 | 1 | 0 | 0 | 3 | 0 | 0 | 1 | 0 |
subtype5 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 6 | 2 | 4 |
P value = 0.841 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 8 | 61.5 (11.8) |
subtype1 | 5 | 62.2 (13.4) |
subtype3 | 3 | 60.3 (11.2) |
P value = 0.679 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 7 | 1 |
subtype1 | 1 | 4 | 1 |
subtype3 | 1 | 3 | 0 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2 | 8 |
subtype1 | 1 | 5 |
subtype3 | 1 | 3 |
P value = 0.109 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N2A | N2B | N3 | NX |
---|---|---|---|---|---|---|
ALL | 2 | 1 | 1 | 3 | 1 | 1 |
subtype1 | 0 | 1 | 1 | 3 | 0 | 1 |
subtype3 | 2 | 0 | 0 | 0 | 1 | 0 |
P value = 0.443 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC |
---|---|---|---|---|---|
ALL | 1 | 2 | 1 | 2 | 2 |
subtype1 | 0 | 1 | 1 | 2 | 1 |
subtype3 | 1 | 1 | 0 | 0 | 1 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 4 | 2 | 6 |
P value = 0.841 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 8 | 61.5 (11.8) |
subtype1 | 3 | 60.3 (11.2) |
subtype3 | 5 | 62.2 (13.4) |
P value = 0.679 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 7 | 1 |
subtype1 | 1 | 3 | 0 |
subtype3 | 1 | 4 | 1 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 2 | 8 |
subtype1 | 1 | 3 |
subtype3 | 1 | 5 |
P value = 0.109 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N2A | N2B | N3 | NX |
---|---|---|---|---|---|---|
ALL | 2 | 1 | 1 | 3 | 1 | 1 |
subtype1 | 2 | 0 | 0 | 0 | 1 | 0 |
subtype3 | 0 | 1 | 1 | 3 | 0 | 1 |
P value = 0.443 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC |
---|---|---|---|---|---|
ALL | 1 | 2 | 1 | 2 | 2 |
subtype1 | 1 | 1 | 0 | 0 | 1 |
subtype3 | 0 | 1 | 1 | 2 | 1 |
Cluster Labels | 1 | 2 |
---|---|---|
Number of samples | 16 | 11 |
P value = 0.918 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 20 | 4 | 0.0 - 27.0 (0.9) |
subtype1 | 12 | 3 | 0.1 - 27.0 (2.5) |
subtype2 | 8 | 1 | 0.0 - 24.0 (0.5) |
P value = 0.303 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 24 | 60.7 (15.9) |
subtype1 | 13 | 63.8 (17.8) |
subtype2 | 11 | 57.1 (13.1) |
P value = 0.468 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 23 | 2 |
subtype1 | 2 | 13 | 1 |
subtype2 | 0 | 10 | 1 |
P value = 0.231 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 9 | 18 |
subtype1 | 7 | 9 |
subtype2 | 2 | 9 |
P value = 0.517 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|
ALL | 14 | 1 | 1 | 1 | 3 | 1 | 2 | 3 |
subtype1 | 7 | 0 | 1 | 1 | 2 | 1 | 2 | 1 |
subtype2 | 7 | 1 | 0 | 0 | 1 | 0 | 0 | 2 |
P value = 0.325 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 14 | 1 | 3 | 3 | 1 |
subtype1 | 0 | 1 | 0 | 7 | 0 | 2 | 3 | 1 |
subtype2 | 1 | 0 | 1 | 7 | 1 | 1 | 0 | 0 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 10 | 1 | 16 |
P value = 0.918 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 19 | 4 | 0.0 - 27.0 (0.5) |
subtype1 | 7 | 1 | 0.0 - 24.0 (0.4) |
subtype3 | 12 | 3 | 0.1 - 27.0 (2.5) |
P value = 0.215 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 23 | 60.2 (16.0) |
subtype1 | 10 | 55.6 (12.8) |
subtype3 | 13 | 63.8 (17.8) |
P value = 0.492 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 22 | 2 |
subtype1 | 0 | 9 | 1 |
subtype3 | 2 | 13 | 1 |
P value = 0.399 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 9 | 17 |
subtype1 | 2 | 8 |
subtype3 | 7 | 9 |
P value = 0.366 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|
ALL | 14 | 1 | 1 | 1 | 2 | 1 | 2 | 3 |
subtype1 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
subtype3 | 7 | 0 | 1 | 1 | 2 | 1 | 2 | 1 |
P value = 0.212 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 14 | 1 | 2 | 3 | 1 |
subtype1 | 1 | 0 | 1 | 7 | 1 | 0 | 0 | 0 |
subtype3 | 0 | 1 | 0 | 7 | 0 | 2 | 3 | 1 |
Cluster Labels | 1 | 2 |
---|---|---|
Number of samples | 15 | 13 |
P value = 0.302 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 21 | 4 | 0.0 - 27.0 (1.2) |
subtype1 | 13 | 2 | 0.0 - 24.0 (0.5) |
subtype2 | 8 | 2 | 0.2 - 27.0 (7.0) |
P value = 0.776 (t-test), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 25 | 60.7 (15.5) |
subtype1 | 15 | 61.5 (15.8) |
subtype2 | 10 | 59.6 (15.9) |
P value = 0.132 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 24 | 2 |
subtype1 | 0 | 13 | 2 |
subtype2 | 2 | 11 | 0 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 9 | 19 |
subtype1 | 5 | 10 |
subtype2 | 4 | 9 |
P value = 0.485 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|
ALL | 15 | 1 | 1 | 1 | 3 | 1 | 2 | 3 |
subtype1 | 8 | 1 | 1 | 0 | 2 | 1 | 0 | 2 |
subtype2 | 7 | 0 | 0 | 1 | 1 | 0 | 2 | 1 |
P value = 0.586 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 15 | 1 | 3 | 3 | 1 |
subtype1 | 0 | 1 | 1 | 8 | 1 | 2 | 1 | 0 |
subtype2 | 1 | 0 | 0 | 7 | 0 | 1 | 2 | 1 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 9 | 6 | 13 |
P value = 0.336 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 21 | 4 | 0.0 - 27.0 (1.2) |
subtype1 | 6 | 2 | 0.0 - 17.2 (6.3) |
subtype2 | 5 | 1 | 0.2 - 27.0 (3.9) |
subtype3 | 10 | 1 | 0.1 - 24.0 (0.9) |
P value = 0.201 (ANOVA), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 25 | 60.7 (15.5) |
subtype1 | 7 | 53.1 (18.6) |
subtype2 | 5 | 69.4 (9.1) |
subtype3 | 13 | 61.5 (14.7) |
P value = 0.617 (Chi-square test), Q value = 1
nPatients | DISTANT METASTASIS | PRIMARY TUMOR | REGIONAL CUTANEOUS OR SUBCUTANEOUS TISSUE (INCLUDES SATELLITE AND IN-TRANSIT METASTASIS) |
---|---|---|---|
ALL | 2 | 24 | 2 |
subtype1 | 1 | 7 | 1 |
subtype2 | 1 | 5 | 0 |
subtype3 | 0 | 12 | 1 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 9 | 19 |
subtype1 | 3 | 6 |
subtype2 | 2 | 4 |
subtype3 | 4 | 9 |
P value = 0.708 (Chi-square test), Q value = 1
nPatients | N0 | N1A | N1B | N2A | N2B | N2C | N3 | NX |
---|---|---|---|---|---|---|---|---|
ALL | 15 | 1 | 1 | 1 | 3 | 1 | 2 | 3 |
subtype1 | 5 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
subtype2 | 3 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
subtype3 | 7 | 1 | 1 | 0 | 2 | 0 | 0 | 2 |
P value = 0.523 (Chi-square test), Q value = 1
nPatients | STAGE IB | STAGE II | STAGE IIA | STAGE IIC | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV |
---|---|---|---|---|---|---|---|---|
ALL | 1 | 1 | 1 | 15 | 1 | 3 | 3 | 1 |
subtype1 | 0 | 0 | 0 | 6 | 0 | 2 | 0 | 1 |
subtype2 | 0 | 0 | 0 | 3 | 0 | 0 | 2 | 0 |
subtype3 | 1 | 1 | 1 | 6 | 1 | 1 | 1 | 0 |
-
Cluster data file = SKCM-All_Primary.mergedcluster.txt
-
Clinical data file = SKCM-All_Primary.clin.merged.picked.txt
-
Number of patients = 31
-
Number of clustering approaches = 8
-
Number of selected clinical features = 7
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Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, one-way analysis of variance (Howell 2002) was applied to compare the clinical values between tumor subtypes using 'anova' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between two tumor subtypes using 't.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.