rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(1), E2F1(2), MDM2(1), MYC(1), PIK3CA(1), PIK3R1(4), POLR1B(1), TP53(4) 1134716 15 13 15 1 3 1 3 3 5 0 0.0234 0.00210 0.754 2 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 HRAS(1), MEF2B(1), MEF2C(1), MEF2D(1), NTRK1(4), PIK3CA(1), PIK3R1(4), RPS6KA1(3), SHC1(2) 1061373 18 13 18 2 5 3 3 2 5 0 0.0151 0.00245 0.754 3 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), KLRC1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), PTK2B(1), SYK(2), VAV1(2) 1042544 15 12 13 1 8 1 1 2 3 0 0.0139 0.00390 0.801 4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN2A(1), E2F1(2), MDM2(1), PRB1(5), TP53(4) 471635 13 9 13 1 7 1 2 1 2 0 0.0205 0.00580 0.893 5 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(6), MEF2B(1), MEF2C(1), MEF2D(1) 421151 12 9 12 1 8 1 0 1 2 0 0.0239 0.0144 1.000 6 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(3), PRKACA(1), PRKAR1A(1) 366518 8 8 7 1 6 0 0 1 1 0 0.149 0.0164 1.000 7 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 HRAS(1), IGF1R(1), IRS1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1) 1068570 14 12 12 1 6 0 2 2 4 0 0.0357 0.0178 1.000 8 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 HRAS(1), MAP2K1(3), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(1), SHC1(2), SOS1(1) 899557 14 12 12 1 8 2 1 2 1 0 0.0131 0.0207 1.000 9 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ6(1), NDUFA13(1) 224210 5 5 5 1 2 0 1 1 1 0 0.393 0.0250 1.000 10 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(3) 113730 10 8 10 4 5 1 0 3 1 0 0.449 0.0328 1.000 11 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 HRAS(1), MAP2K1(3), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1) 1069366 14 12 12 2 7 0 2 2 3 0 0.0701 0.0396 1.000 12 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(1), GNAS(3), HRAS(1), IGF1R(1), MAP2K1(3), MAP2K2(1), MYC(1), NGFR(1), PDGFRA(5), PTPRR(2), RPS6KA1(3), SHC1(2), SOS1(1), STAT3(1) 1847884 26 18 24 2 18 2 4 2 0 0 0.000761 0.0437 1.000 13 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(1), CDC42(1), PDGFRA(5), PIK3CA(1), PIK3R1(4) 755052 12 11 12 3 3 2 2 2 3 0 0.305 0.0474 1.000 14 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FHL5(1), FSHR(4), GNAS(3) 532879 11 10 10 1 10 1 0 0 0 0 0.0338 0.0482 1.000 15 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(5), CCNE2(2), CDKN2A(1), E2F1(2), PRB1(5) 501991 15 8 15 1 10 0 2 2 1 0 0.0170 0.0495 1.000 16 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8IP3(1), PAPPA(9), RPS6KA1(3), SHC1(2), SOS1(1), SYK(2), VAV1(2), VAV2(1), VAV3(1) 1790599 31 17 29 2 24 3 2 2 0 0 5.68e-05 0.0560 1.000 17 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 CAT(1), GHR(5), HRAS(1), IGF1R(1), PIK3CA(1), PIK3R1(4), SHC1(2) 747769 15 11 15 3 8 0 2 1 4 0 0.0925 0.0561 1.000 18 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ANGPTL2(1), DAG1(1), DGKA(1), ITGA9(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), PDE3A(3), PIK3C2G(7), PIK3CA(1), PIK3R1(4) 2727281 34 21 32 4 17 3 3 6 5 0 0.000688 0.0573 1.000 19 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(1), HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), MYC(1), PIK3CA(1), PIK3R1(4), SOS1(1), STAT5A(1) 1572793 15 14 13 1 6 1 1 4 3 0 0.0245 0.0621 1.000 20 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(2), HDC(3), TPH1(4) 336252 10 7 10 1 7 1 0 2 0 0 0.0379 0.0691 1.000 21 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), CAMK2B(3), CAMK2G(1), GNAS(3), HRAS(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), PRKCA(1), RPS6KA1(3), SOS1(1) 1626999 22 16 21 4 12 2 2 2 4 0 0.0476 0.0851 1.000 22 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), BCMO1(3) 219636 5 5 5 2 3 0 0 1 1 0 0.496 0.0855 1.000 23 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(5), CUL1(2), E2F1(2), TFDP1(1) 479089 10 8 10 0 8 1 0 1 0 0 0.0126 0.0879 1.000 24 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 HRAS(1), IGF1R(1), IRS1(1), MAP2K1(3), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1) 1391370 16 13 14 2 7 0 2 3 4 0 0.0644 0.0979 1.000 25 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(1), CREB5(2), DUSP4(2), EEF2K(2), EIF4E(1), MAP2K1(3), MAP2K2(1), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2) 1566109 21 16 19 2 14 3 2 2 0 0 0.00595 0.104 1.000 26 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), GAD1(2), GAD2(3), GGT1(1) 319432 9 6 9 1 7 0 0 2 0 0 0.0708 0.106 1.000 27 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(1), EGFR(1), HGS(1), TF(2), TFRC(1) 720711 8 8 8 2 2 0 3 1 2 0 0.364 0.113 1.000 28 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD80(1), CD86(2), HLA-DRB1(1), ITK(1), LCK(2), PIK3CA(1), PIK3R1(4), PTPN11(1) 717699 13 8 13 3 5 0 2 2 4 0 0.221 0.116 1.000 29 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC1A(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1) 857481 10 9 10 1 5 3 0 1 1 0 0.0856 0.120 1.000 30 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5) 987513 18 14 18 4 13 1 1 2 1 0 0.0494 0.125 1.000 31 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1) 1958767 22 19 20 4 11 2 3 3 3 0 0.0413 0.125 1.000 32 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 HRAS(1), NTRK1(4), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1) 873858 14 11 14 3 4 2 2 3 3 0 0.176 0.126 1.000 33 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(4), PLCB2(1), VIP(1) 618577 12 10 12 3 6 2 1 2 1 0 0.150 0.130 1.000 34 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1), GNAQ(2), ITPKA(1) 337647 4 4 4 0 1 1 0 2 0 0 0.250 0.136 1.000 35 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 MAP3K14(1), RELA(1), TP53(4) 544617 6 6 6 1 2 2 0 0 2 0 0.285 0.137 1.000 36 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CDC42(1), HRAS(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), RELA(1) 1061052 11 10 9 2 5 0 1 2 3 0 0.183 0.142 1.000 37 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1) 543122 10 8 10 2 7 1 0 1 1 0 0.0761 0.146 1.000 38 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1) 543122 10 8 10 2 7 1 0 1 1 0 0.0761 0.146 1.000 39 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GGT1(1), SHMT2(1) 303423 4 4 4 1 2 1 0 1 0 0 0.407 0.164 1.000 40 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), HLA-DRB1(1), IL1B(1), IL5RA(2) 299287 5 5 5 1 3 1 0 0 1 0 0.233 0.177 1.000 41 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(2), NEK1(1), WEE1(1) 388736 4 4 4 1 1 1 0 1 1 0 0.638 0.187 1.000 42 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TAL1(1) 1145157 13 11 13 3 7 1 0 4 1 0 0.0941 0.200 1.000 43 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 GHR(5), PIK3CA(1), PIK3R1(4), RELA(1) 786604 11 9 11 3 5 0 1 1 4 0 0.335 0.203 1.000 44 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFAT5(1), PDE6A(3), PDE6B(2), PDE6C(4), SLC6A13(2), TF(2) 2004054 31 19 31 5 20 4 1 5 1 0 0.00185 0.214 1.000 45 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(3), FYN(1), IL7R(6), JAK3(1), LCK(2), PIK3CA(1), PIK3R1(4), PTK2B(1), STAT5A(1) 1565441 20 13 20 4 6 2 2 5 5 0 0.103 0.225 1.000 46 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 86771 1 1 1 0 0 0 1 0 0 0 0.624 0.233 1.000 47 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(2), E2F1(2), FBXW7(1), TFDP1(1) 459151 6 6 6 0 5 1 0 0 0 0 0.0702 0.233 1.000 48 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 HRAS(1), JAK3(1), LCK(2), MAP2K1(3), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1), SYK(2) 1295784 14 11 12 0 9 1 2 2 0 0 0.00248 0.241 1.000 49 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 102044 1 1 1 0 0 1 0 0 0 0 0.642 0.243 1.000 50 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3CA(1), PIK3R1(4), RELA(1) 1087613 13 11 11 3 5 1 2 1 4 0 0.218 0.252 1.000 51 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), GNAS(3), PLCE1(5), PRKAR1A(1) 822197 12 11 11 3 9 0 0 2 1 0 0.210 0.256 1.000 52 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 CBL(3), E2F1(2), HRAS(1), IRS1(1), JAK3(1), MYC(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), STAT5A(1), SYK(2) 2021874 20 12 20 1 6 1 2 6 5 0 0.00717 0.261 1.000 53 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP9(1), RECK(2) 418971 4 4 4 1 2 0 1 0 1 0 0.390 0.261 1.000 54 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2) 673675 7 7 7 1 3 0 1 0 3 0 0.272 0.269 1.000 55 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(1), EGF(1), EGFR(1), MET(4), PDGFRA(5), PRKCA(1) 1091821 16 13 16 4 6 3 3 3 1 0 0.170 0.282 1.000 56 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 HRAS(1), INSR(2), IRS1(1), MAP2K1(3), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1) 1435454 17 12 15 3 7 0 2 4 4 0 0.113 0.288 1.000 57 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), EGFR(1), ERBB3(1), NRG1(3) 578413 6 6 6 1 3 1 2 0 0 0 0.266 0.289 1.000 58 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(3), DRD2(2), GRM1(1), PLCB1(4), PPP1CA(1), PRKAR1A(1) 894207 12 10 12 4 5 3 1 1 2 0 0.344 0.293 1.000 59 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 93001 2 2 2 0 2 0 0 0 0 0 0.344 0.299 1.000 60 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 ATF1(1), CREB5(2), CREBBP(3), DAG1(1), FRS2(1), GNAQ(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NTRK1(4), OPN1LW(1), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), TERF2IP(1) 2780342 39 19 39 5 19 3 3 9 5 0 0.00131 0.311 1.000 61 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1) 451692 5 5 5 0 4 1 0 0 0 0 0.0873 0.322 1.000 62 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), EGFR(1), GNAQ(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP3K1(1), MAPK8(1), MEF2B(1), MEF2C(1), MEF2D(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1) 1874937 21 15 19 4 12 2 2 3 2 0 0.0397 0.336 1.000 63 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), CRK(1), CXCR4(1), GNAQ(2), HRAS(1), MAP2K1(3), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PRKCA(1), PTK2B(1), RELA(1) 1541001 24 15 22 6 13 2 2 3 4 0 0.0726 0.339 1.000 64 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(1), KARS(2) 263246 3 3 3 0 2 0 1 0 0 0 0.300 0.346 1.000 65 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 HRAS(1), MAP2K1(3), MAP2K2(1), NGFR(1) 456708 6 6 4 1 6 0 0 0 0 0 0.110 0.354 1.000 66 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 HRAS(1), MAP2K1(3), MPL(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), THPO(1) 1679055 17 13 15 3 8 1 2 3 3 0 0.0814 0.365 1.000 67 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1), SHMT2(1) 230400 2 2 2 1 1 1 0 0 0 0 0.628 0.382 1.000 68 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACSL1(2), CPT1A(1), EHHADH(1), SCP2(2) 950646 7 7 7 1 4 1 0 2 0 0 0.226 0.397 1.000 69 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CUL1(2), E2F1(2), TFDP1(1) 483056 5 5 5 0 4 1 0 0 0 0 0.0968 0.404 1.000 70 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1) 475994 5 5 5 1 3 1 0 1 0 0 0.289 0.408 1.000 71 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2) 436504 5 5 5 1 4 0 0 1 0 0 0.312 0.413 1.000 72 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRB1(1) 170264 2 2 2 0 1 1 0 0 0 0 0.346 0.414 1.000 73 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(4) 206828 5 4 5 2 5 0 0 0 0 0 0.437 0.425 1.000 74 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR1H4(2) 305149 4 4 4 1 4 0 0 0 0 0 0.299 0.428 1.000 75 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC1A(1), CDC42(1), WASF1(1) 456250 4 4 4 1 2 1 0 1 0 0 0.513 0.431 1.000 76 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(3), CDC25C(1), GNAS(3), HRAS(1), MYT1(2), PRKAR1A(1), RPS6KA1(3) 1151859 15 13 14 4 11 1 1 1 1 0 0.145 0.432 1.000 77 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), HRAS(1), IL3RA(1), MAP2K1(3), SHC1(2), SOS1(1), STAT5A(1) 988279 10 9 8 2 6 0 1 2 1 0 0.163 0.435 1.000 78 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SULT1A2(2), SULT1E1(4), SULT2A1(1), SUOX(1) 343556 8 6 8 3 6 1 0 0 1 0 0.403 0.437 1.000 79 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 BCAR1(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1) 1034063 9 9 9 2 2 0 2 2 3 0 0.334 0.439 1.000 80 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 APOA4(1), CYP7A1(1), HMGCR(6), LDLR(2), LIPC(1), LRP1(9), SCARB1(1) 1543544 21 13 21 3 11 1 0 7 2 0 0.0159 0.442 1.000 81 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 EIF4A2(1), EIF4E(1), EIF4G1(1), GHR(5), IRS1(1), PIK3CA(1), PIK3R1(4), PRKCA(1) 1541076 15 12 15 4 7 0 1 1 6 0 0.305 0.444 1.000 82 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(1), CRK(1), HGF(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), MET(4), PIK3CA(1), PIK3R1(4), PTK2B(1), PTPN11(1), SOS1(1), STAT3(1) 2407008 22 18 20 3 11 2 1 4 4 0 0.0228 0.450 1.000 83 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNB1(1), PIK3CA(1), PIK3R1(4), PTK2B(1), TERT(3) 914556 10 7 10 3 2 3 1 1 3 0 0.270 0.463 1.000 84 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TKTL1(1), TKTL2(5) 1358888 18 14 18 5 10 2 0 5 1 0 0.0986 0.468 1.000 85 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3) 1274929 16 13 15 3 13 0 1 1 1 0 0.0577 0.469 1.000 86 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3) 1274929 16 13 15 3 13 0 1 1 1 0 0.0577 0.469 1.000 87 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(3), PRF1(2) 593872 6 6 6 1 4 0 0 1 1 0 0.238 0.469 1.000 88 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 EIF4E(1), IGF1R(1), PIK3CA(1), PIK3R1(4) 1059280 7 7 7 2 2 0 1 1 3 0 0.421 0.474 1.000 89 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(1), TP53(4), WT1(1) 397838 6 6 6 3 1 1 0 1 3 0 0.693 0.478 1.000 90 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3) 701493 30 13 30 9 24 2 0 2 2 0 0.0710 0.480 1.000 91 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IL4R(1), IRS1(1), JAK3(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1) 2051114 16 12 16 1 6 1 2 3 4 0 0.0187 0.480 1.000 92 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2), SELP(1) 887550 8 8 8 2 4 0 1 0 3 0 0.359 0.488 1.000 93 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 PIK3CA(1), PTK2B(1), RBL2(2), SHC1(2), SOS1(1) 1105901 7 7 7 1 1 1 2 2 1 0 0.253 0.497 1.000 94 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(1), EGFR(1), HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1) 2101954 19 14 17 4 8 1 4 3 3 0 0.101 0.505 1.000 95 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 96602 1 1 1 1 1 0 0 0 0 0 0.853 0.517 1.000 96 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(1), PTK2B(1), SHC1(2), SOS1(1) 494953 5 4 5 0 2 1 1 1 0 0 0.149 0.518 1.000 97 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), RBL1(1), TFDP1(1) 903066 11 8 11 2 8 0 1 2 0 0 0.135 0.521 1.000 98 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(1) 221391 3 3 3 1 3 0 0 0 0 0 0.416 0.529 1.000 99 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 FYN(1), HLA-DRB1(1), LCK(2), PTPRC(3) 498126 7 4 7 0 5 0 1 0 1 0 0.0373 0.537 1.000 100 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(1), EIF5(1), PPP1CA(1) 651806 5 5 5 0 2 0 1 1 1 0 0.240 0.538 1.000 101 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1) 447276 6 6 6 3 4 1 0 0 1 0 0.483 0.544 1.000 102 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1) 447276 6 6 6 3 4 1 0 0 1 0 0.483 0.544 1.000 103 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1) 279183 4 3 4 1 3 0 0 0 1 0 0.375 0.547 1.000 104 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), PRKAR1A(1), PRKCA(1) 533508 5 5 5 2 4 0 0 0 1 0 0.617 0.548 1.000 105 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(1), E2F1(2), MDM2(1), TP53(4) 1017334 8 8 8 2 3 1 1 1 2 0 0.328 0.554 1.000 106 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), IL1B(1), MST1(1), MST1R(1) 368467 4 4 4 1 3 0 0 0 1 0 0.533 0.561 1.000 107 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), RELA(1), XDH(6) 553453 8 7 8 3 7 1 0 0 0 0 0.386 0.566 1.000 108 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CDK6(1), E2F1(2), HRAS(1), PIK3CA(1), PIK3R1(4), RELA(1), TFDP1(1) 1132551 11 9 11 3 5 0 1 2 3 0 0.331 0.578 1.000 109 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT9(3), HEXA(2), NAGA(1) 566756 7 6 7 2 5 0 1 1 0 0 0.278 0.579 1.000 110 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASS(1), KARS(2) 389447 3 3 3 0 2 0 1 0 0 0 0.303 0.579 1.000 111 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(3), PRKAA2(2), PRKAG2(2), PRKAR1A(1) 857937 11 10 10 4 9 1 0 0 1 0 0.371 0.581 1.000 112 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), MUT(2) 283496 3 3 3 0 2 0 0 1 0 0 0.322 0.584 1.000 113 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ICAM1(1), ITGB2(1), SELE(2) 577785 5 5 5 1 3 0 0 0 2 0 0.321 0.594 1.000 114 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(1) 352468 2 2 2 1 0 0 0 0 2 0 0.804 0.595 1.000 115 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3) 272232 3 3 3 1 3 0 0 0 0 0 0.504 0.597 1.000 116 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(1), ATR(5), CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), TFDP1(1), TP53(4) 1693749 20 14 20 4 10 1 2 4 3 0 0.0889 0.597 1.000 117 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(2) 148134 2 2 2 1 2 0 0 0 0 0 0.630 0.599 1.000 118 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), UGP2(1) 275948 2 2 2 0 1 0 0 0 1 0 0.408 0.601 1.000 119 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), ICAM1(1), ITGB2(1), PRF1(2) 486744 5 5 5 2 3 0 0 1 1 0 0.421 0.607 1.000 120 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(1), E2F1(2), ETS1(1), ETS2(1), HDAC5(1), HRAS(1), NCOR2(2), RBL1(1), RBL2(2), SIN3A(3) 1450925 16 10 16 2 9 2 1 3 1 0 0.0227 0.607 1.000 121 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), EGFR(1), MAP2K1(3), MAP3K1(1), NCOR2(2), THRA(2), THRB(3) 960492 13 11 11 4 7 2 2 1 1 0 0.224 0.620 1.000 122 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), XYLT1(3) 359670 5 5 5 2 4 1 0 0 0 0 0.319 0.624 1.000 123 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), XYLT1(3) 359670 5 5 5 2 4 1 0 0 0 0 0.319 0.624 1.000 124 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 DAG1(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2) 2512798 24 15 23 7 8 2 2 10 2 0 0.211 0.624 1.000 125 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), EHHADH(1) 469265 3 3 3 0 2 0 1 0 0 0 0.254 0.635 1.000 126 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(1), ATR(5), CDC25C(1), TP53(4) 900674 11 10 11 4 3 1 1 3 3 0 0.656 0.638 1.000 127 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CSF1(1), LDLR(2) 300636 3 3 3 0 3 0 0 0 0 0 0.213 0.640 1.000 128 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(5), HRAS(1), INSR(2), IRS1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), PRKCA(1), RPS6KA1(3), SHC1(2), SOS1(1), STAT5A(1) 1860212 25 16 23 6 12 1 3 4 5 0 0.0714 0.640 1.000 129 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), VAV1(2) 721294 12 10 12 6 5 0 2 2 3 0 0.627 0.651 1.000 130 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), TPK1(1) 359971 2 2 2 0 1 0 0 0 1 0 0.443 0.666 1.000 131 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(1), TRAF2(1) 462260 4 4 4 1 4 0 0 0 0 0 0.356 0.667 1.000 132 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRB1(1) 131815 1 1 1 1 1 0 0 0 0 0 0.834 0.670 1.000 133 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), HRAS(1), MAP2K1(3), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1) 1197732 10 9 8 2 7 0 1 2 0 0 0.159 0.673 1.000 134 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3) 973231 41 17 41 10 31 3 1 3 3 0 0.00827 0.675 1.000 135 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(3), CSF2RB(1), IGF1R(1), IL3RA(1), KIT(1), KITLG(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1) 1231595 14 11 13 5 6 0 2 1 5 0 0.330 0.682 1.000 136 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1), KERA(1), LUM(1) 199830 3 3 3 2 3 0 0 0 0 0 0.646 0.685 1.000 137 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), HMGCR(6), MVK(1), SQLE(1) 616813 9 5 9 0 4 0 0 4 1 0 0.0487 0.688 1.000 138 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SRD5A1(1), SRD5A2(1) 1307400 26 17 26 8 20 2 1 2 1 0 0.0509 0.693 1.000 139 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 APC(3), CCL13(1), DAG1(1), EGFR(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), MAPK10(1), PIK3CA(1), PIK3R1(4) 2902986 33 19 33 9 16 2 3 9 3 0 0.0595 0.694 1.000 140 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(2), PRKAR1A(1) 678735 3 3 3 1 0 0 1 0 2 0 0.712 0.704 1.000 141 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 BTK(2), EEA1(2), LYN(1), PFKM(1), PRKCZ(1), VAV2(1) 1390778 8 7 8 2 5 0 0 1 2 0 0.222 0.711 1.000 142 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(1), IL22RA1(1), JAK3(1), STAT3(1), STAT5A(1), TYK2(1) 1023676 7 6 7 1 3 2 0 2 0 0 0.203 0.712 1.000 143 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CDO1(1), GOT2(2), LDHA(1), LDHAL6A(1), SULT1C2(1), SULT4A1(1) 704427 8 7 8 2 6 0 0 1 1 0 0.299 0.712 1.000 144 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(1), HLA-DRB1(1) 221509 2 2 2 1 2 0 0 0 0 0 0.615 0.715 1.000 145 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), GOT2(2), LDHA(1) 385554 4 3 4 2 3 0 0 0 1 0 0.697 0.725 1.000 146 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(1) 374957 2 2 2 1 1 0 1 0 0 0 0.730 0.728 1.000 147 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GPHN(2), UBQLN1(1) 662976 8 6 8 2 7 0 0 1 0 0 0.232 0.735 1.000 148 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(2), SREBF2(2) 668714 4 4 4 2 2 0 0 1 1 0 0.744 0.738 1.000 149 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 SULT1A2(2), SULT1E1(4), SULT2A1(1), SULT2B1(1), SUOX(1) 512958 9 7 9 4 7 1 0 0 1 0 0.349 0.738 1.000 150 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 HRAS(1), JAK3(1), MAP2K1(3), PTPN11(1), SHC1(2), SOS1(1), STAT3(1) 1334918 10 8 8 0 6 1 1 2 0 0 0.0189 0.739 1.000 151 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 BFAR(1), CREB5(2), TERF2IP(1) 543516 4 3 4 1 2 0 0 2 0 0 0.550 0.744 1.000 152 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 178374 1 1 1 0 1 0 0 0 0 0 0.609 0.745 1.000 153 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), MASP1(1) 1158249 47 19 47 11 35 4 1 3 4 0 0.00295 0.746 1.000 154 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), EIF4E(1), LDHA(1) 503425 3 2 3 1 1 0 1 0 1 0 0.708 0.748 1.000 155 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), EHHADH(1) 680576 7 7 7 3 5 1 0 0 1 0 0.395 0.748 1.000 156 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), THBS1(3) 415999 4 3 4 1 3 0 0 0 1 0 0.392 0.750 1.000 157 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(1) 167006 2 1 2 1 2 0 0 0 0 0 0.660 0.758 1.000 158 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(1), ABCG2(1), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1) 1284804 11 9 11 2 9 1 0 1 0 0 0.0594 0.763 1.000 159 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1) 306466 1 1 1 0 0 0 0 1 0 0 0.832 0.763 1.000 160 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(3), AXIN1(1), BTRC(1), CREBBP(3), CSNK1A1(1), CTNNB1(2), MYC(1), NLK(2), TLE1(1), WIF1(1) 1640685 16 12 16 4 7 0 2 5 2 0 0.269 0.766 1.000 161 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT3(2), ST3GAL3(1) 280936 3 2 3 1 2 0 0 1 0 0 0.505 0.766 1.000 162 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(2) 475919 3 3 3 1 2 0 0 0 1 0 0.645 0.769 1.000 163 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), NPAS2(3), PER2(2) 956355 6 5 6 2 3 1 1 0 1 0 0.407 0.772 1.000 164 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT9(3) 336328 3 3 3 1 3 0 0 0 0 0 0.433 0.780 1.000 165 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 EIF4A2(1), EIF4E(1), EIF4G1(1), PIK3CA(1), PIK3R1(4), TSC2(1) 1505792 9 7 9 3 3 0 1 1 4 0 0.524 0.783 1.000 166 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), AOX1(3), BCKDHA(1), EHHADH(1), MCCC2(2), MUT(2), OXCT1(1), PCCA(2), PCCB(1) 2025923 24 14 24 5 17 1 2 2 2 0 0.0354 0.788 1.000 167 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), HMGCR(6), MVK(1), SQLE(1) 737196 9 5 9 0 4 0 0 4 1 0 0.0549 0.799 1.000 168 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1) 219521 1 1 1 1 1 0 0 0 0 0 0.832 0.801 1.000 169 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(1) 358385 4 4 4 8 2 1 0 0 1 0 0.987 0.801 1.000 170 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), IL10RA(1), STAT3(1), STAT5A(1) 686847 4 4 4 0 2 0 0 2 0 0 0.227 0.813 1.000 171 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1) 238079 1 1 1 1 1 0 0 0 0 0 0.853 0.814 1.000 172 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(6), ATM(1), CSNK1A1(1), MAPK8(1), MDM2(1), TP53(4) 1169756 14 11 14 4 7 1 2 2 2 0 0.248 0.820 1.000 173 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO2(1), IDH1(3) 502443 4 4 3 2 3 1 0 0 0 0 0.606 0.825 1.000 174 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 STX1A(1) 183803 1 1 1 1 1 0 0 0 0 0 0.787 0.828 1.000 175 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), ITGB1BP3(2), MYST3(1), MYST4(2) 1460909 12 9 12 3 6 1 2 2 1 0 0.253 0.830 1.000 176 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), GGCX(1), HMGCR(6), HSD17B7(1), MVK(1), SQLE(1), TM7SF2(1) 1079542 12 7 12 0 7 0 0 4 1 0 0.0102 0.830 1.000 177 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK3(1), STAT3(1), TYK2(1) 653740 3 3 3 1 1 2 0 0 0 0 0.537 0.835 1.000 178 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(3), APOBEC2(1) 414701 4 4 4 2 4 0 0 0 0 0 0.580 0.835 1.000 179 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3), MASP1(1), MBL2(1) 1186699 43 17 43 11 32 4 1 3 3 0 0.00836 0.836 1.000 180 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 SQLE(1) 238765 1 1 1 0 1 0 0 0 0 0 0.616 0.841 1.000 181 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(1), EGFR(1), HRAS(1), MAP2K1(3), PTPRB(12), SHC1(2), SOS1(1), SPRY3(1), SPRY4(1) 1400414 26 16 24 6 15 0 3 6 2 0 0.106 0.848 1.000 182 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1) 428560 2 2 2 2 1 0 0 1 0 0 0.909 0.850 1.000 183 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), GNAS(3), PRKAR1A(1) 727624 9 9 8 4 7 0 0 0 2 0 0.521 0.850 1.000 184 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1) 173494 1 1 1 0 1 0 0 0 0 0 0.607 0.852 1.000 185 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT3(1), B4GALT5(1), ST3GAL3(1) 439468 3 3 3 2 2 0 0 0 1 0 0.681 0.852 1.000 186 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 189754 1 1 1 0 1 0 0 0 0 0 0.655 0.854 1.000 187 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(2), C6(10), C7(9), ICAM1(1), ITGA4(2), ITGB2(1), SELP(1), VCAM1(2) 1382673 31 14 31 9 23 2 2 1 3 0 0.0380 0.857 1.000 188 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(2), GLI3(2), PRKAR1A(1), SHH(1), SMO(1), SUFU(1) 930334 9 8 9 3 6 2 0 0 1 0 0.366 0.859 1.000 189 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL4R(1), IRS1(1), JAK3(1), SHC1(2), STAT6(1) 828013 6 4 6 0 3 1 1 0 1 0 0.0968 0.863 1.000 190 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 GNAS(3), NOS3(1), PIK3CA(1), PIK3R1(4), RELA(1), SYT1(1) 999611 11 11 11 9 6 0 1 1 3 0 0.924 0.863 1.000 191 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFB2(1) 392185 1 1 1 0 0 0 1 0 0 0 0.677 0.870 1.000 192 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 GATA1(1), HMBS(1) 436169 2 2 2 1 1 0 0 0 1 0 0.640 0.872 1.000 193 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1) 216519 1 1 1 0 1 0 0 0 0 0 0.632 0.874 1.000 194 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), GNAQ(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK8(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1) 1596328 18 13 16 5 10 2 2 3 1 0 0.142 0.877 1.000 195 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), MAP2K1(3), MAP3K1(1), MAPK8(1), RELA(1), TRAF2(1) 1144218 8 8 6 2 7 1 0 0 0 0 0.259 0.879 1.000 196 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(2), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1) 1514752 25 13 25 6 16 2 0 4 3 0 0.0449 0.881 1.000 197 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(3), AXIN1(1), BTRC(1), CTNNB1(2), DLL1(2) 1189128 9 7 9 2 6 0 1 1 1 0 0.224 0.882 1.000 198 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCS2(1), OXCT1(1), OXCT2(1) 402058 3 3 3 3 1 0 0 1 1 0 0.891 0.883 1.000 199 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 BTK(2), CDKN2A(1), DAPP1(1), INPP5D(6), PIK3CA(1), PPP1R13B(2), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2) 1976952 22 14 22 5 13 2 4 2 1 0 0.0797 0.884 1.000 200 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(1), DBH(1), GAD1(2), GAD2(3), HDC(3), MAOA(1), PAH(1), SLC18A3(1), TPH1(4) 794189 17 10 17 5 14 1 0 2 0 0 0.0842 0.887 1.000 201 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1), TRAF6(1) 808459 5 5 5 1 4 1 0 0 0 0 0.349 0.888 1.000 202 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 SDHA(2), SDHC(1) 374105 3 3 3 2 3 0 0 0 0 0 0.738 0.888 1.000 203 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CDH1(2), CREBBP(3), MAP2K1(3) 1444189 11 10 9 2 10 0 0 1 0 0 0.194 0.891 1.000 204 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), ME1(1), PC(1) 521617 3 3 3 2 1 1 0 1 0 0 0.750 0.893 1.000 205 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), ALOX15B(2), ALOX5(1), DPEP1(1), GGT1(1), PLA2G6(2), PTGS2(1), TBXAS1(3) 838295 12 11 12 5 8 1 0 1 2 0 0.290 0.894 1.000 206 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), PELP1(2) 826026 5 4 5 1 4 0 0 1 0 0 0.424 0.902 1.000 207 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK3(1), PTPRU(1), REG1A(1), STAT3(1) 851973 4 4 4 1 2 1 0 0 1 0 0.327 0.902 1.000 208 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(1), IGF1R(1), MYC(1), POLR2A(1), PRKCA(1), TEP1(1), TERT(3), TP53(4) 1583574 13 10 13 4 6 3 1 1 2 0 0.182 0.905 1.000 209 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CAMK2B(3), CAMK2G(1), CLCA1(1), CLCA2(1), CLCA4(4), CNGA3(2), CNGB1(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKG1(1), PRKG2(3), PRKX(1) 1696325 25 14 25 7 17 2 0 4 2 0 0.0531 0.908 1.000 210 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), AOC2(1) 338086 3 2 3 2 2 0 0 0 1 0 0.668 0.909 1.000 211 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(1), SNCAIP(7), UBE2F(1) 361868 9 8 9 6 7 0 1 0 1 0 0.762 0.913 1.000 212 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT9(3), HEXA(2), NAGA(1) 601902 7 6 7 4 5 0 1 1 0 0 0.593 0.913 1.000 213 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(2), CYP11B2(1), HSD3B2(1) 387284 5 5 5 5 3 1 0 0 1 0 0.770 0.918 1.000 214 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(1), G6PD(1), GGT1(1), GPX5(1), IDH1(3), PGD(1) 1016033 8 8 7 3 6 0 1 1 0 0 0.300 0.918 1.000 215 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(3), ITGB3(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), SMPD2(1) 1544614 20 17 19 8 11 1 3 2 3 0 0.319 0.918 1.000 216 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACAA2(1), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), AOX1(3), BCAT2(1), BCKDHA(1), EHHADH(1), HMGCS2(1), MCCC2(2), MUT(2), OXCT1(1), OXCT2(1), PCCA(2), PCCB(1) 2419190 26 17 26 5 17 1 2 4 2 0 0.0263 0.918 1.000 217 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRB1(1), IL12B(1), IL12RB1(2), IL4R(1) 710194 7 7 7 3 6 0 0 0 1 0 0.431 0.918 1.000 218 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK3(1), PTPRU(1), REG1A(1) 766131 3 3 3 1 1 1 0 0 1 0 0.494 0.919 1.000 219 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CD8B(1), CIITA(2), CTSB(2), CTSL1(1), CTSS(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), IFNA16(1), IFNA21(2), IFNA6(1), KIR2DL4(1), KIR2DS4(2), KIR3DL1(1), KIR3DL3(3), KLRC1(1), LGMN(1), NFYA(1), NFYC(1), PDIA3(1), TAP1(1) 2587009 30 17 30 7 17 5 2 5 1 0 0.0295 0.921 1.000 220 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA5(1) 493051 2 2 2 0 1 0 0 0 1 0 0.523 0.924 1.000 221 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), MECR(1) 476390 2 2 2 0 1 0 0 1 0 0 0.509 0.925 1.000 222 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1) 307027 1 1 1 0 1 0 0 0 0 0 0.613 0.927 1.000 223 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 IL4R(1), INPP5D(6), JAK3(1), PIK3CA(1), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1), TYK2(1) 2067778 20 12 20 3 13 3 1 2 1 0 0.0193 0.927 1.000 224 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IKBKB(1), RELA(1), TP53(4), WT1(1) 1013495 7 7 7 3 3 1 0 0 3 0 0.565 0.929 1.000 225 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT2(2) 264740 2 2 2 2 2 0 0 0 0 0 0.827 0.929 1.000 226 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25B(2), CDC25C(1), SHH(1) 490559 4 3 4 3 0 2 0 1 1 0 0.928 0.929 1.000 227 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(1), CDC25B(2), CDC25C(1), MYT1(2), TP53(4), WEE1(1) 990254 11 10 11 6 3 2 1 2 3 0 0.790 0.929 1.000 228 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXTL3(1), GLCE(1), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), NDST3(2), NDST4(5) 1147535 16 8 16 6 11 2 1 1 1 0 0.195 0.930 1.000 229 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC2(1), ANAPC5(1), BTRC(1), CDC16(1), CDC27(1), CUL1(2), CUL3(2), FBXW7(1), FZR1(1), ITCH(1) 2244050 13 12 13 3 6 1 3 1 2 0 0.236 0.930 1.000 230 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(3), NCOA3(3), PRKAR1A(1) 1160492 7 6 7 1 4 1 0 1 1 0 0.329 0.931 1.000 231 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(1), IARS2(1), LARS2(1), PDHA2(2) 1055053 5 5 5 1 5 0 0 0 0 0 0.277 0.933 1.000 232 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK3(2), IMPA1(1), ISYNA1(1), PGM3(3) 652450 10 7 10 6 4 2 0 2 2 0 0.583 0.935 1.000 233 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 CASP8AP2(2) 604414 2 2 2 0 1 0 0 0 1 0 0.436 0.938 1.000 234 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), F2R(1), GNAQ(2), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), PTK2B(1) 1448116 17 15 16 7 7 1 2 4 3 0 0.450 0.939 1.000 235 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), METTL2B(1), METTL6(1), PCYT1B(1) 787862 4 4 4 1 3 0 0 1 0 0 0.434 0.940 1.000 236 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 PTPRU(1), REG1A(1) 641018 2 2 2 1 1 0 0 0 1 0 0.658 0.940 1.000 237 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 OPRK1(2), POLR2A(1), PRKAR1A(1) 722932 4 4 4 2 3 0 0 0 1 0 0.661 0.943 1.000 238 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS2(1), PDHA2(2) 565212 3 3 3 0 3 0 0 0 0 0 0.280 0.943 1.000 239 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), FYN(1), RELN(6) 785182 9 7 9 9 6 0 1 0 2 0 0.974 0.944 1.000 240 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1) 566605 1 1 1 1 0 1 0 0 0 0 0.878 0.947 1.000 241 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ARG1(1), CPS1(1), PYCR1(1), SMS(1) 974453 5 5 5 2 2 1 1 0 1 0 0.606 0.947 1.000 242 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(1), SHMT2(1), TPO(5) 654036 7 4 6 2 6 1 0 0 0 0 0.197 0.948 1.000 243 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CP(1), EPRS(2), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5) 1543139 23 16 23 6 18 1 1 2 1 0 0.0533 0.949 1.000 244 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4), XYLB(1) 1515928 34 18 34 10 23 3 1 2 5 0 0.0500 0.949 1.000 245 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), IKBKB(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1) 1335540 9 9 9 3 5 2 1 0 1 0 0.343 0.951 1.000 246 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 EHHADH(1) 438508 1 1 1 0 1 0 0 0 0 0 0.613 0.951 1.000 247 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(3), AXIN1(1), CTNNB1(2), GJA1(1), IRAK1(1), LBP(1), PIK3CA(1), PIK3R1(4), RELA(1), TLR4(3) 1712803 18 10 18 5 8 2 3 2 3 0 0.202 0.953 1.000 248 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25B(2), CDC25C(1), PRKCA(1) 521024 4 3 4 5 1 1 0 1 1 0 0.973 0.954 1.000 249 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1) 1629728 26 14 26 8 17 2 0 3 4 0 0.0945 0.954 1.000 250 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF6(1) 1013183 5 4 5 1 3 2 0 0 0 0 0.369 0.955 1.000 251 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA2(1), POLE(1), POLG(1), POLG2(2), POLI(3), POLQ(2), PRIM2(1), REV1(3), REV3L(2) 2271990 16 12 16 4 9 1 1 3 2 0 0.254 0.957 1.000 252 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), ENPP1(2), ENPP3(1) 815580 6 5 6 3 3 2 1 0 0 0 0.608 0.959 1.000 253 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), HDC(3), MAOA(1), PRPS2(1) 1366091 15 11 15 6 11 2 0 0 2 0 0.182 0.960 1.000 254 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), HEMK1(1), METTL2B(1), METTL6(1) 844543 4 4 4 1 3 0 0 1 0 0 0.405 0.961 1.000 255 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), DHRS2(1), PON1(1), PON3(1) 1006757 13 12 13 9 7 2 1 1 2 0 0.734 0.962 1.000 256 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1) 1058916 8 8 8 3 4 2 0 1 1 0 0.415 0.962 1.000 257 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), SPN(1), TNFRSF8(3), TNFSF8(1) 726987 10 8 10 5 6 1 0 1 2 0 0.602 0.965 1.000 258 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(1), BMPR1B(1), ESR2(2), FSHR(4), LHCGR(3), MSH5(2), NCOR1(1), NRIP1(1), PRLR(1), VDR(1), ZP2(1) 1958389 18 14 18 5 9 1 3 1 4 0 0.219 0.965 1.000 259 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(3), NRG3(1), PRKCA(1) 501083 5 4 5 3 3 0 0 1 1 0 0.786 0.966 1.000 260 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1) 841314 5 5 5 3 0 2 1 1 1 0 0.777 0.966 1.000 261 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 BIRC3(1), CASP7(1), CASP8(1) 757545 3 3 3 1 3 0 0 0 0 0 0.536 0.967 1.000 262 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 BAIAP2(2), CASP1(1), CASP7(1), CASP8(1), GAPDH(2), INSR(2), ITCH(1), MAGI1(2), MAGI2(7) 1348832 19 9 19 8 13 1 0 3 2 0 0.412 0.968 1.000 263 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 MAFK(1), MAPK8(1), PRKCA(1) 494718 3 2 3 1 3 0 0 0 0 0 0.496 0.968 1.000 264 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(3), CYP11B1(3), CYP11B2(1), HSD17B2(1), HSD17B3(1), HSD3B2(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5) 1527950 33 18 33 10 25 3 1 3 1 0 0.0291 0.969 1.000 265 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CYP2C19(7), CYP2C9(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2) 1736023 25 14 25 8 13 2 2 6 2 0 0.198 0.970 1.000 266 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(2) 516524 2 2 2 1 2 0 0 0 0 0 0.634 0.971 1.000 267 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 TOB1(1) 593198 1 1 1 2 0 0 0 0 1 0 0.944 0.973 1.000 268 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 HMBS(1) 424834 1 1 1 1 1 0 0 0 0 0 0.847 0.973 1.000 269 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK3(2), IMPA1(1), PGM3(3) 572913 9 7 9 6 4 2 0 2 1 0 0.686 0.973 1.000 270 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF2(1) 1253332 5 5 5 1 3 2 0 0 0 0 0.347 0.973 1.000 271 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNAQ(2), GNAS(3), HRAS(1), MAP2K1(3), PIK3C2G(7), PLCB1(4), PRKCA(1), ROCK2(1) 1404977 23 15 21 8 14 2 2 3 2 0 0.228 0.974 1.000 272 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3R1(4), SYT1(1), TRAF2(1), TRAF6(1) 1874591 20 15 20 7 12 0 2 2 4 0 0.227 0.974 1.000 273 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPT(1), ENPP1(2), ENPP3(1) 541476 4 4 4 3 0 2 1 1 0 0 0.857 0.976 1.000 274 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(2), GPR109B(1), GPR18(1), GPR39(1), GPR81(1) 549471 7 6 7 7 5 1 0 0 1 0 0.731 0.976 1.000 275 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(1) 432747 2 2 2 2 1 1 0 0 0 0 0.869 0.976 1.000 276 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGB2(1), PTPRC(3) 597674 5 4 5 2 5 0 0 0 0 0 0.410 0.977 1.000 277 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC3(1), CASP10(1), CASP7(1), CASP8(1), PRF1(2), SREBF2(2) 1023382 8 8 8 5 5 0 0 1 2 0 0.724 0.977 1.000 278 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX3(2), FADS2(1) 797972 4 4 4 3 3 0 1 0 0 0 0.680 0.977 1.000 279 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(1), MAPK8(1), MDM2(1), MRE11A(1), RAD51(1), RBBP8(2), RELA(1), TP53(4) 1670201 12 9 12 4 7 1 1 1 2 0 0.427 0.979 1.000 280 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(1), POLR2I(1) 753329 3 3 3 2 1 0 1 1 0 0 0.805 0.981 1.000 281 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IKBKB(1), MAP3K1(1), MAP3K5(2), MAPK8(1), RELA(1), TRAF2(1) 1075378 7 7 7 3 6 1 0 0 0 0 0.549 0.981 1.000 282 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ICAM1(1), ITGB2(1), PTPRC(3) 626578 5 4 5 2 5 0 0 0 0 0 0.405 0.982 1.000 283 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), FUT3(2), ST3GAL3(1) 401636 4 3 4 3 3 0 0 1 0 0 0.758 0.982 1.000 284 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH9A1(1), EHHADH(1), GAD1(2), GAD2(3), OXCT1(1), PDHA2(2) 1451462 16 10 16 5 12 1 0 2 1 0 0.154 0.982 1.000 285 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SLC27A5(1), SRD5A1(1), SRD5A2(1) 1778438 26 18 26 9 19 3 1 3 0 0 0.0890 0.982 1.000 286 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(2), FADS2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2) 568420 10 7 10 6 8 0 0 2 0 0 0.645 0.982 1.000 287 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 CDC42(1), DUSP4(2), DUSP8(1), GCK(3), IL1R1(1), MAP3K1(1), MAP3K12(1), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK8(1), MAPK9(2), PAPPA(9), SHC1(2), TP53(4), TRAF6(1), ZAK(1) 2816626 35 16 35 7 21 8 1 1 4 0 0.0119 0.983 1.000 288 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2) 932068 6 4 6 3 3 0 2 1 0 0 0.726 0.983 1.000 289 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 GBA(2), TPO(5) 470215 7 5 6 3 6 0 0 1 0 0 0.392 0.983 1.000 290 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B2(1), FLT4(4), HRAS(1), KDR(3), NOS3(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2) 1912555 18 13 18 7 11 0 2 1 4 0 0.327 0.983 1.000 291 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), POLG(1), PRPS2(1) 698244 3 2 3 1 2 0 0 0 1 0 0.645 0.984 1.000 292 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B4GALT3(1), CHST4(2), ST3GAL3(1) 695896 4 4 4 7 3 0 0 0 1 0 0.952 0.984 1.000 293 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO2(1), HAO1(1), HAO2(3) 717924 5 4 5 4 3 1 0 0 1 0 0.821 0.985 1.000 294 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT4(2), GALNT6(2), GALNT8(1), GCNT1(1), WBSCR17(2) 812003 8 6 8 4 6 0 1 0 1 0 0.532 0.985 1.000 295 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BIRC3(1), CASP7(1), CASP8(1), MAP3K1(1), MAP3K14(1), MAPK10(1), MDM2(1), MYC(1), PARP1(2), PRF1(2), RELA(1), TNFSF10(1), TP53(4), TRAF2(1) 2090059 19 17 19 7 9 4 0 3 3 0 0.286 0.985 1.000 296 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT3(1), B4GALT5(1), DDOST(1), MAN1A1(2), MGAT2(1), MGAT5(1) 1118698 7 7 7 5 3 1 1 0 2 0 0.764 0.985 1.000 297 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), DAXX(1), HRAS(1), MAP3K1(1), MAP3K5(2), MAP3K9(2), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), SHC1(2), TRAF2(1) 2040314 15 11 15 4 8 2 1 2 2 0 0.201 0.986 1.000 298 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 EIF4E(1), IL1R1(1), WDR1(1) 597799 3 3 3 2 3 0 0 0 0 0 0.732 0.987 1.000 299 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(1), PDHA2(2), SLC18A3(1) 386030 4 4 4 3 4 0 0 0 0 0 0.744 0.987 1.000 300 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1) 556106 2 2 2 1 2 0 0 0 0 0 0.603 0.988 1.000 301 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO2(1), AFMID(1), HAO1(1), HAO2(3) 751964 6 4 6 4 4 1 0 0 1 0 0.725 0.988 1.000 302 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 CYP11A1(2), EDN1(1), EDNRA(1), EDNRB(1), PTGFR(2), PTGIR(1), PTGS2(1), TBXAS1(3) 1151998 12 9 12 6 8 1 0 1 2 0 0.514 0.989 1.000 303 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(1), CR2(1), HLA-DRB1(1), ICAM1(1), ITGB2(1), PTPRC(3) 844066 9 5 9 2 9 0 0 0 0 0 0.193 0.989 1.000 304 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 DAXX(1), HRAS(1), IKBKB(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP3K9(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK4(3), MAPK8(1), MAPK9(2), MAPKAPK3(1), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), RELA(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), SHC1(2), TRAF2(1) 5213519 40 24 38 7 27 4 3 3 3 0 0.00195 0.989 1.000 305 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(2), F2R(1), FGA(4), FGG(1), PLAT(1), PLG(3), SERPINB2(3) 749356 15 13 15 8 10 2 0 2 1 0 0.663 0.990 1.000 306 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(1), CDC25B(2), CDC25C(1), MYT1(2), WEE1(1) 775335 7 6 7 6 2 1 1 2 1 0 0.958 0.990 1.000 307 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(3), HDAC3(1), IKBKB(1), RELA(1), TRAF6(1) 1247786 7 6 7 3 5 0 0 1 1 0 0.647 0.990 1.000 308 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(1), CASP1(1), CASP10(1), CASP8(1), PRF1(2) 724299 6 5 6 4 5 0 0 0 1 0 0.728 0.990 1.000 309 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), CYP2A6(1), NAT2(1), XDH(6) 449615 11 9 11 7 9 1 0 1 0 0 0.424 0.991 1.000 310 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1) 779335 11 8 11 6 6 3 1 0 1 0 0.624 0.991 1.000 311 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA5(1), UBE3A(1) 726853 3 3 3 3 2 0 0 0 1 0 0.928 0.991 1.000 312 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), EHHADH(1), LDHA(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1) 1862067 17 11 17 5 13 1 0 1 2 0 0.193 0.991 1.000 313 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASS(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), PLOD2(1), PLOD3(1), SHMT2(1), TMLHE(1) 2070062 17 14 17 5 13 3 0 0 1 0 0.103 0.991 1.000 314 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(3), AXIN1(1), BMP10(2), BMP2(2), BMP5(2), BMPR2(1), CTNNB1(2), GATA4(1), MEF2C(1), NKX2-5(1), RFC1(2) 2033868 20 9 20 4 13 1 1 3 2 0 0.0719 0.991 1.000 315 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), PGK1(1) 515025 2 2 2 2 1 0 0 1 0 0 0.843 0.991 1.000 316 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3) 894613 7 6 7 4 5 0 0 1 1 0 0.563 0.992 1.000 317 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(3), BCAR1(1), CTNNA2(4), CTNNB1(2) 1062487 10 7 10 6 7 0 1 0 2 0 0.513 0.992 1.000 318 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1) 846277 3 2 3 2 1 1 0 0 1 0 0.792 0.993 1.000 319 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1) 846277 3 2 3 2 1 1 0 0 1 0 0.792 0.993 1.000 320 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1) 846277 3 2 3 2 1 1 0 0 1 0 0.792 0.993 1.000 321 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHPF(1), DSE(1), XYLT1(3) 756015 6 5 6 4 3 2 0 1 0 0 0.612 0.993 1.000 322 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(3), DAXX(1), HRAS(1), PAX3(1), SP100(2), TP53(4) 1057508 12 8 12 6 6 2 1 1 2 0 0.555 0.994 1.000 323 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 PTPRU(1), REG1A(1), TYK2(1) 702606 3 3 3 3 1 1 0 0 1 0 0.840 0.994 1.000 324 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PYGL(2) 741966 5 4 5 5 4 0 0 0 1 0 0.856 0.994 1.000 325 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(1), ACO2(1), IDH1(3) 749348 5 5 4 3 3 1 0 1 0 0 0.686 0.995 1.000 326 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(1), AGPS(2), ENPP2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3) 1306635 17 11 17 9 11 0 1 3 2 0 0.597 0.995 1.000 327 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA5(1) 903807 2 2 2 0 1 0 0 0 1 0 0.520 0.995 1.000 328 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2I(1), UBE3A(1) 593128 2 1 2 2 2 0 0 0 0 0 0.923 0.995 1.000 329 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(4), PIGA(1), PIGN(1), PIGO(1), PIGU(1) 1341384 8 8 8 6 4 1 0 1 2 0 0.813 0.996 1.000 330 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(1), CHRM2(1), CHRM3(3), DRD1(3), DRD2(2), DRD3(1), DRD5(1), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1) 1418344 26 17 26 14 12 10 1 0 3 0 0.153 0.996 1.000 331 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1) 900546 3 2 3 2 1 1 0 0 1 0 0.789 0.996 1.000 332 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2) 2938856 31 16 31 6 18 5 1 4 3 0 0.00566 0.996 1.000 333 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2) 2938856 31 16 31 6 18 5 1 4 3 0 0.00566 0.996 1.000 334 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), DAXX(1), MAPKAPK3(1) 638975 3 2 3 2 3 0 0 0 0 0 0.689 0.996 1.000 335 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(3), GNPDA2(1), HEXA(2), HK3(2), PGM3(3) 949220 12 9 12 6 7 2 1 1 1 0 0.471 0.996 1.000 336 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), PPP1CA(1) 1016146 5 5 5 2 4 0 1 0 0 0 0.557 0.997 1.000 337 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(2), FYN(1), L1CAM(1), LYN(1), SELP(1) 886792 9 7 9 6 6 1 0 1 1 0 0.774 0.997 1.000 338 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(1), BLNK(2), BTK(2), CD22(4), CR2(1), DAG1(1), INPP5D(6), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), PTPRC(3), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2) 4148905 48 21 48 12 30 2 3 10 3 0 0.00995 0.997 1.000 339 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 EDN1(1), EPO(1), LDHA(1), NOS3(1), P4HB(1) 958170 5 3 5 3 3 1 0 0 1 0 0.850 0.998 1.000 340 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(1), HRAS(1), MAP2K1(3), PLCB1(4), PRKCA(1), SYK(2), TBXAS1(3) 1363711 15 13 13 6 12 0 1 1 1 0 0.341 0.998 1.000 341 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(1), DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1), VNN1(1) 966873 13 10 13 7 8 3 1 0 1 0 0.565 0.998 1.000 342 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(1), CCR3(1), CCR4(1), CXCR3(1), CXCR4(1), IL12B(1), IL12RB1(2), IL4R(1) 1120301 10 9 10 7 8 1 0 0 1 0 0.555 0.998 1.000 343 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), PGK2(3), RPIA(1), TKTL1(1), TKTL2(5) 1134029 17 9 17 8 11 1 0 4 1 0 0.355 0.998 1.000 344 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(3), ITGB3(1), SPTAN1(1), TLN1(2) 1582936 8 8 8 6 5 0 0 0 3 0 0.753 0.998 1.000 345 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 EGFR(1), ERBB4(3), ETS1(1), ETS2(1), ETV6(2), FMN2(3), MAP2K1(3), NOTCH2(4), NOTCH4(3), PIWIL1(1), PIWIL2(2), PIWIL4(2), SOS1(1), SOS2(2) 2853642 29 17 27 9 15 1 1 7 5 0 0.236 0.998 1.000 346 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 ARHGEF11(2), CDC42(1), DLG4(2), LPA(6), MAP3K1(1), MAP3K5(2), MAPK8(1), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2), ROCK2(1), SERPINA4(2) 2748740 27 17 26 9 15 1 1 6 4 0 0.230 0.998 1.000 347 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CLOCK(1), ETV6(2), HERPUD1(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER2(2), PSMA4(1), TOB1(1), UGP2(1), ZFR(1) 2047961 14 10 14 6 7 1 2 0 4 0 0.451 0.998 1.000 348 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(1), G6PD(1), GGT1(1), GPX5(1), GPX6(1), GSR(1), IDH1(3), OPLAH(2) 1229750 11 10 10 5 10 0 1 0 0 0 0.297 0.998 1.000 349 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), LDHA(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2) 2075753 15 12 15 6 10 2 0 1 2 0 0.354 0.998 1.000 350 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(4), COPA(1), GPLD1(4), KDELR3(1) 917297 10 8 10 8 7 0 1 1 1 0 0.821 0.998 1.000 351 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 TPO(5) 542072 5 3 4 4 5 0 0 0 0 0 0.712 0.998 1.000 352 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), TYK2(1) 587082 2 2 2 2 1 1 0 0 0 0 0.870 0.998 1.000 353 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), TYK2(1) 587082 2 2 2 2 1 1 0 0 0 0 0.870 0.998 1.000 354 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 DAG1(1), DRD2(2), EGFR(1), EPHB2(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), SHC1(2), SOS1(1), SOS2(2), STAT3(1), TERF2IP(1) 3194919 48 20 47 16 23 5 5 12 3 0 0.0874 0.998 1.000 355 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ACY1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), ARG1(1), ASS1(1), CPS1(1), MAOA(1), SMS(1) 1640757 14 12 14 6 8 2 1 1 2 0 0.370 0.998 1.000 356 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACB(4), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), EHHADH(1), LDHA(1), LDHAL6A(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1) 2229712 21 12 21 5 15 2 0 3 1 0 0.0788 0.999 1.000 357 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(1), POLG(1), POLQ(2) 936648 4 3 4 3 2 0 0 1 1 0 0.895 0.999 1.000 358 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), RPIA(1) 1013636 8 6 8 6 5 0 0 2 1 0 0.721 0.999 1.000 359 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), MAPK8(1), RELA(1), TRAF6(1) 620140 4 4 4 3 4 0 0 0 0 0 0.829 0.999 1.000 360 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(1), GGT1(1), HEMK1(1), MAT2B(1), METTL2B(1), METTL6(1) 1404737 6 6 6 3 4 0 0 2 0 0 0.597 0.999 1.000 361 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AMDHD1(1), AOC2(1), CNDP1(1), FTCD(1), HDC(3), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), PRPS2(1), UROC1(2) 2215490 21 13 21 5 15 2 0 3 1 0 0.0307 0.999 1.000 362 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 BRD4(1), CBL(3), CDC42(1), CDKN2A(1), IRS1(1), PARD3(2), PARD6A(1), PIK3CA(1), PIK3R1(4), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2) 3303452 24 15 24 9 6 2 4 7 5 0 0.503 0.999 1.000 363 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 GNAQ(2), MAP3K1(1), MYC(1), PRKAR1A(1), RELA(1), SYT1(1), VIP(1) 1564867 8 8 8 6 2 1 0 3 2 0 0.930 0.999 1.000 364 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1) 1183869 8 8 8 4 4 2 0 1 1 0 0.569 0.999 1.000 365 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), NCOA1(1) 1041758 4 4 4 2 3 0 0 1 0 0 0.790 0.999 1.000 366 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IKBKB(1), IL1B(1), IL1R1(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF6(1) 1654462 11 8 11 4 7 2 1 0 1 0 0.348 0.999 1.000 367 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GUSB(1), HEXA(2), LCT(3) 803420 6 3 6 4 6 0 0 0 0 0 0.656 0.999 1.000 368 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1) 742311 13 10 13 6 11 1 0 1 0 0 0.344 0.999 1.000 369 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC2A3(1) 1400270 27 15 27 6 22 3 1 1 0 0 0.266 0.999 1.000 370 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG13(1), ALG6(1), B4GALT3(1), DDOST(1), DOLPP1(1), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), STT3B(2) 2376182 15 9 15 8 7 2 1 1 4 0 0.549 0.999 1.000 371 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), LMNA(1), PRF1(2) 1094306 8 8 8 6 6 1 0 0 1 0 0.742 0.999 1.000 372 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(1), SHMT2(1), TPO(5) 662664 7 4 6 3 6 1 0 0 0 0 0.332 1.000 1.000 373 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB11(1), ABCB4(2), ABCC3(3) 799655 12 10 12 8 11 0 0 1 0 0 0.476 1.000 1.000 374 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(1), ATR(5), BRCA2(2), FANCD2(1), MRE11A(1), RAD51(1), RAD9A(1), TP53(4) 2477961 16 12 16 7 7 1 2 2 4 0 0.594 1.000 1.000 375 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), CREB5(2), DAG1(1), EPHB2(2), GNAQ(2), ITPKA(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2) 1596584 19 13 19 9 13 1 0 3 2 0 0.551 1.000 1.000 376 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(1), BIN1(1), SYNJ1(3), SYNJ2(1), SYT1(1) 1204938 7 5 7 4 6 1 0 0 0 0 0.625 1.000 1.000 377 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 ATM(1), CASP7(1), PRKCA(1), TLN1(2), TP53(4) 1535116 9 8 9 6 5 1 1 0 2 0 0.697 1.000 1.000 378 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ADSL(1), ASNS(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1) 1463863 15 9 15 5 11 1 0 3 0 0 0.194 1.000 1.000 379 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(3), CYP11B1(3), CYP11B2(1), CYP19A1(2), HEMK1(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1), METTL2B(1), METTL6(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4) 2794747 55 22 55 17 40 5 2 4 4 0 0.00945 1.000 1.000 380 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CDS1(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPP5D(6), ITGB1BP3(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PRKCA(1), PRKCG(1), SYNJ1(3), SYNJ2(1) 6906787 95 28 94 28 53 9 6 17 10 0 0.00172 1.000 1.000 381 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(1), EGF(1), EGFR(1), ETS1(1), ETS2(1), HRAS(1), IKBKB(1), MAP2K1(3), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK13(1), MAPK8(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), RELA(1), TRAF2(1) 2742452 25 17 23 9 16 4 3 0 2 0 0.153 1.000 1.000 382 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SMPD2(1), UGCG(1) 1347112 12 9 12 8 8 0 0 3 1 0 0.780 1.000 1.000 383 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH3A1(2), AOC2(1), GOT2(2), MAOA(1), TPO(5) 1229144 13 6 12 7 12 0 0 0 1 0 0.305 1.000 1.000 384 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1R1(1), IRAK1(1), MAP3K1(1), MAP3K14(1), RELA(1), TLR4(3), TRAF6(1) 1349719 10 6 10 4 6 4 0 0 0 0 0.419 1.000 1.000 385 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPS4Y1(1), RPS5(1), RPSA(1) 1264619 4 3 4 3 1 1 1 0 1 0 0.793 1.000 1.000 386 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), HDAC3(1), NCOA1(1), NCOA3(3), NCOR2(2), POLR2A(1) 1392567 9 6 9 5 6 1 0 1 1 0 0.624 1.000 1.000 387 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), ZNRD1(1) 1318974 6 6 6 4 3 0 1 1 1 0 0.797 1.000 1.000 388 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), GCK(3), GMPPA(1), HK3(2), PFKM(1) 1335688 8 6 8 8 5 2 0 0 1 0 0.777 1.000 1.000 389 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(2), CMAS(1), GNPDA2(1), HEXA(2), HK3(2), MTMR2(1), PGM3(3) 1605454 12 9 12 6 9 0 1 1 1 0 0.479 1.000 1.000 390 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(2), EPHB2(2), F2RL1(1), MAPK8(1), PLD1(1), PLD2(2), VAV1(2) 1534752 13 12 13 8 9 0 1 2 1 0 0.717 1.000 1.000 391 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACB(4), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), LDHA(1), LDHAL6A(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2) 2624694 19 13 19 7 12 3 0 3 1 0 0.259 1.000 1.000 392 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(1), AGTR1(1), AGTR2(3), CMA1(1), COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3) 1414968 31 14 31 7 28 2 1 0 0 0 0.320 1.000 1.000 393 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 APC(3), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(2), DACT1(1), DKK2(3), LRP1(9), MVP(1), NKD2(1), SENP2(1), TSHB(1), WIF1(1) 2246687 27 12 27 10 14 1 5 7 0 0 0.319 1.000 1.000 394 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), CDC42(1), CREB5(2), EEF2K(2), EIF4E(1), IL1R1(1), MAP2K3(2), MAP3K5(2), MAPK12(1), MAPK13(1), TRAF6(1) 1863991 15 9 15 5 12 0 1 1 1 0 0.229 1.000 1.000 395 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(2), AOC2(1), DDHD1(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2) 1421697 11 6 11 5 6 0 2 2 1 0 0.607 1.000 1.000 396 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BIRC3(1), CASP10(1), CASP7(1), CASP8(1), GAS2(1), LMNA(1), MAP3K14(1), RELA(1), SPTAN1(1), TNFRSF10B(1), TNFSF10(1), TRAF2(1) 1873046 12 11 12 6 8 3 0 0 1 0 0.524 1.000 1.000 397 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CREBBP(3), ERCC3(1), GRIP1(1), HDAC3(1), HDAC5(1), MEF2C(1), NCOR2(2), NRIP1(1), PELP1(2), POLR2A(1) 2558648 14 10 14 7 9 0 0 2 3 0 0.635 1.000 1.000 398 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(3), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K14(1), RELA(1), TLR2(2) 1663571 11 9 11 6 6 1 1 2 1 0 0.758 1.000 1.000 399 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF2K(2), EIF2AK1(1), EIF2AK2(1), EIF2AK3(2), EIF2B2(1), EIF4A2(1), EIF4E(1), EIF4G1(1), EIF5(1), PABPC3(1) 2448944 12 9 12 6 7 0 2 1 2 0 0.687 1.000 1.000 400 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BTRC(1), CSNK1A1(1), CSNK1A1L(1), GLI1(2), GLI2(2), GLI3(2), HHIP(2), IHH(2), LRP2(7), PRKACA(1), PRKX(1), PTCH1(2), PTCH2(2), SHH(1), SMO(1), STK36(1), SUFU(1), WNT2B(1), WNT3(1), WNT7A(1) 3385564 39 16 39 11 27 2 3 4 3 0 0.0275 1.000 1.000 401 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP8(1), LMNA(1), MADD(1), MAP3K1(1), MAPK8(1), PRKDC(2), SPTAN1(1), TRAF2(1) 2181575 10 10 10 7 6 2 0 0 2 0 0.805 1.000 1.000 402 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL2(2), ARAF(1), BTC(2), CAMK2B(3), CAMK2G(1), CBL(3), CBLB(3), CBLC(1), CRK(1), EGF(1), EGFR(1), ERBB3(1), ERBB4(3), EREG(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), MYC(1), NCK2(2), NRG1(3), NRG3(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), STAT5A(1), TGFA(1) 5646882 66 24 63 17 37 4 4 14 7 0 0.0113 1.000 1.000 403 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(3), BCAR1(1), BCR(1), CAV1(1), FYN(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), SHC1(2), SOS1(1), TLN1(2), ZYX(1) 2621343 20 13 18 9 13 0 2 2 3 0 0.346 1.000 1.000 404 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), ATP7B(2), COX10(1), NDUFB2(1), SDHA(2) 2150830 10 9 10 5 6 1 1 1 1 0 0.554 1.000 1.000 405 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAPK8(1), PRKDC(2), PTPN13(1), RIPK2(1), SPTAN1(1) 2295244 12 11 12 7 8 2 0 0 2 0 0.722 1.000 1.000 406 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CXCR3(1), EGF(1), EGFR(1), HRAS(1), MYLK(2), PRKAR1A(1), TLN1(2) 1821661 10 9 10 9 7 0 2 0 1 0 0.908 1.000 1.000 407 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ADSL(1), ASNS(1), ASS1(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1), PDHA2(2) 2123837 19 12 19 7 15 1 0 3 0 0 0.199 1.000 1.000 408 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 BTK(2), FCER1A(2), FYN(1), HRAS(1), INPP5D(6), LCP2(1), LYN(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PRKCA(1), SOS1(1), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1) 4021888 55 23 52 17 34 1 2 10 8 0 0.0337 1.000 1.000 409 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 BLNK(2), BTK(2), CARD11(3), CD22(4), CR2(1), HRAS(1), IKBKB(1), INPP5D(6), LYN(1), MALT1(1), NFAT5(1), NFKB2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), RASGRP3(2), SYK(2), VAV1(2), VAV2(1), VAV3(1) 4149233 46 22 45 15 29 1 1 8 7 0 0.0678 1.000 1.000 410 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), GNAQ(2), GNAS(3), HRAS(1), MAP2K1(3), PRKAR1A(1), PRKCA(1), SYT1(1) 1951103 15 13 12 9 12 0 0 2 1 0 0.710 1.000 1.000 411 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 BCR(1), BTK(2), CDKN2A(1), DAPP1(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PPP1R13B(2), PTPRC(3), RPS6KA1(3), RPS6KA2(1), SYK(2), VAV1(2) 3047771 31 20 31 10 19 2 4 5 1 0 0.0720 1.000 1.000 412 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH3A1(2), AOC2(1), ESCO1(1), ESCO2(1), GOT2(2), MAOA(1), MYST3(1), MYST4(2), TPO(5) 1918885 18 9 17 8 14 0 2 1 1 0 0.325 1.000 1.000 413 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ASS1(1), CPS1(1), EPRS(2), GOT2(2), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), PYCR1(1), PYCR2(1), RARS(1) 2011395 20 13 20 9 16 2 1 1 0 0 0.301 1.000 1.000 414 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2) 1863850 16 8 16 6 12 1 0 3 0 0 0.287 1.000 1.000 415 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(1), GTF2H4(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3E(1), POLR3H(1), TAF6(1) 1970625 8 6 8 7 4 1 1 1 1 0 0.905 1.000 1.000 416 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP4A(2), ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), COX10(1), COX6B2(1), NDUFA13(1), NDUFB2(1), SDHA(2), SDHC(1), UQCRC2(1) 3140466 15 13 15 6 10 1 2 1 1 0 0.321 1.000 1.000 417 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), ESR2(2), ESRRA(1), HNF4A(1), NR1D2(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(1), PPARA(1), ROR1(3), RORC(1), THRA(2), THRB(3), VDR(1) 2337608 22 12 22 8 14 3 1 2 2 0 0.135 1.000 1.000 418 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 ATM(1), ATR(5), BAI1(2), CASP8(1), CCNB3(2), CCNE2(2), CDK6(1), CDKN2A(1), GADD45G(1), GTSE1(2), LRDD(1), MDM2(1), RFWD2(1), RRM2B(1), SESN2(1), STEAP3(2), THBS1(3), TNFRSF10B(1), TP53(4), TP53I3(1), TSC2(1) 3594755 35 18 35 11 18 2 3 7 5 0 0.131 1.000 1.000 419 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), IKBKB(1), IRF3(1), IRF5(1), IRF6(4), MAP3K1(1), MAPK10(1), MDM2(1), MYC(1), PLEKHG5(3), PRF1(2), RELA(1), TNFRSF10B(1), TNFSF10(1), TP53(4), TRAF2(1) 3203347 29 20 29 11 20 4 0 2 3 0 0.173 1.000 1.000 420 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), AKAP1(1), AKAP11(5), AKAP3(5), AKAP6(4), AKAP9(4), GNAI3(1), GNAQ(2), GNB5(1), HRAS(1), ITPR1(7), KCNJ3(4), PDE1A(2), PDE1B(1), PDE1C(3), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), SLC9A1(1) 6529539 73 23 72 21 47 5 2 15 4 0 0.00609 1.000 1.000 421 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRA(1), COX10(1), CP(1), EPRS(2), FTMT(1), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4) 2353172 40 18 40 13 30 3 1 2 4 0 0.0504 1.000 1.000 422 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), GOT2(2), MAOA(1), TPO(5) 1773946 25 10 24 12 24 0 0 0 1 0 0.178 1.000 1.000 423 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 CASP1(1), CASP10(1), CASP7(1), CASP8(1), DAXX(1), IKBKE(3), NGFR(1), NTRK1(4), PTPN13(1), TRAF2(1), TRAF6(1) 2430045 16 10 16 7 13 2 0 1 0 0 0.397 1.000 1.000 424 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2), GSR(1) 2216812 17 9 17 8 13 1 0 3 0 0 0.441 1.000 1.000 425 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2H4(1), GTF2I(1), GTF2IRD1(1), STON1(1), TAF1L(6), TAF4(1), TAF4B(1), TAF6(1) 2027572 13 11 13 6 11 1 0 1 0 0 0.525 1.000 1.000 426 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), INPP4A(1), INPP4B(2), ISYNA1(1), ITGB1BP3(2), ITPKA(1), OCRL(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), SYNJ1(3), SYNJ2(1) 4094787 47 21 46 16 25 4 2 10 6 0 0.0632 1.000 1.000 427 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(1), BLNK(2), BTK(2), DAG1(1), EPHB2(2), ITPKA(1), LYN(1), MAP2K1(3), MAP2K2(1), NFAT5(1), NFKB2(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2) 2957715 34 21 32 13 23 1 2 4 4 0 0.197 1.000 1.000 428 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), ARG1(1), CPS1(1), GOT2(2), MAOA(1), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(1) 2473432 28 15 28 11 20 4 1 0 3 0 0.138 1.000 1.000 429 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PRKCA(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2) 2142801 20 13 18 9 16 1 1 2 0 0 0.419 1.000 1.000 430 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 DDIT4(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKAA2(2), RHEB(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), STK11(1), TSC2(1), ULK1(1), ULK2(1), VEGFA(2) 2877132 27 16 26 10 11 1 3 5 7 0 0.378 1.000 1.000 431 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(3), DAG1(1), DLG4(2), EPHB2(2), GNAQ(2), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), RYR1(6) 2563659 34 17 34 17 23 1 1 7 2 0 0.337 1.000 1.000 432 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1) 2499672 35 16 34 16 16 3 3 7 6 0 0.406 1.000 1.000 433 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 ENPP1(2), ENPP3(1), G6PC(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), PGM3(3), PYGL(2), SI(10), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5) 3179420 55 21 55 20 37 5 3 4 6 0 0.0670 1.000 1.000 434 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACB(4), ARAF(1), CBL(3), CBLB(3), CBLC(1), CRK(1), G6PC(2), G6PC2(3), GCK(3), GYS2(2), HRAS(1), IKBKB(1), INPP5D(6), INSR(2), IRS1(1), LIPE(1), MAP2K1(3), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), PDE3A(3), PFKM(1), PHKA1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PRKAA2(2), PRKACA(1), PRKAG2(2), PRKAR1A(1), PRKCZ(1), PRKX(1), PTPRF(1), PYGL(2), RHEB(1), SH2B2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), TSC2(1) 8722705 86 22 83 24 50 5 2 14 14 1 0.00193 1.000 1.000 435 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), EHHADH(1), PECI(1) 2755449 36 16 36 14 31 1 1 3 0 0 0.0919 1.000 1.000 436 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(2), AFMID(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP1A2(2), EHHADH(1), HEMK1(1), INMT(2), LNX1(2), MAOA(1), METTL2B(1), METTL6(1), NFX1(1), OGDHL(5), TPH1(4), TPH2(4) 3389043 39 16 38 15 30 3 0 4 2 0 0.0810 1.000 1.000 437 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(1), CD1B(1), CD1E(3), CD22(4), CD33(1), CD44(1), CD5(1), CD8B(1), CR1(1), CR2(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF3(1), CSF3R(2), DNTT(1), EPO(1), GYPA(1), HLA-DRB1(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGB3(1), KIT(1), KITLG(1), MME(2), MS4A1(1), TFRC(1), THPO(1), TPO(5) 4556914 66 19 65 25 43 4 5 7 7 0 0.0866 1.000 1.000 438 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), DRD1(3), DRD2(2), EGF(1), EGFR(1), GJA1(1), GJD2(2), GNAI3(1), GNAQ(2), GNAS(3), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), NPR1(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), PRKX(1), SOS1(1), SOS2(2), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2) 7360448 109 27 105 31 70 11 8 15 5 0 6.21e-05 1.000 1.000 439 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), AMHR2(1), BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BMPR1B(1), BMPR2(1), CREBBP(3), CUL1(2), GDF5(1), INHBA(3), INHBB(1), LEFTY1(1), LTBP1(2), MYC(1), PPP2R2B(1), RBL1(1), RBL2(2), ROCK2(1), SMAD1(1), SMAD7(1), TFDP1(1), THBS1(3), THBS2(1), THBS3(1) 5554505 38 20 38 12 23 3 2 6 4 0 0.117 1.000 1.000 440 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 CARD11(3), CBL(3), CBLB(3), CBLC(1), CD8B(1), CDC42(1), FYN(1), GRAP2(1), HRAS(1), IKBKB(1), ITK(1), LCK(2), LCP2(1), MALT1(1), MAP3K14(1), NCK2(2), NFAT5(1), NFKB2(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKCQ(2), PTPRC(3), RASGRP1(2), SOS1(1), SOS2(2), VAV1(2), VAV2(1), VAV3(1) 5659862 57 21 56 21 30 4 3 10 10 0 0.158 1.000 1.000 441 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), NSD1(1), OGDHL(5), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(1), SHMT2(1), SUV39H2(1), TMLHE(1) 3249561 25 15 25 11 18 5 0 2 0 0 0.278 1.000 1.000 442 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AGPAT6(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CEL(2), DGAT2(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), GK2(3), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3) 3296320 42 20 42 20 32 5 1 3 1 0 0.201 1.000 1.000 443 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), ESCO1(1), ESCO2(1), GOT2(2), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), MYST3(1), MYST4(2), TPO(5) 3328573 33 13 32 14 28 0 2 2 1 0 0.180 1.000 1.000 444 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(3), DLL1(2), DLL3(1), DLL4(1), DTX1(1), DTX3(2), JAG1(2), JAG2(1), MAML3(2), MFNG(1), NCOR2(2), NOTCH2(4), NOTCH4(3), NUMB(2), NUMBL(1), PSENEN(1) 3851023 29 14 29 12 19 3 0 6 1 0 0.349 1.000 1.000 445 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ANAPC1(1), ANAPC2(1), ANAPC5(1), ATM(1), ATR(5), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC16(1), CDC25B(2), CDC25C(1), CDC27(1), CDC7(1), CDK6(1), CDKN2A(1), CREBBP(3), CUL1(2), E2F1(2), E2F3(1), FZR1(1), GADD45G(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), PRKDC(2), RBL1(1), RBL2(2), SMC1B(1), TFDP1(1), TP53(4), WEE1(1) 7645431 57 26 56 18 23 3 8 14 9 0 0.203 1.000 1.000 446 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 BDNF(2), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CACNA2D1(4), CACNA2D2(1), CACNA2D3(4), CACNA2D4(1), CACNB2(1), CACNG3(1), CACNG5(2), CACNG6(1), CACNG7(1), CDC25B(2), CDC42(1), CRK(1), DAXX(1), DUSP16(1), DUSP3(1), DUSP4(2), DUSP8(1), ECSIT(2), EGF(1), EGFR(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FLNB(5), FLNC(4), GADD45G(1), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(2), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MAPKAPK3(1), MAPT(2), MEF2C(1), MRAS(1), MYC(1), NF1(7), NFKB2(1), NLK(2), NR4A1(1), NTRK1(4), PDGFB(1), PDGFRA(5), PDGFRB(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(2), RAPGEF2(1), RASA2(1), RASGRF1(3), RASGRF2(1), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), RPS6KA6(1), SOS1(1), SOS2(2), TAOK1(1), TAOK2(2), TAOK3(1), TP53(4), TRAF2(1), TRAF6(1), ZAK(1) 15770441 179 33 175 93 108 18 10 25 18 0 0.303 1.000 1.000 447 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CRHR1(1), CRHR2(2), CYSLTR1(1), CYSLTR2(2), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GABBR1(1), GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GABRB2(1), GABRB3(2), GABRG1(1), GABRG2(1), GABRP(2), GABRQ(4), GABRR1(1), GALR2(1), GHR(5), GHSR(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(3), GPR50(3), GPR83(1), GRIA1(7), GRIA2(4), GRIA4(1), GRID1(2), GRID2(1), GRIK1(1), GRIK2(1), GRIK3(2), GRIK4(2), GRIK5(2), GRIN2A(5), GRIN2B(3), GRIN3A(2), GRIN3B(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM6(3), GRM7(7), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LEPR(3), LHCGR(3), MAS1(1), MC5R(1), MCHR1(1), MCHR2(3), NMBR(2), NMUR2(1), NPBWR2(2), NPFFR2(1), NPY2R(2), NPY5R(2), OPRK1(2), P2RX1(1), P2RX2(1), P2RX3(1), P2RY10(1), P2RY14(1), P2RY8(2), PARD3(2), PRLHR(1), PRLR(1), PRSS1(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(4), RXFP2(2), SCTR(3), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TAAR5(1), TACR1(1), TACR2(1), TACR3(3), THRA(2), THRB(3), TRHR(2), TSHB(1), TSHR(3) 12186333 225 33 224 129 139 29 11 21 25 0 0.0285 1.000 1.000 448 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADRA1A(2), ADRA1B(1), ATP1B2(2), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1S(2), CAMK1(1), CAMK2B(3), CAMK2G(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(1), CHRM3(3), GJA1(1), GJB4(1), GNAI3(1), GNAQ(2), GNB5(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNB1(6), KCNJ3(4), KCNJ5(3), MIB1(1), PKIA(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A3(5) 10452721 144 32 142 72 94 14 6 19 11 0 0.0473 1.000 1.000 449 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(3), ADCY3(1), ADCY4(2), ADCY8(6), ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), ATP2B4(1), BDKRB2(1), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CYSLTR1(1), CYSLTR2(2), DRD1(3), EDNRA(1), EDNRB(1), EGFR(1), ERBB3(1), ERBB4(3), F2R(1), GNAQ(2), GNAS(3), GRIN2A(5), GRM1(1), GRM5(2), HRH1(4), HRH2(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), LHCGR(3), MYLK(2), MYLK2(3), NOS1(7), NOS3(1), P2RX1(1), P2RX2(1), P2RX3(1), PDE1A(2), PDE1B(1), PDE1C(3), PDGFRA(5), PDGFRB(2), PHKA1(4), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTGFR(2), PTK2B(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A2(2), SLC8A3(5), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TRPC1(1) 14975352 225 32 223 120 147 22 10 28 17 1 0.0342 1.000 1.000 450 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(3), DMD(3), MYBPC1(1), MYBPC2(2), MYBPC3(3), MYH7(4), MYH8(7), MYOM1(1), NEB(12), TNNI1(1), TNNI2(1), TTN(132) 7537263 171 32 170 66 126 9 5 20 11 0 0.0192 1.000 1.000 451 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTN2(3), ARHGAP5(1), BCAR1(1), BIRC3(1), CAV1(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), CRK(1), CTNNB1(2), EGF(1), EGFR(1), FARP2(1), FLNB(5), FLNC(4), FN1(4), FYN(1), GRLF1(1), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), KDR(3), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), MAP2K1(3), MAPK10(1), MAPK8(1), MAPK9(2), MET(4), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PARVA(1), PARVG(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP1CA(1), PPP1R12A(1), PRKCA(1), PRKCG(1), RELN(6), ROCK2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), THBS1(3), THBS2(1), THBS3(1), TLN1(2), TLN2(2), TNR(6), TNXB(15), VAV1(2), VAV2(1), VAV3(1), VEGFA(2), VWF(2), ZYX(1) 20657408 249 30 245 101 174 15 12 28 20 0 0.0275 1.000 1.000 452 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 CHAD(1), COL11A1(7), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DSC1(5), DSC3(3), DSG1(5), DSG2(1), DSG3(5), DSG4(6), FN1(4), GJA1(1), GJA10(1), GJB4(1), GJC1(1), GJC2(1), GJC3(1), GJD2(2), GJD4(1), IBSP(1), INA(2), ITGB4(2), KRT10(1), KRT12(1), KRT15(2), KRT16(1), KRT17(1), KRT18(1), KRT2(1), KRT24(1), KRT28(1), KRT3(3), KRT31(3), KRT32(1), KRT35(1), KRT38(1), KRT39(1), KRT4(1), KRT5(3), KRT6A(1), KRT6B(2), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT78(1), KRT8(1), KRT82(1), KRT83(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), LMNA(1), RELN(6), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2) 13970829 209 29 208 103 156 16 5 15 17 0 0.330 1.000 1.000 453 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB2(1), C1QA(1), C1QB(2), C1QC(1), C1R(1), C1S(5), C2(2), C3(3), C3AR1(1), C4BPA(2), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), CFB(1), CFH(6), CFI(3), CR1(1), CR2(1), F10(2), F11(3), F13A1(2), F13B(1), F2R(1), F3(2), F5(7), F7(2), F8(4), FGA(4), FGG(1), KLKB1(2), KNG1(3), MASP1(1), MBL2(1), PLAT(1), PLG(3), PROC(1), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINF2(2), TFPI(2), VWF(2) 5063859 117 29 117 41 84 7 2 13 11 0 0.0191 1.000 1.000 454 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ACTN2(3), APC(3), ARAF(1), ARHGEF12(1), ARHGEF4(2), ARHGEF7(1), ARPC1A(1), BAIAP2(2), BCAR1(1), BDKRB2(1), CDC42(1), CHRM2(1), CHRM3(3), CRK(1), CYFIP2(1), DIAPH3(1), EGF(1), EGFR(1), F2R(1), FGD1(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FN1(4), GRLF1(1), HRAS(1), IQGAP2(2), IQGAP3(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K1(3), MAP2K2(1), MRAS(1), MYLK(2), MYLK2(3), NCKAP1(2), NCKAP1L(3), PAK3(2), PAK7(1), PDGFB(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PPP1CA(1), PPP1R12A(1), ROCK2(1), SCIN(1), SLC9A1(1), SOS1(1), SOS2(2), SSH2(1), TIAM1(2), TIAM2(2), VAV1(2), VAV2(1), VAV3(1), WASF1(1), WASF2(1) 15317916 133 29 130 85 86 4 6 23 14 0 0.832 1.000 1.000 455 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTN2(3), ASH1L(2), CASK(1), CDC42(1), CGN(1), CLDN11(1), CLDN17(1), CLDN6(1), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CTTN(1), EPB41L1(1), EPB41L2(2), GNAI3(1), HCLS1(5), HRAS(1), IGSF5(1), INADL(3), LLGL2(2), MAGI1(2), MAGI2(7), MPDZ(1), MRAS(1), MYH1(11), MYH11(2), MYH13(3), MYH15(3), MYH2(9), MYH4(6), MYH7(4), MYH8(7), PARD3(2), PARD6A(1), PARD6B(1), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), SPTAN1(1), SYMPK(1), TJP2(1), TJP3(3), ZAK(1) 10776347 111 28 111 73 78 17 1 9 6 0 0.619 1.000 1.000 456 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(3), ADCY8(6), ARAF(1), CACNA1C(3), CAMK2B(3), CAMK2G(1), CAMK4(2), CREBBP(3), GNAQ(2), GRIA1(7), GRIA2(4), GRIN2A(5), GRIN2B(3), GRM1(1), GRM5(2), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP1CA(1), PPP1R12A(1), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), RAPGEF3(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1) 5432211 87 28 84 35 59 4 4 15 5 0 0.0336 1.000 1.000 457 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ATF1(1), ATP2A2(2), ATP2A3(2), CAMK2B(3), CAMK2G(1), CNN1(1), CORIN(5), CRHR1(1), DGKZ(1), ETS2(1), GABPB2(1), GJA1(1), GNAQ(2), GNB5(1), GUCY1A3(5), IL1B(1), ITPR1(7), ITPR2(1), ITPR3(3), MIB1(1), MYLK2(3), NOS1(7), NOS3(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), TNXB(15) 9733860 127 28 125 57 85 12 6 15 9 0 0.0289 1.000 1.000 458 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(2), AMHR2(1), BMP2(2), BMPR1B(1), BMPR2(1), CCL13(1), CCL23(1), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), CXCL9(1), CXCR3(1), CXCR4(1), EDA2R(1), EGF(1), EGFR(1), EPO(1), FLT4(4), GDF5(1), GHR(5), HGF(1), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL17A(1), IL17RA(2), IL18RAP(3), IL19(1), IL1B(1), IL1R1(1), IL1R2(2), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), INHBA(3), INHBB(1), KDR(3), KIT(1), KITLG(1), LEPR(3), MET(4), MPL(1), NGFR(1), OSM(3), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(5), PDGFRB(2), PRLR(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF8(3), TNFSF10(1), TNFSF14(4), TNFSF8(1), TPO(5), VEGFA(2) 9909965 133 27 132 71 90 10 7 12 14 0 0.282 1.000 1.000 459 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CCRL1(1), CHRM2(1), CHRM3(3), CMKLR1(1), CXCR3(1), CXCR4(1), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), GPR50(3), GPR83(1), GPR87(1), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LHCGR(3), MAS1(1), MC5R(1), NMBR(2), NMUR2(1), NPY2R(2), NPY5R(2), OPRK1(2), OR11A1(1), OR1C1(2), OR1F1(2), OR1Q1(1), OR5V1(1), OR7A5(1), P2RY10(1), P2RY14(1), PTGFR(2), PTGIR(1), RGR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), SUCNR1(1), TRHR(2) 6784654 104 26 104 88 61 19 3 9 12 0 0.614 1.000 1.000 460 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(3), AXIN1(1), AXIN2(1), BTRC(1), CAMK2B(3), CAMK2G(1), CER1(1), CHD8(2), CREBBP(3), CSNK1A1(1), CSNK1A1L(1), CSNK2B(1), CTNNB1(2), CUL1(2), DAAM2(1), DKK2(3), FZD4(1), FZD8(2), LRP5(1), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(2), MMP7(2), MYC(1), NFAT5(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PORCN(1), PPP2R2B(1), PPP3R2(2), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), ROCK2(1), SENP2(1), SFRP2(1), TCF7(1), TP53(4), VANGL2(1), WIF1(1), WNT2B(1), WNT3(1), WNT7A(1) 9006767 81 26 81 39 40 6 7 19 9 0 0.524 1.000 1.000 461 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), CD244(1), CD48(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-G(1), HRAS(1), ICAM1(1), IFNA16(1), IFNA21(2), IFNA6(1), ITGB2(1), KIR2DL4(1), KIR3DL1(1), KLRC1(1), LCK(2), LCP2(1), MAP2K1(3), MAP2K2(1), MICA(1), MICB(1), NFAT5(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRF1(2), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), SYK(2), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TYROBP(1), VAV1(2), VAV2(1), VAV3(1) 6224536 63 26 60 25 37 5 3 9 9 0 0.109 1.000 1.000 462 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), BMPR2(1), BUB1(3), CDS1(2), COL4A3BP(1), CSNK2B(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), NEK1(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLK3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), STK11(1), VRK1(1) 6300021 74 26 73 32 39 7 5 12 11 0 0.260 1.000 1.000 463 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(2), CTCFL(3), DOT1L(3), EED(1), EHMT1(1), EZH1(1), EZH2(4), HCFC1(2), HSF4(2), JMJD6(1), KDM6A(1), MEN1(2), MLL(1), MLL2(7), MLL3(5), NSD1(1), PAXIP1(1), PPP1CA(1), PRDM9(5), PRMT1(1), SETD1A(1), SETD2(1), SETD7(1), SETDB2(1), SMYD3(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(1), WHSC1L1(1) 6635022 55 25 52 17 33 2 2 10 8 0 0.180 1.000 1.000 464 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABLIM1(1), ABLIM3(2), ARHGEF12(1), CDC42(1), CXCR4(1), DCC(5), DPYSL5(2), EFNB3(3), EPHA1(2), EPHA3(1), EPHA4(2), EPHA6(9), EPHA7(2), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(1), EPHB6(5), FES(2), FYN(1), GNAI3(1), HRAS(1), L1CAM(1), MET(4), NCK2(2), NFAT5(1), NGEF(1), NRP1(5), NTN4(1), NTNG1(1), PAK3(2), PAK7(1), PLXNA2(4), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3R2(2), RGS3(1), ROBO1(1), ROBO2(5), ROCK2(1), SEMA3A(2), SEMA3D(2), SEMA3E(3), SEMA3G(1), SEMA4A(2), SEMA4D(1), SEMA4G(1), SEMA5A(1), SEMA5B(1), SEMA6C(1), SEMA6D(1), SLIT1(2), SLIT2(5), SLIT3(8), SRGAP3(2), UNC5A(1), UNC5B(3), UNC5C(3), UNC5D(4) 10937759 130 25 129 72 89 12 8 10 11 0 0.427 1.000 1.000 465 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN2(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(3), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), EGFR(1), FARP2(1), FYN(1), IGF1R(1), INSR(2), LMO7(1), MET(4), NLK(2), PARD3(2), PTPRB(12), PTPRF(1), PTPRJ(4), PTPRM(1), PVRL2(1), TCF7(1), WASF1(1), WASF2(1) 6729754 57 25 57 22 33 2 3 12 7 0 0.237 1.000 1.000 466 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN2(3), ARHGAP5(1), BCAR1(1), CD99(1), CDC42(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CXCR4(1), GNAI3(1), GRLF1(1), ICAM1(1), ITGA4(2), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MMP9(1), NOX3(3), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), RAPGEF3(1), RAPGEF4(2), RASSF5(1), ROCK2(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2) 6930331 63 25 62 27 34 4 5 8 12 0 0.122 1.000 1.000 467 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(1), CACNA1A(4), CRHR1(1), GNAI3(1), GNAQ(2), GNAS(3), GRIA1(7), GRIA2(4), GRID2(1), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), IGF1R(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), MAP2K1(3), MAP2K2(1), NOS1(7), NOS3(1), NPR1(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), RYR1(6) 6039548 97 25 94 47 70 5 4 13 5 0 0.0923 1.000 1.000 468 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CAMK2B(3), CAMK2G(1), CREB3L1(2), CREB3L3(1), CREBBP(3), CTNNB1(2), EDN1(1), EDNRB(1), FZD4(1), FZD8(2), GNAI3(1), GNAQ(2), GNAS(3), HRAS(1), KIT(1), KITLG(1), MAP2K1(3), MAP2K2(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1) 6035699 64 25 61 30 45 6 5 7 1 0 0.141 1.000 1.000 469 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NPR1(2), PDE1A(2), PDE4C(2), PDE4D(1), PDE6B(2), PDE6C(4), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), PRPS1L1(1), PRPS2(1), PRUNE(1) 7170188 70 25 68 29 53 6 2 5 4 0 0.0459 1.000 1.000 470 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD44(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), HSPG2(2), IBSP(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), RELN(6), SDC1(1), SV2B(1), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2) 12558478 169 24 168 68 124 11 4 18 12 0 0.146 1.000 1.000 471 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM3(2), CD22(4), CD6(3), CD80(1), CD86(2), CD8B(1), CD99(1), CDH1(2), CDH15(1), CDH2(1), CDH4(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CNTN2(1), CNTNAP2(6), GLG1(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), ICAM1(1), ITGA4(2), ITGA9(1), ITGB2(1), L1CAM(1), MAG(1), MPZ(1), NCAM1(1), NCAM2(2), NEO1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(2), NRXN3(3), PTPRC(3), PTPRF(1), PTPRM(1), PVRL2(1), SDC1(1), SELE(2), SELP(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(7) 8212462 83 24 83 34 57 7 4 7 8 0 0.0553 1.000 1.000 472 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 CBL(3), CBLB(3), CBLC(1), CREBBP(3), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), EPO(1), GHR(5), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL19(1), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), IRF9(1), JAK3(1), LEPR(3), MPL(1), MYC(1), OSM(3), OSMR(5), PIAS2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIM1(1), PRLR(1), PTPN11(1), SOS1(1), SOS2(2), SPRY3(1), SPRY4(1), STAT3(1), STAT5A(1), STAT6(1), TPO(5), TYK2(1) 8151102 95 24 93 35 57 5 1 18 14 0 0.0666 1.000 1.000 473 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CACNA1C(3), CACNA1D(5), CACNA1F(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CDC42(1), EGFR(1), GNAQ(2), GNAS(3), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLD1(1), PLD2(2), PRKACA(1), PRKCA(1), PRKX(1), PTK2B(1), SOS1(1), SOS2(2) 7060041 90 24 86 34 55 6 7 17 5 0 0.0248 1.000 1.000 474 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(1), CAPN10(1), CAPN11(2), CAPN5(3), CAPN6(1), CAPN7(1), CAPN9(1), CAV1(1), CDC42(1), CRK(1), FYN(1), GIT2(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MYLK2(3), PAK3(2), ROCK2(1), SDCCAG8(2), SHC1(2), SHC3(1), SOS1(1), TLN1(2), VAV2(1), VAV3(1), ZYX(1) 7449437 74 24 72 34 50 1 5 11 7 0 0.178 1.000 1.000 475 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), LHCGR(3), MC5R(1), NMBR(2), NPY2R(2), NPY5R(2), OPRK1(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TSHR(3) 2934523 54 24 54 48 34 6 3 5 6 0 0.759 1.000 1.000 476 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1C1(1), AKR1C3(3), ALDH3A1(2), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4) 3199352 64 23 64 34 46 5 1 5 7 0 0.273 1.000 1.000 477 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NME6(1), NPR1(2), NT5C1B(2), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(3), PDE2A(1), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2B(1), XDH(6), ZNRD1(1) 9154208 88 22 86 40 65 9 3 5 6 0 0.0813 1.000 1.000 478 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), ENPP1(2), ENPP3(1), EP400(3), ERCC3(1), G6PC(2), G6PC2(3), GANC(1), GBA(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), MOV10L1(2), PGM3(3), PYGL(2), SI(10), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4) 6881704 86 22 86 36 56 8 3 6 13 0 0.132 1.000 1.000 479 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 CASP8(1), CD80(1), CD86(2), CXCL9(1), IFNA16(1), IFNA21(2), IFNA6(1), IKBKB(1), IKBKE(3), IL12B(1), IL1B(1), IRAK1(1), IRF3(1), IRF5(1), LBP(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), RELA(1), TLR1(1), TLR2(2), TLR3(1), TLR4(3), TLR5(1), TLR6(1), TLR7(1), TLR8(4), TRAF6(1) 5020124 60 22 57 26 37 4 4 8 7 0 0.169 1.000 1.000 480 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ANGPTL2(1), ARHGEF7(1), BCAR1(1), CAV1(1), CDC42(1), CDKN2A(1), CRK(1), EPHB2(2), FYN(1), GRB7(1), GRLF1(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(2), MYLK2(3), P4HB(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), ROCK2(1), SHC1(2), SOS1(1), SOS2(2), TERF2IP(1), TLN1(2), TLN2(2), ZYX(1) 6690089 65 22 64 32 37 1 4 15 8 0 0.501 1.000 1.000 481 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(2), F11(3), F13B(1), F5(7), F7(2), F8(4), FGA(4), FGG(1), LPA(6), PLAT(1), PLG(3), SERPINB2(3), SERPINF2(2), VWF(2) 1971658 41 21 41 18 28 3 1 5 4 0 0.392 1.000 1.000 482 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(1), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC25B(2), CDC25C(1), CDC7(1), CDH1(2), CDKN2A(1), E2F1(2), E2F3(1), HDAC3(1), HDAC5(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MPEG1(1), MPL(1), PRKDC(2), RBL1(1), TBC1D8(1), TFDP1(1), TP53(4), WEE1(1) 6156148 43 21 42 19 20 2 4 9 8 0 0.539 1.000 1.000 483 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), G6PC2(3), GAPDH(2), GCK(3), HK3(2), LDHA(1), LDHAL6A(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3), PGM3(3) 3259799 39 21 39 20 25 3 1 5 5 0 0.293 1.000 1.000 484 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA12(7), ABCA13(7), ABCA3(1), ABCA4(2), ABCA5(1), ABCA6(2), ABCA7(1), ABCA8(2), ABCA9(3), ABCB1(6), ABCB11(1), ABCB4(2), ABCB5(4), ABCC11(1), ABCC12(1), ABCC2(1), ABCC3(3), ABCC6(3), ABCC8(2), ABCC9(4), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG8(2), CFTR(2), TAP1(1) 6607080 65 21 65 42 48 4 2 6 5 0 0.481 1.000 1.000 485 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), F10(2), F11(3), F2R(1), F5(7), F8(4), FGA(4), FGG(1), KLKB1(2), PROC(1), SERPINC1(1) 2490503 50 21 50 17 37 3 2 4 4 0 0.508 1.000 1.000 486 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(1), BTK(2), CAD(3), CASP10(1), CASP8(1), CASP8AP2(2), CSNK1A1(1), DAXX(1), EGFR(1), EPHB2(2), MAP3K1(1), MAP3K5(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MET(4), NFAT5(1), NFKB2(1), PTPN13(1), TP53(4), TPX2(2), TRAF2(1), TUFM(1) 4063144 41 21 41 19 27 3 2 4 5 0 0.381 1.000 1.000 487 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(1), CCNA1(5), CCNE2(2), CDKN2A(1), CREB3L1(2), CREB3L3(1), E2F1(2), E2F3(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MYC(1), MYT1(2), POLA2(1), POLE(1), RBL1(1), TFDP1(1), TNXB(15), TP53(4), WEE1(1) 4399879 47 20 46 21 29 4 3 7 4 0 0.314 1.000 1.000 488 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), CEL(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3) 2705565 35 20 35 20 28 3 1 2 1 0 0.397 1.000 1.000 489 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), AQP7(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), CYP7A1(1), CYP8B1(1), EHHADH(1), FABP1(1), FABP5(1), FADS2(1), GK2(3), HMGCS2(1), ME1(1), MMP1(1), PPARA(1), SCP2(2), SLC27A2(2), SLC27A5(1), SLC27A6(2) 3677672 41 20 41 23 31 3 1 4 2 0 0.410 1.000 1.000 490 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AGT(1), CAMK1(1), CAMK1G(2), CAMK4(2), CREBBP(3), CSNK1A1(1), EDN1(1), GATA4(1), HRAS(1), MAP2K1(3), MAPK8(1), MEF2C(1), MYH2(9), NKX2-5(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), SYT1(1) 2847402 36 20 34 19 23 2 2 4 5 0 0.531 1.000 1.000 491 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 CDC42(1), CDKN2A(1), CREB5(2), ERBB4(3), IRS1(1), MET(4), MYC(1), PAK3(2), PAK7(1), PARD3(2), PARD6A(1), PIK3CA(1), PPP1R13B(2), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2), TSC2(1) 4291356 32 20 32 15 16 3 3 7 3 0 0.567 1.000 1.000 492 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(2), CAMK2B(3), CAMK4(2), CREBBP(3), CSNK2B(1), FCER1A(2), FCGR3A(1), GATA4(1), GRLF1(1), HRAS(1), IL1B(1), ITK(1), MAPK8(1), MAPK9(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(2), NFAT5(1), NFKB2(1), NUP214(2), PTPRC(3), RELA(1), TRAF2(1), TRPV6(2), VAV1(2), VAV2(1), VAV3(1) 5101653 44 19 44 19 33 4 0 6 1 0 0.241 1.000 1.000 493 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3) 2738319 33 19 33 19 22 3 1 2 5 0 0.412 1.000 1.000 494 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3) 2738319 33 19 33 19 22 3 1 2 5 0 0.412 1.000 1.000 495 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG13(1), ALG6(1), B4GALT3(1), B4GALT5(1), CHPF(1), CHST4(2), DDOST(1), EXTL3(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(2), NDST4(5), ST3GAL3(1), STT3B(2), WBSCR17(2), XYLT1(3) 6138607 58 19 58 36 37 7 4 2 8 0 0.567 1.000 1.000 496 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 CDC42(1), HRAS(1), KDR(3), MAP2K1(3), MAP2K2(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NOS3(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKCA(1), PRKCG(1), PTGS2(1), VEGFA(2) 4016999 40 19 37 20 25 0 2 7 6 0 0.450 1.000 1.000 497 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK3(2), COL2A1(1), CPSF1(1), CPSF3(1), CSTF2T(1), DHX9(1), DICER1(1), GIPC1(1), LOC440563(3), NONO(2), NXF1(1), POLR2A(1), PRPF4(1), PRPF8(2), RBM5(2), RNGTT(2), SF3A2(1), SF3B1(2), SFRS12(1), SFRS7(2), SNRPA1(1), SNRPN(1), SNURF(1), SRRM1(3), U2AF2(1) 5958269 36 19 36 21 24 2 1 5 4 0 0.911 1.000 1.000 498 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ANGPTL2(1), ARHGAP4(1), ARHGEF11(2), BTK(2), CDC42(1), ITPR1(7), ITPR2(1), ITPR3(3), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PIK3CA(1), PIK3CG(1), PIK3R1(4), PPP1R13B(2), ROCK2(1), WASF1(1) 3882776 36 19 36 19 23 1 2 6 4 0 0.472 1.000 1.000 499 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(3), CAMK2B(3), CAMK2G(1), FYN(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), MAPT(2), MYLK(2), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), SYT1(1) 2327703 27 18 24 14 21 2 1 2 1 0 0.376 1.000 1.000 500 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), FCER1A(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2) 2408946 24 18 22 11 14 1 2 4 3 0 0.547 1.000 1.000 501 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ALG6(1), CCKBR(2), CCR2(1), CCR3(1), CELSR2(1), CELSR3(2), CHRM2(1), CHRM3(3), CXCR3(1), EDNRA(1), EMR2(1), F2R(1), FSHR(4), GPR116(1), GPR133(1), GPR135(1), GPR18(1), GRM1(1), LGR6(1), LPHN2(4), LPHN3(1), OR2M4(1), OR8G2(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(3) 3726992 41 18 41 23 25 5 2 6 3 0 0.327 1.000 1.000 502 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT6(1), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), ESCO1(1), ESCO2(1), GPD1(1), GPD1L(1), MYST3(1), MYST4(2), PCYT1B(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3), PTDSS2(1) 3660070 39 18 39 20 24 3 4 6 2 0 0.545 1.000 1.000 503 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX15(1), ALOX15B(2), ALOX5(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP4A11(5), CYP4A22(2), CYP4F3(1), GGT1(1), GPX5(1), GPX6(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3) 2171245 43 18 43 33 33 1 0 5 4 0 0.792 1.000 1.000 504 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 ATM(1), BIRC3(1), CASP10(1), CASP7(1), CASP8(1), CSF2RB(1), IKBKB(1), IL1B(1), IL1R1(1), IL3RA(1), IRAK1(1), MAP3K14(1), NFKB2(1), NTRK1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKACA(1), PRKAR1A(1), RELA(1), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TP53(4), TRAF2(1) 4665186 42 18 41 19 19 5 2 6 10 0 0.400 1.000 1.000 505 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(6), CACNA1A(4), CACNA1B(2), GNAS(3), GRM4(1), ITPR3(3), KCNB1(6), PDE1A(2), PLCB2(1), PRKACA(1), PRKX(1), SCNN1B(1), SCNN1G(2), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R13(1), TAS2R16(2), TAS2R38(2), TAS2R41(3), TAS2R5(1), TAS2R60(3), TAS2R8(1), TAS2R9(1) 3173334 55 18 55 30 42 5 2 5 1 0 0.0796 1.000 1.000 506 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), DAG1(1), EPHB2(2), FBXW7(1), GRAP2(1), ITK(1), ITPKA(1), LCK(2), LCP2(1), NFAT5(1), NFKB2(1), PAK3(2), PAK7(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), SOS1(1), SOS2(2), VAV1(2) 3108015 32 18 32 17 19 1 2 5 5 0 0.678 1.000 1.000 507 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), CAMK1G(2), FPR1(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3C2G(7), PLCB1(4), RELA(1), SYT1(1) 2136079 26 17 24 14 16 2 3 2 3 0 0.627 1.000 1.000 508 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 G6PC(2), G6PC2(3), GALE(1), GALK2(1), GANC(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3), UGP2(1) 2158300 30 17 30 16 20 2 0 1 7 0 0.290 1.000 1.000 509 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(3), DPYD(5), DPYS(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), NME6(1), NT5C1B(2), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), RRM2B(1), TXNRD1(2), ZNRD1(1) 4540457 29 17 29 18 19 2 1 3 4 0 0.710 1.000 1.000 510 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(4), ACSL1(2), ACSL5(3), ACSL6(1), ADIPOR2(1), CAMKK2(1), CPT1A(1), CPT1C(2), G6PC(2), G6PC2(3), IKBKB(1), IRS1(1), JAK3(1), LEPR(3), MAPK10(1), MAPK8(1), MAPK9(2), NFKB2(1), PPARA(1), PPARGC1A(2), PRKAA2(2), PRKAG2(2), PRKCQ(2), PTPN11(1), RELA(1), STAT3(1), STK11(1), TRAF2(1), TYK2(1) 4646869 46 17 46 23 32 5 1 4 4 0 0.353 1.000 1.000 511 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), BDKRB2(1), CAV1(1), FLT4(4), KDR(3), NOS3(1), PDE2A(1), PDE3A(3), PRKAR1A(1), PRKG1(1), PRKG2(3), RYR2(6), SYT1(1), TNNI1(1) 2281103 28 16 28 15 21 1 1 1 4 0 0.383 1.000 1.000 512 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(3), DPYD(5), DPYS(2), ENTPD1(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), TXNRD1(2) 3212623 20 16 20 11 12 1 1 4 2 0 0.625 1.000 1.000 513 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(1), MAP3K1(1), MYLK(2), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLD1(1), TRIO(1), VAV1(2), WASF1(1) 1967278 19 16 19 11 9 2 3 2 3 0 0.690 1.000 1.000 514 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(1), ANGPTL2(1), CDC42(1), FLNC(4), MYH2(9), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), ROCK2(1), WASF1(1) 2678150 26 16 26 21 20 2 0 3 1 0 0.840 1.000 1.000 515 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 FYN(1), HRAS(1), LCK(2), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), PTPN7(1), RELA(1), SHC1(2), SOS1(1), SYT1(1), VAV1(2) 2676081 23 16 21 10 13 1 3 2 4 0 0.446 1.000 1.000 516 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2R(1), F3(2), F5(7), F7(2), FGA(4), FGG(1), PROC(1), SERPINC1(1), TFPI(2) 920149 23 15 23 12 14 1 1 5 2 0 0.748 1.000 1.000 517 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 G6PC(2), GALE(1), GALK2(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3) 1820427 25 15 25 13 18 2 0 1 4 0 0.278 1.000 1.000 518 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPS(2), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), GPD1(1), PCYT1B(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB2(1), PPAP2B(3) 2799984 27 15 27 19 18 3 1 4 1 0 0.772 1.000 1.000 519 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 12 CASR(4), GABBR1(1), GPRC5D(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM7(7) 1070532 24 15 23 16 13 2 2 2 5 0 0.518 1.000 1.000 520 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP3A4(1), CYP3A43(1), CYP3A7(3), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2) 1338677 29 15 29 22 20 2 0 5 2 0 0.829 1.000 1.000 521 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CREBBP(3), EHHADH(1), FABP1(1), ME1(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(2), NRIP1(1), PIK3CA(1), PIK3R1(4), PPARA(1), PRKAR1A(1), PRKCA(1), PTGS2(1), RELA(1), STAT5A(1) 3548666 23 15 23 13 11 0 1 6 5 0 0.845 1.000 1.000 522 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), EHHADH(1), MAOA(1), TPH1(4) 3080018 45 15 45 30 34 2 1 4 4 0 0.630 1.000 1.000 523 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(3), AXIN1(1), CTNNB1(2), FZD8(2), LDLR(2), MAPK10(1), MAPK9(2), MYC(1), PPP2R5C(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1) 3349047 25 15 25 16 17 2 3 3 0 0 0.709 1.000 1.000 524 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), FYN(1), HRAS(1), MAP2K1(3), MYLK(2), PIK3CA(1), PIK3R1(4), SHC1(2), TLN1(2) 2092633 17 14 15 11 10 0 2 1 4 0 0.740 1.000 1.000 525 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(1), ATR(5), CDC25B(2), CDC25C(1), MDM2(1), MYT1(2), PRKDC(2), RPS6KA1(3), TP53(4), WEE1(1) 2358795 22 14 22 10 7 3 2 5 5 0 0.764 1.000 1.000 526 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), PON1(1) 1635328 31 14 31 29 19 2 2 5 3 0 0.952 1.000 1.000 527 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), G6PC(2), GAPDH(2), GCK(3), GOT2(2), HK3(2), LDHA(1), PC(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3) 2381229 21 14 21 13 12 3 0 2 4 0 0.548 1.000 1.000 528 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), CAMK1(1), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(2), MEF2B(1), MEF2C(1), MEF2D(1), PIK3CA(1), PIK3R1(4), SYT1(1) 1954000 18 14 18 11 9 0 1 3 5 0 0.674 1.000 1.000 529 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(2), ACSM1(2), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), DDHD1(1), EHHADH(1), GAD1(2), GAD2(3), HMGCS2(1), OXCT1(1), OXCT2(1), PDHA2(2) 2276648 22 14 22 12 15 1 0 5 1 0 0.546 1.000 1.000 530 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX15(1), ALOX5(1), CYP4F3(1), GGT1(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3), TPO(5) 1560520 23 14 22 17 19 0 0 2 2 0 0.685 1.000 1.000 531 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 CALCR(2), CALCRL(1), CRHR1(1), CRHR2(2), ELTD1(2), EMR2(1), GPR64(1), LPHN1(3), LPHN2(4), LPHN3(1), SCTR(3) 1425649 21 13 21 11 11 3 1 4 2 0 0.423 1.000 1.000 532 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 BAG4(1), BIRC3(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(1), PRKDC(2), RELA(1), SPTAN1(1), TRAF2(1) 3878429 17 13 17 10 11 3 0 1 2 0 0.697 1.000 1.000 533 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(1), AGTR2(3), EDN1(1), EDNRA(1), EDNRB(1), EGF(1), EGFR(1), HRAS(1), MYC(1), PRKCA(1), RELA(1) 1149062 14 12 14 9 10 1 2 1 0 0 0.763 1.000 1.000 534 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), WBSCR17(2) 1810144 22 12 22 15 15 2 2 0 3 0 0.764 1.000 1.000 535 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), CDC42(1), EGFR(1), IGSF5(1), IKBKB(1), LYN(1), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), MET(4), NFKB2(1), PTPN11(1), PTPRZ1(2), RELA(1) 3939925 25 12 25 13 12 4 2 6 1 0 0.637 1.000 1.000 536 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP5(1), ARHGEF11(2), ARHGEF5(2), ARPC1A(1), BAIAP2(2), MYLK(2), PIP5K1B(2), TLN1(2) 2527146 15 12 15 14 12 1 0 1 1 0 0.890 1.000 1.000 537 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(1), CDR1(3), DGKI(3), RPLP2(1), RPS27A(2), RPS4Y1(1), RPS5(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), RPSA(1), SLC36A2(1), TSPAN9(1) 2919511 20 12 20 12 13 2 2 2 1 0 0.704 1.000 1.000 538 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 IKBKB(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(1), TLR4(3), TLR6(1), TLR7(1), TRAF6(1) 2035812 19 12 19 13 9 5 2 2 1 0 0.805 1.000 1.000 539 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SGPP2(1), SMPD2(1), SMPD3(1), SMPD4(2), UGCG(1) 1989752 16 11 16 10 11 1 0 3 1 0 0.670 1.000 1.000 540 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), ESRRA(1), HDAC5(1), MEF2B(1), MEF2C(1), MEF2D(1), PPARA(1), SYT1(1) 1126221 16 11 16 11 11 1 0 2 2 0 0.723 1.000 1.000 541 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), AGT(1), AGTR1(1), AGTR2(3), BDKRB2(1), KNG1(3), NOS3(1) 555110 11 10 11 9 11 0 0 0 0 0 0.607 1.000 1.000 542 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), MCM2(1), MCM4(2), MCM6(1), POLA2(1), POLE(1), RFC1(2), RFC2(1), RPS27A(2) 2840049 12 10 11 11 8 0 1 2 1 0 0.958 1.000 1.000 543 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2) 1403236 14 10 14 9 11 0 2 1 0 0 0.765 1.000 1.000 544 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(1), ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), EP400(3), ERCC3(1), MOV10L1(2) 3499159 14 10 14 17 9 2 0 1 2 0 0.995 1.000 1.000 545 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT1(1), B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3), PIGA(1), PIGN(1), PIGO(1), PIGU(1), ST3GAL3(1), ST6GALNAC3(1), UGCG(1) 2711168 16 10 16 13 8 1 1 4 2 0 0.887 1.000 1.000 546 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), GNAQ(2), MYLK(2), PLCB1(4), PRKCA(1) 1164656 10 10 10 10 6 0 1 3 0 0 0.963 1.000 1.000 547 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(2), GRIN2A(5), GRIN2B(3), NOS1(7), PRKAR1A(1), PRKCA(1), SYT1(1) 1431022 20 10 20 13 15 1 1 1 2 0 0.579 1.000 1.000 548 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), HRAS(1), MAP2K1(3), MYC(1), PLCB1(4), PRKCA(1), RELA(1) 871668 12 9 10 8 8 0 1 3 0 0 0.776 1.000 1.000 549 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(1), ACO2(1), IDH1(3), OGDHL(5), PC(1), SDHA(2), SDHC(1) 1681237 14 9 13 9 9 4 0 1 0 0 0.641 1.000 1.000 550 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), CARS(1), EPRS(2), FARS2(1), IARS2(1), KARS(2), LARS2(1), RARS(1) 3063253 11 9 11 13 9 0 1 1 0 0 0.983 1.000 1.000 551 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), PC(1), PDHA2(2), PDK4(1), PDP2(1), SDHA(2), SDHC(1) 1595189 9 9 9 9 6 2 0 1 0 0 0.928 1.000 1.000 552 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CAMKK2(1), SYT1(1) 651215 11 8 11 8 8 1 0 2 0 0 0.753 1.000 1.000 553 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD33(1), CD5(1), IL12B(1), ITGAX(2), TLR2(2), TLR4(3), TLR7(1) 1043040 12 8 12 10 7 2 2 1 0 0 0.763 1.000 1.000 554 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), PLCB2(1), SARDH(1), SHMT2(1) 2357609 12 8 12 12 5 3 1 2 1 0 0.937 1.000 1.000 555 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), SARDH(1), SHMT2(1) 2395548 11 8 11 13 5 2 1 2 1 0 0.974 1.000 1.000 556 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(1), BECN1(1), IFNA16(1), IFNA21(2), IFNA6(1), PIK3R4(1), PRKAA2(2), ULK1(1), ULK2(1) 1179022 11 8 11 7 9 1 0 1 0 0 0.728 1.000 1.000 557 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(1), ADCY3(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V1C2(1), GNAS(3), PRKCA(1), SEC61A2(1) 2077242 11 8 11 9 8 1 0 2 0 0 0.812 1.000 1.000 558 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(1), EPRS(2), FARS2(1), KARS(2), LARS2(1), RARS(1) 1807235 9 7 9 9 7 0 1 1 0 0 0.949 1.000 1.000 559 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO2(1), IDH1(3), PC(1), SDHA(2) 1161077 7 7 6 5 5 2 0 0 0 0 0.731 1.000 1.000 560 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), ENPP1(2), ENPP3(1), NT5C1B(2) 1205341 8 7 8 5 5 2 1 0 0 0 0.692 1.000 1.000 561 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(1), GBA(2), GUSB(1), HEXA(2), LCT(3), SPAM1(3) 1916185 12 7 12 8 11 0 0 1 0 0 0.662 1.000 1.000 562 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 CPT1A(1), LEPR(3), PRKAA2(2), PRKAG2(2) 816866 8 7 8 6 7 1 0 0 0 0 0.817 1.000 1.000 563 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(1), CREBBP(3), CTNNB1(2) 1863996 9 7 9 6 6 0 1 2 0 0 0.827 1.000 1.000 564 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(2), PLCB1(4), PRKCA(1), RELA(1) 459458 8 7 8 5 4 0 1 3 0 0 0.841 1.000 1.000 565 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(2), HTR2C(2), PLCB1(4) 400712 8 7 8 6 3 1 1 3 0 0 0.844 1.000 1.000 566 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1) 317238 8 6 8 5 8 0 0 0 0 0 0.631 1.000 1.000 567 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), GNAQ(2), MAPK8(1), PRKCA(1), PTK2B(1), SYT1(1) 773956 7 6 7 5 4 1 0 2 0 0 0.742 1.000 1.000 568 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOB(1), GMPPA(1), HK3(2), MTMR2(1), PFKFB2(1), PFKM(1), PGM2(1) 2071571 8 6 8 10 6 0 0 1 1 0 0.927 1.000 1.000 569 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1) 1171907 7 6 7 5 5 0 0 2 0 0 0.775 1.000 1.000 570 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), ACE2(1), AGT(1), AGTR1(1), AGTR2(3), ANPEP(1), CMA1(1), ENPEP(1), MAS1(1), MME(2), NLN(1) 1184910 14 6 14 13 11 0 1 0 2 0 0.890 1.000 1.000 571 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CXCR3(1), IL12B(1), IL12RB1(2), MAPK8(1), TYK2(1) 1041985 6 6 6 6 5 1 0 0 0 0 0.904 1.000 1.000 572 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1) 984552 7 6 7 5 5 0 0 2 0 0 0.768 1.000 1.000 573 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACB(4), OLAH(2) 880349 6 5 6 5 5 1 0 0 0 0 0.718 1.000 1.000 574 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GUSB(1), HEXA(2), LCT(3), SPAM1(3) 1141775 9 5 9 6 9 0 0 0 0 0 0.644 1.000 1.000 575 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), STX11(1), STX17(1), STX6(1) 933537 5 5 5 5 3 1 1 0 0 0 0.920 1.000 1.000 576 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CXCR3(1), IL12B(1), IL12RB1(2), TYK2(1) 818134 5 5 5 5 4 1 0 0 0 0 0.877 1.000 1.000 577 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC3(1), CASP8(1), NFKB2(1), TRAF2(1) 1516759 5 5 5 4 5 0 0 0 0 0 0.810 1.000 1.000 578 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(2), PRKCA(1), SYT1(1) 1174535 4 4 4 9 2 0 0 2 0 0 0.999 1.000 1.000 579 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), HEXA(2), LCT(3) 1136452 6 4 6 5 6 0 0 0 0 0 0.771 1.000 1.000 580 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 HEXA(2), LCT(3), ST6GALNAC3(1) 923311 6 4 6 5 5 0 0 1 0 0 0.790 1.000 1.000 581 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 AMT(1), FTCD(1), GART(1), MTR(1), SHMT2(1) 1062376 5 4 5 4 2 2 0 1 0 0 0.903 1.000 1.000 582 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), CSF3(1), HLA-DRB1(1), IL12B(1) 740567 4 4 4 4 4 0 0 0 0 0 0.742 1.000 1.000 583 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), MEF2D(1), PRKCA(1), SYT1(1) 1374164 5 4 5 10 5 0 0 0 0 0 0.998 1.000 1.000 584 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), HEXA(2), LCT(3) 921713 6 4 6 5 6 0 0 0 0 0 0.795 1.000 1.000 585 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 AMT(1), GART(1), MTR(1), SHMT2(1) 1004373 4 4 4 4 1 2 0 1 0 0 0.953 1.000 1.000 586 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CSNK1A1(1), MAPT(2) 508649 5 4 4 4 3 0 1 1 0 0 0.861 1.000 1.000 587 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 DNMT1(1), PTGFR(2), PTGIR(1) 624894 4 4 4 6 3 0 0 1 0 0 0.916 1.000 1.000 588 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), EPO(1), KITLG(1) 462933 3 3 3 6 3 0 0 0 0 0 0.974 1.000 1.000 589 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(1), PON1(1), PON3(1) 506352 3 3 3 3 2 0 1 0 0 0 0.821 1.000 1.000 590 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), GOT2(2), PAH(1) 488976 4 3 4 4 3 0 0 1 0 0 0.920 1.000 1.000 591 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), SDHA(2) 530707 3 3 3 4 2 1 0 0 0 0 0.903 1.000 1.000 592 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 FARS2(1), GOT2(2), PAH(1) 468513 4 3 4 4 3 0 0 1 0 0 0.896 1.000 1.000 593 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), GGT1(1), MAT2B(1) 699564 3 3 3 3 2 0 0 1 0 0 0.856 1.000 1.000 594 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(1), CSF3(1), EPO(1) 339972 3 3 3 4 3 0 0 0 0 0 0.835 1.000 1.000 595 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS2(1) 301591 3 2 3 4 3 0 0 0 0 0 0.883 1.000 1.000 596 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(1), RELA(1) 704639 2 2 2 4 2 0 0 0 0 0 0.984 1.000 1.000 597 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CSF3(1), KITLG(1) 344695 2 2 2 3 2 0 0 0 0 0 0.902 1.000 1.000 598 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2B(2) 334227 2 2 2 3 2 0 0 0 0 0 0.772 1.000 1.000 599 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(1) 271197 1 1 1 2 1 0 0 0 0 0 0.934 1.000 1.000 600 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1) 476178 1 1 1 2 0 0 1 0 0 0 0.962 1.000 1.000 601 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(1) 500260 1 1 1 2 1 0 0 0 0 0 0.963 1.000 1.000 602 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(1) 664603 1 1 1 3 1 0 0 0 0 0 0.984 1.000 1.000 603 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 TYK2(1) 605765 1 1 1 3 0 1 0 0 0 0 0.983 1.000 1.000 604 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PRKCA(1), PTK2B(1) 377901 2 1 2 3 1 1 0 0 0 0 0.885 1.000 1.000 605 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 MTA3(1) 602382 1 1 1 2 1 0 0 0 0 0 0.915 1.000 1.000 606 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 318260 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 254854 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 40470 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 269329 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 28800 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 125914 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 119079 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 458643 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 179980 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 615 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 63601 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 327364 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000