Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.1 -9999.0 0.0 -0.23 8.0 8.0 epithelial cell differentiation -0.025 0.108 -9999.0 0.0 -0.251 8.0 8.0 CYFIP2 -0.019 0.118 -9999.0 0.0 -0.436 3.0 3.0 ENAH -0.009 0.097 -9999.0 0.0 -0.322 1.0 1.0 EGFR -0.083 0.182 -9999.0 0.0 -0.396 10.0 10.0 EPHA2 -0.024 0.134 -9999.0 0.0 -0.515 3.0 3.0 MYO6 -0.038 0.116 -9999.0 0.0 -0.236 11.0 11.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.006 0.073 -9999.0 0.0 -0.304 2.0 2.0 AQP5 -0.062 0.165 -9999.0 0.0 -0.485 4.0 4.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.019 0.102 -9999.0 0.0 -0.232 8.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.109 -9999.0 0.0 -0.247 8.0 8.0 EGF -0.1 0.208 -9999.0 0.0 -0.468 10.0 10.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.069 0.148 -9999.0 0.0 -0.431 4.0 4.0 cortical microtubule organization -0.025 0.108 -9999.0 0.0 -0.251 8.0 8.0 GO:0000145 -0.019 0.097 -9999.0 0.0 -0.222 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.11 -9999.0 0.0 -0.254 8.0 8.0 MLLT4 0.0 0.08 -9999.0 0.0 -0.515 1.0 1.0 ARF6/GDP -0.049 0.083 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.011 0.077 -9999.0 0.0 -0.27 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.009 0.098 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.103 -9999.0 0.0 -0.236 8.0 8.0 ARF6/GTP 0.016 0.071 -9999.0 0.0 -0.245 3.0 3.0 CDH1 -0.086 0.205 -9999.0 0.0 -0.515 8.0 8.0 EGFR/EGFR/EGF/EGF -0.127 0.15 -9999.0 0.0 -0.447 5.0 5.0 RhoA/GDP -0.043 0.091 -9999.0 0.0 -0.233 8.0 8.0 actin cytoskeleton organization -0.032 0.112 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.024 0.134 -9999.0 0.0 -0.515 3.0 3.0 DIAPH1 -0.023 0.118 -9999.0 0.0 -0.558 2.0 2.0 Wnt receptor signaling pathway 0.025 0.108 0.251 8.0 -9999.0 0.0 8.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.083 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.114 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.013 0.099 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.057 0.098 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.043 0.096 -9999.0 0.0 -0.435 1.0 1.0 MGAT3 -0.025 0.111 -9999.0 0.0 -0.251 8.0 8.0 HGF/MET -0.093 0.128 -9999.0 0.0 -0.287 8.0 8.0 HGF -0.012 0.111 -9999.0 0.0 -0.515 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.022 0.1 -9999.0 0.0 -0.232 8.0 8.0 actin cable formation 0.005 0.087 -9999.0 0.0 -0.26 1.0 1.0 KIAA1543 -0.067 0.115 -9999.0 0.0 -0.338 1.0 1.0 KIFC3 -0.026 0.108 -9999.0 0.0 -0.236 9.0 9.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.103 -9999.0 0.0 -0.236 8.0 8.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.025 0.108 -9999.0 0.0 -0.251 8.0 8.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.019 0.103 -9999.0 0.0 -0.236 8.0 8.0 PIP5K1C -0.019 0.103 -9999.0 0.0 -0.236 8.0 8.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.018 0.11 -9999.0 0.0 -0.385 1.0 1.0 adherens junction assembly -0.056 0.136 -9999.0 0.0 -0.444 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.057 0.098 -9999.0 0.0 -0.225 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.01 0.058 -9999.0 0.0 -0.366 1.0 1.0 MET -0.088 0.191 -9999.0 0.0 -0.42 10.0 10.0 PLEKHA7 -0.026 0.108 -9999.0 0.0 -0.236 9.0 9.0 mol:GTP 0.01 0.076 -9999.0 0.0 -0.268 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.002 0.108 -9999.0 0.0 -0.414 1.0 1.0 cortical actin cytoskeleton stabilization -0.022 0.1 -9999.0 0.0 -0.23 8.0 8.0 regulation of cell-cell adhesion -0.032 0.112 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.022 0.1 -9999.0 0.0 -0.232 8.0 8.0