Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.082 -9999.0 0.0 -0.2 7.0 7.0 epithelial cell differentiation 0.005 0.099 -9999.0 0.0 -0.199 8.0 8.0 CYFIP2 0.01 0.09 0.146 1.0 -0.389 2.0 3.0 ENAH -0.042 0.07 -9999.0 0.0 -0.274 1.0 1.0 EGFR -0.001 0.131 0.146 5.0 -0.389 4.0 9.0 EPHA2 0.006 0.087 -9999.0 0.0 -0.389 2.0 2.0 MYO6 -0.05 0.084 0.181 1.0 -0.194 10.0 11.0 CTNNB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.036 0.064 -9999.0 0.0 -0.234 2.0 2.0 AQP5 -0.051 0.146 -9999.0 0.0 -0.376 5.0 5.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.042 0.077 0.179 1.0 -0.191 8.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.042 0.072 -9999.0 0.0 -0.191 7.0 7.0 EGF -0.036 0.158 0.146 2.0 -0.389 7.0 9.0 NCKAP1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.048 0.134 -9999.0 0.0 -0.363 2.0 2.0 cortical microtubule organization 0.005 0.099 -9999.0 0.0 -0.199 8.0 8.0 GO:0000145 -0.04 0.074 0.172 1.0 -0.182 8.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.008 0.102 -9999.0 0.0 -0.2 8.0 8.0 MLLT4 0.015 0.063 -9999.0 0.0 -0.389 1.0 1.0 ARF6/GDP -0.047 0.061 -9999.0 0.0 -0.183 7.0 7.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.065 -9999.0 0.0 -0.214 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.032 0.065 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.036 0.075 0.181 1.0 -0.193 7.0 8.0 ARF6/GTP 0.044 0.065 -9999.0 0.0 -0.202 2.0 2.0 CDH1 -0.051 0.162 -9999.0 0.0 -0.389 8.0 8.0 EGFR/EGFR/EGF/EGF -0.04 0.139 -9999.0 0.0 -0.246 12.0 12.0 RhoA/GDP 0.007 0.097 -9999.0 0.0 -0.192 8.0 8.0 actin cytoskeleton organization -0.046 0.08 0.164 1.0 -0.193 9.0 10.0 IGF-1R heterotetramer 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.002 0.106 -9999.0 0.0 -0.389 3.0 3.0 DIAPH1 -0.047 0.225 -9999.0 0.0 -0.601 3.0 3.0 Wnt receptor signaling pathway -0.005 0.099 0.199 8.0 -9999.0 0.0 8.0 RHOA 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.061 -9999.0 0.0 -0.184 7.0 7.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.047 0.081 0.165 1.0 -0.196 9.0 10.0 EFNA1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.047 0.068 -9999.0 0.0 -0.188 8.0 8.0 Ephrin A1/EPHA2 -0.005 0.087 -9999.0 0.0 -0.191 7.0 7.0 SEC6/SEC8 -0.046 0.076 -9999.0 0.0 -0.209 7.0 7.0 MGAT3 -0.043 0.073 -9999.0 0.0 -0.193 7.0 7.0 HGF/MET -0.032 0.124 -9999.0 0.0 -0.219 12.0 12.0 HGF 0.004 0.087 -9999.0 0.0 -0.389 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.082 -9999.0 0.0 -0.202 7.0 7.0 actin cable formation -0.02 0.093 0.194 2.0 -0.228 1.0 3.0 KIAA1543 -0.045 0.078 0.173 1.0 -0.185 9.0 10.0 KIFC3 -0.051 0.074 -9999.0 0.0 -0.194 9.0 9.0 NCK1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.046 0.071 -9999.0 0.0 -0.193 8.0 8.0 NCK1/GIT1 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.005 0.099 -9999.0 0.0 -0.199 8.0 8.0 EXOC4 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.043 0.078 0.181 1.0 -0.193 8.0 9.0 PIP5K1C -0.042 0.078 0.181 1.0 -0.193 8.0 9.0 LIMA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.032 0.102 0.301 1.0 -0.317 1.0 2.0 adherens junction assembly -0.052 0.08 -9999.0 0.0 -0.298 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.009 0.096 -9999.0 0.0 -0.191 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.03 0.049 -9999.0 0.0 -0.275 1.0 1.0 MET -0.016 0.139 -9999.0 0.0 -0.389 5.0 5.0 PLEKHA7 -0.046 0.082 0.181 1.0 -0.194 9.0 10.0 mol:GTP 0.039 0.064 -9999.0 0.0 -0.213 2.0 2.0 establishment of epithelial cell apical/basal polarity -0.003 0.12 -9999.0 0.0 -0.335 1.0 1.0 cortical actin cytoskeleton stabilization -0.016 0.082 -9999.0 0.0 -0.2 7.0 7.0 regulation of cell-cell adhesion -0.046 0.08 0.164 1.0 -0.193 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.082 -9999.0 0.0 -0.202 7.0 7.0