rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(24), CREB5(2), TERF2IP(1)	628058	28	25	8	1	3	0	1	24	0	0	0.0138	5.11e-15	3.15e-12
2	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(24), CREB5(2), DUSP4(2), EEF2K(2), EIF4E(1), MAP2K1(3), MAP2K2(1), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	1650651	45	28	23	2	15	3	3	24	0	0	0.000114	6.49e-12	2.00e-09
3	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ATF1(1), BRAF(24), CREB5(2), CREBBP(3), DAG1(1), FRS2(1), GNAQ(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NTRK1(4), OPN1LW(1), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), TERF2IP(1)	2864884	63	30	43	5	20	3	4	31	5	0	3.42e-05	5.11e-09	1.05e-06
4	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(3), BRAF(24), CCL13(1), DAG1(1), EGFR(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), MAPK10(1), PIK3CA(1), PIK3R1(4)	2987528	57	29	37	9	17	2	4	31	3	0	0.00449	0.000369	0.0569
5	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(24), DAXX(1), HRAS(1), IKBKB(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP3K9(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK4(3), MAPK8(1), MAPK9(2), MAPKAPK3(1), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), RELA(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), SHC1(2), TRAF2(1)	5298061	64	32	42	7	28	4	4	25	3	0	6.65e-05	0.00157	0.184
6	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(24), EGFR(1), ERBB4(3), ETS1(1), ETS2(1), ETV6(2), FMN2(3), MAP2K1(3), NOTCH2(4), NOTCH4(3), PIWIL1(1), PIWIL2(2), PIWIL4(2), SOS1(1), SOS2(2)	2938184	53	27	31	9	16	1	2	29	5	0	0.0256	0.00208	0.184
7	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(1), E2F1(2), MDM2(1), MYC(1), PIK3CA(1), PIK3R1(4), POLR1B(1), TP53(4)	1134716	15	13	15	1	3	1	3	3	5	0	0.0234	0.00210	0.184
8	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	HRAS(1), MEF2B(1), MEF2C(1), MEF2D(1), NTRK1(4), PIK3CA(1), PIK3R1(4), RPS6KA1(3), SHC1(2)	1061373	18	13	18	2	5	3	3	2	5	0	0.0151	0.00245	0.189
9	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), KLRC1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), PTK2B(1), SYK(2), VAV1(2)	1042544	15	12	13	1	8	1	1	2	3	0	0.0139	0.00390	0.267
10	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN2A(1), E2F1(2), MDM2(1), PRB1(5), TP53(4)	471635	13	9	13	1	7	1	2	1	2	0	0.0205	0.00580	0.357
11	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(6), MEF2B(1), MEF2C(1), MEF2D(1)	421151	12	9	12	1	8	1	0	1	2	0	0.0239	0.0144	0.796
12	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(3), PRKACA(1), PRKAR1A(1)	366518	8	8	7	1	6	0	0	1	1	0	0.149	0.0164	0.796
13	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	HRAS(1), IGF1R(1), IRS1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1)	1068570	14	12	12	1	6	0	2	2	4	0	0.0357	0.0178	0.796
14	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF4E(1), IGF1R(1), PIK3CA(1), PIK3R1(4), PTEN(5)	1102966	12	11	12	2	3	0	2	1	6	0	0.204	0.0194	0.796
15	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), PIK3CA(1), PIK3R1(4), PTEN(5), SHC1(2), SOS1(1)	1077749	14	12	14	2	3	0	3	2	6	0	0.158	0.0205	0.796
16	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	HRAS(1), MAP2K1(3), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(1), SHC1(2), SOS1(1)	899557	14	12	12	1	8	2	1	2	1	0	0.0131	0.0207	0.796
17	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(1), NDUFA13(1)	224210	5	5	5	1	2	0	1	1	1	0	0.393	0.0250	0.905
18	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(1), EIF4E(1), EIF4G1(1), GHR(5), IRS1(1), PIK3CA(1), PIK3R1(4), PRKCA(1), PTEN(5)	1584762	20	15	20	4	8	0	2	1	9	0	0.168	0.0299	1.000
19	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7), CYP2C9(3)	113730	10	8	10	4	5	1	0	3	1	0	0.449	0.0328	1.000
20	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	HRAS(1), MAP2K1(3), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1)	1069366	14	12	12	2	7	0	2	2	3	0	0.0701	0.0396	1.000
21	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), GNAS(3), HRAS(1), IGF1R(1), MAP2K1(3), MAP2K2(1), MYC(1), NGFR(1), PDGFRA(5), PTPRR(2), RPS6KA1(3), SHC1(2), SOS1(1), STAT3(1)	1847884	26	18	24	2	18	2	4	2	0	0	0.000761	0.0437	1.000
22	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), CDC42(1), PDGFRA(5), PIK3CA(1), PIK3R1(4)	755052	12	11	12	3	3	2	2	2	3	0	0.305	0.0474	1.000
23	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FHL5(1), FSHR(4), GNAS(3)	532879	11	10	10	1	10	1	0	0	0	0	0.0338	0.0482	1.000
24	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNE2(2), CDKN2A(1), E2F1(2), PRB1(5)	501991	15	8	15	1	10	0	2	2	1	0	0.0170	0.0495	1.000
25	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8IP3(1), PAPPA(9), RPS6KA1(3), SHC1(2), SOS1(1), SYK(2), VAV1(2), VAV2(1), VAV3(1)	1790599	31	17	29	2	24	3	2	2	0	0	5.68e-05	0.0560	1.000
26	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	CAT(1), GHR(5), HRAS(1), IGF1R(1), PIK3CA(1), PIK3R1(4), SHC1(2)	747769	15	11	15	3	8	0	2	1	4	0	0.0925	0.0561	1.000
27	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(1), DAG1(1), DGKA(1), ITGA9(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), PDE3A(3), PIK3C2G(7), PIK3CA(1), PIK3R1(4)	2727281	34	21	32	4	17	3	3	6	5	0	0.000688	0.0573	1.000
28	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(1), HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), MYC(1), PIK3CA(1), PIK3R1(4), SOS1(1), STAT5A(1)	1572793	15	14	13	1	6	1	1	4	3	0	0.0245	0.0621	1.000
29	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(2), HDC(3), TPH1(4)	336252	10	7	10	1	7	1	0	2	0	0	0.0379	0.0691	1.000
30	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), CAMK2B(3), CAMK2G(1), GNAS(3), HRAS(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), PRKCA(1), RPS6KA1(3), SOS1(1)	1626999	22	16	21	4	12	2	2	2	4	0	0.0476	0.0851	1.000
31	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), BCMO1(3)	219636	5	5	5	2	3	0	0	1	1	0	0.496	0.0855	1.000
32	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CUL1(2), E2F1(2), TFDP1(1)	479089	10	8	10	0	8	1	0	1	0	0	0.0126	0.0879	1.000
33	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	HRAS(1), IGF1R(1), IRS1(1), MAP2K1(3), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1)	1391370	16	13	14	2	7	0	2	3	4	0	0.0644	0.0979	1.000
34	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRK(1), HGF(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), MET(4), PIK3CA(1), PIK3R1(4), PTEN(5), PTK2B(1), PTPN11(1), SOS1(1), STAT3(1)	2450694	27	20	25	3	12	2	2	4	7	0	0.00954	0.102	1.000
35	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), GAD1(2), GAD2(3), GGT1(1)	319432	9	6	9	1	7	0	0	2	0	0	0.0708	0.106	1.000
36	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(24), DDIT4(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKAA2(2), RHEB(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), STK11(1), TSC2(1), ULK1(1), ULK2(1), VEGFA(2)	2961674	51	28	30	10	12	1	4	27	7	0	0.0576	0.107	1.000
37	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(1), EIF4E(1), EIF4G1(1), PIK3CA(1), PIK3R1(4), PTEN(5), TSC2(1)	1549478	14	11	14	3	4	0	2	1	7	0	0.296	0.109	1.000
38	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(1), EGFR(1), HGS(1), TF(2), TFRC(1)	720711	8	8	8	2	2	0	3	1	2	0	0.364	0.113	1.000
39	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD80(1), CD86(2), HLA-DRB1(1), ITK(1), LCK(2), PIK3CA(1), PIK3R1(4), PTPN11(1)	717699	13	8	13	3	5	0	2	2	4	0	0.221	0.116	1.000
40	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1)	857481	10	9	10	1	5	3	0	1	1	0	0.0856	0.120	1.000
41	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	987513	18	14	18	4	13	1	1	2	1	0	0.0494	0.125	1.000
42	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1)	1958767	22	19	20	4	11	2	3	3	3	0	0.0413	0.125	1.000
43	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	HRAS(1), NTRK1(4), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1)	873858	14	11	14	3	4	2	2	3	3	0	0.176	0.126	1.000
44	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(2), PDE1B(1), PLCB1(4), PLCB2(1), VIP(1)	618577	12	10	12	3	6	2	1	2	1	0	0.150	0.130	1.000
45	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1), GNAQ(2), ITPKA(1)	337647	4	4	4	0	1	1	0	2	0	0	0.250	0.136	1.000
46	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	MAP3K14(1), RELA(1), TP53(4)	544617	6	6	6	1	2	2	0	0	2	0	0.285	0.137	1.000
47	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CDC42(1), HRAS(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), RELA(1)	1061052	11	10	9	2	5	0	1	2	3	0	0.183	0.142	1.000
48	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1)	543122	10	8	10	2	7	1	0	1	1	0	0.0761	0.146	1.000
49	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(3), CYP11A1(2), CYP11B1(3), CYP11B2(1), HSD3B2(1)	543122	10	8	10	2	7	1	0	1	1	0	0.0761	0.146	1.000
50	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(1), SHMT2(1)	303423	4	4	4	1	2	1	0	1	0	0	0.407	0.164	1.000
51	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRB1(1), IL1B(1), IL5RA(2)	299287	5	5	5	1	3	1	0	0	1	0	0.233	0.177	1.000
52	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	PIK3CA(1), PTEN(5), PTK2B(1), RBL2(2), SHC1(2), SOS1(1)	1149587	12	8	12	1	2	1	3	2	4	0	0.0969	0.185	1.000
53	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(2), NEK1(1), WEE1(1)	388736	4	4	4	1	1	1	0	1	1	0	0.638	0.187	1.000
54	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TAL1(1)	1145157	13	11	13	3	7	1	0	4	1	0	0.0941	0.200	1.000
55	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	GHR(5), PIK3CA(1), PIK3R1(4), RELA(1)	786604	11	9	11	3	5	0	1	1	4	0	0.335	0.203	1.000
56	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(24), DAG1(1), DRD2(2), EGFR(1), EPHB2(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), PIK3CB(5), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), SHC1(2), SOS1(1), SOS2(2), STAT3(1), TERF2IP(1)	3279461	72	29	51	16	24	5	6	34	3	0	0.0117	0.213	1.000
57	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFAT5(1), PDE6A(3), PDE6B(2), PDE6C(4), SLC6A13(2), TF(2)	2004054	31	19	31	5	20	4	1	5	1	0	0.00185	0.214	1.000
58	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(3), FYN(1), IL7R(6), JAK3(1), LCK(2), PIK3CA(1), PIK3R1(4), PTK2B(1), STAT5A(1)	1565441	20	13	20	4	6	2	2	5	5	0	0.103	0.225	1.000
59	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	86771	1	1	1	0	0	0	1	0	0	0	0.624	0.233	1.000
60	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), E2F1(2), FBXW7(1), TFDP1(1)	459151	6	6	6	0	5	1	0	0	0	0	0.0702	0.233	1.000
61	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	HRAS(1), JAK3(1), LCK(2), MAP2K1(3), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1), SYK(2)	1295784	14	11	12	0	9	1	2	2	0	0	0.00248	0.241	1.000
62	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(1)	102044	1	1	1	0	0	1	0	0	0	0	0.642	0.243	1.000
63	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3CA(1), PIK3R1(4), RELA(1)	1087613	13	11	11	3	5	1	2	1	4	0	0.218	0.252	1.000
64	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), GNAS(3), PLCE1(5), PRKAR1A(1)	822197	12	11	11	3	9	0	0	2	1	0	0.210	0.256	1.000
65	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	CBL(3), E2F1(2), HRAS(1), IRS1(1), JAK3(1), MYC(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), STAT5A(1), SYK(2)	2021874	20	12	20	1	6	1	2	6	5	0	0.00717	0.261	1.000
66	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP9(1), RECK(2)	418971	4	4	4	1	2	0	1	0	1	0	0.390	0.261	1.000
67	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2)	673675	7	7	7	1	3	0	1	0	3	0	0.272	0.269	1.000
68	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(1), EGF(1), EGFR(1), MET(4), PDGFRA(5), PRKCA(1)	1091821	16	13	16	4	6	3	3	3	1	0	0.170	0.282	1.000
69	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	HRAS(1), INSR(2), IRS1(1), MAP2K1(3), MAPK8(1), PIK3CA(1), PIK3R1(4), PTPN11(1), SHC1(2), SOS1(1)	1435454	17	12	15	3	7	0	2	4	4	0	0.113	0.288	1.000
70	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(1), ERBB3(1), NRG1(3)	578413	6	6	6	1	3	1	2	0	0	0	0.266	0.289	1.000
71	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(3), DRD2(2), GRM1(1), PLCB1(4), PPP1CA(1), PRKAR1A(1)	894207	12	10	12	4	5	3	1	1	2	0	0.344	0.293	1.000
72	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	93001	2	2	2	0	2	0	0	0	0	0	0.344	0.299	1.000
73	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1)	451692	5	5	5	0	4	1	0	0	0	0	0.0873	0.322	1.000
74	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), EGFR(1), GNAQ(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP3K1(1), MAPK8(1), MEF2B(1), MEF2C(1), MEF2D(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1)	1874937	21	15	19	4	12	2	2	3	2	0	0.0397	0.336	1.000
75	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	BTK(2), CDKN2A(1), DAPP1(1), INPP5D(6), PIK3CA(1), PPP1R13B(2), PTEN(5), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	2020638	27	17	27	5	14	2	5	2	4	0	0.0398	0.337	1.000
76	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CRK(1), CXCR4(1), GNAQ(2), HRAS(1), MAP2K1(3), PIK3C2G(7), PIK3CA(1), PIK3R1(4), PRKCA(1), PTK2B(1), RELA(1)	1541001	24	15	22	6	13	2	2	3	4	0	0.0726	0.339	1.000
77	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL2(2), ARAF(1), BRAF(24), BTC(2), CAMK2B(3), CAMK2G(1), CBL(3), CBLB(3), CBLC(1), CRK(1), EGF(1), EGFR(1), ERBB3(1), ERBB4(3), EREG(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), MYC(1), NCK2(2), NRAS(6), NRG1(3), NRG3(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), STAT5A(1), TGFA(1)	5753687	96	34	68	17	38	4	10	37	7	0	0.000370	0.344	1.000
78	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(1), KARS(2)	263246	3	3	3	0	2	0	1	0	0	0	0.300	0.346	1.000
79	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	HRAS(1), MAP2K1(3), MAP2K2(1), NGFR(1)	456708	6	6	4	1	6	0	0	0	0	0	0.110	0.354	1.000
80	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	HRAS(1), MAP2K1(3), MPL(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), THPO(1)	1679055	17	13	15	3	8	1	2	3	3	0	0.0814	0.365	1.000
81	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT2(1)	230400	2	2	2	1	1	1	0	0	0	0	0.628	0.382	1.000
82	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACSL1(2), CPT1A(1), EHHADH(1), SCP2(2)	950646	7	7	7	1	4	1	0	2	0	0	0.226	0.397	1.000
83	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(2), E2F1(2), TFDP1(1)	483056	5	5	5	0	4	1	0	0	0	0	0.0968	0.404	1.000
84	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1)	475994	5	5	5	1	3	1	0	1	0	0	0.289	0.408	1.000
85	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2)	436504	5	5	5	1	4	0	0	1	0	0	0.312	0.413	1.000
86	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRB1(1)	170264	2	2	2	0	1	1	0	0	0	0	0.346	0.414	1.000
87	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(4)	206828	5	4	5	2	5	0	0	0	0	0	0.437	0.425	1.000
88	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR1H4(2)	305149	4	4	4	1	4	0	0	0	0	0	0.299	0.428	1.000
89	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(1), CDC42(1), WASF1(1)	456250	4	4	4	1	2	1	0	1	0	0	0.513	0.431	1.000
90	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(3), CDC25C(1), GNAS(3), HRAS(1), MYT1(2), PRKAR1A(1), RPS6KA1(3)	1151859	15	13	14	4	11	1	1	1	1	0	0.145	0.432	1.000
91	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), HRAS(1), IL3RA(1), MAP2K1(3), SHC1(2), SOS1(1), STAT5A(1)	988279	10	9	8	2	6	0	1	2	1	0	0.163	0.435	1.000
92	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SULT1A2(2), SULT1E1(4), SULT2A1(1), SUOX(1)	343556	8	6	8	3	6	1	0	0	1	0	0.403	0.437	1.000
93	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	APOA4(1), CYP7A1(1), HMGCR(6), LDLR(2), LIPC(1), LRP1(9), SCARB1(1)	1543544	21	13	21	3	11	1	0	7	2	0	0.0159	0.442	1.000
94	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNB1(1), PIK3CA(1), PIK3R1(4), PTK2B(1), TERT(3)	914556	10	7	10	3	2	3	1	1	3	0	0.270	0.463	1.000
95	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), G6PD(1), H6PD(2), PFKM(1), PGD(1), PGM3(3), PRPS1L1(1), PRPS2(1), RPIA(1), TKTL1(1), TKTL2(5)	1358888	18	14	18	5	10	2	0	5	1	0	0.0986	0.468	1.000
96	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3)	1274929	16	13	15	3	13	0	1	1	1	0	0.0577	0.469	1.000
97	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CREBBP(3), GNAS(3), HLA-DRB1(1), LCK(2), PRKAR1A(1), PTPRC(3)	1274929	16	13	15	3	13	0	1	1	1	0	0.0577	0.469	1.000
98	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(3), PRF1(2)	593872	6	6	6	1	4	0	0	1	1	0	0.238	0.469	1.000
99	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(1), TP53(4), WT1(1)	397838	6	6	6	3	1	1	0	1	3	0	0.693	0.478	1.000
100	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3)	701493	30	13	30	9	24	2	0	2	2	0	0.0710	0.480	1.000
101	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IL4R(1), IRS1(1), JAK3(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1)	2051114	16	12	16	1	6	1	2	3	4	0	0.0187	0.480	1.000
102	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ICAM1(1), ITGA4(2), ITGB2(1), SELE(2), SELP(1)	887550	8	8	8	2	4	0	1	0	3	0	0.359	0.488	1.000
103	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(1), EGFR(1), HRAS(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1)	2101954	19	14	17	4	8	1	4	3	3	0	0.101	0.505	1.000
104	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	96602	1	1	1	1	1	0	0	0	0	0	0.853	0.517	1.000
105	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	HRAS(1), PTK2B(1), SHC1(2), SOS1(1)	494953	5	4	5	0	2	1	1	1	0	0	0.149	0.518	1.000
106	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), RBL1(1), TFDP1(1)	903066	11	8	11	2	8	0	1	2	0	0	0.135	0.521	1.000
107	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(1)	221391	3	3	3	1	3	0	0	0	0	0	0.416	0.529	1.000
108	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	FYN(1), HLA-DRB1(1), LCK(2), PTPRC(3)	498126	7	4	7	0	5	0	1	0	1	0	0.0373	0.537	1.000
109	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(1), EIF5(1), PPP1CA(1)	651806	5	5	5	0	2	0	1	1	1	0	0.240	0.538	1.000
110	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1)	447276	6	6	6	3	4	1	0	0	1	0	0.483	0.544	1.000
111	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1)	447276	6	6	6	3	4	1	0	0	1	0	0.483	0.544	1.000
112	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(1), TGM2(1)	279183	4	3	4	1	3	0	0	0	1	0	0.375	0.547	1.000
113	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKAR1A(1), PRKCA(1)	533508	5	5	5	2	4	0	0	0	1	0	0.617	0.548	1.000
114	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(1), E2F1(2), MDM2(1), TP53(4)	1017334	8	8	8	2	3	1	1	1	2	0	0.328	0.554	1.000
115	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), MST1(1), MST1R(1)	368467	4	4	4	1	3	0	0	0	1	0	0.533	0.561	1.000
116	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), RELA(1), XDH(6)	553453	8	7	8	3	7	1	0	0	0	0	0.386	0.566	1.000
117	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK6(1), E2F1(2), HRAS(1), PIK3CA(1), PIK3R1(4), RELA(1), TFDP1(1)	1132551	11	9	11	3	5	0	1	2	3	0	0.331	0.578	1.000
118	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT9(3), HEXA(2), NAGA(1)	566756	7	6	7	2	5	0	1	1	0	0	0.278	0.579	1.000
119	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASS(1), KARS(2)	389447	3	3	3	0	2	0	1	0	0	0	0.303	0.579	1.000
120	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(3), PRKAA2(2), PRKAG2(2), PRKAR1A(1)	857937	11	10	10	4	9	1	0	0	1	0	0.371	0.581	1.000
121	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), MUT(2)	283496	3	3	3	0	2	0	0	1	0	0	0.322	0.584	1.000
122	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ICAM1(1), ITGB2(1), SELE(2)	577785	5	5	5	1	3	0	0	0	2	0	0.321	0.594	1.000
123	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(1)	352468	2	2	2	1	0	0	0	0	2	0	0.804	0.595	1.000
124	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3)	272232	3	3	3	1	3	0	0	0	0	0	0.504	0.597	1.000
125	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(1), ATR(5), CCNA1(5), CDK6(1), CDKN2A(1), E2F1(2), TFDP1(1), TP53(4)	1693749	20	14	20	4	10	1	2	4	3	0	0.0889	0.597	1.000
126	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(2)	148134	2	2	2	1	2	0	0	0	0	0	0.630	0.599	1.000
127	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), UGP2(1)	275948	2	2	2	0	1	0	0	0	1	0	0.408	0.601	1.000
128	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), ICAM1(1), ITGB2(1), PRF1(2)	486744	5	5	5	2	3	0	0	1	1	0	0.421	0.607	1.000
129	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), E2F1(2), ETS1(1), ETS2(1), HDAC5(1), HRAS(1), NCOR2(2), RBL1(1), RBL2(2), SIN3A(3)	1450925	16	10	16	2	9	2	1	3	1	0	0.0227	0.607	1.000
130	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(1), MAP2K1(3), MAP3K1(1), NCOR2(2), THRA(2), THRB(3)	960492	13	11	11	4	7	2	2	1	1	0	0.224	0.620	1.000
131	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), XYLT1(3)	359670	5	5	5	2	4	1	0	0	0	0	0.319	0.624	1.000
132	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), XYLT1(3)	359670	5	5	5	2	4	1	0	0	0	0	0.319	0.624	1.000
133	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	DAG1(1), GNAQ(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2)	2512798	24	15	23	7	8	2	2	10	2	0	0.211	0.624	1.000
134	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), EHHADH(1)	469265	3	3	3	0	2	0	1	0	0	0	0.254	0.635	1.000
135	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(1), ATR(5), CDC25C(1), TP53(4)	900674	11	10	11	4	3	1	1	3	3	0	0.656	0.638	1.000
136	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), LDLR(2)	300636	3	3	3	0	3	0	0	0	0	0	0.213	0.640	1.000
137	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(5), HRAS(1), INSR(2), IRS1(1), MAP2K1(3), PIK3CA(1), PIK3R1(4), PRKCA(1), RPS6KA1(3), SHC1(2), SOS1(1), STAT5A(1)	1860212	25	16	23	6	12	1	3	4	5	0	0.0714	0.640	1.000
138	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), VAV1(2)	721294	12	10	12	6	5	0	2	2	3	0	0.627	0.651	1.000
139	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), TPK1(1)	359971	2	2	2	0	1	0	0	0	1	0	0.443	0.666	1.000
140	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(1), TRAF2(1)	462260	4	4	4	1	4	0	0	0	0	0	0.356	0.667	1.000
141	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(1)	131815	1	1	1	1	1	0	0	0	0	0	0.834	0.670	1.000
142	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), HRAS(1), MAP2K1(3), MAPK8(1), SHC1(2), SOS1(1), STAT5A(1)	1197732	10	9	8	2	7	0	1	2	0	0	0.159	0.673	1.000
143	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3)	973231	41	17	41	10	31	3	1	3	3	0	0.00827	0.675	1.000
144	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), CSF2RB(1), IGF1R(1), IL3RA(1), KIT(1), KITLG(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1)	1231595	14	11	13	5	6	0	2	1	5	0	0.330	0.682	1.000
145	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1), KERA(1), LUM(1)	199830	3	3	3	2	3	0	0	0	0	0	0.646	0.685	1.000
146	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), HMGCR(6), MVK(1), SQLE(1)	616813	9	5	9	0	4	0	0	4	1	0	0.0487	0.688	1.000
147	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SRD5A1(1), SRD5A2(1)	1307400	26	17	26	8	20	2	1	2	1	0	0.0509	0.693	1.000
148	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(2), PRKAR1A(1)	678735	3	3	3	1	0	0	1	0	2	0	0.712	0.704	1.000
149	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BTK(2), EEA1(2), LYN(1), PFKM(1), PRKCZ(1), VAV2(1)	1390778	8	7	8	2	5	0	0	1	2	0	0.222	0.711	1.000
150	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), JAK3(1), STAT3(1), STAT5A(1), TYK2(1)	1023676	7	6	7	1	3	2	0	2	0	0	0.203	0.712	1.000
151	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CDO1(1), GOT2(2), LDHA(1), LDHAL6A(1), SULT1C2(1), SULT4A1(1)	704427	8	7	8	2	6	0	0	1	1	0	0.299	0.712	1.000
152	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(1), HLA-DRB1(1)	221509	2	2	2	1	2	0	0	0	0	0	0.615	0.715	1.000
153	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT2(2), LDHA(1)	385554	4	3	4	2	3	0	0	0	1	0	0.697	0.725	1.000
154	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(1)	374957	2	2	2	1	1	0	1	0	0	0	0.730	0.728	1.000
155	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GPHN(2), UBQLN1(1)	662976	8	6	8	2	7	0	0	1	0	0	0.232	0.735	1.000
156	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), SREBF2(2)	668714	4	4	4	2	2	0	0	1	1	0	0.744	0.738	1.000
157	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	SULT1A2(2), SULT1E1(4), SULT2A1(1), SULT2B1(1), SUOX(1)	512958	9	7	9	4	7	1	0	0	1	0	0.349	0.738	1.000
158	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	HRAS(1), JAK3(1), MAP2K1(3), PTPN11(1), SHC1(2), SOS1(1), STAT3(1)	1334918	10	8	8	0	6	1	1	2	0	0	0.0189	0.739	1.000
159	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	178374	1	1	1	0	1	0	0	0	0	0	0.609	0.745	1.000
160	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), MASP1(1)	1158249	47	19	47	11	35	4	1	3	4	0	0.00295	0.746	1.000
161	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), EIF4E(1), LDHA(1)	503425	3	2	3	1	1	0	1	0	1	0	0.708	0.748	1.000
162	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), EHHADH(1)	680576	7	7	7	3	5	1	0	0	1	0	0.395	0.748	1.000
163	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), THBS1(3)	415999	4	3	4	1	3	0	0	0	1	0	0.392	0.750	1.000
164	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1)	167006	2	1	2	1	2	0	0	0	0	0	0.660	0.758	1.000
165	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC2(1), ABCG2(1), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1)	1284804	11	9	11	2	9	1	0	1	0	0	0.0594	0.763	1.000
166	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1)	306466	1	1	1	0	0	0	0	1	0	0	0.832	0.763	1.000
167	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(3), AXIN1(1), BTRC(1), CREBBP(3), CSNK1A1(1), CTNNB1(2), MYC(1), NLK(2), TLE1(1), WIF1(1)	1640685	16	12	16	4	7	0	2	5	2	0	0.269	0.766	1.000
168	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT3(2), ST3GAL3(1)	280936	3	2	3	1	2	0	0	1	0	0	0.505	0.766	1.000
169	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(2)	475919	3	3	3	1	2	0	0	0	1	0	0.645	0.769	1.000
170	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), NPAS2(3), PER2(2)	956355	6	5	6	2	3	1	1	0	1	0	0.407	0.772	1.000
171	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT9(3)	336328	3	3	3	1	3	0	0	0	0	0	0.433	0.780	1.000
172	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), AOX1(3), BCKDHA(1), EHHADH(1), MCCC2(2), MUT(2), OXCT1(1), PCCA(2), PCCB(1)	2025923	24	14	24	5	17	1	2	2	2	0	0.0354	0.788	1.000
173	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), HMGCR(6), MVK(1), SQLE(1)	737196	9	5	9	0	4	0	0	4	1	0	0.0549	0.799	1.000
174	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	219521	1	1	1	1	1	0	0	0	0	0	0.832	0.801	1.000
175	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(1)	358385	4	4	4	8	2	1	0	0	1	0	0.987	0.801	1.000
176	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), IL10RA(1), STAT3(1), STAT5A(1)	686847	4	4	4	0	2	0	0	2	0	0	0.227	0.813	1.000
177	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1)	238079	1	1	1	1	1	0	0	0	0	0	0.853	0.814	1.000
178	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(6), ATM(1), CSNK1A1(1), MAPK8(1), MDM2(1), TP53(4)	1169756	14	11	14	4	7	1	2	2	2	0	0.248	0.820	1.000
179	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO2(1), IDH1(3)	502443	4	4	3	2	3	1	0	0	0	0	0.606	0.825	1.000
180	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	BRD4(1), CBL(3), CDC42(1), CDKN2A(1), IRS1(1), PARD3(2), PARD6A(1), PIK3CA(1), PIK3R1(4), PTEN(5), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2)	3347138	29	19	29	9	7	2	5	7	8	0	0.354	0.827	1.000
181	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	STX1A(1)	183803	1	1	1	1	1	0	0	0	0	0	0.787	0.828	1.000
182	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), ITGB1BP3(2), MYST3(1), MYST4(2)	1460909	12	9	12	3	6	1	2	2	1	0	0.253	0.830	1.000
183	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), GGCX(1), HMGCR(6), HSD17B7(1), MVK(1), SQLE(1), TM7SF2(1)	1079542	12	7	12	0	7	0	0	4	1	0	0.0102	0.830	1.000
184	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK3(1), STAT3(1), TYK2(1)	653740	3	3	3	1	1	2	0	0	0	0	0.537	0.835	1.000
185	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(3), APOBEC2(1)	414701	4	4	4	2	4	0	0	0	0	0	0.580	0.835	1.000
186	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(2), C1R(1), C1S(5), C2(2), C3(3), C5(2), C6(10), C7(9), C8A(3), C9(3), MASP1(1), MBL2(1)	1186699	43	17	43	11	32	4	1	3	3	0	0.00836	0.836	1.000
187	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	238765	1	1	1	0	1	0	0	0	0	0	0.616	0.841	1.000
188	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(1), EGFR(1), HRAS(1), MAP2K1(3), PTPRB(12), SHC1(2), SOS1(1), SPRY3(1), SPRY4(1)	1400414	26	16	24	6	15	0	3	6	2	0	0.106	0.848	1.000
189	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1)	428560	2	2	2	2	1	0	0	1	0	0	0.909	0.850	1.000
190	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), GNAS(3), PRKAR1A(1)	727624	9	9	8	4	7	0	0	0	2	0	0.521	0.850	1.000
191	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	173494	1	1	1	0	1	0	0	0	0	0	0.607	0.852	1.000
192	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT3(1), B4GALT5(1), ST3GAL3(1)	439468	3	3	3	2	2	0	0	0	1	0	0.681	0.852	1.000
193	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	189754	1	1	1	0	1	0	0	0	0	0	0.655	0.854	1.000
194	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(2), C6(10), C7(9), ICAM1(1), ITGA4(2), ITGB2(1), SELP(1), VCAM1(2)	1382673	31	14	31	9	23	2	2	1	3	0	0.0380	0.857	1.000
195	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(2), GLI3(2), PRKAR1A(1), SHH(1), SMO(1), SUFU(1)	930334	9	8	9	3	6	2	0	0	1	0	0.366	0.859	1.000
196	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL4R(1), IRS1(1), JAK3(1), SHC1(2), STAT6(1)	828013	6	4	6	0	3	1	1	0	1	0	0.0968	0.863	1.000
197	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(3), NOS3(1), PIK3CA(1), PIK3R1(4), RELA(1), SYT1(1)	999611	11	11	11	9	6	0	1	1	3	0	0.924	0.863	1.000
198	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFB2(1)	392185	1	1	1	0	0	0	1	0	0	0	0.677	0.870	1.000
199	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	GATA1(1), HMBS(1)	436169	2	2	2	1	1	0	0	0	1	0	0.640	0.872	1.000
200	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1)	216519	1	1	1	0	1	0	0	0	0	0	0.632	0.874	1.000
201	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GNAQ(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK8(1), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), SYT1(1)	1596328	18	13	16	5	10	2	2	3	1	0	0.142	0.877	1.000
202	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP2K1(3), MAP3K1(1), MAPK8(1), RELA(1), TRAF2(1)	1144218	8	8	6	2	7	1	0	0	0	0	0.259	0.879	1.000
203	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(2), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1)	1514752	25	13	25	6	16	2	0	4	3	0	0.0449	0.881	1.000
204	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(3), AXIN1(1), BTRC(1), CTNNB1(2), DLL1(2)	1189128	9	7	9	2	6	0	1	1	1	0	0.224	0.882	1.000
205	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCS2(1), OXCT1(1), OXCT2(1)	402058	3	3	3	3	1	0	0	1	1	0	0.891	0.883	1.000
206	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(1), DBH(1), GAD1(2), GAD2(3), HDC(3), MAOA(1), PAH(1), SLC18A3(1), TPH1(4)	794189	17	10	17	5	14	1	0	2	0	0	0.0842	0.887	1.000
207	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1), TRAF6(1)	808459	5	5	5	1	4	1	0	0	0	0	0.349	0.888	1.000
208	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	SDHA(2), SDHC(1)	374105	3	3	3	2	3	0	0	0	0	0	0.738	0.888	1.000
209	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(2), CREBBP(3), MAP2K1(3)	1444189	11	10	9	2	10	0	0	1	0	0	0.194	0.891	1.000
210	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(1), PC(1)	521617	3	3	3	2	1	1	0	1	0	0	0.750	0.893	1.000
211	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), ALOX15B(2), ALOX5(1), DPEP1(1), GGT1(1), PLA2G6(2), PTGS2(1), TBXAS1(3)	838295	12	11	12	5	8	1	0	1	2	0	0.290	0.894	1.000
212	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), PELP1(2)	826026	5	4	5	1	4	0	0	1	0	0	0.424	0.902	1.000
213	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK3(1), PTPRU(1), REG1A(1), STAT3(1)	851973	4	4	4	1	2	1	0	0	1	0	0.327	0.902	1.000
214	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(1), IGF1R(1), MYC(1), POLR2A(1), PRKCA(1), TEP1(1), TERT(3), TP53(4)	1583574	13	10	13	4	6	3	1	1	2	0	0.182	0.905	1.000
215	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2B(3), CAMK2G(1), CLCA1(1), CLCA2(1), CLCA4(4), CNGA3(2), CNGB1(1), GUCA1C(1), PDC(1), PDE1C(3), PRKACA(1), PRKG1(1), PRKG2(3), PRKX(1)	1696325	25	14	25	7	17	2	0	4	2	0	0.0531	0.908	1.000
216	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), AOC2(1)	338086	3	2	3	2	2	0	0	0	1	0	0.668	0.909	1.000
217	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(1), SNCAIP(7), UBE2F(1)	361868	9	8	9	6	7	0	1	0	1	0	0.762	0.913	1.000
218	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT9(3), HEXA(2), NAGA(1)	601902	7	6	7	4	5	0	1	1	0	0	0.593	0.913	1.000
219	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(1), HSD3B2(1)	387284	5	5	5	5	3	1	0	0	1	0	0.770	0.918	1.000
220	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(1), G6PD(1), GGT1(1), GPX5(1), IDH1(3), PGD(1)	1016033	8	8	7	3	6	0	1	1	0	0	0.300	0.918	1.000
221	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), ITGB3(1), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), SMPD2(1)	1544614	20	17	19	8	11	1	3	2	3	0	0.319	0.918	1.000
222	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACAA2(1), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), AOX1(3), BCAT2(1), BCKDHA(1), EHHADH(1), HMGCS2(1), MCCC2(2), MUT(2), OXCT1(1), OXCT2(1), PCCA(2), PCCB(1)	2419190	26	17	26	5	17	1	2	4	2	0	0.0263	0.918	1.000
223	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(2), HLA-DRB1(1), IL12B(1), IL12RB1(2), IL4R(1)	710194	7	7	7	3	6	0	0	0	1	0	0.431	0.918	1.000
224	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK3(1), PTPRU(1), REG1A(1)	766131	3	3	3	1	1	1	0	0	1	0	0.494	0.919	1.000
225	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CD8B(1), CIITA(2), CTSB(2), CTSL1(1), CTSS(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), HSP90AA1(1), HSP90AB1(1), IFNA16(1), IFNA21(2), IFNA6(1), KIR2DL4(1), KIR2DS4(2), KIR3DL1(1), KIR3DL3(3), KLRC1(1), LGMN(1), NFYA(1), NFYC(1), PDIA3(1), TAP1(1)	2587009	30	17	30	7	17	5	2	5	1	0	0.0295	0.921	1.000
226	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1)	493051	2	2	2	0	1	0	0	0	1	0	0.523	0.924	1.000
227	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), MECR(1)	476390	2	2	2	0	1	0	0	1	0	0	0.509	0.925	1.000
228	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1)	307027	1	1	1	0	1	0	0	0	0	0	0.613	0.927	1.000
229	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	IL4R(1), INPP5D(6), JAK3(1), PIK3CA(1), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), STAT6(1), TYK2(1)	2067778	20	12	20	3	13	3	1	2	1	0	0.0193	0.927	1.000
230	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IKBKB(1), RELA(1), TP53(4), WT1(1)	1013495	7	7	7	3	3	1	0	0	3	0	0.565	0.929	1.000
231	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT2(2)	264740	2	2	2	2	2	0	0	0	0	0	0.827	0.929	1.000
232	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25B(2), CDC25C(1), SHH(1)	490559	4	3	4	3	0	2	0	1	1	0	0.928	0.929	1.000
233	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(1), CDC25B(2), CDC25C(1), MYT1(2), TP53(4), WEE1(1)	990254	11	10	11	6	3	2	1	2	3	0	0.790	0.929	1.000
234	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL3(1), GLCE(1), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), NDST3(2), NDST4(5)	1147535	16	8	16	6	11	2	1	1	1	0	0.195	0.930	1.000
235	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC2(1), ANAPC5(1), BTRC(1), CDC16(1), CDC27(1), CUL1(2), CUL3(2), FBXW7(1), FZR1(1), ITCH(1)	2244050	13	12	13	3	6	1	3	1	2	0	0.236	0.930	1.000
236	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(3), NCOA3(3), PRKAR1A(1)	1160492	7	6	7	1	4	1	0	1	1	0	0.329	0.931	1.000
237	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(1), IARS2(1), LARS2(1), PDHA2(2)	1055053	5	5	5	1	5	0	0	0	0	0	0.277	0.933	1.000
238	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK3(2), IMPA1(1), ISYNA1(1), PGM3(3)	652450	10	7	10	6	4	2	0	2	2	0	0.583	0.935	1.000
239	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	CASP8AP2(2)	604414	2	2	2	0	1	0	0	0	1	0	0.436	0.938	1.000
240	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), F2R(1), GNAQ(2), PIK3CA(1), PIK3R1(4), PLCB1(4), PRKCA(1), PTK2B(1)	1448116	17	15	16	7	7	1	2	4	3	0	0.450	0.939	1.000
241	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), METTL2B(1), METTL6(1), PCYT1B(1)	787862	4	4	4	1	3	0	0	1	0	0	0.434	0.940	1.000
242	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	PTPRU(1), REG1A(1)	641018	2	2	2	1	1	0	0	0	1	0	0.658	0.940	1.000
243	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(2), POLR2A(1), PRKAR1A(1)	722932	4	4	4	2	3	0	0	0	1	0	0.661	0.943	1.000
244	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS2(1), PDHA2(2)	565212	3	3	3	0	3	0	0	0	0	0	0.280	0.943	1.000
245	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), RELN(6)	785182	9	7	9	9	6	0	1	0	2	0	0.974	0.944	1.000
246	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACB(4), ARAF(1), BRAF(24), CBL(3), CBLB(3), CBLC(1), CRK(1), G6PC(2), G6PC2(3), GCK(3), GYS2(2), HRAS(1), IKBKB(1), INPP5D(6), INSR(2), IRS1(1), LIPE(1), MAP2K1(3), MAP2K2(1), MAPK10(1), MAPK8(1), MAPK9(2), NRAS(6), PDE3A(3), PFKM(1), PHKA1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(7), PRKAA2(2), PRKACA(1), PRKAG2(2), PRKAR1A(1), PRKCZ(1), PRKX(1), PTPRF(1), PYGL(2), RHEB(1), SH2B2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), TSC2(1)	8954807	123	33	95	25	56	5	9	38	14	1	2.66e-05	0.945	1.000
247	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1)	566605	1	1	1	1	0	1	0	0	0	0	0.878	0.947	1.000
248	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG1(1), CPS1(1), PYCR1(1), SMS(1)	974453	5	5	5	2	2	1	1	0	1	0	0.606	0.947	1.000
249	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), SHMT2(1), TPO(5)	654036	7	4	6	2	6	1	0	0	0	0	0.197	0.948	1.000
250	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(1), EPRS(2), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	1543139	23	16	23	6	18	1	1	2	1	0	0.0533	0.949	1.000
251	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4), XYLB(1)	1515928	34	18	34	10	23	3	1	2	5	0	0.0500	0.949	1.000
252	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), IKBKB(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF2(1)	1335540	9	9	9	3	5	2	1	0	1	0	0.343	0.951	1.000
253	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	EHHADH(1)	438508	1	1	1	0	1	0	0	0	0	0	0.613	0.951	1.000
254	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(3), AXIN1(1), CTNNB1(2), GJA1(1), IRAK1(1), LBP(1), PIK3CA(1), PIK3R1(4), RELA(1), TLR4(3)	1712803	18	10	18	5	8	2	3	2	3	0	0.202	0.953	1.000
255	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(2), CDC25C(1), PRKCA(1)	521024	4	3	4	5	1	1	0	1	1	0	0.973	0.954	1.000
256	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), DPYD(5), DPYS(2), EHHADH(1), GAD1(2), GAD2(3), MLYCD(1), SMS(1)	1629728	26	14	26	8	17	2	0	3	4	0	0.0945	0.954	1.000
257	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF6(1)	1013183	5	4	5	1	3	2	0	0	0	0	0.369	0.955	1.000
258	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	BLNK(2), BTK(2), CARD11(3), CD22(4), CR2(1), HRAS(1), IKBKB(1), INPP5D(6), LYN(1), MALT1(1), NFAT5(1), NFKB2(1), NRAS(6), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), RASGRP3(2), SYK(2), VAV1(2), VAV2(1), VAV3(1)	4171496	52	25	46	15	29	1	6	9	7	0	0.0309	0.955	1.000
259	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLE(1), POLG(1), POLG2(2), POLI(3), POLQ(2), PRIM2(1), REV1(3), REV3L(2)	2271990	16	12	16	4	9	1	1	3	2	0	0.254	0.957	1.000
260	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), ENPP1(2), ENPP3(1)	815580	6	5	6	3	3	2	1	0	0	0	0.608	0.959	1.000
261	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), CNDP1(1), HDC(3), MAOA(1), PRPS2(1)	1366091	15	11	15	6	11	2	0	0	2	0	0.182	0.960	1.000
262	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), HEMK1(1), METTL2B(1), METTL6(1)	844543	4	4	4	1	3	0	0	1	0	0	0.405	0.961	1.000
263	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), DHRS2(1), PON1(1), PON3(1)	1006757	13	12	13	9	7	2	1	1	2	0	0.734	0.962	1.000
264	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1)	1058916	8	8	8	3	4	2	0	1	1	0	0.415	0.962	1.000
265	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), SPN(1), TNFRSF8(3), TNFSF8(1)	726987	10	8	10	5	6	1	0	1	2	0	0.602	0.965	1.000
266	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(1), BMPR1B(1), ESR2(2), FSHR(4), LHCGR(3), MSH5(2), NCOR1(1), NRIP1(1), PRLR(1), VDR(1), ZP2(1)	1958389	18	14	18	5	9	1	3	1	4	0	0.219	0.965	1.000
267	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(3), NRG3(1), PRKCA(1)	501083	5	4	5	3	3	0	0	1	1	0	0.786	0.966	1.000
268	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1)	841314	5	5	5	3	0	2	1	1	1	0	0.777	0.966	1.000
269	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	BIRC3(1), CASP7(1), CASP8(1)	757545	3	3	3	1	3	0	0	0	0	0	0.536	0.967	1.000
270	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	BAIAP2(2), CASP1(1), CASP7(1), CASP8(1), GAPDH(2), INSR(2), ITCH(1), MAGI1(2), MAGI2(7)	1348832	19	9	19	8	13	1	0	3	2	0	0.412	0.968	1.000
271	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	MAFK(1), MAPK8(1), PRKCA(1)	494718	3	2	3	1	3	0	0	0	0	0	0.496	0.968	1.000
272	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(3), CYP11B1(3), CYP11B2(1), HSD17B2(1), HSD17B3(1), HSD3B2(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	1527950	33	18	33	10	25	3	1	3	1	0	0.0291	0.969	1.000
273	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CYP2C19(7), CYP2C9(3), DHRS2(1), EHHADH(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1736023	25	14	25	8	13	2	2	6	2	0	0.198	0.970	1.000
274	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(2)	516524	2	2	2	1	2	0	0	0	0	0	0.634	0.971	1.000
275	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TOB1(1)	593198	1	1	1	2	0	0	0	0	1	0	0.944	0.973	1.000
276	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	HMBS(1)	424834	1	1	1	1	1	0	0	0	0	0	0.847	0.973	1.000
277	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK3(2), IMPA1(1), PGM3(3)	572913	9	7	9	6	4	2	0	2	1	0	0.686	0.973	1.000
278	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKB(1), MAP3K1(1), MAP3K14(1), RELA(1), TRAF2(1)	1253332	5	5	5	1	3	2	0	0	0	0	0.347	0.973	1.000
279	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAQ(2), GNAS(3), HRAS(1), MAP2K1(3), PIK3C2G(7), PLCB1(4), PRKCA(1), ROCK2(1)	1404977	23	15	21	8	14	2	2	3	2	0	0.228	0.974	1.000
280	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3R1(4), SYT1(1), TRAF2(1), TRAF6(1)	1874591	20	15	20	7	12	0	2	2	4	0	0.227	0.974	1.000
281	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPT(1), ENPP1(2), ENPP3(1)	541476	4	4	4	3	0	2	1	1	0	0	0.857	0.976	1.000
282	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR109B(1), GPR18(1), GPR39(1), GPR81(1)	549471	7	6	7	7	5	1	0	0	1	0	0.731	0.976	1.000
283	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(1)	432747	2	2	2	2	1	1	0	0	0	0	0.869	0.976	1.000
284	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGB2(1), PTPRC(3)	597674	5	4	5	2	5	0	0	0	0	0	0.410	0.977	1.000
285	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC3(1), CASP10(1), CASP7(1), CASP8(1), PRF1(2), SREBF2(2)	1023382	8	8	8	5	5	0	0	1	2	0	0.724	0.977	1.000
286	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX3(2), FADS2(1)	797972	4	4	4	3	3	0	1	0	0	0	0.680	0.977	1.000
287	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(1), MAPK8(1), MDM2(1), MRE11A(1), RAD51(1), RBBP8(2), RELA(1), TP53(4)	1670201	12	9	12	4	7	1	1	1	2	0	0.427	0.979	1.000
288	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(1), POLR2I(1)	753329	3	3	3	2	1	0	1	1	0	0	0.805	0.981	1.000
289	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IKBKB(1), MAP3K1(1), MAP3K5(2), MAPK8(1), RELA(1), TRAF2(1)	1075378	7	7	7	3	6	1	0	0	0	0	0.549	0.981	1.000
290	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGB2(1), PTPRC(3)	626578	5	4	5	2	5	0	0	0	0	0	0.405	0.982	1.000
291	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), FUT3(2), ST3GAL3(1)	401636	4	3	4	3	3	0	0	1	0	0	0.758	0.982	1.000
292	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH9A1(1), EHHADH(1), GAD1(2), GAD2(3), OXCT1(1), PDHA2(2)	1451462	16	10	16	5	12	1	0	2	1	0	0.154	0.982	1.000
293	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1D1(3), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP7A1(1), SLC27A5(1), SRD5A1(1), SRD5A2(1)	1778438	26	18	26	9	19	3	1	3	0	0	0.0890	0.982	1.000
294	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2)	568420	10	7	10	6	8	0	0	2	0	0	0.645	0.982	1.000
295	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	CDC42(1), DUSP4(2), DUSP8(1), GCK(3), IL1R1(1), MAP3K1(1), MAP3K12(1), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK8(1), MAPK9(2), PAPPA(9), SHC1(2), TP53(4), TRAF6(1), ZAK(1)	2816626	35	16	35	7	21	8	1	1	4	0	0.0119	0.983	1.000
296	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	932068	6	4	6	3	3	0	2	1	0	0	0.726	0.983	1.000
297	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	GBA(2), TPO(5)	470215	7	5	6	3	6	0	0	1	0	0	0.392	0.983	1.000
298	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B2(1), FLT4(4), HRAS(1), KDR(3), NOS3(1), PIK3CA(1), PIK3R1(4), PRKCA(1), SHC1(2)	1912555	18	13	18	7	11	0	2	1	4	0	0.327	0.983	1.000
299	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), POLG(1), PRPS2(1)	698244	3	2	3	1	2	0	0	0	1	0	0.645	0.984	1.000
300	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B4GALT3(1), CHST4(2), ST3GAL3(1)	695896	4	4	4	7	3	0	0	0	1	0	0.952	0.984	1.000
301	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO2(1), HAO1(1), HAO2(3)	717924	5	4	5	4	3	1	0	0	1	0	0.821	0.985	1.000
302	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT4(2), GALNT6(2), GALNT8(1), GCNT1(1), WBSCR17(2)	812003	8	6	8	4	6	0	1	0	1	0	0.532	0.985	1.000
303	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BIRC3(1), CASP7(1), CASP8(1), MAP3K1(1), MAP3K14(1), MAPK10(1), MDM2(1), MYC(1), PARP1(2), PRF1(2), RELA(1), TNFSF10(1), TP53(4), TRAF2(1)	2090059	19	17	19	7	9	4	0	3	3	0	0.286	0.985	1.000
304	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT3(1), B4GALT5(1), DDOST(1), MAN1A1(2), MGAT2(1), MGAT5(1)	1118698	7	7	7	5	3	1	1	0	2	0	0.764	0.985	1.000
305	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), DAXX(1), HRAS(1), MAP3K1(1), MAP3K5(2), MAP3K9(2), MEF2B(1), MEF2C(1), MEF2D(1), MYC(1), SHC1(2), TRAF2(1)	2040314	15	11	15	4	8	2	1	2	2	0	0.201	0.986	1.000
306	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	EIF4E(1), IL1R1(1), WDR1(1)	597799	3	3	3	2	3	0	0	0	0	0	0.732	0.987	1.000
307	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(1), PDHA2(2), SLC18A3(1)	386030	4	4	4	3	4	0	0	0	0	0	0.744	0.987	1.000
308	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1)	556106	2	2	2	1	2	0	0	0	0	0	0.603	0.988	1.000
309	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO2(1), AFMID(1), HAO1(1), HAO2(3)	751964	6	4	6	4	4	1	0	0	1	0	0.725	0.988	1.000
310	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	BTK(2), FCER1A(2), FYN(1), HRAS(1), INPP5D(6), LCP2(1), LYN(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), NRAS(6), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PRKCA(1), SOS1(1), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1)	4044151	61	26	53	17	34	1	7	11	8	0	0.0155	0.989	1.000
311	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	CYP11A1(2), EDN1(1), EDNRA(1), EDNRB(1), PTGFR(2), PTGIR(1), PTGS2(1), TBXAS1(3)	1151998	12	9	12	6	8	1	0	1	2	0	0.514	0.989	1.000
312	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BRAF(24), CD244(1), CD48(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-G(1), HRAS(1), ICAM1(1), IFNA16(1), IFNA21(2), IFNA6(1), ITGB2(1), KIR2DL4(1), KIR3DL1(1), KLRC1(1), LCK(2), LCP2(1), MAP2K1(3), MAP2K2(1), MICA(1), MICB(1), NFAT5(1), NRAS(6), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRF1(2), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), SYK(2), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TYROBP(1), VAV1(2), VAV2(1), VAV3(1)	6331341	93	34	65	25	38	5	9	32	9	0	0.00982	0.989	1.000
313	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(1), CR2(1), HLA-DRB1(1), ICAM1(1), ITGB2(1), PTPRC(3)	844066	9	5	9	2	9	0	0	0	0	0	0.193	0.989	1.000
314	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), F2R(1), FGA(4), FGG(1), PLAT(1), PLG(3), SERPINB2(3)	749356	15	13	15	8	10	2	0	2	1	0	0.663	0.990	1.000
315	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(1), CDC25B(2), CDC25C(1), MYT1(2), WEE1(1)	775335	7	6	7	6	2	1	1	2	1	0	0.958	0.990	1.000
316	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(3), HDAC3(1), IKBKB(1), RELA(1), TRAF6(1)	1247786	7	6	7	3	5	0	0	1	1	0	0.647	0.990	1.000
317	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(1), CASP1(1), CASP10(1), CASP8(1), PRF1(2)	724299	6	5	6	4	5	0	0	0	1	0	0.728	0.990	1.000
318	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), CYP2A6(1), NAT2(1), XDH(6)	449615	11	9	11	7	9	1	0	1	0	0	0.424	0.991	1.000
319	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1)	779335	11	8	11	6	6	3	1	0	1	0	0.624	0.991	1.000
320	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), UBE3A(1)	726853	3	3	3	3	2	0	0	0	1	0	0.928	0.991	1.000
321	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH9A1(1), EHHADH(1), LDHA(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1)	1862067	17	11	17	5	13	1	0	1	2	0	0.193	0.991	1.000
322	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASS(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), PLOD2(1), PLOD3(1), SHMT2(1), TMLHE(1)	2070062	17	14	17	5	13	3	0	0	1	0	0.103	0.991	1.000
323	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(3), AXIN1(1), BMP10(2), BMP2(2), BMP5(2), BMPR2(1), CTNNB1(2), GATA4(1), MEF2C(1), NKX2-5(1), RFC1(2)	2033868	20	9	20	4	13	1	1	3	2	0	0.0719	0.991	1.000
324	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), PGK1(1)	515025	2	2	2	2	1	0	0	1	0	0	0.843	0.991	1.000
325	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3)	894613	7	6	7	4	5	0	0	1	1	0	0.563	0.992	1.000
326	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(3), BCAR1(1), CTNNA2(4), CTNNB1(2)	1062487	10	7	10	6	7	0	1	0	2	0	0.513	0.992	1.000
327	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
328	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
329	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	846277	3	2	3	2	1	1	0	0	1	0	0.792	0.993	1.000
330	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHPF(1), DSE(1), XYLT1(3)	756015	6	5	6	4	3	2	0	1	0	0	0.612	0.993	1.000
331	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(1), HRAS(1), PAX3(1), SP100(2), TP53(4)	1057508	12	8	12	6	6	2	1	1	2	0	0.555	0.994	1.000
332	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	PTPRU(1), REG1A(1), TYK2(1)	702606	3	3	3	3	1	1	0	0	1	0	0.840	0.994	1.000
333	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PYGL(2)	741966	5	4	5	5	4	0	0	0	1	0	0.856	0.994	1.000
334	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(1), BTK(2), CDKN2A(1), DAPP1(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PPP1R13B(2), PTEN(5), PTPRC(3), RPS6KA1(3), RPS6KA2(1), SYK(2), VAV1(2)	3091457	36	22	36	10	20	2	5	5	4	0	0.0401	0.994	1.000
335	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO2(1), IDH1(3)	749348	5	5	4	3	3	1	0	1	0	0	0.686	0.995	1.000
336	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(1), AGPS(2), ENPP2(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3)	1306635	17	11	17	9	11	0	1	3	2	0	0.597	0.995	1.000
337	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1)	903807	2	2	2	0	1	0	0	0	1	0	0.520	0.995	1.000
338	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2I(1), UBE3A(1)	593128	2	1	2	2	2	0	0	0	0	0	0.923	0.995	1.000
339	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(4), PIGA(1), PIGN(1), PIGO(1), PIGU(1)	1341384	8	8	8	6	4	1	0	1	2	0	0.813	0.996	1.000
340	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(1), CHRM2(1), CHRM3(3), DRD1(3), DRD2(2), DRD3(1), DRD5(1), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1)	1418344	26	17	26	14	12	10	1	0	3	0	0.153	0.996	1.000
341	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1)	900546	3	2	3	2	1	1	0	0	1	0	0.789	0.996	1.000
342	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	2938856	31	16	31	6	18	5	1	4	3	0	0.00566	0.996	1.000
343	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	CDC42(1), CDH1(2), CTNNB1(2), CTTN(1), FYN(1), HCLS1(5), KRT18(1), NCK2(2), PRKCA(1), ROCK2(1), TLR4(3), TLR5(1), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	2938856	31	16	31	6	18	5	1	4	3	0	0.00566	0.996	1.000
344	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), DAXX(1), MAPKAPK3(1)	638975	3	2	3	2	3	0	0	0	0	0	0.689	0.996	1.000
345	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(3), GNPDA2(1), HEXA(2), HK3(2), PGM3(3)	949220	12	9	12	6	7	2	1	1	1	0	0.471	0.996	1.000
346	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPP5D(6), ITGB1BP3(2), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PRKCA(1), PRKCG(1), PTEN(5), SYNJ1(3), SYNJ2(1)	6950473	100	30	99	28	54	9	7	17	13	0	0.000993	0.997	1.000
347	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(4), PPP1CA(1)	1016146	5	5	5	2	4	0	1	0	0	0	0.557	0.997	1.000
348	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(2), FYN(1), L1CAM(1), LYN(1), SELP(1)	886792	9	7	9	6	6	1	0	1	1	0	0.774	0.997	1.000
349	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(1), BLNK(2), BTK(2), CD22(4), CR2(1), DAG1(1), INPP5D(6), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), PTPRC(3), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2)	4148905	48	21	48	12	30	2	3	10	3	0	0.00995	0.997	1.000
350	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	EDN1(1), EPO(1), LDHA(1), NOS3(1), P4HB(1)	958170	5	3	5	3	3	1	0	0	1	0	0.850	0.998	1.000
351	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(1), HRAS(1), MAP2K1(3), PLCB1(4), PRKCA(1), SYK(2), TBXAS1(3)	1363711	15	13	13	6	12	0	1	1	1	0	0.341	0.998	1.000
352	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(1), DPYD(5), DPYS(2), ENPP1(2), ENPP3(1), PANK3(1), VNN1(1)	966873	13	10	13	7	8	3	1	0	1	0	0.565	0.998	1.000
353	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(1), CCR3(1), CCR4(1), CXCR3(1), CXCR4(1), IL12B(1), IL12RB1(2), IL4R(1)	1120301	10	9	10	7	8	1	0	0	1	0	0.555	0.998	1.000
354	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), PGK2(3), RPIA(1), TKTL1(1), TKTL2(5)	1134029	17	9	17	8	11	1	0	4	1	0	0.355	0.998	1.000
355	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN2(3), ITGB3(1), SPTAN1(1), TLN1(2)	1582936	8	8	8	6	5	0	0	0	3	0	0.753	0.998	1.000
356	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	ARHGEF11(2), CDC42(1), DLG4(2), LPA(6), MAP3K1(1), MAP3K5(2), MAPK8(1), NFKB2(1), PIK3CB(5), PLD1(1), PLD2(2), ROCK2(1), SERPINA4(2)	2748740	27	17	26	9	15	1	1	6	4	0	0.230	0.998	1.000
357	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CLOCK(1), ETV6(2), HERPUD1(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER2(2), PSMA4(1), TOB1(1), UGP2(1), ZFR(1)	2047961	14	10	14	6	7	1	2	0	4	0	0.451	0.998	1.000
358	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(1), G6PD(1), GGT1(1), GPX5(1), GPX6(1), GSR(1), IDH1(3), OPLAH(2)	1229750	11	10	10	5	10	0	1	0	0	0	0.297	0.998	1.000
359	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), LDHA(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2)	2075753	15	12	15	6	10	2	0	1	2	0	0.354	0.998	1.000
360	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(4), COPA(1), GPLD1(4), KDELR3(1)	917297	10	8	10	8	7	0	1	1	1	0	0.821	0.998	1.000
361	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	TPO(5)	542072	5	3	4	4	5	0	0	0	0	0	0.712	0.998	1.000
362	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), TYK2(1)	587082	2	2	2	2	1	1	0	0	0	0	0.870	0.998	1.000
363	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL4R(1), TYK2(1)	587082	2	2	2	2	1	1	0	0	0	0	0.870	0.998	1.000
364	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ACY1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), ARG1(1), ASS1(1), CPS1(1), MAOA(1), SMS(1)	1640757	14	12	14	6	8	2	1	1	2	0	0.370	0.998	1.000
365	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(4), ACADM(1), ALDH1B1(1), ALDH3A1(2), ALDH6A1(2), ALDH7A1(1), ALDH9A1(1), EHHADH(1), LDHA(1), LDHAL6A(1), MLYCD(1), MUT(2), PCCA(2), PCCB(1)	2229712	21	12	21	5	15	2	0	3	1	0	0.0788	0.999	1.000
366	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(1), POLG(1), POLQ(2)	936648	4	3	4	3	2	0	0	1	1	0	0.895	0.999	1.000
367	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), GOT2(2), ME1(1), ME3(2), PGK1(1), RPIA(1)	1013636	8	6	8	6	5	0	0	2	1	0	0.721	0.999	1.000
368	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), MAPK8(1), RELA(1), TRAF6(1)	620140	4	4	4	3	4	0	0	0	0	0	0.829	0.999	1.000
369	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(1), GGT1(1), HEMK1(1), MAT2B(1), METTL2B(1), METTL6(1)	1404737	6	6	6	3	4	0	0	2	0	0	0.597	0.999	1.000
370	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AMDHD1(1), AOC2(1), CNDP1(1), FTCD(1), HDC(3), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), PRPS2(1), UROC1(2)	2215490	21	13	21	5	15	2	0	3	1	0	0.0307	0.999	1.000
371	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	GNAQ(2), MAP3K1(1), MYC(1), PRKAR1A(1), RELA(1), SYT1(1), VIP(1)	1564867	8	8	8	6	2	1	0	3	2	0	0.930	0.999	1.000
372	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(1), CA1(2), CA2(1), CA4(1), CA7(1), CPS1(1)	1183869	8	8	8	4	4	2	0	1	1	0	0.569	0.999	1.000
373	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), NCOA1(1)	1041758	4	4	4	2	3	0	0	1	0	0	0.790	0.999	1.000
374	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IKBKB(1), IL1B(1), IL1R1(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), RELA(1), TRAF6(1)	1654462	11	8	11	4	7	2	1	0	1	0	0.348	0.999	1.000
375	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GUSB(1), HEXA(2), LCT(3)	803420	6	3	6	4	6	0	0	0	0	0	0.656	0.999	1.000
376	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1)	742311	13	10	13	6	11	1	0	1	0	0	0.344	0.999	1.000
377	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC2A3(1)	1400270	27	15	27	6	22	3	1	1	0	0	0.266	0.999	1.000
378	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG13(1), ALG6(1), B4GALT3(1), DDOST(1), DOLPP1(1), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), STT3B(2)	2376182	15	9	15	8	7	2	1	1	4	0	0.549	0.999	1.000
379	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), LMNA(1), PRF1(2)	1094306	8	8	8	6	6	1	0	0	1	0	0.742	0.999	1.000
380	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), INPP4A(1), INPP4B(2), ISYNA1(1), ITGB1BP3(2), ITPKA(1), OCRL(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIP5K1B(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PTEN(5), SYNJ1(3), SYNJ2(1)	4138473	52	24	51	16	26	4	3	10	9	0	0.0385	0.999	1.000
381	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), SHMT2(1), TPO(5)	662664	7	4	6	3	6	1	0	0	0	0	0.332	1.000	1.000
382	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(1), ABCB4(2), ABCC3(3)	799655	12	10	12	8	11	0	0	1	0	0	0.476	1.000	1.000
383	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(1), ATR(5), BRCA2(2), FANCD2(1), MRE11A(1), RAD51(1), RAD9A(1), TP53(4)	2477961	16	12	16	7	7	1	2	2	4	0	0.594	1.000	1.000
384	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), CREB5(2), DAG1(1), EPHB2(2), GNAQ(2), ITPKA(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2)	1596584	19	13	19	9	13	1	0	3	2	0	0.551	1.000	1.000
385	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(1), BIN1(1), SYNJ1(3), SYNJ2(1), SYT1(1)	1204938	7	5	7	4	6	1	0	0	0	0	0.625	1.000	1.000
386	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	ATM(1), CASP7(1), PRKCA(1), TLN1(2), TP53(4)	1535116	9	8	9	6	5	1	1	0	2	0	0.697	1.000	1.000
387	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSL(1), ASNS(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1)	1463863	15	9	15	5	11	1	0	3	0	0	0.194	1.000	1.000
388	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(3), CYP11B1(3), CYP11B2(1), CYP19A1(2), HEMK1(1), HSD17B2(1), HSD17B3(1), HSD17B7(1), HSD3B2(1), METTL2B(1), METTL6(1), SRD5A1(1), SRD5A2(1), SULT1E1(4), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	2794747	55	22	55	17	40	5	2	4	4	0	0.00945	1.000	1.000
389	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), DRD1(3), DRD2(2), EGF(1), EGFR(1), GJA1(1), GJD2(2), GNAI3(1), GNAQ(2), GNAS(3), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), NPR1(2), NRAS(6), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), PRKX(1), SOS1(1), SOS2(2), TUBA1B(1), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBAL3(2), TUBB4(1), TUBB4Q(1), TUBB8(2)	7382711	115	29	106	31	70	11	13	16	5	0	2.63e-05	1.000	1.000
390	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), AKAP1(1), AKAP11(5), AKAP3(5), AKAP6(4), AKAP9(4), GNAI3(1), GNAQ(2), GNB5(1), HRAS(1), ITPR1(7), KCNJ3(4), NRAS(6), PDE1A(2), PDE1B(1), PDE1C(3), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), SLC9A1(1)	6551802	79	26	73	21	47	5	7	16	4	0	0.00259	1.000	1.000
391	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(1), EGF(1), EGFR(1), ETS1(1), ETS2(1), HRAS(1), IKBKB(1), MAP2K1(3), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK13(1), MAPK8(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), RELA(1), TRAF2(1)	2742452	25	17	23	9	16	4	3	0	2	0	0.153	1.000	1.000
392	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SMPD2(1), UGCG(1)	1347112	12	9	12	8	8	0	0	3	1	0	0.780	1.000	1.000
393	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH3A1(2), AOC2(1), GOT2(2), MAOA(1), TPO(5)	1229144	13	6	12	7	12	0	0	0	1	0	0.305	1.000	1.000
394	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1R1(1), IRAK1(1), MAP3K1(1), MAP3K14(1), RELA(1), TLR4(3), TRAF6(1)	1349719	10	6	10	4	6	4	0	0	0	0	0.419	1.000	1.000
395	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GABBR1(1), GPRC5D(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM7(7), GRM8(7)	1176071	31	16	30	16	16	3	4	2	6	0	0.233	1.000	1.000
396	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPS4Y1(1), RPS5(1), RPSA(1)	1264619	4	3	4	3	1	1	1	0	1	0	0.793	1.000	1.000
397	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), HDAC3(1), NCOA1(1), NCOA3(3), NCOR2(2), POLR2A(1)	1392567	9	6	9	5	6	1	0	1	1	0	0.624	1.000	1.000
398	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), ZNRD1(1)	1318974	6	6	6	4	3	0	1	1	1	0	0.797	1.000	1.000
399	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), GCK(3), GMPPA(1), HK3(2), PFKM(1)	1335688	8	6	8	8	5	2	0	0	1	0	0.777	1.000	1.000
400	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(2), CMAS(1), GNPDA2(1), HEXA(2), HK3(2), MTMR2(1), PGM3(3)	1605454	12	9	12	6	9	0	1	1	1	0	0.479	1.000	1.000
401	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(2), EPHB2(2), F2RL1(1), MAPK8(1), PLD1(1), PLD2(2), VAV1(2)	1534752	13	12	13	8	9	0	1	2	1	0	0.717	1.000	1.000
402	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACB(4), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), LDHA(1), LDHAL6A(1), LDHD(2), ME1(1), ME3(2), PC(1), PDHA2(2)	2624694	19	13	19	7	12	3	0	3	1	0	0.259	1.000	1.000
403	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(2), CALCRL(1), CRHR1(1), CRHR2(2), ELTD1(2), EMR2(1), GPR64(1), LPHN1(3), LPHN2(4), LPHN3(1), SCTR(3)	1480337	26	17	26	12	13	4	2	4	3	0	0.259	1.000	1.000
404	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(1), AGTR2(3), CMA1(1), COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3)	1414968	31	14	31	7	28	2	1	0	0	0	0.320	1.000	1.000
405	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	APC(3), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(2), DACT1(1), DKK2(3), LRP1(9), MVP(1), NKD2(1), SENP2(1), TSHB(1), WIF1(1)	2246687	27	12	27	10	14	1	5	7	0	0	0.319	1.000	1.000
406	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), CDC42(1), CREB5(2), EEF2K(2), EIF4E(1), IL1R1(1), MAP2K3(2), MAP3K5(2), MAPK12(1), MAPK13(1), TRAF6(1)	1863991	15	9	15	5	12	0	1	1	1	0	0.229	1.000	1.000
407	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(2), AOC2(1), DDHD1(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1421697	11	6	11	5	6	0	2	2	1	0	0.607	1.000	1.000
408	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BIRC3(1), CASP10(1), CASP7(1), CASP8(1), GAS2(1), LMNA(1), MAP3K14(1), RELA(1), SPTAN1(1), TNFRSF10B(1), TNFSF10(1), TRAF2(1)	1873046	12	11	12	6	8	3	0	0	1	0	0.524	1.000	1.000
409	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CREBBP(3), ERCC3(1), GRIP1(1), HDAC3(1), HDAC5(1), MEF2C(1), NCOR2(2), NRIP1(1), PELP1(2), POLR2A(1)	2558648	14	10	14	7	9	0	0	2	3	0	0.635	1.000	1.000
410	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(3), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K14(1), RELA(1), TLR2(2)	1663571	11	9	11	6	6	1	1	2	1	0	0.758	1.000	1.000
411	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2K(2), EIF2AK1(1), EIF2AK2(1), EIF2AK3(2), EIF2B2(1), EIF4A2(1), EIF4E(1), EIF4G1(1), EIF5(1), PABPC3(1)	2448944	12	9	12	6	7	0	2	1	2	0	0.687	1.000	1.000
412	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BTRC(1), CSNK1A1(1), CSNK1A1L(1), GLI1(2), GLI2(2), GLI3(2), HHIP(2), IHH(2), LRP2(7), PRKACA(1), PRKX(1), PTCH1(2), PTCH2(2), SHH(1), SMO(1), STK36(1), SUFU(1), WNT2B(1), WNT3(1), WNT7A(1)	3385564	39	16	39	11	27	2	3	4	3	0	0.0275	1.000	1.000
413	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP8(1), LMNA(1), MADD(1), MAP3K1(1), MAPK8(1), PRKDC(2), SPTAN1(1), TRAF2(1)	2181575	10	10	10	7	6	2	0	0	2	0	0.805	1.000	1.000
414	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN2(3), BCAR1(1), BCR(1), CAV1(1), FYN(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), SHC1(2), SOS1(1), TLN1(2), ZYX(1)	2621343	20	13	18	9	13	0	2	2	3	0	0.346	1.000	1.000
415	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	ATM(1), ATR(5), BAI1(2), CASP8(1), CCNB3(2), CCNE2(2), CDK6(1), CDKN2A(1), GADD45G(1), GTSE1(2), LRDD(1), MDM2(1), PTEN(5), RFWD2(1), RRM2B(1), SESN2(1), STEAP3(2), THBS1(3), TNFRSF10B(1), TP53(4), TP53I3(1), TSC2(1)	3638441	40	20	40	11	19	2	4	7	8	0	0.0798	1.000	1.000
416	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), ATP7B(2), COX10(1), NDUFB2(1), SDHA(2)	2150830	10	9	10	5	6	1	1	1	1	0	0.554	1.000	1.000
417	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAPK8(1), PRKDC(2), PTPN13(1), RIPK2(1), SPTAN1(1)	2295244	12	11	12	7	8	2	0	0	2	0	0.722	1.000	1.000
418	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CXCR3(1), EGF(1), EGFR(1), HRAS(1), MYLK(2), PRKAR1A(1), TLN1(2)	1821661	10	9	10	9	7	0	2	0	1	0	0.908	1.000	1.000
419	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ADSL(1), ASNS(1), ASS1(1), CAD(3), CRAT(1), GAD1(2), GAD2(3), GOT2(2), PC(1), PDHA2(2)	2123837	19	12	19	7	15	1	0	3	0	0	0.199	1.000	1.000
420	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), GNAQ(2), GNAS(3), HRAS(1), MAP2K1(3), PRKAR1A(1), PRKCA(1), SYT1(1)	1951103	15	13	12	9	12	0	0	2	1	0	0.710	1.000	1.000
421	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH3A1(2), AOC2(1), ESCO1(1), ESCO2(1), GOT2(2), MAOA(1), MYST3(1), MYST4(2), TPO(5)	1918885	18	9	17	8	14	0	2	1	1	0	0.325	1.000	1.000
422	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ASS1(1), CPS1(1), EPRS(2), GOT2(2), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), PYCR1(1), PYCR2(1), RARS(1)	2011395	20	13	20	9	16	2	1	1	0	0	0.301	1.000	1.000
423	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2)	1863850	16	8	16	6	12	1	0	3	0	0	0.287	1.000	1.000
424	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(1), GTF2H4(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3E(1), POLR3H(1), TAF6(1)	1970625	8	6	8	7	4	1	1	1	1	0	0.905	1.000	1.000
425	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP4A(2), ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), COX10(1), COX6B2(1), NDUFA13(1), NDUFB2(1), SDHA(2), SDHC(1), UQCRC2(1)	3140466	15	13	15	6	10	1	2	1	1	0	0.321	1.000	1.000
426	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), ESR2(2), ESRRA(1), HNF4A(1), NR1D2(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(1), PPARA(1), ROR1(3), RORC(1), THRA(2), THRB(3), VDR(1)	2337608	22	12	22	8	14	3	1	2	2	0	0.135	1.000	1.000
427	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(6), ARAF(1), BRAF(24), CACNA1C(3), CAMK2B(3), CAMK2G(1), CAMK4(2), CREBBP(3), GNAQ(2), GRIA1(7), GRIA2(4), GRIN2A(5), GRIN2B(3), GRM1(1), GRM5(2), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), NRAS(6), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP1CA(1), PPP1R12A(1), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), RAPGEF3(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1)	5539016	117	35	89	35	60	4	10	38	5	0	0.00326	1.000	1.000
428	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BIRC3(1), CASP1(1), CASP10(1), CASP7(1), CASP8(1), IKBKB(1), IRF3(1), IRF5(1), IRF6(4), MAP3K1(1), MAPK10(1), MDM2(1), MYC(1), PLEKHG5(3), PRF1(2), RELA(1), TNFRSF10B(1), TNFSF10(1), TP53(4), TRAF2(1)	3203347	29	20	29	11	20	4	0	2	3	0	0.173	1.000	1.000
429	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRA(1), COX10(1), CP(1), EPRS(2), FTMT(1), GUSB(1), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	2353172	40	18	40	13	30	3	1	2	4	0	0.0504	1.000	1.000
430	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), GOT2(2), MAOA(1), TPO(5)	1773946	25	10	24	12	24	0	0	0	1	0	0.178	1.000	1.000
431	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	CASP1(1), CASP10(1), CASP7(1), CASP8(1), DAXX(1), IKBKE(3), NGFR(1), NTRK1(4), PTPN13(1), TRAF2(1), TRAF6(1)	2430045	16	10	16	7	13	2	0	1	0	0	0.397	1.000	1.000
432	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH5A1(1), CAD(3), CPS1(1), EPRS(2), GAD1(2), GAD2(3), GMPS(2), GOT2(2), GSR(1)	2216812	17	9	17	8	13	1	0	3	0	0	0.441	1.000	1.000
433	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2H4(1), GTF2I(1), GTF2IRD1(1), STON1(1), TAF1L(6), TAF4(1), TAF4B(1), TAF6(1)	2027572	13	11	13	6	11	1	0	1	0	0	0.525	1.000	1.000
434	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(1), BLNK(2), BTK(2), DAG1(1), EPHB2(2), ITPKA(1), LYN(1), MAP2K1(3), MAP2K2(1), NFAT5(1), NFKB2(1), PIK3CA(1), PIK3R1(4), PPP1R13B(2), SERPINA4(2), SHC1(2), SOS1(1), SOS2(2), SYK(2), VAV1(2)	2957715	34	21	32	13	23	1	2	4	4	0	0.197	1.000	1.000
435	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), ARG1(1), CPS1(1), GOT2(2), MAOA(1), NOS1(7), NOS3(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(1)	2473432	28	15	28	11	20	4	1	0	3	0	0.138	1.000	1.000
436	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PRKCA(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	2142801	20	13	18	9	16	1	1	2	0	0	0.419	1.000	1.000
437	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(3), DAG1(1), DLG4(2), EPHB2(2), GNAQ(2), ITPR1(7), ITPR2(1), ITPR3(3), KCNJ3(4), KCNJ5(3), RYR1(6)	2563659	34	17	34	17	23	1	1	7	2	0	0.337	1.000	1.000
438	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1)	2499672	35	16	34	16	16	3	3	7	6	0	0.406	1.000	1.000
439	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	ENPP1(2), ENPP3(1), G6PC(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), PGM3(3), PYGL(2), SI(10), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2B15(4), UGT2B4(5)	3179420	55	21	55	20	37	5	3	4	6	0	0.0670	1.000	1.000
440	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	CARD11(3), CBL(3), CBLB(3), CBLC(1), CD8B(1), CDC42(1), FYN(1), GRAP2(1), HRAS(1), IKBKB(1), ITK(1), LCK(2), LCP2(1), MALT1(1), MAP3K14(1), NCK2(2), NFAT5(1), NFKB2(1), NRAS(6), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKCQ(2), PTPRC(3), RASGRP1(2), SOS1(1), SOS2(2), VAV1(2), VAV2(1), VAV3(1)	5682125	63	24	57	21	30	4	8	11	10	0	0.0858	1.000	1.000
441	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), EHHADH(1), PECI(1)	2755449	36	16	36	14	31	1	1	3	0	0	0.0919	1.000	1.000
442	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(2), AFMID(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP1A2(2), EHHADH(1), HEMK1(1), INMT(2), LNX1(2), MAOA(1), METTL2B(1), METTL6(1), NFX1(1), OGDHL(5), TPH1(4), TPH2(4)	3389043	39	16	38	15	30	3	0	4	2	0	0.0810	1.000	1.000
443	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(1), CD1B(1), CD1E(3), CD22(4), CD33(1), CD44(1), CD5(1), CD8B(1), CR1(1), CR2(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF3(1), CSF3R(2), DNTT(1), EPO(1), GYPA(1), HLA-DRB1(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGB3(1), KIT(1), KITLG(1), MME(2), MS4A1(1), TFRC(1), THPO(1), TPO(5)	4556914	66	19	65	25	43	4	5	7	7	0	0.0866	1.000	1.000
444	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	CDC42(1), CDKN2A(1), CREB5(2), ERBB4(3), IRS1(1), MET(4), MYC(1), PAK3(2), PAK7(1), PARD3(2), PARD6A(1), PIK3CA(1), PPP1R13B(2), PTEN(5), RPS6KA1(3), RPS6KA2(1), SHC1(2), SOS1(1), SOS2(2), TSC2(1)	4335042	37	22	37	15	17	3	4	7	6	0	0.441	1.000	1.000
445	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), AMHR2(1), BMP2(2), BMP5(2), BMP6(1), BMP8B(1), BMPR1B(1), BMPR2(1), CREBBP(3), CUL1(2), GDF5(1), INHBA(3), INHBB(1), LEFTY1(1), LTBP1(2), MYC(1), PPP2R2B(1), RBL1(1), RBL2(2), ROCK2(1), SMAD1(1), SMAD7(1), TFDP1(1), THBS1(3), THBS2(1), THBS3(1)	5554505	38	20	38	12	23	3	2	6	4	0	0.117	1.000	1.000
446	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), EHHADH(1), EHMT1(1), NSD1(1), OGDHL(5), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(1), SHMT2(1), SUV39H2(1), TMLHE(1)	3249561	25	15	25	11	18	5	0	2	0	0	0.278	1.000	1.000
447	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AGPAT6(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), CEL(2), DGAT2(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), GK2(3), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3)	3296320	42	20	42	20	32	5	1	3	1	0	0.201	1.000	1.000
448	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH3A1(2), AOC2(1), AOX1(3), DBH(1), ESCO1(1), ESCO2(1), GOT2(2), HEMK1(1), MAOA(1), METTL2B(1), METTL6(1), MYST3(1), MYST4(2), TPO(5)	3328573	33	13	32	14	28	0	2	2	1	0	0.180	1.000	1.000
449	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(3), DLL1(2), DLL3(1), DLL4(1), DTX1(1), DTX3(2), JAG1(2), JAG2(1), MAML3(2), MFNG(1), NCOR2(2), NOTCH2(4), NOTCH4(3), NUMB(2), NUMBL(1), PSENEN(1)	3851023	29	14	29	12	19	3	0	6	1	0	0.349	1.000	1.000
450	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC1(1), ANAPC2(1), ANAPC5(1), ATM(1), ATR(5), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC16(1), CDC25B(2), CDC25C(1), CDC27(1), CDC7(1), CDK6(1), CDKN2A(1), CREBBP(3), CUL1(2), E2F1(2), E2F3(1), FZR1(1), GADD45G(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), PRKDC(2), RBL1(1), RBL2(2), SMC1B(1), TFDP1(1), TP53(4), WEE1(1)	7645431	57	26	56	18	23	3	8	14	9	0	0.203	1.000	1.000
451	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ANGPTL2(1), ARHGAP4(1), ARHGEF11(2), BTK(2), CDC42(1), ITPR1(7), ITPR2(1), ITPR3(3), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PIK3CA(1), PIK3CG(1), PIK3R1(4), PPP1R13B(2), PTEN(5), ROCK2(1), WASF1(1)	3926462	41	21	41	19	24	1	3	6	7	0	0.364	1.000	1.000
452	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	BDNF(2), BRAF(24), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CACNA2D1(4), CACNA2D2(1), CACNA2D3(4), CACNA2D4(1), CACNB2(1), CACNG3(1), CACNG5(2), CACNG6(1), CACNG7(1), CDC25B(2), CDC42(1), CRK(1), DAXX(1), DUSP16(1), DUSP3(1), DUSP4(2), DUSP8(1), ECSIT(2), EGF(1), EGFR(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FLNB(5), FLNC(4), GADD45G(1), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(2), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAP3K12(1), MAP3K14(1), MAP3K5(2), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MAPKAPK3(1), MAPT(2), MEF2C(1), MRAS(1), MYC(1), NF1(7), NFKB2(1), NLK(2), NR4A1(1), NRAS(6), NTRK1(4), PDGFB(1), PDGFRA(5), PDGFRB(2), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(2), RAPGEF2(1), RASA2(1), RASGRF1(3), RASGRF2(1), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), RPS6KA6(1), SOS1(1), SOS2(2), TAOK1(1), TAOK2(2), TAOK3(1), TP53(4), TRAF2(1), TRAF6(1), ZAK(1)	15877246	209	37	180	93	109	18	16	48	18	0	0.112	1.000	1.000
453	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(24), CACNA1A(4), CRHR1(1), GNAI3(1), GNAQ(2), GNAS(3), GRIA1(7), GRIA2(4), GRID2(1), GRM1(1), GRM5(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), HRAS(1), IGF1R(1), ITPR1(7), ITPR2(1), ITPR3(3), LYN(1), MAP2K1(3), MAP2K2(1), NOS1(7), NOS3(1), NPR1(2), NRAS(6), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(3), RYR1(6)	6146353	127	35	99	47	71	5	10	36	5	0	0.0156	1.000	1.000
454	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN2(3), APC(3), ARAF(1), ARHGEF12(1), ARHGEF4(2), ARHGEF7(1), ARPC1A(1), BAIAP2(2), BCAR1(1), BDKRB2(1), BRAF(24), CDC42(1), CHRM2(1), CHRM3(3), CRK(1), CYFIP2(1), DIAPH3(1), EGF(1), EGFR(1), F2R(1), FGD1(1), FGF13(2), FGF16(1), FGFR2(1), FGFR3(1), FGFR4(1), FN1(4), GRLF1(1), HRAS(1), IQGAP2(2), IQGAP3(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K1(3), MAP2K2(1), MRAS(1), MYLK(2), MYLK2(3), NCKAP1(2), NCKAP1L(3), NRAS(6), PAK3(2), PAK7(1), PDGFB(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIP5K1B(2), PPP1CA(1), PPP1R12A(1), ROCK2(1), SCIN(1), SLC9A1(1), SOS1(1), SOS2(2), SSH2(1), TIAM1(2), TIAM2(2), VAV1(2), VAV2(1), VAV3(1), WASF1(1), WASF2(1)	15424721	163	35	135	85	87	4	12	46	14	0	0.556	1.000	1.000
455	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(5), ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CALCR(2), CALCRL(1), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CRHR1(1), CRHR2(2), CYSLTR1(1), CYSLTR2(2), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GABBR1(1), GABRA2(1), GABRA4(1), GABRA5(1), GABRA6(2), GABRB2(1), GABRB3(2), GABRG1(1), GABRG2(1), GABRP(2), GABRQ(4), GABRR1(1), GALR2(1), GHR(5), GHSR(3), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(3), GPR50(3), GPR83(1), GRIA1(7), GRIA2(4), GRIA4(1), GRID1(2), GRID2(1), GRIK1(1), GRIK2(1), GRIK3(2), GRIK4(2), GRIK5(2), GRIN2A(5), GRIN2B(3), GRIN3A(2), GRIN3B(1), GRM1(1), GRM2(2), GRM3(5), GRM4(1), GRM5(2), GRM6(3), GRM7(7), GRM8(7), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LEPR(3), LHCGR(3), MAS1(1), MC5R(1), MCHR1(1), MCHR2(3), NMBR(2), NMUR2(1), NPBWR2(2), NPFFR2(1), NPY2R(2), NPY5R(2), OPRK1(2), P2RX1(1), P2RX2(1), P2RX3(1), P2RY10(1), P2RY14(1), P2RY8(2), PARD3(2), PRLHR(1), PRLR(1), PRSS1(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(4), RXFP2(2), SCTR(3), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TAAR5(1), TACR1(1), TACR2(1), TACR3(3), THRA(2), THRB(3), TRHR(2), TSHB(1), TSHR(3)	12346560	237	33	236	130	144	31	14	21	27	0	0.0106	1.000	1.000
456	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADRA1A(2), ADRA1B(1), ATP1B2(2), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1S(2), CAMK1(1), CAMK2B(3), CAMK2G(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM2(1), CHRM3(3), GJA1(1), GJB4(1), GNAI3(1), GNAQ(2), GNB5(1), ITPR1(7), ITPR2(1), ITPR3(3), KCNB1(6), KCNJ3(4), KCNJ5(3), MIB1(1), PKIA(1), PLCB3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A3(5)	10452721	144	32	142	72	94	14	6	19	11	0	0.0473	1.000	1.000
457	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY3(1), ADCY4(2), ADCY8(6), ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), ATP2A2(2), ATP2A3(2), ATP2B1(2), ATP2B2(6), ATP2B4(1), BDKRB2(1), CACNA1A(4), CACNA1B(2), CACNA1C(3), CACNA1D(5), CACNA1E(4), CACNA1F(1), CACNA1H(3), CACNA1I(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CCKAR(1), CCKBR(2), CHRM2(1), CHRM3(3), CYSLTR1(1), CYSLTR2(2), DRD1(3), EDNRA(1), EDNRB(1), EGFR(1), ERBB3(1), ERBB4(3), F2R(1), GNAQ(2), GNAS(3), GRIN2A(5), GRM1(1), GRM5(2), HRH1(4), HRH2(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), ITPKA(1), ITPR1(7), ITPR2(1), ITPR3(3), LHCGR(3), MYLK(2), MYLK2(3), NOS1(7), NOS3(1), P2RX1(1), P2RX2(1), P2RX3(1), PDE1A(2), PDE1B(1), PDE1C(3), PDGFRA(5), PDGFRB(2), PHKA1(4), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLCD4(2), PLCE1(5), PLCZ1(6), PPP3R2(2), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), PTGFR(2), PTK2B(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), SLC8A2(2), SLC8A3(5), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TRPC1(1)	14975352	225	32	223	120	147	22	10	28	17	1	0.0342	1.000	1.000
458	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN2(3), ARHGAP5(1), BCAR1(1), BIRC3(1), BRAF(24), CAV1(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), CRK(1), CTNNB1(2), EGF(1), EGFR(1), FARP2(1), FLNB(5), FLNC(4), FN1(4), FYN(1), GRLF1(1), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), KDR(3), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), MAP2K1(3), MAPK10(1), MAPK8(1), MAPK9(2), MET(4), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), PARVA(1), PARVG(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(5), PDGFRB(2), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP1CA(1), PPP1R12A(1), PRKCA(1), PRKCG(1), PTEN(5), RELN(6), ROCK2(1), SHC1(2), SHC3(1), SOS1(1), SOS2(2), THBS1(3), THBS2(1), THBS3(1), TLN1(2), TLN2(2), TNR(6), TNXB(15), VAV1(2), VAV2(1), VAV3(1), VEGFA(2), VWF(2), ZYX(1)	20785636	278	32	254	101	176	15	14	50	23	0	0.00660	1.000	1.000
459	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTN2(3), DMD(3), MYBPC1(1), MYBPC2(2), MYBPC3(3), MYH7(4), MYH8(7), MYOM1(1), NEB(12), TNNI1(1), TNNI2(1), TTN(132)	7537263	171	32	170	66	126	9	5	20	11	0	0.0192	1.000	1.000
460	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ANGPTL2(1), ARHGEF7(1), BCAR1(1), BRAF(24), CAV1(1), CDC42(1), CDKN2A(1), CRK(1), EPHB2(2), FYN(1), GRB7(1), GRLF1(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(2), MYLK2(3), P4HB(1), PAK3(2), PAK7(1), PIK3CA(1), PIK3CB(5), PTEN(5), ROCK2(1), SHC1(2), SOS1(1), SOS2(2), TERF2IP(1), TLN1(2), TLN2(2), ZYX(1)	6818317	94	31	73	32	39	1	6	37	11	0	0.146	1.000	1.000
461	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTN2(3), ASH1L(2), CASK(1), CDC42(1), CGN(1), CLDN11(1), CLDN17(1), CLDN6(1), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CTTN(1), EPB41L1(1), EPB41L2(2), GNAI3(1), HCLS1(5), HRAS(1), IGSF5(1), INADL(3), LLGL2(2), MAGI1(2), MAGI2(7), MPDZ(1), MRAS(1), MYH1(11), MYH11(2), MYH13(3), MYH15(3), MYH2(9), MYH4(6), MYH7(4), MYH8(7), NRAS(6), PARD3(2), PARD6A(1), PARD6B(1), PPP2R2B(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PTEN(5), SPTAN1(1), SYMPK(1), TJP2(1), TJP3(3), ZAK(1)	10842296	122	30	117	73	79	17	7	10	9	0	0.469	1.000	1.000
462	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	CHAD(1), COL11A1(7), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DSC1(5), DSC3(3), DSG1(5), DSG2(1), DSG3(5), DSG4(6), FN1(4), GJA1(1), GJA10(1), GJB4(1), GJC1(1), GJC2(1), GJC3(1), GJD2(2), GJD4(1), IBSP(1), INA(2), ITGB4(2), KRT10(1), KRT12(1), KRT15(2), KRT16(1), KRT17(1), KRT18(1), KRT2(1), KRT24(1), KRT28(1), KRT3(3), KRT31(3), KRT32(1), KRT35(1), KRT38(1), KRT39(1), KRT4(1), KRT5(3), KRT6A(1), KRT6B(2), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT78(1), KRT8(1), KRT82(1), KRT83(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), LMNA(1), RELN(6), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2)	13970829	209	29	208	103	156	16	5	15	17	0	0.330	1.000	1.000
463	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB2(1), C1QA(1), C1QB(2), C1QC(1), C1R(1), C1S(5), C2(2), C3(3), C3AR1(1), C4BPA(2), C5(2), C6(10), C7(9), C8A(3), C8B(5), C9(3), CFB(1), CFH(6), CFI(3), CR1(1), CR2(1), F10(2), F11(3), F13A1(2), F13B(1), F2R(1), F3(2), F5(7), F7(2), F8(4), FGA(4), FGG(1), KLKB1(2), KNG1(3), MASP1(1), MBL2(1), PLAT(1), PLG(3), PROC(1), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINF2(2), TFPI(2), VWF(2)	5063859	117	29	117	41	84	7	2	13	11	0	0.0191	1.000	1.000
464	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CACNA1C(3), CACNA1D(5), CACNA1F(1), CACNA1S(2), CAMK2B(3), CAMK2G(1), CDC42(1), EGFR(1), GNAQ(2), GNAS(3), HRAS(1), ITPR1(7), ITPR2(1), ITPR3(3), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), NRAS(6), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLD1(1), PLD2(2), PRKACA(1), PRKCA(1), PRKX(1), PTK2B(1), SOS1(1), SOS2(2)	7082304	96	28	87	34	55	6	12	18	5	0	0.0139	1.000	1.000
465	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), CAMK2B(3), CAMK2G(1), CREB3L1(2), CREB3L3(1), CREBBP(3), CTNNB1(2), EDN1(1), EDNRB(1), FZD4(1), FZD8(2), GNAI3(1), GNAQ(2), GNAS(3), HRAS(1), KIT(1), KITLG(1), MAP2K1(3), MAP2K2(1), NRAS(6), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1)	6057962	70	28	62	30	45	6	10	8	1	0	0.0892	1.000	1.000
466	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ATF1(1), ATP2A2(2), ATP2A3(2), CAMK2B(3), CAMK2G(1), CNN1(1), CORIN(5), CRHR1(1), DGKZ(1), ETS2(1), GABPB2(1), GJA1(1), GNAQ(2), GNB5(1), GUCY1A3(5), IL1B(1), ITPR1(7), ITPR2(1), ITPR3(3), MIB1(1), MYLK2(3), NOS1(7), NOS3(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCH(1), PRKCQ(2), PRKCZ(1), RGS18(2), RGS3(1), RGS4(1), RGS6(2), RGS7(4), RGS9(1), RYR1(6), RYR2(6), RYR3(3), SLC8A1(6), TNXB(15)	9733860	127	28	125	57	85	12	6	15	9	0	0.0289	1.000	1.000
467	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), AMHR2(1), BMP2(2), BMPR1B(1), BMPR2(1), CCL13(1), CCL23(1), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CSF1(1), CSF1R(1), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), CXCL9(1), CXCR3(1), CXCR4(1), EDA2R(1), EGF(1), EGFR(1), EPO(1), FLT4(4), GDF5(1), GHR(5), HGF(1), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL17A(1), IL17RA(2), IL18RAP(3), IL19(1), IL1B(1), IL1R1(1), IL1R2(2), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), INHBA(3), INHBB(1), KDR(3), KIT(1), KITLG(1), LEPR(3), MET(4), MPL(1), NGFR(1), OSM(3), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(5), PDGFRB(2), PRLR(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF8(3), TNFSF10(1), TNFSF14(4), TNFSF8(1), TPO(5), VEGFA(2)	9909965	133	27	132	71	90	10	7	12	14	0	0.282	1.000	1.000
468	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2B(2), ADRA1A(2), ADRA1B(1), AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CCRL1(1), CHRM2(1), CHRM3(3), CMKLR1(1), CXCR3(1), CXCR4(1), DRD1(3), DRD2(2), DRD3(1), DRD5(1), EDNRA(1), EDNRB(1), F2R(1), F2RL1(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), GPR50(3), GPR83(1), GPR87(1), HCRTR1(1), HCRTR2(3), HRH1(4), HRH2(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(1), LHCGR(3), MAS1(1), MC5R(1), NMBR(2), NMUR2(1), NPY2R(2), NPY5R(2), OPRK1(2), OR11A1(1), OR1C1(2), OR1F1(2), OR1Q1(1), OR5V1(1), OR7A5(1), P2RY10(1), P2RY14(1), PTGFR(2), PTGIR(1), RGR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), SUCNR1(1), TRHR(2)	6784654	104	26	104	88	61	19	3	9	12	0	0.614	1.000	1.000
469	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(3), AXIN1(1), AXIN2(1), BTRC(1), CAMK2B(3), CAMK2G(1), CER1(1), CHD8(2), CREBBP(3), CSNK1A1(1), CSNK1A1L(1), CSNK2B(1), CTNNB1(2), CUL1(2), DAAM2(1), DKK2(3), FZD4(1), FZD8(2), LRP5(1), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(2), MMP7(2), MYC(1), NFAT5(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PORCN(1), PPP2R2B(1), PPP3R2(2), PRICKLE1(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKX(1), ROCK2(1), SENP2(1), SFRP2(1), TCF7(1), TP53(4), VANGL2(1), WIF1(1), WNT2B(1), WNT3(1), WNT7A(1)	9006767	81	26	81	39	40	6	7	19	9	0	0.524	1.000	1.000
470	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABLIM1(1), ABLIM3(2), ARHGEF12(1), CDC42(1), CXCR4(1), DCC(5), DPYSL5(2), EFNB3(3), EPHA1(2), EPHA3(1), EPHA4(2), EPHA6(9), EPHA7(2), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(1), EPHB6(5), FES(2), FYN(1), GNAI3(1), HRAS(1), L1CAM(1), MET(4), NCK2(2), NFAT5(1), NGEF(1), NRAS(6), NRP1(5), NTN4(1), NTNG1(1), PAK3(2), PAK7(1), PLXNA2(4), PLXNB1(2), PLXNB3(1), PLXNC1(2), PPP3R2(2), RGS3(1), ROBO1(1), ROBO2(5), ROCK2(1), SEMA3A(2), SEMA3D(2), SEMA3E(3), SEMA3G(1), SEMA4A(2), SEMA4D(1), SEMA4G(1), SEMA5A(1), SEMA5B(1), SEMA6C(1), SEMA6D(1), SLIT1(2), SLIT2(5), SLIT3(8), SRGAP3(2), UNC5A(1), UNC5B(3), UNC5C(3), UNC5D(4)	10960022	136	26	130	72	89	12	13	11	11	0	0.343	1.000	1.000
471	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), BMPR2(1), BUB1(3), CDS1(2), COL4A3BP(1), CSNK2B(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), ITPKA(1), NEK1(1), OCRL(1), PIK3C2A(2), PIK3C2B(1), PIK3C2G(7), PIK3CA(1), PIK3CB(5), PIK3CG(1), PLCB1(4), PLCB2(1), PLCB3(2), PLCB4(4), PLCD1(1), PLK3(2), PRKACA(1), PRKAR1A(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(3), RPS6KA2(1), RPS6KA4(1), STK11(1), VRK1(1)	6300021	74	26	73	32	39	7	5	12	11	0	0.260	1.000	1.000
472	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(2), CTCFL(3), DOT1L(3), EED(1), EHMT1(1), EZH1(1), EZH2(4), HCFC1(2), HSF4(2), JMJD6(1), KDM6A(1), MEN1(2), MLL(1), MLL2(7), MLL3(5), NSD1(1), PAXIP1(1), PPP1CA(1), PRDM9(5), PRMT1(1), SETD1A(1), SETD2(1), SETD7(1), SETDB2(1), SMYD3(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(1), WHSC1L1(1)	6635022	55	25	52	17	33	2	2	10	8	0	0.180	1.000	1.000
473	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	CDC42(1), HRAS(1), KDR(3), MAP2K1(3), MAP2K2(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NOS3(1), NRAS(6), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PPP3R2(2), PRKCA(1), PRKCG(1), PTGS2(1), VEGFA(2)	4039262	46	25	38	20	25	0	7	8	6	0	0.300	1.000	1.000
474	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN2(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(3), CSNK2B(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), EGFR(1), FARP2(1), FYN(1), IGF1R(1), INSR(2), LMO7(1), MET(4), NLK(2), PARD3(2), PTPRB(12), PTPRF(1), PTPRJ(4), PTPRM(1), PVRL2(1), TCF7(1), WASF1(1), WASF2(1)	6729754	57	25	57	22	33	2	3	12	7	0	0.237	1.000	1.000
475	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN2(3), ARHGAP5(1), BCAR1(1), CD99(1), CDC42(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CTNNA2(4), CTNNA3(2), CTNNB1(2), CXCR4(1), GNAI3(1), GRLF1(1), ICAM1(1), ITGA4(2), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MMP9(1), NOX3(3), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PRKCA(1), PRKCG(1), PTK2B(1), PTPN11(1), RAPGEF3(1), RAPGEF4(2), RASSF5(1), ROCK2(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2)	6930331	63	25	62	27	34	4	5	8	12	0	0.122	1.000	1.000
476	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NPR1(2), PDE1A(2), PDE4C(2), PDE4D(1), PDE6B(2), PDE6C(4), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), PRPS1L1(1), PRPS2(1), PRUNE(1)	7170188	70	25	68	29	53	6	2	5	4	0	0.0459	1.000	1.000
477	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD44(1), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(3), COL2A1(1), COL3A1(8), COL4A1(5), COL4A2(3), COL4A4(6), COL4A6(3), COL5A1(2), COL5A2(4), COL5A3(4), COL6A1(1), COL6A3(3), COL6A6(6), DAG1(1), FN1(4), FNDC1(8), FNDC3A(2), HSPG2(2), IBSP(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), LAMA1(5), LAMA2(3), LAMA3(6), LAMA5(2), LAMB1(1), LAMB3(4), LAMB4(3), LAMC2(1), LAMC3(1), RELN(6), SDC1(1), SV2B(1), THBS1(3), THBS2(1), THBS3(1), TNR(6), TNXB(15), VWF(2)	12558478	169	24	168	68	124	11	4	18	12	0	0.146	1.000	1.000
478	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM3(2), CD22(4), CD6(3), CD80(1), CD86(2), CD8B(1), CD99(1), CDH1(2), CDH15(1), CDH2(1), CDH4(1), CDH5(3), CLDN11(1), CLDN17(1), CLDN6(1), CNTN2(1), CNTNAP2(6), GLG1(1), HLA-DOA(1), HLA-DRB1(1), HLA-G(1), ICAM1(1), ITGA4(2), ITGA9(1), ITGB2(1), L1CAM(1), MAG(1), MPZ(1), NCAM1(1), NCAM2(2), NEO1(3), NLGN2(1), NRCAM(1), NRXN1(3), NRXN2(2), NRXN3(3), PTPRC(3), PTPRF(1), PTPRM(1), PVRL2(1), SDC1(1), SELE(2), SELP(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(7)	8212462	83	24	83	34	57	7	4	7	8	0	0.0553	1.000	1.000
479	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	CBL(3), CBLB(3), CBLC(1), CREBBP(3), CSF2RA(3), CSF2RB(1), CSF3(1), CSF3R(2), EPO(1), GHR(5), IFNA16(1), IFNA21(2), IFNA6(1), IL10RA(1), IL12B(1), IL12RB1(2), IL15RA(1), IL19(1), IL20RA(1), IL21R(1), IL22(1), IL22RA1(1), IL28A(1), IL29(1), IL3RA(1), IL4R(1), IL5RA(2), IL7R(6), IL9R(1), IRF9(1), JAK3(1), LEPR(3), MPL(1), MYC(1), OSM(3), OSMR(5), PIAS2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PIM1(1), PRLR(1), PTPN11(1), SOS1(1), SOS2(2), SPRY3(1), SPRY4(1), STAT3(1), STAT5A(1), STAT6(1), TPO(5), TYK2(1)	8151102	95	24	93	35	57	5	1	18	14	0	0.0666	1.000	1.000
480	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(1), CAPN10(1), CAPN11(2), CAPN5(3), CAPN6(1), CAPN7(1), CAPN9(1), CAV1(1), CDC42(1), CRK(1), FYN(1), GIT2(1), ITGA10(3), ITGA11(1), ITGA2(3), ITGA2B(1), ITGA4(2), ITGA5(5), ITGA7(2), ITGA9(1), ITGAD(2), ITGAE(3), ITGAX(2), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(3), MYLK2(3), PAK3(2), ROCK2(1), SDCCAG8(2), SHC1(2), SHC3(1), SOS1(1), TLN1(2), VAV2(1), VAV3(1), ZYX(1)	7449437	74	24	72	34	50	1	5	11	7	0	0.178	1.000	1.000
481	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(3), BDKRB2(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR2(1), CCR3(1), CCR4(1), CCR6(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(1), FPR1(2), FSHR(4), GALR2(1), GHSR(3), LHCGR(3), MC5R(1), NMBR(2), NPY2R(2), NPY5R(2), OPRK1(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(1), TACR1(1), TACR2(1), TACR3(3), TRHR(2), TSHR(3)	2934523	54	24	54	48	34	6	3	5	6	0	0.759	1.000	1.000
482	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), AKR1C1(1), AKR1C3(3), ALDH3A1(2), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A7(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	3199352	64	23	64	34	46	5	1	5	7	0	0.273	1.000	1.000
483	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(3), ADCY3(1), ADCY4(2), ADCY5(2), ADCY6(1), ADCY8(6), ADSL(1), AK5(1), ALLC(2), AMPD1(3), ENPP1(2), ENPP3(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(3), GUCY1A3(5), GUCY2D(2), GUCY2F(1), NME6(1), NPR1(2), NT5C1B(2), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(3), PDE2A(1), PDE4C(2), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(1), PDE9A(1), PFAS(1), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2B(1), XDH(6), ZNRD1(1)	9154208	88	22	86	40	65	9	3	5	6	0	0.0813	1.000	1.000
484	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), ENPP1(2), ENPP3(1), EP400(3), ERCC3(1), G6PC(2), G6PC2(3), GANC(1), GBA(2), GBE1(1), GCK(3), GUSB(1), GYS2(2), HK3(2), MGAM(9), MOV10L1(2), PGM3(3), PYGL(2), SI(10), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A7(1), UGT1A8(1), UGT1A9(1), UGT2A1(4), UGT2B10(2), UGT2B11(3), UGT2B15(4), UGT2B28(2), UGT2B4(5), UGT2B7(4)	6881704	86	22	86	36	56	8	3	6	13	0	0.132	1.000	1.000
485	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	CASP8(1), CD80(1), CD86(2), CXCL9(1), IFNA16(1), IFNA21(2), IFNA6(1), IKBKB(1), IKBKE(3), IL12B(1), IL1B(1), IRAK1(1), IRF3(1), IRF5(1), LBP(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), NFKB2(1), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), RELA(1), TLR1(1), TLR2(2), TLR3(1), TLR4(3), TLR5(1), TLR6(1), TLR7(1), TLR8(4), TRAF6(1)	5020124	60	22	57	26	37	4	4	8	7	0	0.169	1.000	1.000
486	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(3), F13B(1), F5(7), F7(2), F8(4), FGA(4), FGG(1), LPA(6), PLAT(1), PLG(3), SERPINB2(3), SERPINF2(2), VWF(2)	1971658	41	21	41	18	28	3	1	5	4	0	0.392	1.000	1.000
487	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(1), BUB1(3), CCNA1(5), CCNB3(2), CCNE2(2), CDC14A(1), CDC25B(2), CDC25C(1), CDC7(1), CDH1(2), CDKN2A(1), E2F1(2), E2F3(1), HDAC3(1), HDAC5(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MPEG1(1), MPL(1), PRKDC(2), RBL1(1), TBC1D8(1), TFDP1(1), TP53(4), WEE1(1)	6156148	43	21	42	19	20	2	4	9	8	0	0.539	1.000	1.000
488	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1B1(1), ALDH3A1(2), ALDH7A1(1), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), G6PC2(3), GAPDH(2), GCK(3), HK3(2), LDHA(1), LDHAL6A(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3), PGM3(3)	3259799	39	21	39	20	25	3	1	5	5	0	0.293	1.000	1.000
489	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA12(7), ABCA13(7), ABCA3(1), ABCA4(2), ABCA5(1), ABCA6(2), ABCA7(1), ABCA8(2), ABCA9(3), ABCB1(6), ABCB11(1), ABCB4(2), ABCB5(4), ABCC11(1), ABCC12(1), ABCC2(1), ABCC3(3), ABCC6(3), ABCC8(2), ABCC9(4), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG8(2), CFTR(2), TAP1(1)	6607080	65	21	65	42	48	4	2	6	5	0	0.481	1.000	1.000
490	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(3), COL4A3(4), COL4A4(6), COL4A5(3), COL4A6(3), F10(2), F11(3), F2R(1), F5(7), F8(4), FGA(4), FGG(1), KLKB1(2), PROC(1), SERPINC1(1)	2490503	50	21	50	17	37	3	2	4	4	0	0.508	1.000	1.000
491	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BFAR(1), BTK(2), CAD(3), CASP10(1), CASP8(1), CASP8AP2(2), CSNK1A1(1), DAXX(1), EGFR(1), EPHB2(2), MAP3K1(1), MAP3K5(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(1), MAPK9(2), MET(4), NFAT5(1), NFKB2(1), PTPN13(1), TP53(4), TPX2(2), TRAF2(1), TUFM(1)	4063144	41	21	41	19	27	3	2	4	5	0	0.381	1.000	1.000
492	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(1), CCNA1(5), CCNE2(2), CDKN2A(1), CREB3L1(2), CREB3L3(1), E2F1(2), E2F3(1), MCM2(1), MCM4(2), MCM6(1), MDM2(1), MYC(1), MYT1(2), POLA2(1), POLE(1), RBL1(1), TFDP1(1), TNXB(15), TP53(4), WEE1(1)	4399879	47	20	46	21	29	4	3	7	4	0	0.314	1.000	1.000
493	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), CEL(2), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), LCT(3), LIPC(1), PNLIP(1), PNLIPRP2(1), PPAP2B(3)	2705565	35	20	35	20	28	3	1	2	1	0	0.397	1.000	1.000
494	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADM(1), ACOX3(2), ACSL1(2), ACSL5(3), ACSL6(1), AQP7(1), CPT1A(1), CPT1C(2), CYP4A11(5), CYP4A22(2), CYP7A1(1), CYP8B1(1), EHHADH(1), FABP1(1), FABP5(1), FADS2(1), GK2(3), HMGCS2(1), ME1(1), MMP1(1), PPARA(1), SCP2(2), SLC27A2(2), SLC27A5(1), SLC27A6(2)	3677672	41	20	41	23	31	3	1	4	2	0	0.410	1.000	1.000
495	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(1), CAMK1(1), CAMK1G(2), CAMK4(2), CREBBP(3), CSNK1A1(1), EDN1(1), GATA4(1), HRAS(1), MAP2K1(3), MAPK8(1), MEF2C(1), MYH2(9), NKX2-5(1), PIK3CA(1), PIK3R1(4), PRKAR1A(1), SYT1(1)	2847402	36	20	34	19	23	2	2	4	5	0	0.531	1.000	1.000
496	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	CABIN1(2), CAMK2B(3), CAMK4(2), CREBBP(3), CSNK2B(1), FCER1A(2), FCGR3A(1), GATA4(1), GRLF1(1), HRAS(1), IL1B(1), ITK(1), MAPK8(1), MAPK9(2), MEF2B(1), MEF2D(1), MYF5(3), NCK2(2), NFAT5(1), NFKB2(1), NUP214(2), PTPRC(3), RELA(1), TRAF2(1), TRPV6(2), VAV1(2), VAV2(1), VAV3(1)	5101653	44	19	44	19	33	4	0	6	1	0	0.241	1.000	1.000
497	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3)	2738319	33	19	33	19	22	3	1	2	5	0	0.412	1.000	1.000
498	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), ALDOB(1), BPGM(1), G6PC(2), GAPDH(2), GCK(3), HK3(2), LDHA(1), PDHA2(2), PFKM(1), PGK1(1), PGM3(3)	2738319	33	19	33	19	22	3	1	2	5	0	0.412	1.000	1.000
499	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG13(1), ALG6(1), B4GALT3(1), B4GALT5(1), CHPF(1), CHST4(2), DDOST(1), EXTL3(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), HS3ST1(1), HS3ST2(1), HS6ST2(1), HS6ST3(4), MAN1A1(2), MAN1A2(2), MAN1C1(1), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(2), NDST4(5), ST3GAL3(1), STT3B(2), WBSCR17(2), XYLT1(3)	6138607	58	19	58	36	37	7	4	2	8	0	0.567	1.000	1.000
500	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK3(2), COL2A1(1), CPSF1(1), CPSF3(1), CSTF2T(1), DHX9(1), DICER1(1), GIPC1(1), LOC440563(3), NONO(2), NXF1(1), POLR2A(1), PRPF4(1), PRPF8(2), RBM5(2), RNGTT(2), SF3A2(1), SF3B1(2), SFRS12(1), SFRS7(2), SNRPA1(1), SNRPN(1), SNURF(1), SRRM1(3), U2AF2(1)	5958269	36	19	36	21	24	2	1	5	4	0	0.911	1.000	1.000
501	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(3), CAMK2B(3), CAMK2G(1), FYN(1), HRAS(1), MAP2K1(3), MAP2K2(1), MAPK8(1), MAPT(2), MYLK(2), PRKCA(1), PTK2B(1), SHC1(2), SOS1(1), STAT3(1), STAT5A(1), SYT1(1)	2327703	27	18	24	14	21	2	1	2	1	0	0.376	1.000	1.000
502	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), FCER1A(2), HRAS(1), LYN(1), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(2)	2408946	24	18	22	11	14	1	2	4	3	0	0.547	1.000	1.000
503	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(1), CCKBR(2), CCR2(1), CCR3(1), CELSR2(1), CELSR3(2), CHRM2(1), CHRM3(3), CXCR3(1), EDNRA(1), EMR2(1), F2R(1), FSHR(4), GPR116(1), GPR133(1), GPR135(1), GPR18(1), GRM1(1), LGR6(1), LPHN2(4), LPHN3(1), OR2M4(1), OR8G2(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(3)	3726992	41	18	41	23	25	5	2	6	3	0	0.327	1.000	1.000
504	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT6(1), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKI(3), DGKZ(1), ESCO1(1), ESCO2(1), GPD1(1), GPD1L(1), MYST3(1), MYST4(2), PCYT1B(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLD1(1), PLD2(2), PPAP2B(3), PTDSS2(1)	3660070	39	18	39	20	24	3	4	6	2	0	0.545	1.000	1.000
505	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX15(1), ALOX15B(2), ALOX5(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP4A11(5), CYP4A22(2), CYP4F3(1), GGT1(1), GPX5(1), GPX6(1), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3)	2171245	43	18	43	33	33	1	0	5	4	0	0.792	1.000	1.000
506	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	ATM(1), BIRC3(1), CASP10(1), CASP7(1), CASP8(1), CSF2RB(1), IKBKB(1), IL1B(1), IL1R1(1), IL3RA(1), IRAK1(1), MAP3K14(1), NFKB2(1), NTRK1(4), PIK3CA(1), PIK3CB(5), PIK3CG(1), PIK3R1(4), PIK3R3(1), PPP3R2(2), PRKACA(1), PRKAR1A(1), RELA(1), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), TP53(4), TRAF2(1)	4665186	42	18	41	19	19	5	2	6	10	0	0.400	1.000	1.000
507	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(6), CACNA1A(4), CACNA1B(2), GNAS(3), GRM4(1), ITPR3(3), KCNB1(6), PDE1A(2), PLCB2(1), PRKACA(1), PRKX(1), SCNN1B(1), SCNN1G(2), TAS1R2(2), TAS1R3(1), TAS2R1(2), TAS2R13(1), TAS2R16(2), TAS2R38(2), TAS2R41(3), TAS2R5(1), TAS2R60(3), TAS2R8(1), TAS2R9(1)	3173334	55	18	55	30	42	5	2	5	1	0	0.0796	1.000	1.000
508	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), DAG1(1), EPHB2(2), FBXW7(1), GRAP2(1), ITK(1), ITPKA(1), LCK(2), LCP2(1), NFAT5(1), NFKB2(1), PAK3(2), PAK7(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), RASGRP4(1), SOS1(1), SOS2(2), VAV1(2)	3108015	32	18	32	17	19	1	2	5	5	0	0.678	1.000	1.000
509	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(2), FPR1(2), HRAS(1), MAP2K1(3), MAP2K2(1), MAP2K3(2), MAP3K1(1), PIK3C2G(7), PLCB1(4), RELA(1), SYT1(1)	2136079	26	17	24	14	16	2	3	2	3	0	0.627	1.000	1.000
510	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	G6PC(2), G6PC2(3), GALE(1), GALK2(1), GANC(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3), UGP2(1)	2158300	30	17	30	16	20	2	0	1	7	0	0.290	1.000	1.000
511	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(3), DPYD(5), DPYS(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), NME6(1), NT5C1B(2), PNPT1(1), POLA2(1), POLE(1), POLR1B(1), POLR2A(1), POLR2I(1), POLR3A(1), POLR3H(1), PRIM2(1), RRM2B(1), TXNRD1(2), ZNRD1(1)	4540457	29	17	29	18	19	2	1	3	4	0	0.710	1.000	1.000
512	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(4), ACSL1(2), ACSL5(3), ACSL6(1), ADIPOR2(1), CAMKK2(1), CPT1A(1), CPT1C(2), G6PC(2), G6PC2(3), IKBKB(1), IRS1(1), JAK3(1), LEPR(3), MAPK10(1), MAPK8(1), MAPK9(2), NFKB2(1), PPARA(1), PPARGC1A(2), PRKAA2(2), PRKAG2(2), PRKCQ(2), PTPN11(1), RELA(1), STAT3(1), STK11(1), TRAF2(1), TYK2(1)	4646869	46	17	46	23	32	5	1	4	4	0	0.353	1.000	1.000
513	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(1), CAV1(1), FLT4(4), KDR(3), NOS3(1), PDE2A(1), PDE3A(3), PRKAR1A(1), PRKG1(1), PRKG2(3), RYR2(6), SYT1(1), TNNI1(1)	2281103	28	16	28	15	21	1	1	1	4	0	0.383	1.000	1.000
514	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), DPYD(5), DPYS(2), ENTPD1(1), POLE(1), POLG(1), POLQ(2), POLR1B(1), POLR2A(1), POLR2I(1), TXNRD1(2)	3212623	20	16	20	11	12	1	1	4	2	0	0.625	1.000	1.000
515	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(1), MAP3K1(1), MYLK(2), PDGFRA(5), PIK3CA(1), PIK3R1(4), PLD1(1), TRIO(1), VAV1(2), WASF1(1)	1967278	19	16	19	11	9	2	3	2	3	0	0.690	1.000	1.000
516	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(1), ANGPTL2(1), CDC42(1), FLNC(4), MYH2(9), MYLK(2), MYLK2(3), PAK3(2), PAK7(1), ROCK2(1), WASF1(1)	2678150	26	16	26	21	20	2	0	3	1	0	0.840	1.000	1.000
517	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FYN(1), HRAS(1), LCK(2), MAP2K1(3), MAP3K1(1), MAPK8(1), PIK3CA(1), PIK3R1(4), PRKCA(1), PTPN7(1), RELA(1), SHC1(2), SOS1(1), SYT1(1), VAV1(2)	2676081	23	16	21	10	13	1	3	2	4	0	0.446	1.000	1.000
518	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2R(1), F3(2), F5(7), F7(2), FGA(4), FGG(1), PROC(1), SERPINC1(1), TFPI(2)	920149	23	15	23	12	14	1	1	5	2	0	0.748	1.000	1.000
519	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	G6PC(2), GALE(1), GALK2(1), GCK(3), HK3(2), LCT(3), MGAM(9), PFKM(1), PGM3(3)	1820427	25	15	25	13	18	2	0	1	4	0	0.278	1.000	1.000
520	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPS(2), CDS1(2), CHAT(1), DGKA(1), DGKB(2), DGKD(2), DGKE(1), DGKG(3), DGKZ(1), GPD1(1), PCYT1B(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PLCB2(1), PPAP2B(3)	2799984	27	15	27	19	18	3	1	4	1	0	0.772	1.000	1.000
521	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(2), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2J2(2), CYP3A4(1), CYP3A43(1), CYP3A7(3), PLA2G2F(1), PLA2G3(3), PLA2G5(1), PLA2G6(2)	1338677	29	15	29	22	20	2	0	5	2	0	0.829	1.000	1.000
522	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CREBBP(3), EHHADH(1), FABP1(1), ME1(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(2), NRIP1(1), PIK3CA(1), PIK3R1(4), PPARA(1), PRKAR1A(1), PRKCA(1), PTGS2(1), RELA(1), STAT5A(1)	3548666	23	15	23	13	11	0	1	6	5	0	0.845	1.000	1.000
523	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH3A1(2), ALDH9A1(1), AOC2(1), AOX1(3), ASMT(1), CAT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), EHHADH(1), MAOA(1), TPH1(4)	3080018	45	15	45	30	34	2	1	4	4	0	0.630	1.000	1.000
524	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(3), AXIN1(1), CTNNB1(2), FZD8(2), LDLR(2), MAPK10(1), MAPK9(2), MYC(1), PPP2R5C(1), PRKCA(1), PRKCG(1), PRKCH(1), PRKCQ(2), PRKCZ(1), TCF7(1), WNT2B(1), WNT3(1), WNT7A(1)	3349047	25	15	25	16	17	2	3	3	0	0	0.709	1.000	1.000
525	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), FYN(1), HRAS(1), MAP2K1(3), MYLK(2), PIK3CA(1), PIK3R1(4), SHC1(2), TLN1(2)	2092633	17	14	15	11	10	0	2	1	4	0	0.740	1.000	1.000
526	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(1), ATR(5), CDC25B(2), CDC25C(1), MDM2(1), MYT1(2), PRKDC(2), RPS6KA1(3), TP53(4), WEE1(1)	2358795	22	14	22	10	7	3	2	5	5	0	0.764	1.000	1.000
527	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPT(1), ALPI(1), ALPP(2), ALPPL2(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C19(7), CYP2C8(1), CYP2C9(3), CYP2D6(1), CYP2J2(2), CYP3A4(1), CYP3A7(3), CYP4B1(1), PON1(1)	1635328	31	14	31	29	19	2	2	5	3	0	0.952	1.000	1.000
528	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), G6PC(2), GAPDH(2), GCK(3), GOT2(2), HK3(2), LDHA(1), PC(1), PDHA2(2), PFKM(1), PGK1(1), PGK2(3)	2381229	21	14	21	13	12	3	0	2	4	0	0.548	1.000	1.000
529	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), CAMK1(1), CAMK1G(2), HDAC5(1), IGF1R(1), INSR(2), MEF2B(1), MEF2C(1), MEF2D(1), PIK3CA(1), PIK3R1(4), SYT1(1)	1954000	18	14	18	11	9	0	1	3	5	0	0.674	1.000	1.000
530	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(2), ACSM1(2), ALDH1B1(1), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), DDHD1(1), EHHADH(1), GAD1(2), GAD2(3), HMGCS2(1), OXCT1(1), OXCT2(1), PDHA2(2)	2276648	22	14	22	12	15	1	0	5	1	0	0.546	1.000	1.000
531	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX15(1), ALOX5(1), CYP4F3(1), GGT1(1), PLA2G3(3), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS2(1), TBXAS1(3), TPO(5)	1560520	23	14	22	17	19	0	0	2	2	0	0.685	1.000	1.000
532	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BAG4(1), BIRC3(1), CASP7(1), CASP8(1), DAXX(1), LMNA(1), MAP3K1(1), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(1), PRKDC(2), RELA(1), SPTAN1(1), TRAF2(1)	3878429	17	13	17	10	11	3	0	1	2	0	0.697	1.000	1.000
533	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), AGTR2(3), EDN1(1), EDNRA(1), EDNRB(1), EGF(1), EGFR(1), HRAS(1), MYC(1), PRKCA(1), RELA(1)	1149062	14	12	14	9	10	1	2	1	0	0	0.763	1.000	1.000
534	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT11(1), GALNT12(1), GALNT13(4), GALNT4(2), GALNT6(2), GALNT8(1), GALNTL1(1), GALNTL2(4), GCNT1(1), GCNT3(2), WBSCR17(2)	1810144	22	12	22	15	15	2	2	0	3	0	0.764	1.000	1.000
535	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ATP6V0A2(1), ATP6V0A4(1), ATP6V1B2(1), ATP6V1C2(1), CDC42(1), EGFR(1), IGSF5(1), IKBKB(1), LYN(1), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK8(1), MAPK9(2), MET(4), NFKB2(1), PTPN11(1), PTPRZ1(2), RELA(1)	3939925	25	12	25	13	12	4	2	6	1	0	0.637	1.000	1.000
536	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(1), ARHGEF11(2), ARHGEF5(2), ARPC1A(1), BAIAP2(2), MYLK(2), PIP5K1B(2), TLN1(2)	2527146	15	12	15	14	12	1	0	1	1	0	0.890	1.000	1.000
537	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(1), CDR1(3), DGKI(3), RPLP2(1), RPS27A(2), RPS4Y1(1), RPS5(1), RPS6KA1(3), RPS6KA2(1), RPS6KA6(1), RPSA(1), SLC36A2(1), TSPAN9(1)	2919511	20	12	20	12	13	2	2	2	1	0	0.704	1.000	1.000
538	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	IKBKB(1), IRAK1(1), MAP2K3(2), MAP3K1(1), MAP3K14(1), MAPK8(1), PPARA(1), RELA(1), TLR10(1), TLR2(2), TLR3(1), TLR4(3), TLR6(1), TLR7(1), TRAF6(1)	2035812	19	12	19	13	9	5	2	2	1	0	0.805	1.000	1.000
539	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	GAL3ST1(1), GALC(1), GBA(2), LCT(3), PPAP2B(3), SGPP2(1), SMPD2(1), SMPD3(1), SMPD4(2), UGCG(1)	1989752	16	11	16	10	11	1	0	3	1	0	0.670	1.000	1.000
540	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), ESRRA(1), HDAC5(1), MEF2B(1), MEF2C(1), MEF2D(1), PPARA(1), SYT1(1)	1126221	16	11	16	11	11	1	0	2	2	0	0.723	1.000	1.000
541	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(1), AGTR1(1), AGTR2(3), BDKRB2(1), KNG1(3), NOS3(1)	555110	11	10	11	9	11	0	0	0	0	0	0.607	1.000	1.000
542	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), MCM2(1), MCM4(2), MCM6(1), POLA2(1), POLE(1), RFC1(2), RFC2(1), RPS27A(2)	2840049	12	10	11	11	8	0	1	2	1	0	0.958	1.000	1.000
543	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1), DHRS2(1), ESCO1(1), ESCO2(1), MYST3(1), MYST4(2)	1403236	14	10	14	9	11	0	2	1	0	0	0.765	1.000	1.000
544	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(1), ASCC3(1), ATP13A2(1), DDX50(1), DDX52(1), EP400(3), ERCC3(1), MOV10L1(2)	3499159	14	10	14	17	9	2	0	1	2	0	0.995	1.000	1.000
545	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT1(1), B3GNT4(1), B4GALT3(1), FUT3(2), FUT9(3), PIGA(1), PIGN(1), PIGO(1), PIGU(1), ST3GAL3(1), ST6GALNAC3(1), UGCG(1)	2711168	16	10	16	13	8	1	1	4	2	0	0.887	1.000	1.000
546	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNAQ(2), MYLK(2), PLCB1(4), PRKCA(1)	1164656	10	10	10	10	6	0	1	3	0	0	0.963	1.000	1.000
547	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(2), GRIN2A(5), GRIN2B(3), NOS1(7), PRKAR1A(1), PRKCA(1), SYT1(1)	1431022	20	10	20	13	15	1	1	1	2	0	0.579	1.000	1.000
548	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), HRAS(1), MAP2K1(3), MYC(1), PLCB1(4), PRKCA(1), RELA(1)	871668	12	9	10	8	8	0	1	3	0	0	0.776	1.000	1.000
549	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO2(1), IDH1(3), OGDHL(5), PC(1), SDHA(2), SDHC(1)	1681237	14	9	13	9	9	4	0	1	0	0	0.641	1.000	1.000
550	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(1), EPRS(2), FARS2(1), IARS2(1), KARS(2), LARS2(1), RARS(1)	3063253	11	9	11	13	9	0	1	1	0	0	0.983	1.000	1.000
551	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), PC(1), PDHA2(2), PDK4(1), PDP2(1), SDHA(2), SDHC(1)	1595189	9	9	9	9	6	2	0	1	0	0	0.928	1.000	1.000
552	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(2), CAMK2B(3), CAMK2G(1), CAMK4(2), CAMKK2(1), SYT1(1)	651215	11	8	11	8	8	1	0	2	0	0	0.753	1.000	1.000
553	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD33(1), CD5(1), IL12B(1), ITGAX(2), TLR2(2), TLR4(3), TLR7(1)	1043040	12	8	12	10	7	2	2	1	0	0	0.763	1.000	1.000
554	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), PLCB2(1), SARDH(1), SHMT2(1)	2357609	12	8	12	12	5	3	1	2	1	0	0.937	1.000	1.000
555	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AMT(1), AOC2(1), BHMT(1), CBS(1), GCAT(1), GLDC(1), MAOA(1), SARDH(1), SHMT2(1)	2395548	11	8	11	13	5	2	1	2	1	0	0.974	1.000	1.000
556	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(1), BECN1(1), IFNA16(1), IFNA21(2), IFNA6(1), PIK3R4(1), PRKAA2(2), ULK1(1), ULK2(1)	1179022	11	8	11	7	9	1	0	1	0	0	0.728	1.000	1.000
557	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(1), ATP6V1C2(1), GNAS(3), PRKCA(1), SEC61A2(1)	2077242	11	8	11	9	8	1	0	2	0	0	0.812	1.000	1.000
558	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), EPRS(2), FARS2(1), KARS(2), LARS2(1), RARS(1)	1807235	9	7	9	9	7	0	1	1	0	0	0.949	1.000	1.000
559	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO2(1), IDH1(3), PC(1), SDHA(2)	1161077	7	7	6	5	5	2	0	0	0	0	0.731	1.000	1.000
560	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), ENPP1(2), ENPP3(1), NT5C1B(2)	1205341	8	7	8	5	5	2	1	0	0	0	0.692	1.000	1.000
561	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(1), GBA(2), GUSB(1), HEXA(2), LCT(3), SPAM1(3)	1916185	12	7	12	8	11	0	0	1	0	0	0.662	1.000	1.000
562	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	CPT1A(1), LEPR(3), PRKAA2(2), PRKAG2(2)	816866	8	7	8	6	7	1	0	0	0	0	0.817	1.000	1.000
563	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(1), CREBBP(3), CTNNB1(2)	1863996	9	7	9	6	6	0	1	2	0	0	0.827	1.000	1.000
564	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(2), PLCB1(4), PRKCA(1), RELA(1)	459458	8	7	8	5	4	0	1	3	0	0	0.841	1.000	1.000
565	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(2), HTR2C(2), PLCB1(4)	400712	8	7	8	6	3	1	1	3	0	0	0.844	1.000	1.000
566	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(4), ADH1C(1), ADHFE1(1)	317238	8	6	8	5	8	0	0	0	0	0	0.631	1.000	1.000
567	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), GNAQ(2), MAPK8(1), PRKCA(1), PTK2B(1), SYT1(1)	773956	7	6	7	5	4	1	0	2	0	0	0.742	1.000	1.000
568	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(1), GMPPA(1), HK3(2), MTMR2(1), PFKFB2(1), PFKM(1), PGM2(1)	2071571	8	6	8	10	6	0	0	1	1	0	0.927	1.000	1.000
569	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1)	1171907	7	6	7	5	5	0	0	2	0	0	0.775	1.000	1.000
570	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), ACE2(1), AGT(1), AGTR1(1), AGTR2(3), ANPEP(1), CMA1(1), ENPEP(1), MAS1(1), MME(2), NLN(1)	1184910	14	6	14	13	11	0	1	0	2	0	0.890	1.000	1.000
571	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CXCR3(1), IL12B(1), IL12RB1(2), MAPK8(1), TYK2(1)	1041985	6	6	6	6	5	1	0	0	0	0	0.904	1.000	1.000
572	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CBS(1), DNMT1(1), DNMT3A(1), DNMT3B(1), MAT2B(1), MTR(1)	984552	7	6	7	5	5	0	0	2	0	0	0.768	1.000	1.000
573	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACB(4), OLAH(2)	880349	6	5	6	5	5	1	0	0	0	0	0.718	1.000	1.000
574	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GUSB(1), HEXA(2), LCT(3), SPAM1(3)	1141775	9	5	9	6	9	0	0	0	0	0	0.644	1.000	1.000
575	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), STX11(1), STX17(1), STX6(1)	933537	5	5	5	5	3	1	1	0	0	0	0.920	1.000	1.000
576	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CXCR3(1), IL12B(1), IL12RB1(2), TYK2(1)	818134	5	5	5	5	4	1	0	0	0	0	0.877	1.000	1.000
577	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC3(1), CASP8(1), NFKB2(1), TRAF2(1)	1516759	5	5	5	4	5	0	0	0	0	0	0.810	1.000	1.000
578	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(2), PRKCA(1), SYT1(1)	1174535	4	4	4	9	2	0	0	2	0	0	0.999	1.000	1.000
579	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), HEXA(2), LCT(3)	1136452	6	4	6	5	6	0	0	0	0	0	0.771	1.000	1.000
580	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	HEXA(2), LCT(3), ST6GALNAC3(1)	923311	6	4	6	5	5	0	0	1	0	0	0.790	1.000	1.000
581	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	AMT(1), FTCD(1), GART(1), MTR(1), SHMT2(1)	1062376	5	4	5	4	2	2	0	1	0	0	0.903	1.000	1.000
582	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(1), HLA-DRB1(1), IL12B(1)	740567	4	4	4	4	4	0	0	0	0	0	0.742	1.000	1.000
583	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), MEF2D(1), PRKCA(1), SYT1(1)	1374164	5	4	5	10	5	0	0	0	0	0	0.998	1.000	1.000
584	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), HEXA(2), LCT(3)	921713	6	4	6	5	6	0	0	0	0	0	0.795	1.000	1.000
585	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	AMT(1), GART(1), MTR(1), SHMT2(1)	1004373	4	4	4	4	1	2	0	1	0	0	0.953	1.000	1.000
586	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CSNK1A1(1), MAPT(2)	508649	5	4	4	4	3	0	1	1	0	0	0.861	1.000	1.000
587	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1), PTGFR(2), PTGIR(1)	624894	4	4	4	6	3	0	0	1	0	0	0.916	1.000	1.000
588	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), EPO(1), KITLG(1)	462933	3	3	3	6	3	0	0	0	0	0	0.974	1.000	1.000
589	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(1), PON1(1), PON3(1)	506352	3	3	3	3	2	0	1	0	0	0	0.821	1.000	1.000
590	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), GOT2(2), PAH(1)	488976	4	3	4	4	3	0	0	1	0	0	0.920	1.000	1.000
591	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), SDHA(2)	530707	3	3	3	4	2	1	0	0	0	0	0.903	1.000	1.000
592	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	FARS2(1), GOT2(2), PAH(1)	468513	4	3	4	4	3	0	0	1	0	0	0.896	1.000	1.000
593	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), GGT1(1), MAT2B(1)	699564	3	3	3	3	2	0	0	1	0	0	0.856	1.000	1.000
594	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), CSF3(1), EPO(1)	339972	3	3	3	4	3	0	0	0	0	0	0.835	1.000	1.000
595	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS2(1)	301591	3	2	3	4	3	0	0	0	0	0	0.883	1.000	1.000
596	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(1), RELA(1)	704639	2	2	2	4	2	0	0	0	0	0	0.984	1.000	1.000
597	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CSF3(1), KITLG(1)	344695	2	2	2	3	2	0	0	0	0	0	0.902	1.000	1.000
598	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2B(2)	334227	2	2	2	3	2	0	0	0	0	0	0.772	1.000	1.000
599	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(1)	271197	1	1	1	2	1	0	0	0	0	0	0.934	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1)	476178	1	1	1	2	0	0	1	0	0	0	0.962	1.000	1.000
601	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(1)	500260	1	1	1	2	1	0	0	0	0	0	0.963	1.000	1.000
602	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(1)	664603	1	1	1	3	1	0	0	0	0	0	0.984	1.000	1.000
603	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	TYK2(1)	605765	1	1	1	3	0	1	0	0	0	0	0.983	1.000	1.000
604	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PRKCA(1), PTK2B(1)	377901	2	1	2	3	1	1	0	0	0	0	0.885	1.000	1.000
605	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	MTA3(1)	602382	1	1	1	2	1	0	0	0	0	0	0.915	1.000	1.000
606	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8		318260	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		254854	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		40470	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		269329	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		28800	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		125914	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		119079	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6		458643	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		179980	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		63601	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7		327364	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
