Clinical Features Time to Death AGE PRIMARY.SITE.OF.DISEASE GENDER RADIATIONS.RADIATION.REGIMENINDICATION DISTANT.METASTASIS LYMPH.NODE.METASTASIS TUMOR.STAGECODE NEOPLASM.DISEASESTAGE nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Chi-square test_P Chi-square test_Q t-test_P t-test_Q Chi-square test_P Chi-square test_Q BRAF 98 (53%) 86 0.31164 1 0.080602 1 0.039338 1 0.54018 1 0.1002 1 0.48054 1 0.63725 1 NA NA 0.45495 1 C15ORF23 11 (6%) 173 0.51556 1 0.70713 1 0.7012 1 0.74865 1 1 1 0.97035 1 0.36209 1 NA NA 0.50649 1 CDKN2A 28 (15%) 156 0.72639 1 0.99936 1 0.10885 1 1 1 0.39237 1 0.8322 1 0.67045 1 NA NA 0.2663 1 NRAS 52 (28%) 132 0.94433 1 0.56842 1 0.092212 1 1 1 0.55982 1 0.57459 1 0.73834 1 NA NA 0.45944 1 OXA1L 5 (3%) 179 0.63823 1 0.63344 1 0.72994 1 1 1 1 1 0.99238 1 1.7268e-05 0.0145 NA NA 0.40395 1 STK19 10 (5%) 174 0.4855 1 0.3152 1 0.84392 1 0.33488 1 1 1 0.97584 1 0.96883 1 NA NA 0.67395 1 TP53 29 (16%) 155 0.668 1 0.028438 1 0.71798 1 1 1 0.40406 1 0.79392 1 0.10964 1 NA NA 0.643 1 TTN 144 (78%) 40 0.19492 1 0.83172 1 0.91036 1 0.19455 1 0.52286 1 0.63998 1 0.44155 1 NA NA 0.17366 1 UGT2B15 18 (10%) 166 0.55816 1 0.61139 1 0.70283 1 0.30108 1 1 1 0.18447 1 0.032635 1 NA NA 0.11887 1 PTEN 17 (9%) 167 0.64091 1 0.37184 1 0.93565 1 0.60835 1 0.25361 1 0.00096857 0.803 0.68588 1 NA NA 0.16825 1 RAC1 12 (7%) 172 0.12808 1 0.45013 1 0.50348 1 1 1 0.18411 1 0.97035 1 0.89501 1 NA NA 0.60874 1 PPP6C 18 (10%) 166 0.0032946 1 0.93642 1 0.97802 1 1 1 1 1 0.67296 1 0.069814 1 NA NA 0.87659 1 PRB2 28 (15%) 156 0.40374 1 0.0019791 1 0.11715 1 0.091502 1 1 1 0.81988 1 0.14566 1 NA NA 0.16198 1 IDH1 10 (5%) 174 0.91209 1 0.20032 1 0.75195 1 0.74756 1 1 1 0.35888 1 0.94188 1 NA NA 0.68846 1 NAP1L2 18 (10%) 166 0.21635 1 0.25079 1 0.62371 1 0.44588 1 1 1 0.67296 1 0.050565 1 NA NA 0.56116 1 FIGLA 3 (2%) 181 0.044369 1 0.50653 1 0.81646 1 0.55394 1 0.048379 1 NA NA 0.9278 1 NA NA NA NA RBM11 13 (7%) 171 0.62481 1 0.10065 1 0.6579 1 0.38369 1 0.19834 1 0.52737 1 0.048624 1 NA NA 0.56582 1 HBG2 7 (4%) 177 0.43551 1 0.16792 1 0.87059 1 1 1 1 1 0.98522 1 0.0022025 1 NA NA 0.82329 1 LCE1B 9 (5%) 175 0.086126 1 0.70773 1 0.9499 1 0.7239 1 1 1 0.98081 1 0.92268 1 NA NA 0.51126 1 MUC7 11 (6%) 173 0.30635 1 0.00028572 0.238 0.7012 1 0.74865 1 1 1 0.96433 1 0.76694 1 NA NA 0.45437 1 DDX3X 17 (9%) 167 0.48642 1 0.62122 1 0.68177 1 0.11764 1 1 1 0.0028301 1 0.93815 1 NA NA 0.7106 1 CDH9 29 (16%) 155 0.2698 1 0.32877 1 0.066022 1 1 1 1 1 0.79435 1 0.14196 1 NA NA 0.060693 1 HIST1H2AA 7 (4%) 177 0.67462 1 0.99883 1 0.55641 1 0.70267 1 1 1 0.98522 1 0.93047 1 NA NA 0.63988 1 GFRAL 25 (14%) 159 0.94134 1 0.94545 1 0.1551 1 0.8232 1 0.3564 1 0.52757 1 0.15798 1 NA NA 0.061137 1 TBC1D3B 4 (2%) 180 0.027633 1 0.31795 1 0.27005 1 1 1 1 1 0.99723 1 0.95821 1 NA NA 0.66626 1 HHLA2 13 (7%) 171 0.5904 1 0.20526 1 0.22483 1 0.77328 1 0.19834 1 0.9578 1 0.0090048 1 NA NA 0.8871 1 COPG2 3 (2%) 181 0.42428 1 0.9857 1 0.81646 1 1 1 1 1 0.99723 1 0.987 1 NA NA 0.014803 1 IL32 8 (4%) 176 0.028746 1 0.76427 1 0.58642 1 1 1 0.1255 1 0.98522 1 0.87785 1 NA NA 0.0029553 1 PRB4 18 (10%) 166 0.041928 1 0.14321 1 0.10829 1 0.30108 1 1 1 0.6439 1 0.067362 1 NA NA 0.77601 1 NBPF7 9 (5%) 175 0.029246 1 0.033523 1 0.4669 1 0.16034 1 0.0062503 1 0.98081 1 0.0040375 1 NA NA 0.77184 1 POM121 12 (7%) 172 0.2193 1 0.96803 1 0.3366 1 0.5419 1 1 1 0.96433 1 0.026142 1 NA NA 0.01674 1 ARID2 28 (15%) 156 0.79023 1 0.046064 1 0.4182 1 0.28428 1 0.39237 1 0.85585 1 0.12594 1 NA NA 0.25102 1 MAP2K1 9 (5%) 175 0.77387 1 0.43902 1 0.066262 1 1 1 1 1 0.083121 1 0.28846 1 NA NA 0.91495 1 DEFB118 7 (4%) 177 0.083151 1 0.61211 1 0.76546 1 1 1 1 1 0.98522 1 0.0026976 1 NA NA 0.64101 1 HBD 9 (5%) 175 0.12475 1 0.88479 1 0.30215 1 0.7239 1 1 1 0.97584 1 0.89419 1 NA NA 0.25013 1 ANKRD20A4 4 (2%) 180 0.4153 1 0.57424 1 0.8621 1 0.29846 1 1 1 0.9951 1 1.3495e-06 0.00113 NA NA 0.45331 1 GLRB 22 (12%) 162 0.5299 1 0.22197 1 0.06025 1 0.81413 1 1 1 0.76639 1 0.25934 1 NA NA 0.93038 1 NR1H4 12 (7%) 172 0.59609 1 0.62875 1 0.89772 1 0.21681 1 1 1 0.96433 1 0.012841 1 NA NA 0.54751 1 OR51S1 19 (10%) 165 0.59461 1 0.23179 1 0.87647 1 0.80327 1 0.28026 1 0.91792 1 0.053831 1 NA NA 0.32161 1 TFEC 15 (8%) 169 0.31644 1 0.12819 1 0.65551 1 1 1 1 1 0.94326 1 0.0012171 1 NA NA 0.4782 1 UNC119B 3 (2%) 181 0.95599 1 0.3689 1 1 1 1 1 1 1 0.99723 1 0.987 1 NA NA 0.44117 1 ZNF479 18 (10%) 166 0.43802 1 0.12864 1 0.73968 1 1 1 1 1 0.38278 1 0.21669 1 NA NA 0.8534 1 FAM19A1 9 (5%) 175 0.34598 1 0.70073 1 0.66514 1 1 1 0.14041 1 0.98081 1 0.52876 1 NA NA 0.76119 1 GIMAP7 13 (7%) 171 0.81226 1 0.037129 1 0.82995 1 0.14005 1 0.19834 1 0.9578 1 0.5189 1 NA NA 0.24964 1 KLHL4 18 (10%) 166 0.11381 1 0.59217 1 0.37136 1 0.79947 1 1 1 0.93527 1 0.081317 1 NA NA 0.5181 1 NOTCH2NL 9 (5%) 175 0.94098 1 0.80115 1 0.1748 1 0.49299 1 1 1 0.98081 1 0.35619 1 NA NA 0.31897 1 PRC1 9 (5%) 175 0.72044 1 0.42021 1 0.60824 1 0.49299 1 1 1 0.98081 1 0.77519 1 NA NA 0.94108 1 ZMAT4 5 (3%) 179 0.24427 1 0.00037487 0.312 0.19577 1 0.65589 1 0.07975 1 0.99238 1 8.1173e-06 0.0068 NA NA 0.92597 1 PDE1A 27 (15%) 157 0.8301 1 0.13537 1 0.10287 1 0.52135 1 1 1 0.8322 1 0.07245 1 NA NA 0.50935 1 GML 9 (5%) 175 0.89333 1 0.061709 1 1 1 0.16034 1 0.14041 1 0.98081 1 0.52876 1 NA NA 0.91331 1 OR4N2 21 (11%) 163 0.85994 1 0.25491 1 0.89118 1 0.0070915 1 0.30627 1 0.068068 1 0.19175 1 NA NA 0.68284 1 ACSM2B 33 (18%) 151 0.51256 1 0.83219 1 0.20009 1 0.0083657 1 0.4493 1 0.75401 1 0.13999 1 NA NA 0.86213 1 USP17L2 16 (9%) 168 0.93647 1 0.71829 1 0.63765 1 0.17653 1 1 1 0.93527 1 0.075796 1 NA NA 0.04534 1 TAF1A 10 (5%) 174 0.14797 1 0.53997 1 0.64592 1 0.33488 1 1 1 0.11888 1 0.80209 1 NA NA 0.76203 1 OR5H2 13 (7%) 171 0.23097 1 0.014507 1 1 1 1 1 1 1 0.95077 1 0.017815 1 NA NA 0.58726 1 PHGDH 8 (4%) 176 0.85225 1 0.72668 1 0.55761 1 0.05215 1 1 1 0.98909 1 0.00045562 0.379 NA NA 0.075075 1 BAGE2 12 (7%) 172 0.51894 1 0.97943 1 0.12043 1 1 1 1 1 0.42094 1 0.037745 1 NA NA 0.36109 1 FUT9 18 (10%) 166 0.22522 1 0.035747 1 0.40869 1 0.60671 1 1 1 0.90858 1 0.085944 1 NA NA 0.20078 1 MPP7 22 (12%) 162 0.8757 1 0.015844 1 1 1 0.23678 1 1 1 0.46604 1 0.11419 1 NA NA 0.92987 1 TRAT1 11 (6%) 173 0.06463 1 0.58232 1 0.92194 1 0.52722 1 1 1 0.97035 1 0.009751 1 NA NA 0.7651 1 C9ORF119 5 (3%) 179 0.30875 1 0.35395 1 1 1 0.16164 1 1 1 0.99238 1 5.7915e-06 0.00486 NA NA 0.75685 1 TUBB8 9 (5%) 175 0.89057 1 0.62966 1 1 1 0.49299 1 0.14041 1 0.98522 1 0.0022025 1 NA NA 0.80048 1 ACD 8 (4%) 176 0.83726 1 0.85206 1 0.20474 1 0.26217 1 1 1 0.98081 1 0.0046099 1 NA NA 0.41796 1 C8A 23 (12%) 161 0.48001 1 0.06816 1 1 1 0.062335 1 0.33165 1 0.079692 1 0.3451 1 NA NA 0.45014 1 KIAA1257 8 (4%) 176 0.25853 1 0.34278 1 0.68248 1 0.26217 1 1 1 0.98909 1 0.91923 1 NA NA 0.76557 1 SNAP91 22 (12%) 162 0.63416 1 0.184 1 0.50683 1 0.095587 1 1 1 0.48882 1 0.25846 1 NA NA 0.93142 1 CCK 5 (3%) 179 0.10206 1 0.75564 1 0.72994 1 0.65589 1 1 1 0.9951 1 0.0075241 1 NA NA 0.70048 1 SPINK13 6 (3%) 178 0.11609 1 0.18086 1 0.91814 1 0.42233 1 1 1 0.98909 1 3.3267e-06 0.00279 NA NA 0.74304 1 ANXA10 11 (6%) 173 0.37478 1 0.83238 1 0.82802 1 0.33243 1 0.0094773 1 0.97584 1 0.010025 1 NA NA 0.62712 1 LIN7A 9 (5%) 175 0.72509 1 0.61048 1 0.30215 1 0.49299 1 1 1 0.98522 1 0.0021241 1 NA NA 0.4282 1 C2 8 (4%) 176 0.82394 1 0.67803 1 0.79573 1 0.71331 1 1 1 0.98522 1 0.00052216 0.434 NA NA 0.26248 1 DGAT2L6 10 (5%) 174 0.33129 1 0.36999 1 0.40507 1 0.74756 1 1 1 0.97584 1 0.0041253 1 NA NA 0.70497 1 RAPGEF5 9 (5%) 175 0.92951 1 0.41463 1 0.15035 1 0.49299 1 1 1 0.98522 1 5.2434e-05 0.0438 NA NA 0.38548 1 OR2L3 15 (8%) 169 0.90068 1 0.89519 1 0.13925 1 0.78181 1 1 1 0.020192 1 0.069465 1 NA NA 0.23457 1 ZNF679 16 (9%) 168 0.95956 1 0.27905 1 0.78016 1 1 1 1 1 0.93527 1 0.79409 1 NA NA 0.26366 1 NAP1L4 7 (4%) 177 0.20667 1 0.17127 1 0.81748 1 0.70267 1 0.11042 1 0.98522 1 0.38613 1 NA NA 0.39507 1 PARM1 14 (8%) 170 0.3598 1 0.26074 1 0.24274 1 0.77314 1 1 1 0.95077 1 0.00064162 0.533 NA NA 0.10991 1 DEFB119 6 (3%) 178 0.23696 1 0.17358 1 0.21448 1 1 1 1 1 0.99238 1 0.95298 1 NA NA 0.36237 1 RGS18 8 (4%) 176 0.83944 1 0.23902 1 0.39028 1 0.05215 1 1 1 0.98522 1 0.94848 1 NA NA 0.88946 1 VEGFC 16 (9%) 168 0.94354 1 0.84935 1 0.2077 1 0.58717 1 1 1 0.94326 1 0.011345 1 NA NA 0.18475 1 ARL16 5 (3%) 179 0.19056 1 0.030471 1 0.051271 1 0.65589 1 1 1 0.99238 1 0.85307 1 NA NA 0.086782 1 CACNA1H 20 (11%) 164 0.41017 1 0.68864 1 0.94505 1 0.62969 1 1 1 0.91792 1 0.16921 1 NA NA 0.50684 1 CCNE2 10 (5%) 174 0.049477 1 0.91499 1 0.070135 1 0.74756 1 1 1 0.97035 1 0.89589 1 NA NA 0.32624 1 FRG2B 11 (6%) 173 0.7318 1 0.026926 1 0.95777 1 0.20557 1 1 1 0.96433 1 0.85903 1 NA NA 0.58093 1 SPAG16 14 (8%) 170 0.5975 1 0.43705 1 0.94286 1 0.77314 1 1 1 0.9578 1 0.038218 1 NA NA 0.3733 1 USP29 30 (16%) 154 0.23816 1 0.029337 1 0.72109 1 0.30171 1 1 1 0.81988 1 0.20599 1 NA NA 0.14957 1 GH2 10 (5%) 174 0.48235 1 0.51716 1 0.39078 1 1 1 1 1 0.98081 1 0.0016559 1 NA NA 0.033459 1 ST18 36 (20%) 148 0.84707 1 0.17312 1 0.74277 1 1 1 1 1 0.74009 1 0.35313 1 NA NA 0.27345 1 CCDC102B 21 (11%) 163 0.44822 1 0.50202 1 0.89118 1 1 1 1 1 0.89882 1 0.076584 1 NA NA 0.83378 1 B2M 4 (2%) 180 0.53487 1 0.38306 1 0.8621 1 0.29846 1 1 1 0.99723 1 0.987 1 NA NA 0.59531 1 CD2 15 (8%) 169 0.32828 1 0.29089 1 0.3599 1 0.78181 1 1 1 0.047733 1 0.098293 1 NA NA 0.65844 1 SLC38A4 24 (13%) 160 0.9822 1 0.11991 1 0.38987 1 0.040478 1 1 1 0.86716 1 0.30356 1 NA NA 0.96322 1 OR8D4 9 (5%) 175 0.030709 1 0.65576 1 0.3937 1 1 1 1 1 0.98081 1 0.0051014 1 NA NA 0.93412 1 MKX 11 (6%) 173 0.31874 1 0.71855 1 0.67867 1 0.74865 1 1 1 0.98081 1 0.0050124 1 NA NA 0.01309 1 SPATA8 8 (4%) 176 0.70216 1 0.034781 1 1 1 1 1 1 1 0.98081 1 0.002429 1 NA NA 0.31173 1 GPR137 8 (4%) 176 0.048435 1 0.96456 1 0.64756 1 0.05215 1 1 1 0.98522 1 0.0022025 1 NA NA 0.85582 1 GRXCR2 12 (7%) 172 0.22861 1 0.90556 1 0.57707 1 1 1 1 1 0.97035 1 0.014517 1 NA NA 0.57766 1 C2ORF40 4 (2%) 180 0.89061 1 0.42223 1 0.064711 1 0.61884 1 1 1 0.99723 1 0.95821 1 NA NA NA NA CADM2 18 (10%) 166 0.34934 1 0.99949 1 0.36145 1 1 1 1 1 0.90858 1 0.062641 1 NA NA 0.49435 1 OR5J2 11 (6%) 173 0.60457 1 0.80481 1 0.54283 1 0.20557 1 1 1 0.97584 1 0.9943 1 NA NA 0.71546 1 SIGLEC14 8 (4%) 176 0.6518 1 0.046808 1 0.16355 1 0.05215 1 1 1 0.98522 1 0.0026976 1 NA NA 0.26699 1 CX3CL1 3 (2%) 181 0.40842 1 0.92532 1 0.63471 1 1 1 1 1 NA NA NA NA NA NA NA NA GNAI2 4 (2%) 180 0.17845 1 0.50459 1 0.65727 1 0.61884 1 1 1 0.99723 1 1.5544e-10 1.31e-07 NA NA 0.44297 1 OR52J3 12 (7%) 172 0.21491 1 0.29567 1 0.61053 1 1 1 1 1 0.96433 1 0.021288 1 NA NA 0.75181 1 AREG 6 (3%) 178 0.45245 1 0.28134 1 0.91814 1 0.66839 1 1 1 0.99238 1 5.8576e-05 0.0489 NA NA 0.33932 1 RUNDC3B 13 (7%) 171 0.69236 1 0.11101 1 0.85519 1 0.14005 1 0.19834 1 0.96433 1 0.057046 1 NA NA 0.91312 1